Antibody data
- Antibody Data
- Antigen structure
- References [82]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
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- Product number
- 14351-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14351-1-AP, RRID:AB_10640525
- Product name
- NR1H3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated NR1H3 antibody (Cat. #14351-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Toosendanin induces hepatotoxicity via disrupting LXRα/Lipin1/SREBP1 mediated lipid metabolism.
Maternal PFOS exposure in mice induces hepatic lipid accumulation and inflammation in adult female offspring: Involvement of microbiome-gut-liver axis and autophagy.
Mecp2 fine-tunes quiescence exit by targeting nuclear receptors.
Dock5 Deficiency Promotes Proteinuric Kidney Diseases via Modulating Podocyte Lipid Metabolism.
Protective effect of Saussurea involucrata polysaccharide against skin dryness induced by ultraviolet radiation.
Diterpenoids inhibit ox-LDL-induced foam cell formation in RAW264.7 cells by promoting ABCA1 mediated cholesterol efflux.
HuangQi ChiFeng decoction maintains gut microbiota and bile acid homeostasis through FXR signaling to improve atherosclerosis.
The cellular trajectories of tumor-associated macrophages decipher the heterogeneity of pancreatic cancer.
Liver X receptor agonists exert antitumor effects against hepatocellular carcinoma via inducing REPS2 expression.
Gamma-Muricholic Acid Inhibits Nonalcoholic Steatohepatitis: Abolishment of Steatosis-Dependent Peroxidative Impairment by FXR/SHP/LXRα/FASN Signaling.
Supplemental Clostridium butyricum modulates lipid metabolism by reshaping the gut microbiota composition and bile acid profile in IUGR suckling piglets.
Cabernet sauvignon dry red wine ameliorates atherosclerosis in mice by regulating inflammation and endothelial function, activating AMPK phosphorylation, and modulating gut microbiota.
Resveratrol Modulates the Redox Response and Bile Acid Metabolism to Maintain the Cholesterol Homeostasis in Fish Megalobrama amblycephala Offered a High-Carbohydrate Diet.
T0901317, a liver X receptor agonist, ameliorates perinatal white matter injury induced by ischemia and hypoxia in neonatal rats.
Cholesterol-Lowering Activity of Vitisin A Is Mediated by Inhibiting Cholesterol Biosynthesis and Enhancing LDL Uptake in HepG2 Cells.
Hepatic Huwe1 loss protects mice from non-alcoholic fatty liver disease through lipid metabolic rewiring.
p21-activated kinase 4 suppresses fatty acid β-oxidation and ketogenesis by phosphorylating NCoR1.
Therapeutic role of Artemether in the prevention of hepatic steatosis through miR-34a-5p/PPARα pathway.
Camellia (Camellia oleifera bel.) seed oil reprograms gut microbiota and alleviates lipid accumulation in high fat-fed mice through the mTOR pathway.
Pseudorabies Virus Inhibits Expression of Liver X Receptors to Assist Viral Infection.
KLF2 alleviates endothelial cell injury and inhibits the formation of THP‑1 macrophage‑derived foam cells by activating Nrf2 and enhancing autophagy.
Clitoria ternatea blue petal extract protects against obesity, oxidative stress, and inflammation induced by a high-fat, high-fructose diet in C57BL/6 mice.
Opuntia dillenii Haw. Polysaccharide Promotes Cholesterol Efflux in THP-1-Derived Foam Cells via the PPARγ-LXRα Signaling Pathway.
Metformin mitigates cholesterol accumulation via the AMPK/SIRT1 pathway to protect osteoarthritis chondrocytes.
The protective effects of sulforaphane on high-fat diet-induced metabolic associated fatty liver disease in mice via mediating the FXR/LXRα pathway.
Melatonin ameliorates diabetic hyperglycaemia-induced impairment of Leydig cell steroidogenic function through activation of SIRT1 pathway.
Aldehyde dehydrogenase 2 and PARP1 interaction modulates hepatic HDL biogenesis by LXRα-mediated ABCA1 expression.
B-cell lymphoma 6 alleviates nonalcoholic fatty liver disease in mice through suppression of fatty acid transporter CD36.
Encapsulation of LXR ligand by D-Nap-GFFY hydrogel enhances anti-tumorigenic actions of LXR and removes LXR-induced lipogenesis.
Relationships between di-(2-ethylhexyl) phthalate exposure and lipid metabolism in adolescents: Human data and experimental rat model analyses.
Polysaccharide MCP extracted from Morchella esculenta reduces atherosclerosis in LDLR-deficient mice.
Diosmetin Ameliorates Nonalcoholic Steatohepatitis through Modulating Lipogenesis and Inflammatory Response in a STAT1/CXCL10-Dependent Manner.
Cordycepin attenuates high-fat diet-induced non-alcoholic fatty liver disease via down-regulation of lipid metabolism and inflammatory responses.
Dingxin Recipe IV attenuates atherosclerosis by regulating lipid metabolism through LXR-α/SREBP1 pathway and modulating the gut microbiota in ApoE(-/-) mice fed with HFD.
Xinnaokang improves cecal microbiota and lipid metabolism to target atherosclerosis.
Novel Metabolic Regulation of Bile Acid Responses to Low Cholesterol in Whole-Grain-Diet-Fed Mice.
2-Hydroxypropyl-β-cyclodextrin Regulates the Epithelial to Mesenchymal Transition in Breast Cancer Cells by Modulating Cholesterol Homeostasis and Endoplasmic Reticulum Stress.
Betaine prevented high-fat diet-induced NAFLD by regulating the FGF10/AMPK signaling pathway in ApoE(-/-) mice.
Targeting macrophage liver X receptors by hydrogel-encapsulated T0901317 reduces atherosclerosis without effect on hepatic lipogenesis.
EGFR/FOXO3A/LXR-α Axis Promotes Prostate Cancer Proliferation and Metastasis and Dual-Targeting LXR-α/EGFR Shows Synthetic Lethality.
Didymin ameliorates dexamethasone-induced non-alcoholic fatty liver disease by inhibiting TLR4/NF-κB and PI3K/Akt pathways in C57BL/6J mice.
Regulation mechanism of silkworm pupa oil PUFAs on cholesterol metabolism in hepatic cell L-02.
Geniposide reduces cholesterol accumulation and increases its excretion by regulating the FXR-mediated liver-gut crosstalk of bile acids.
Transcriptome analysis reveals a protective role of liver X receptor alpha against silica particle-induced experimental silicosis.
Hydrogen sulfide accumulates LDL receptor precursor via downregulating PCSK9 in HepG2 cells.
Thioredoxin-1 promotes macrophage reverse cholesterol transport and protects liver from steatosis.
Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1.
Therapeutic Effect of Chitooligosaccharide Tablets on Lipids in High-Fat Diets Induced Hyperlipidemic Rats.
Metformin ameliorates Ox-LDL-induced foam cell formation in raw264.7 cells by promoting ABCG-1 mediated cholesterol efflux.
Endogenous cholesterol ester hydroperoxides modulate cholesterol levels and inhibit cholesterol uptake in hepatocytes and macrophages.
LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma.
Simvastatin improves olanzapine-induced dyslipidemia in rats through inhibiting hepatic mTOR signaling pathway.
Correction: Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Cholesterol-lowering effects and potential mechanisms of chitooligosaccharide capsules in hyperlipidemic rats.
Upregulation of 24(R/S),25-epoxycholesterol and 27-hydroxycholesterol suppresses the proliferation and migration of gastric cancer cells.
Functional interplay between liver X receptor and AMP-activated protein kinase α inhibits atherosclerosis in apolipoprotein E-deficient mice - a new anti-atherogenic strategy.
25-Hydroxycholesterol activates the expression of cholesterol 25-hydroxylase in an LXR-dependent mechanism.
Activation of hepatic Nogo-B receptor expression-A new anti-liver steatosis mechanism of statins.
Asiatic acid from Potentilla chinensis alleviates non-alcoholic fatty liver by regulating endoplasmic reticulum stress and lipid metabolism.
Activation of liver X receptor plays a central role in antiviral actions of 25-hydroxycholesterol.
Liver X receptors agonists suppress NLRP3 inflammasome activation.
Medium-chain fatty acid reduces lipid accumulation by regulating expression of lipid-sensing genes in human liver cells with steatosis.
MEK1/2 inhibitors activate macrophage ABCG1 expression and reverse cholesterol transport-An anti-atherogenic function of ERK1/2 inhibition.
Arsenic trioxide suppresses liver X receptor β and enhances cholesteryl ester transfer protein expression without affecting the liver X receptor α in HepG2 cells.
Activation of liver X receptor inhibits the development of pulmonary carcinomas induced by 3-methylcholanthrene and butylated hydroxytoluene in BALB/c mice.
VNN1 promotes atherosclerosis progression in apoE-/- mice fed a high-fat/high-cholesterol diet.
Lipoxin A4 promotes ABCA1 expression and cholesterol efflux through the LXRα signaling pathway in THP-1 macrophage-derived foam cells.
Protective effects of heparin on endothelial cells in sepsis.
Regulation of Hepatic Cholesteryl Ester Transfer Protein Expression and Reverse Cholesterol Transport by Inhibition of DNA Topoisomerase II.
Propofol up-regulates expression of ABCA1, ABCG1, and SR-B1 through the PPARγ/LXRα signaling pathway in THP-1 macrophage-derived foam cells.
RP5-833A20.1/miR-382-5p/NFIA-dependent signal transduction pathway contributes to the regulation of cholesterol homeostasis and inflammatory reaction.
Potent effects of dioscin against obesity in mice.
Inhibition of tumor growth by U0126 is associated with induction of interferon-γ production.
LXRalpha gene downregulation by lentiviral-based RNA interference enhances liver function after fatty liver transplantation in rats.
Chronic unpredictable mild stress combined with a high-fat diets aggravates atherosclerosis in rats.
Dihydrocapsaicin down-regulates apoM expression through inhibiting Foxa2 expression and enhancing LXRα expression in HepG2 cells.
Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
A lincRNA-DYNLRB2-2/GPR119/GLP-1R/ABCA1-dependent signal transduction pathway is essential for the regulation of cholesterol homeostasis.
Identification of interferon-γ as a new molecular target of liver X receptor.
Dihydrocapsaicin Attenuates Plaque Formation through a PPARγ/LXRα Pathway in apoE(-/-) Mice Fed a High-Fat/High-Cholesterol Diet.
Protein tyrosine phosphatase inhibition down-regulates ligand-induced ABCA1 expression.
DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux-an LXR-dependent mechanism.
Chen S, Ni J, Luo L, Lin J, Peng H, Shen F, Huang Z
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 May;187:114631
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 May;187:114631
Maternal PFOS exposure in mice induces hepatic lipid accumulation and inflammation in adult female offspring: Involvement of microbiome-gut-liver axis and autophagy.
Yi W, Shi J, Wang L, Wang D, Wang Y, Song J, Xin L, Jiang F
Journal of hazardous materials 2024 May 15;470:134177
Journal of hazardous materials 2024 May 15;470:134177
Mecp2 fine-tunes quiescence exit by targeting nuclear receptors.
Yang J, Zou S, Qiu Z, Lai M, Long Q, Chen H, Lai PL, Zhang S, Rao Z, Xie X, Gong Y, Liu A, Li M, Bai X
eLife 2024 May 15;12
eLife 2024 May 15;12
Dock5 Deficiency Promotes Proteinuric Kidney Diseases via Modulating Podocyte Lipid Metabolism.
Qu H, Liu X, Zhu J, Xiong X, Li L, He Q, Wang Y, Yang G, Zhang L, Yang Q, Luo G, Zheng Y, Zheng H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(11):e2306365
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(11):e2306365
Protective effect of Saussurea involucrata polysaccharide against skin dryness induced by ultraviolet radiation.
Wang L, Yang K, Jing R, Zhao W, Guo K, Hu Z, Liu G, Xu N, Zhao J, Lin L, Gao S
Frontiers in pharmacology 2023;14:1089537
Frontiers in pharmacology 2023;14:1089537
Diterpenoids inhibit ox-LDL-induced foam cell formation in RAW264.7 cells by promoting ABCA1 mediated cholesterol efflux.
Zhang C, Wu X, Shi P, Ma H, Fang F, Feng Q, Zhao S, Zhang R, Huang J, Xu X, Xiao W, Cao G, Ji X
Frontiers in pharmacology 2023;14:1066758
Frontiers in pharmacology 2023;14:1066758
HuangQi ChiFeng decoction maintains gut microbiota and bile acid homeostasis through FXR signaling to improve atherosclerosis.
Fu J, Liang Y, Shi Y, Yu D, Wang Y, Chen P, Liu S, Lu F
Heliyon 2023 Nov;9(11):e21935
Heliyon 2023 Nov;9(11):e21935
The cellular trajectories of tumor-associated macrophages decipher the heterogeneity of pancreatic cancer.
Lin J, Lu F, Wu Y, Huang H, Pan Y
Functional & integrative genomics 2023 Nov 22;23(4):343
Functional & integrative genomics 2023 Nov 22;23(4):343
Liver X receptor agonists exert antitumor effects against hepatocellular carcinoma via inducing REPS2 expression.
He XY, Zhu MM, Zheng J, Wang CY, Zhao XK, Zhang BT, Zhou DC, Zhang S, Yang XX, Duan YJ, Han JH, Chen YL
Acta pharmacologica Sinica 2023 Mar;44(3):635-646
Acta pharmacologica Sinica 2023 Mar;44(3):635-646
Gamma-Muricholic Acid Inhibits Nonalcoholic Steatohepatitis: Abolishment of Steatosis-Dependent Peroxidative Impairment by FXR/SHP/LXRα/FASN Signaling.
Xie Y, Shen F, He Y, Guo C, Yang R, Cao H, Pan Q, Fan J
Nutrients 2023 Mar 2;15(5)
Nutrients 2023 Mar 2;15(5)
Supplemental Clostridium butyricum modulates lipid metabolism by reshaping the gut microbiota composition and bile acid profile in IUGR suckling piglets.
Zhang X, Yun Y, Lai Z, Ji S, Yu G, Xie Z, Zhang H, Zhong X, Wang T, Zhang L
Journal of animal science and biotechnology 2023 Mar 13;14(1):36
Journal of animal science and biotechnology 2023 Mar 13;14(1):36
Cabernet sauvignon dry red wine ameliorates atherosclerosis in mice by regulating inflammation and endothelial function, activating AMPK phosphorylation, and modulating gut microbiota.
Cheng X, Han X, Zhou L, Sun Y, Zhou Q, Lin X, Gao Z, Wang J, Zhao W
Food research international (Ottawa, Ont.) 2023 Jul;169:112942
Food research international (Ottawa, Ont.) 2023 Jul;169:112942
Resveratrol Modulates the Redox Response and Bile Acid Metabolism to Maintain the Cholesterol Homeostasis in Fish Megalobrama amblycephala Offered a High-Carbohydrate Diet.
Ge Y, Zhang L, Chen W, Sun M, Liu W, Li X
Antioxidants (Basel, Switzerland) 2023 Jan 3;12(1)
Antioxidants (Basel, Switzerland) 2023 Jan 3;12(1)
T0901317, a liver X receptor agonist, ameliorates perinatal white matter injury induced by ischemia and hypoxia in neonatal rats.
Gao T, Qian T, Wang T, Su Y, Qiu H, Tang W, Xing Q, Wang L
Neuroscience letters 2023 Jan 10;793:136994
Neuroscience letters 2023 Jan 10;793:136994
Cholesterol-Lowering Activity of Vitisin A Is Mediated by Inhibiting Cholesterol Biosynthesis and Enhancing LDL Uptake in HepG2 Cells.
Yuan Y, Zhu Y, Li Y, Li X, Jiao R, Bai W
International journal of molecular sciences 2023 Feb 7;24(4)
International journal of molecular sciences 2023 Feb 7;24(4)
Hepatic Huwe1 loss protects mice from non-alcoholic fatty liver disease through lipid metabolic rewiring.
Feng WW, Bang S, Takacs EM, Day C, Crawford KJ, Al-Sheyab R, Almufarrej DB, Wells W, Ilchenko S, Kasumov T, Kon N, Novak CM, Gu W, Kurokawa M
iScience 2023 Dec 15;26(12):108405
iScience 2023 Dec 15;26(12):108405
p21-activated kinase 4 suppresses fatty acid β-oxidation and ketogenesis by phosphorylating NCoR1.
Shi MY, Yu HC, Han CY, Bang IH, Park HS, Jang KY, Lee S, Son JB, Kim ND, Park BH, Bae EJ
Nature communications 2023 Aug 17;14(1):4987
Nature communications 2023 Aug 17;14(1):4987
Therapeutic role of Artemether in the prevention of hepatic steatosis through miR-34a-5p/PPARα pathway.
Chen L, Yu S, Hong S, Lin X, Zhu X, Cao X, Li Y, Xiao H
Drug development research 2023 Apr;84(2):156-171
Drug development research 2023 Apr;84(2):156-171
Camellia (Camellia oleifera bel.) seed oil reprograms gut microbiota and alleviates lipid accumulation in high fat-fed mice through the mTOR pathway.
Gao J, Ma L, Yin J, Liu G, Ma J, Xia S, Gong S, Han Q, Li T, Chen Y, Yin Y
Food & function 2022 May 10;13(9):4977-4992
Food & function 2022 May 10;13(9):4977-4992
Pseudorabies Virus Inhibits Expression of Liver X Receptors to Assist Viral Infection.
Wang Y, Li GL, Qi YL, Li LY, Wang LF, Wang CR, Niu XR, Liu TX, Wang J, Yang GY, Zeng L, Chu BB
Viruses 2022 Mar 3;14(3)
Viruses 2022 Mar 3;14(3)
KLF2 alleviates endothelial cell injury and inhibits the formation of THP‑1 macrophage‑derived foam cells by activating Nrf2 and enhancing autophagy.
Tan Z, Ren H, Liu Y, Yang H, Luo Q, Deng X
Experimental and therapeutic medicine 2022 Dec;24(6):737
Experimental and therapeutic medicine 2022 Dec;24(6):737
Clitoria ternatea blue petal extract protects against obesity, oxidative stress, and inflammation induced by a high-fat, high-fructose diet in C57BL/6 mice.
Wang Y, Liu T, Xie Y, Li N, Liu Y, Wen J, Zhang M, Feng W, Huang J, Guo Y, Kabbas Junior T, Wang D, Granato D
Food research international (Ottawa, Ont.) 2022 Dec;162(Pt A):112008
Food research international (Ottawa, Ont.) 2022 Dec;162(Pt A):112008
Opuntia dillenii Haw. Polysaccharide Promotes Cholesterol Efflux in THP-1-Derived Foam Cells via the PPARγ-LXRα Signaling Pathway.
Li H, Huang Z, Zeng F
Molecules (Basel, Switzerland) 2022 Dec 7;27(24)
Molecules (Basel, Switzerland) 2022 Dec 7;27(24)
Metformin mitigates cholesterol accumulation via the AMPK/SIRT1 pathway to protect osteoarthritis chondrocytes.
Xing H, Liang C, Wang C, Xu X, Hu Y, Qiu B
Biochemical and biophysical research communications 2022 Dec 3;632:113-121
Biochemical and biophysical research communications 2022 Dec 3;632:113-121
The protective effects of sulforaphane on high-fat diet-induced metabolic associated fatty liver disease in mice via mediating the FXR/LXRα pathway.
Ma S, Pang X, Tian S, Sun J, Hu Q, Li X, Lu Y
Food & function 2022 Dec 13;13(24):12966-12982
Food & function 2022 Dec 13;13(24):12966-12982
Melatonin ameliorates diabetic hyperglycaemia-induced impairment of Leydig cell steroidogenic function through activation of SIRT1 pathway.
Wang P, Zhang S, Lin S, Lv Z
Reproductive biology and endocrinology : RB&E 2022 Aug 12;20(1):117
Reproductive biology and endocrinology : RB&E 2022 Aug 12;20(1):117
Aldehyde dehydrogenase 2 and PARP1 interaction modulates hepatic HDL biogenesis by LXRα-mediated ABCA1 expression.
Li L, Zhong S, Li R, Liang N, Zhang L, Xia S, Xu X, Chen X, Chen S, Tao Y, Yin H
JCI insight 2022 Apr 8;7(7)
JCI insight 2022 Apr 8;7(7)
B-cell lymphoma 6 alleviates nonalcoholic fatty liver disease in mice through suppression of fatty acid transporter CD36.
Zhang H, Li Y, Zhang C, Huang K, Zhao J, Le S, Jiang L, Liu H, Yang P, Xiao X, Yu J, Wu J, Ye P, Xia J
Cell death & disease 2022 Apr 18;13(4):359
Cell death & disease 2022 Apr 18;13(4):359
Encapsulation of LXR ligand by D-Nap-GFFY hydrogel enhances anti-tumorigenic actions of LXR and removes LXR-induced lipogenesis.
Feng K, Ma C, Liu Y, Yang X, Yang Z, Chen Y, Xu T, Yang C, Zhang S, Li Q, Wei Z, Zhao D, Zeng P, Han J, Gao J, Chen Y, Duan Y
Theranostics 2021;11(6):2634-2654
Theranostics 2021;11(6):2634-2654
Relationships between di-(2-ethylhexyl) phthalate exposure and lipid metabolism in adolescents: Human data and experimental rat model analyses.
Ding S, Qi W, Xu Q, Zhao T, Li X, Yin J, Zhang R, Huo C, Zhou L, Ye L
Environmental pollution (Barking, Essex : 1987) 2021 Oct 1;286:117570
Environmental pollution (Barking, Essex : 1987) 2021 Oct 1;286:117570
Polysaccharide MCP extracted from Morchella esculenta reduces atherosclerosis in LDLR-deficient mice.
Wang D, Yin Z, Ma L, Han L, Chen Y, Pan W, Gong K, Gao Y, Yang X, Chen Y, Han J, Duan Y
Food & function 2021 Jun 7;12(11):4842-4854
Food & function 2021 Jun 7;12(11):4842-4854
Diosmetin Ameliorates Nonalcoholic Steatohepatitis through Modulating Lipogenesis and Inflammatory Response in a STAT1/CXCL10-Dependent Manner.
Luo N, Yang C, Zhu Y, Chen Q, Zhang B
Journal of agricultural and food chemistry 2021 Jan 20;69(2):655-667
Journal of agricultural and food chemistry 2021 Jan 20;69(2):655-667
Cordycepin attenuates high-fat diet-induced non-alcoholic fatty liver disease via down-regulation of lipid metabolism and inflammatory responses.
Gong X, Li T, Wan R, Sha L
International immunopharmacology 2021 Feb;91:107173
International immunopharmacology 2021 Feb;91:107173
Dingxin Recipe IV attenuates atherosclerosis by regulating lipid metabolism through LXR-α/SREBP1 pathway and modulating the gut microbiota in ApoE(-/-) mice fed with HFD.
Zhang Y, Gu Y, Chen Y, Huang Z, Li M, Jiang W, Chen J, Rao W, Luo S, Chen Y, Chen J, Li L, Jia Y, Liu M, Zhou F
Journal of ethnopharmacology 2021 Feb 10;266:113436
Journal of ethnopharmacology 2021 Feb 10;266:113436
Xinnaokang improves cecal microbiota and lipid metabolism to target atherosclerosis.
Yang R, Yin D, Yang D, Liu X, Zhou Q, Pan Y, Li J, Li S
Letters in applied microbiology 2021 Dec;73(6):779-792
Letters in applied microbiology 2021 Dec;73(6):779-792
Novel Metabolic Regulation of Bile Acid Responses to Low Cholesterol in Whole-Grain-Diet-Fed Mice.
Liu J, Wang Y, Xue L, Nie C, Sun J, Fan M, Qian H, Wang L, Li Y
Journal of agricultural and food chemistry 2021 Aug 4;69(30):8440-8447
Journal of agricultural and food chemistry 2021 Aug 4;69(30):8440-8447
2-Hydroxypropyl-β-cyclodextrin Regulates the Epithelial to Mesenchymal Transition in Breast Cancer Cells by Modulating Cholesterol Homeostasis and Endoplasmic Reticulum Stress.
Zhao Y, He L, Wang T, Zhu L, Yan N
Metabolites 2021 Aug 23;11(8)
Metabolites 2021 Aug 23;11(8)
Betaine prevented high-fat diet-induced NAFLD by regulating the FGF10/AMPK signaling pathway in ApoE(-/-) mice.
Chen W, Zhang X, Xu M, Jiang L, Zhou M, Liu W, Chen Z, Wang Y, Zou Q, Wang L
European journal of nutrition 2021 Apr;60(3):1655-1668
European journal of nutrition 2021 Apr;60(3):1655-1668
Targeting macrophage liver X receptors by hydrogel-encapsulated T0901317 reduces atherosclerosis without effect on hepatic lipogenesis.
Ma C, Feng K, Yang X, Yang Z, Wang Z, Shang Y, Fan G, Liu L, Yang S, Li X, Han J, Duan Y, Chen Y
British journal of pharmacology 2021 Apr;178(7):1620-1638
British journal of pharmacology 2021 Apr;178(7):1620-1638
EGFR/FOXO3A/LXR-α Axis Promotes Prostate Cancer Proliferation and Metastasis and Dual-Targeting LXR-α/EGFR Shows Synthetic Lethality.
Chen T, Xu J, Fu W
Frontiers in oncology 2020;10:1688
Frontiers in oncology 2020;10:1688
Didymin ameliorates dexamethasone-induced non-alcoholic fatty liver disease by inhibiting TLR4/NF-κB and PI3K/Akt pathways in C57BL/6J mice.
Feng Z, Pang L, Chen S, Pang X, Huang Y, Qiao Q, Wang Y, Vonglorkham S, Huang Q, Lin X, Wei J
International immunopharmacology 2020 Nov;88:107003
International immunopharmacology 2020 Nov;88:107003
Regulation mechanism of silkworm pupa oil PUFAs on cholesterol metabolism in hepatic cell L-02.
Luo Y, Wang L, Lv Y, Wu X, Hou C, Li J
Journal of the science of food and agriculture 2020 Mar 15;100(4):1418-1425
Journal of the science of food and agriculture 2020 Mar 15;100(4):1418-1425
Geniposide reduces cholesterol accumulation and increases its excretion by regulating the FXR-mediated liver-gut crosstalk of bile acids.
Liu J, Li Y, Sun C, Liu S, Yan Y, Pan H, Fan M, Xue L, Nie C, Zhang H, Qian H, Ying H, Wang L
Pharmacological research 2020 Feb;152:104631
Pharmacological research 2020 Feb;152:104631
Transcriptome analysis reveals a protective role of liver X receptor alpha against silica particle-induced experimental silicosis.
Yao W, Yang P, Qi Y, Jin L, Zhao A, Ding M, Wang D, Li Y, Hao C
The Science of the total environment 2020 Dec 10;747:141531
The Science of the total environment 2020 Dec 10;747:141531
Hydrogen sulfide accumulates LDL receptor precursor via downregulating PCSK9 in HepG2 cells.
Huang Y, Ning K, Li WW, Lin G, Hou CL, Wang MJ, Zhu YC
American journal of physiology. Cell physiology 2020 Dec 1;319(6):C1082-C1096
American journal of physiology. Cell physiology 2020 Dec 1;319(6):C1082-C1096
Thioredoxin-1 promotes macrophage reverse cholesterol transport and protects liver from steatosis.
Wang X, Zhao H, Yan W, Liu Y, Yin T, Wang S, Fan M, Li C, Zhang L, Tao L
Biochemical and biophysical research communications 2019 Sep 3;516(4):1103-1109
Biochemical and biophysical research communications 2019 Sep 3;516(4):1103-1109
Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1.
Zhang Y, Li C, Hu C, Wu Q, Cai Y, Xing S, Lu H, Wang L, Huang D, Sun L, Li T, He X, Zhong X, Wang J, Gao P, Smith ZJ, Jia W, Zhang H
EMBO reports 2019 Oct 4;20(10):e48115
EMBO reports 2019 Oct 4;20(10):e48115
Therapeutic Effect of Chitooligosaccharide Tablets on Lipids in High-Fat Diets Induced Hyperlipidemic Rats.
Yang D, Hu C, Deng X, Bai Y, Cao H, Guo J, Su Z
Molecules (Basel, Switzerland) 2019 Jan 31;24(3)
Molecules (Basel, Switzerland) 2019 Jan 31;24(3)
Metformin ameliorates Ox-LDL-induced foam cell formation in raw264.7 cells by promoting ABCG-1 mediated cholesterol efflux.
He X, Chen X, Wang L, Wang W, Liang Q, Yi L, Wang Y, Gao Q
Life sciences 2019 Jan 1;216:67-74
Life sciences 2019 Jan 1;216:67-74
Endogenous cholesterol ester hydroperoxides modulate cholesterol levels and inhibit cholesterol uptake in hepatocytes and macrophages.
Guo S, Lu J, Zhuo Y, Xiao M, Xue X, Zhong S, Shen X, Yin C, Li L, Chen Q, Zhu M, Chen B, Zhao M, Zheng L, Tao Y, Yin H
Redox biology 2019 Feb;21:101069
Redox biology 2019 Feb;21:101069
LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma.
Wang K, Xu T, Ruan H, Xiao H, Liu J, Song Z, Cao Q, Bao L, Liu D, Wang C, Cheng G, Liang H, Chen Z, Yang H, Chen K, Zhang X
Cell death & disease 2019 Feb 15;10(3):159
Cell death & disease 2019 Feb 15;10(3):159
Simvastatin improves olanzapine-induced dyslipidemia in rats through inhibiting hepatic mTOR signaling pathway.
Liu XM, Zhao XM, Deng C, Zeng YP, Hu CH
Acta pharmacologica Sinica 2019 Aug;40(8):1049-1057
Acta pharmacologica Sinica 2019 Aug;40(8):1049-1057
Correction: Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Dong D, Qi Y, Xu L, Yin L, Xu Y, Han X, Zhao Y, Peng J
Food & function 2019 Aug 1;10(8):5240-5241
Food & function 2019 Aug 1;10(8):5240-5241
Cholesterol-lowering effects and potential mechanisms of chitooligosaccharide capsules in hyperlipidemic rats.
Jiang Y, Fu C, Liu G, Guo J, Su Z
Food & nutrition research 2018;62
Food & nutrition research 2018;62
Upregulation of 24(R/S),25-epoxycholesterol and 27-hydroxycholesterol suppresses the proliferation and migration of gastric cancer cells.
Guo F, Hong W, Yang M, Xu D, Bai Q, Li X, Chen Z
Biochemical and biophysical research communications 2018 Oct 12;504(4):892-898
Biochemical and biophysical research communications 2018 Oct 12;504(4):892-898
Functional interplay between liver X receptor and AMP-activated protein kinase α inhibits atherosclerosis in apolipoprotein E-deficient mice - a new anti-atherogenic strategy.
Ma C, Zhang W, Yang X, Liu Y, Liu L, Feng K, Zhang X, Yang S, Sun L, Yu M, Yang J, Li X, Hu W, Miao RQ, Zhu Y, Li L, Han J, Chen Y, Duan Y
British journal of pharmacology 2018 May;175(9):1486-1503
British journal of pharmacology 2018 May;175(9):1486-1503
25-Hydroxycholesterol activates the expression of cholesterol 25-hydroxylase in an LXR-dependent mechanism.
Liu Y, Wei Z, Ma X, Yang X, Chen Y, Sun L, Ma C, Miao QR, Hajjar DP, Han J, Duan Y
Journal of lipid research 2018 Mar;59(3):439-451
Journal of lipid research 2018 Mar;59(3):439-451
Activation of hepatic Nogo-B receptor expression-A new anti-liver steatosis mechanism of statins.
Zhang W, Yang X, Chen Y, Hu W, Liu L, Zhang X, Liu M, Sun L, Liu Y, Yu M, Li X, Li L, Zhu Y, Miao QR, Han J, Duan Y
Biochimica et biophysica acta. Molecular and cell biology of lipids 2018 Feb;1863(2):177-190
Biochimica et biophysica acta. Molecular and cell biology of lipids 2018 Feb;1863(2):177-190
Asiatic acid from Potentilla chinensis alleviates non-alcoholic fatty liver by regulating endoplasmic reticulum stress and lipid metabolism.
Wang D, Lao L, Pang X, Qiao Q, Pang L, Feng Z, Bai F, Sun X, Lin X, Wei J
International immunopharmacology 2018 Dec;65:256-267
International immunopharmacology 2018 Dec;65:256-267
Activation of liver X receptor plays a central role in antiviral actions of 25-hydroxycholesterol.
Liu Y, Wei Z, Zhang Y, Ma X, Chen Y, Yu M, Ma C, Li X, Cao Y, Liu J, Han J, Yang X, Duan Y
Journal of lipid research 2018 Dec;59(12):2287-2296
Journal of lipid research 2018 Dec;59(12):2287-2296
Liver X receptors agonists suppress NLRP3 inflammasome activation.
Yu SX, Chen W, Hu XZ, Feng SY, Li KY, Qi S, Lei QQ, Hu GQ, Li N, Zhou FH, Ma CY, Du CT, Yang YJ
Cytokine 2017 Mar;91:30-37
Cytokine 2017 Mar;91:30-37
Medium-chain fatty acid reduces lipid accumulation by regulating expression of lipid-sensing genes in human liver cells with steatosis.
Wang B, Fu J, Li L, Gong D, Wen X, Yu P, Zeng Z
International journal of food sciences and nutrition 2016;67(3):288-97
International journal of food sciences and nutrition 2016;67(3):288-97
MEK1/2 inhibitors activate macrophage ABCG1 expression and reverse cholesterol transport-An anti-atherogenic function of ERK1/2 inhibition.
Zhang L, Chen Y, Yang X, Yang J, Cao X, Li X, Li L, Miao QR, Hajjar DP, Duan Y, Han J
Biochimica et biophysica acta 2016 Sep;1861(9 Pt A):1180-1191
Biochimica et biophysica acta 2016 Sep;1861(9 Pt A):1180-1191
Arsenic trioxide suppresses liver X receptor β and enhances cholesteryl ester transfer protein expression without affecting the liver X receptor α in HepG2 cells.
Cheng TJ, Lin SW, Chen CW, Guo HR, Wang YJ
Chemico-biological interactions 2016 Oct 25;258:288-96
Chemico-biological interactions 2016 Oct 25;258:288-96
Activation of liver X receptor inhibits the development of pulmonary carcinomas induced by 3-methylcholanthrene and butylated hydroxytoluene in BALB/c mice.
Wang Q, Sun L, Yang X, Ma X, Li Q, Chen Y, Liu Y, Zhang D, Li X, Xiang R, Wei Y, Han J, Duan Y
Scientific reports 2016 Jun 2;6:27295
Scientific reports 2016 Jun 2;6:27295
VNN1 promotes atherosclerosis progression in apoE-/- mice fed a high-fat/high-cholesterol diet.
Hu YW, Wu SG, Zhao JJ, Ma X, Lu JB, Xiu JC, Zhang Y, Huang C, Qiu YR, Sha YH, Gao JJ, Wang YC, Li SF, Zhao JY, Zheng L, Wang Q
Journal of lipid research 2016 Aug;57(8):1398-411
Journal of lipid research 2016 Aug;57(8):1398-411
Lipoxin A4 promotes ABCA1 expression and cholesterol efflux through the LXRα signaling pathway in THP-1 macrophage-derived foam cells.
Sha YH, Hu YW, Gao JJ, Wang YC, Ma X, Qiu YR, Li SF, Zhao JY, Huang C, Zhao JJ, Lu JB, Kang CM, Zheng L, Wang Q
International journal of clinical and experimental pathology 2015;8(6):6708-15
International journal of clinical and experimental pathology 2015;8(6):6708-15
Protective effects of heparin on endothelial cells in sepsis.
Ma J, Bai J
International journal of clinical and experimental medicine 2015;8(4):5547-52
International journal of clinical and experimental medicine 2015;8(4):5547-52
Regulation of Hepatic Cholesteryl Ester Transfer Protein Expression and Reverse Cholesterol Transport by Inhibition of DNA Topoisomerase II.
Liu M, Chen Y, Zhang L, Wang Q, Ma X, Li X, Xiang R, Zhu Y, Qin S, Yu Y, Jiang XC, Duan Y, Han J
The Journal of biological chemistry 2015 Jun 5;290(23):14418-29
The Journal of biological chemistry 2015 Jun 5;290(23):14418-29
Propofol up-regulates expression of ABCA1, ABCG1, and SR-B1 through the PPARγ/LXRα signaling pathway in THP-1 macrophage-derived foam cells.
Ma X, Li SF, Qin ZS, Ye J, Zhao ZL, Fang HH, Yao ZW, Gu MN, Hu YW
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2015 Jul-Aug;24(4):230-5
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2015 Jul-Aug;24(4):230-5
RP5-833A20.1/miR-382-5p/NFIA-dependent signal transduction pathway contributes to the regulation of cholesterol homeostasis and inflammatory reaction.
Hu YW, Zhao JY, Li SF, Huang JL, Qiu YR, Ma X, Wu SG, Chen ZP, Hu YR, Yang JY, Wang YC, Gao JJ, Sha YH, Zheng L, Wang Q
Arteriosclerosis, thrombosis, and vascular biology 2015 Jan;35(1):87-101
Arteriosclerosis, thrombosis, and vascular biology 2015 Jan;35(1):87-101
Potent effects of dioscin against obesity in mice.
Liu M, Xu L, Yin L, Qi Y, Xu Y, Han X, Zhao Y, Sun H, Yao J, Lin Y, Liu K, Peng J
Scientific reports 2015 Jan 22;5:7973
Scientific reports 2015 Jan 22;5:7973
Inhibition of tumor growth by U0126 is associated with induction of interferon-γ production.
Ma X, Wang Q, Liu Y, Chen Y, Zhang L, Jiang M, Li X, Xiang R, Miao RQ, Duan Y, Han J
International journal of cancer 2015 Feb 15;136(4):771-83
International journal of cancer 2015 Feb 15;136(4):771-83
LXRalpha gene downregulation by lentiviral-based RNA interference enhances liver function after fatty liver transplantation in rats.
Zhao YP, Li L, Ma JP, Chen G, Bai JH
Hepatobiliary & pancreatic diseases international : HBPD INT 2015 Aug;14(4):386-93
Hepatobiliary & pancreatic diseases international : HBPD INT 2015 Aug;14(4):386-93
Chronic unpredictable mild stress combined with a high-fat diets aggravates atherosclerosis in rats.
Wang S, Xiaoling G, Pingting L, Shuqiang L, Yuaner Z
Lipids in health and disease 2014 May 10;13:77
Lipids in health and disease 2014 May 10;13:77
Dihydrocapsaicin down-regulates apoM expression through inhibiting Foxa2 expression and enhancing LXRα expression in HepG2 cells.
Zhao JY, Hu YW, Li SF, Hu YR, Ma X, Wu SG, Wang YC, Gao JJ, Sha YH, Zheng L, Wang Q
Lipids in health and disease 2014 Mar 19;13:50
Lipids in health and disease 2014 Mar 19;13:50
Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Dong D, Qi Y, Xu L, Yin L, Xu Y, Han X, Zhao Y, Peng J
Food & function 2014 Dec;5(12):3065-3075
Food & function 2014 Dec;5(12):3065-3075
A lincRNA-DYNLRB2-2/GPR119/GLP-1R/ABCA1-dependent signal transduction pathway is essential for the regulation of cholesterol homeostasis.
Hu YW, Yang JY, Ma X, Chen ZP, Hu YR, Zhao JY, Li SF, Qiu YR, Lu JB, Wang YC, Gao JJ, Sha YH, Zheng L, Wang Q
Journal of lipid research 2014 Apr;55(4):681-97
Journal of lipid research 2014 Apr;55(4):681-97
Identification of interferon-γ as a new molecular target of liver X receptor.
Wang Q, Ma X, Chen Y, Zhang L, Jiang M, Li X, Xiang R, Miao R, Hajjar DP, Duan Y, Han J
The Biochemical journal 2014 Apr 15;459(2):345-54
The Biochemical journal 2014 Apr 15;459(2):345-54
Dihydrocapsaicin Attenuates Plaque Formation through a PPARγ/LXRα Pathway in apoE(-/-) Mice Fed a High-Fat/High-Cholesterol Diet.
Hu YW, Ma X, Huang JL, Mao XR, Yang JY, Zhao JY, Li SF, Qiu YR, Yang J, Zheng L, Wang Q
PloS one 2013;8(6):e66876
PloS one 2013;8(6):e66876
Protein tyrosine phosphatase inhibition down-regulates ligand-induced ABCA1 expression.
Luu W, Sharpe LJ, Brown AJ
Atherosclerosis 2013 Jun;228(2):362-9
Atherosclerosis 2013 Jun;228(2):362-9
DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux-an LXR-dependent mechanism.
Zhang L, Jiang M, Shui Y, Chen Y, Wang Q, Hu W, Ma X, Li X, Liu X, Cao X, Liu M, Duan Y, Han J
Biochimica et biophysica acta 2013 Jun;1831(6):1134-45
Biochimica et biophysica acta 2013 Jun;1831(6):1134-45
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The NR1H3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human NR1H3. This antibody recognizes human,mouse,rat antigen. The NR1H3 antibody has been validated for the following applications: ELISA, WB analysis.