Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- BS6785 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- NR1H3 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human NR1H3.
- Description
- The cooperation of liver X receptors (LXRs) Ï« and ÉÇ and retinoic X receptor (RXR) modulate the expression of several genes involved in lipid metabolism in hepatocyte and macrophages. RXR is the receptor for 9-cis retinoic acid and dimerizes with VDR, TR, PPAR and several novel receptors including liver X receptors LXRÏ« (also referred to as RLD-1), LXRÉÇ and FXR. FXR and LXR fall into a category of proteins termed ¡ùorphan receptors¡ì because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. Both LXR/ RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid. LXRÏ« and LXRÉÇ share considerable sequence homology and several functions, respond to the same endogenous levels of and synthetic ligands and play critical roles in maintaining lipid homeostasis. LXRÉÇ is ubiquitously expressed and enriched in tissues of neuronal and endocrine origin.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
No comments: Submit comment
Supportive validation
- Submitted by
- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot analysis of NR1H3 polyclonal antibody