BS2422

antibody from Bioworld Technology, Inc
Targeting: RAD21 hHR21, KIAA0078, SCC1
Provider product page for BS2422
Western blot
Immunohistochemistry

Antibody data

Product number
BS2422 - Provider product page
Provider
Bioworld Technology, Inc
Product name
Rad21 (D548) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 521-570 of Human Rad21.
Description
Rad21 is one of the major cohesin subunits that holds sister chromatids together until anaphase, when proteolytic cleavage by separase, a caspaselike enzyme, allows chromosomal separation. Rad21 interacts with Rec8 to form a cohesin complex that functions in sister chromatid alignment. Rad21 is also involved in the repair of double-strand breaks in DNA and is essential for mitotic growth. Rad21 undergoes a C-terminal cleavage induced by diverse stimuli right before apoptosis. The cleavage product migrates to the cytoplasm and is involved in early events in the apoptotic pathway and it amplifiies the cell death signal in a positive-feedback manner.
Reactivity
Human, Mouse
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
RAD21 protein structure - BS2422 shown in red.