14386-1-AP

antibody from Proteintech Group

Targeting: MAG GMA, S-MAG, SIGLEC-4A, SIGLEC4A

Provider product page for 14386-1-AP

Western blot

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Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [32]
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Validations
Western blot [1]

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Product number: 14386-1-AP - Provider product page
Provider: Proteintech Group
Product name: MAG antibody
Antibody type: Polyclonal
Description: MAG antibody (Cat. #14386-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

MAG protein structure - 14386-1-AP shown in red.

Submitted references Fecal microbiota transplantation alleviates chronic cerebral hypoperfusion-induced axonal hypomyelination by regulating gut microbiota-derived metabolism and oligodendrogenesis.

Su SH, Chen M, Lu DD, Wu YF, Huang XS, Zhang L
The Journal of nutritional biochemistry 2026 Jan;147:110122

Rewiring brain structural and functional disconnection with acupuncture in rat model of vascular cognitive impairment and dementia.

Wang L, Zhao JP, Cao Y, Ma SM, Yang JW, Su XT, Huang J, Wang QY, Liu CZ
Biological research 2026 Jan 19;59(1):10

Transcriptomics and functional genomics implicate WNT3 in hemispheric lateralization of speech production.

Wang Z, Chen Y, Feng Y, Zu G, Wang W, Liang L, Liu X, Mei Y, Yang J, Wang T, Liu M, Jiang L, Snell RG, Highet B, Curtis M, Chen L, Li SB, Wu J, Zhang M, Li W, Wei GH, You L
iScience 2026 Feb 20;29(2):114692

Aryl hydrocarbon receptor facilitates HSV-1 lytic infection by enhancing viral gene transcription and receptor expression.

Huang P, Pan X, Chen H, Lei M, Ma Y, Guo X, Xie J, Li J, Sun J, Hu Y, Shi J
Frontiers in cellular and infection microbiology 2025;15:1548038

Progranulin deficiency does not exacerbate TDP-43 pathology in TDP-43 transgenic mouse models.

Yang C, Feng T, Hu F
NPJ dementia 2025;1(1):16

The role of astrocyte-derived extracellular vesicles in cellular microenvironment remodeling after spinal cord injury: A study based on quantitative proteomics analysis.

Zhu Z, Xu Y, Wang K, Xu X, Song Y, Zhao B, Ding W, Liu J, Song Z
Experimental neurology 2025 Sep;391:115321

Development, validation, and preliminary phenotypic characterization of a Col6a3 knockout mouse model targeting exon 3.

ElChoueiry M, Sidhu H, Lévesque M, Lévesque D, Jacques JF, Sarrhini O, Beaudoin JF, Caron M, Gaudette B, Lecomte R, Roucou X, Boisvert FM, Brosseau JP
Animal models and experimental medicine 2025 Oct;8(10):1824-1835

IGFBP2-Ceramide Pathway Mediates Divergent Myelin Breakdown in the PNS and CNS Following Injury.

Ma S, Fu X, Lyu J, Guo W, Wang J, Li J, Ying Z
The Journal of neuroscience : the official journal of the Society for Neuroscience 2025 Oct 22;45(43)

Glycyrrhizin Attenuates White Matter Injury by Inhibiting Neuroinflammation through the HMGB1/TLR4 Pathway.

Lou J, Ding B, Fang M, Xie W, Wang X, Wang X, Guo X, Zhu J
Molecular neurobiology 2025 May;62(5):6070-6087

Intermittent Fasting Enhances Motor Coordination Through Myelin Preservation in Aged Mice.

Liu Z, Zhao Z, Du H, Zhou Q, Li M, Gui Z, Wu J, Gao Y, Zheng N, Zhang Y, Du A, Wang H, Wang J
Aging cell 2025 May;24(5):e14476

Electroacupuncture ameliorates cognitive impairment and white matter injury in vascular dementia rats via activating HIF-1α/VEGF/VEGFR2 pathway.

Yang Y, Rao T, Jiang Y, Zhan Y, Cheng J, Yin Z, Ma K, Zhong X, Guo X, Yang S
Neuroscience 2025 May 7;573:364-380

FGF21 Alleviates Hypoxic-Ischemic White Matter Injury in Neonatal Mice by Mediating Inflammation and Oxidative Stress Through PPAR-γ Signaling Pathway.

Fang M, Lu L, Lou J, Ou J, Yu Q, Tao X, Zhu J, Lin Z
Molecular neurobiology 2025 Apr;62(4):4743-4768

SIRT6 modulates lesion microenvironment in LPC induced demyelination by targeting astrocytic CHI3L1.

Du J, Yin Y, Wu D, Diao C, Zhao T, Peng F, Li N, Wang D, Shi J, Wang L, Kong L, Zhou W, Hao A
Journal of neuroinflammation 2024 Sep 28;21(1):243

The dynamics of oligodendrocyte populations following permanent ischemia promotes long-term spontaneous remyelination of damaged area.

Martín-Lopez G, Mallavibarrena PR, Villa-Gonzalez M, Vidal N, Pérez-Alvarez MJ
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167270

The Neuroprotective Mechanisms of PPAR-γ: Inhibition of Microglia-Mediated Neuroinflammation and Oxidative Stress in a Neonatal Mouse Model of Hypoxic-Ischemic White Matter Injury.

Fang M, Yu Q, Ou J, Lou J, Zhu J, Lin Z
CNS neuroscience & therapeutics 2024 Nov;30(11):e70081

PRRC2B modulates oligodendrocyte progenitor cell development and myelination by stabilizing Sox2 mRNA.

Zhang Y, Song Z, Wu R, Kong X, Zhang H, Li S, Gong X, Gong S, Cheng J, Yuan F, Wu H, Wang S, Yuan Z
Cell reports 2024 Mar 26;43(3):113930

Selective bioaccumulation of polystyrene nanoplastics in fetal rat brain and damage to myelin development.

Zhang Y, Tian L, Chen J, Liu X, Li K, Liu H, Lai W, Shi Y, Lin B, Xi Z
Ecotoxicology and environmental safety 2024 Jun 15;278:116393

L-ascorbyl-2-phosphate alleviates white matter injury caused by chronic hypoxia through the PRMT5/P53/NF-κB pathway.

Ding B, Lou J, Qin T, Xie W, Li D, Li P, Wang X, Lin Z, Guo X, Zhu J
Journal of neurochemistry 2024 Feb;168(2):142-160

A Novel Hybrid of Telmisartan and Borneol Ameliorates Neuroinflammation and White Matter Injury in Ischemic Stroke Through ATF3/CH25H Axis.

Guan X, Wu J, Geng J, Ji D, Wei D, Ling Y, Zhang Y, Jiang G, Pang T, Huang Z
Translational stroke research 2024 Feb;15(1):195-218

RNF220-mediated K63-linked polyubiquitination stabilizes Olig proteins during oligodendroglial development and myelination.

Li Y, Wan LP, Song NN, Ding YQ, Zhao S, Niu J, Mao B, Sheng N, Ma P
Science advances 2024 Feb 9;10(6):eadk3931

Nose to brain delivery of Astragaloside IV by β-Asarone modified chitosan nanoparticles for multiple sclerosis therapy.

Zhao X, Sun L, Wang J, Xu X, Ni S, Liu M, Hu K
International journal of pharmaceutics 2023 Sep 25;644:123351

Combined VEGF and bFGF loaded nanofiber membrane protects against neuronal injury and hypomyelination in a rat model of chronic cerebral hypoperfusion.

Wu YF, Sun J, Chen M, Lin Q, Jin KY, Su SH, Hai J
International immunopharmacology 2023 Dec;125(Pt A):111108

Neuron-Derived Exosomes Promote the Recovery of Spinal Cord Injury by Modulating Nerve Cells in the Cellular Microenvironment of the Lesion Area.

Xu Y, Zhu ZH, Xu X, Sun HT, Zheng HM, Zhang JL, Wang HH, Fang JW, Liu YZ, Huang LL, Song ZW, Liu JB
Molecular neurobiology 2023 Aug;60(8):4502-4516

Quercetin Alleviates Demyelination Through Regulating Microglial Phenotype Transformation to Mitigate Neuropsychiatric Symptoms in Mice with Vascular Dementia.

Tan Z, Yang G, Qiu J, Yan W, Liu Y, Ma Z, Li J, Liu J, Shan N
Molecular neurobiology 2022 May;59(5):3140-3158

TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss.

Feng T, Luan L, Katz II, Ullah M, Van Deerlin VM, Trojanowski JQ, Lee EB, Hu F
Acta neuropathologica communications 2022 Mar 14;10(1):33

Proteomic analysis of the effects of caffeine in a neonatal rat model of hypoxic-ischemic white matter damage.

Yang L, Yu X, Zhang Y, Liu N, Li D, Xue X, Fu J
CNS neuroscience & therapeutics 2022 Jul;28(7):1019-1032

Digoxin Ameliorates Glymphatic Transport and Cognitive Impairment in a Mouse Model of Chronic Cerebral Hypoperfusion.

Cao J, Yao D, Li R, Guo X, Hao J, Xie M, Li J, Pan D, Luo X, Yu Z, Wang M, Wang W
Neuroscience bulletin 2022 Feb;38(2):181-199

Depletion of regulatory T cells exacerbates inflammatory responses after chronic cerebral hypoperfusion in mice.

Wang Y, Wu Q, Fang Y, Song G, Xu L, Wang W, Pan D, Xie M
Molecular and cellular neurosciences 2022 Dec;123:103788

Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation.

Lim RG, Al-Dalahmah O, Wu J, Gold MP, Reidling JC, Tang G, Adam M, Dansu DK, Park HJ, Casaccia P, Miramontes R, Reyes-Ortiz AM, Lau A, Hickman RA, Khan F, Paryani F, Tang A, Ofori K, Miyoshi E, Michael N, McClure N, Flowers XE, Vonsattel JP, Davidson S, Menon V, Swarup V, Fraenkel E, Goldman JE, Thompson LM
Nature communications 2022 Dec 21;13(1):7791

Overexpression of miR-338-5p in exosomes derived from mesenchymal stromal cells provides neuroprotective effects by the Cnr1/Rap1/Akt pathway after spinal cord injury in rats.

Zhang A, Bai Z, Yi W, Hu Z, Hao J
Neuroscience letters 2021 Sep 14;761:136124

Connexin43 promotes angiogenesis through activating the HIF-1α/VEGF signaling pathway under chronic cerebral hypoperfusion.

Yu W, Jin H, Sun W, Nan D, Deng J, Jia J, Yu Z, Huang Y
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2021 Oct;41(10):2656-2675

A role of the frontotemporal lobar degeneration risk factor TMEM106B in myelination.

Feng T, Sheng RR, Solé-Domènech S, Ullah M, Zhou X, Mendoza CS, Enriquez LCM, Katz II, Paushter DH, Sullivan PM, Wu X, Maxfield FR, Hu F
Brain : a journal of neurology 2020 Jul 1;143(7):2255-2271

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Submitted by: Proteintech Group (provider)
Main image
Experimental details: rat brain tissue were subjected to SDS PAGE followed by western blot with 14386-1-AP( MAG Antibody) at dilution of 1:600
Other comments: WB
Appendix: 14386-1-AP.pdf

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