BS6785

antibody from Bioworld Technology, Inc
Targeting: NR1H3 LXR-a, LXRa, RLD-1
Provider product page for BS6785
Western blot
Immunohistochemistry

Antibody data

Product number
BS6785 - Provider product page
Provider
Bioworld Technology, Inc
Product name
NR1H3 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human NR1H3.
Description
The cooperation of liver X receptors (LXRs) Ï« and ÉÇ and retinoic X receptor (RXR) modulate the expression of several genes involved in lipid metabolism in hepatocyte and macrophages. RXR is the receptor for 9-cis retinoic acid and dimerizes with VDR, TR, PPAR and several novel receptors including liver X receptors LXRÏ« (also referred to as RLD-1), LXRÉÇ and FXR. FXR and LXR fall into a category of proteins termed ¡ùorphan receptors¡ì because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. Both LXR/ RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid. LXRÏ« and LXRÉÇ share considerable sequence homology and several functions, respond to the same endogenous levels of and synthetic ligands and play critical roles in maintaining lipid homeostasis. LXRÉÇ is ubiquitously expressed and enriched in tissues of neuronal and endocrine origin.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
NR1H3 protein structure - BS6785 shown in red.