Antibody data

Product number
Ab124351 - Provider product page
Provider
Aladdin Scientific
Product name
Recombinant Rad21 Antibody
Antibody type
Recombinant
Description
Rabbit anti Human Rad21 Antibody, Recombinant,Êcould be used forÊÊWB, IHC, ICC, IF and so on.Application:á WB: 1/500-1/1000áÊIHC: 1/50-1/100Êá ICC/IF: 1/50-1/200Protein Function_Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway.
Reactivity
Human, Hamster
Host
Rabbit
Conjugate
Unconjugated
Antigen sequence
AA 600-631
Vial size
100_l,10_l,1ml,50_l
Concentration
0,6 mg/ml
Storage
Store at 4¡C short term (1-2 weeks). Store at -20¡C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
RAD21 protein structure - Ab124351 shown in red.