KCNN2

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

Description

Potassium calcium-activated channel subfamily N member 2

Tissue specificity

Tissue enhanced (adrenal gland, brain, liver)

Subcell location

Nucleoplasm, Plasma membrane

Predicted location

Membrane

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters
Voltage-gated ion channels

Chromosome

5 (114055926 - 114496500)

Ensembl ID

ENSG00000080709  (ver. 103.38)

Orthologs

Mouse Kcnn2: ENSMUSG00000054477

UniProt

Q9H2S1

neXtProt

NX_Q9H2S1

Human splice variants
Mouse splice variants

Protein structure