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- References [20]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 13505-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13505-1-AP, RRID:AB_2061192
- Product name
- ATX3,ATXN3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ATX3,ATXN3 antibody (Cat. #13505-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Fructose-2,6-bisphosphate restores DNA repair activity of PNKP and ameliorates neurodegenerative symptoms in Huntington's disease.
Impaired interactions of ataxin-3 with protein complexes reveals their specific structure and functions in SCA3 Ki150 model.
ATXN3 deubiquitinates YAP1 to promote tumor growth.
Human DNA polymerase η promotes RNA-templated error-free repair of DNA double-strand breaks.
CircHIPK3 negatively regulates autophagy by blocking VCP binding to the Beclin 1 complex in bladder cancer.
ATXN3 promotes prostate cancer progression by stabilizing YAP.
CRISPR screening identifies the deubiquitylase ATXN3 as a PD-L1-positive regulator for tumor immune evasion.
The Mechano-Ubiquitinome of Articular Cartilage: Differential Ubiquitination and Activation of a Group of ER-Associated DUBs and ER Stress Regulators.
Involvement of miR-619-5p in resistance to cisplatin by regulating ATXN3 in oral squamous cell carcinoma.
DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases.
USP15 participates in DBP-induced testicular oxidative stress injury through regulating the Keap1/Nrf2 signaling pathway.
TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling.
CRISPR/Cas9-Targeted Deletion of Polyglutamine in Spinocerebellar Ataxia Type 3-Derived Induced Pluripotent Stem Cells.
ATXN3 Positively Regulates Type I IFN Antiviral Response by Deubiquitinating and Stabilizing HDAC3.
An Interaction Landscape of Ubiquitin Signaling.
Rescue of ATXN3 neuronal toxicity in Caenorhabditiselegans by chemical modification of endoplasmic reticulum stress.
A new humanized ataxin-3 knock-in mouse model combines the genetic features, pathogenesis of neurons and glia and late disease onset of SCA3/MJD.
Inactivation of PNKP by mutant ATXN3 triggers apoptosis by activating the DNA damage-response pathway in SCA3.
The role of the mammalian DNA end-processing enzyme polynucleotide kinase 3'-phosphatase in spinocerebellar ataxia type 3 pathogenesis.
A deubiquitinase negatively regulates retro-translocation of nonubiquitinated substrates.
Chakraborty A, Sreenivasmurthy SG, Miller W, Huai W, Biswas T, Mandal SM, Boscá L, Krishnan B, Ghosh G, Hazra T
bioRxiv : the preprint server for biology 2024 Jul 16;
bioRxiv : the preprint server for biology 2024 Jul 16;
Impaired interactions of ataxin-3 with protein complexes reveals their specific structure and functions in SCA3 Ki150 model.
Piasecki P, Wiatr K, Ruszkowski M, Marczak Ł, Trottier Y, Figiel M
Frontiers in molecular neuroscience 2023;16:1122308
Frontiers in molecular neuroscience 2023;16:1122308
ATXN3 deubiquitinates YAP1 to promote tumor growth.
Wang S, Liu K, Han X, Cheng Y, Zhao E, Brat DJ, Sun Z, Fang D
American journal of cancer research 2023;13(9):4222-4234
American journal of cancer research 2023;13(9):4222-4234
Human DNA polymerase η promotes RNA-templated error-free repair of DNA double-strand breaks.
Chakraborty A, Tapryal N, Islam A, Sarker AH, Manohar K, Mitra J, Hegde ML, Hazra T
The Journal of biological chemistry 2023 Mar;299(3):102991
The Journal of biological chemistry 2023 Mar;299(3):102991
CircHIPK3 negatively regulates autophagy by blocking VCP binding to the Beclin 1 complex in bladder cancer.
Wang C, Liu T, Wang J, Cheng C, Zhang Z, Zhang J, Huang H, Li Y
Discover oncology 2023 Jun 3;14(1):86
Discover oncology 2023 Jun 3;14(1):86
ATXN3 promotes prostate cancer progression by stabilizing YAP.
Wu L, Ou Z, Liu P, Zhao C, Tong S, Wang R, Li Y, Yuan J, Chen M, Fan B, Zu X, Wang Y, Tang J
Cell communication and signaling : CCS 2023 Jun 22;21(1):152
Cell communication and signaling : CCS 2023 Jun 22;21(1):152
CRISPR screening identifies the deubiquitylase ATXN3 as a PD-L1-positive regulator for tumor immune evasion.
Wang S, Iyer R, Han X, Wei J, Li N, Cheng Y, Zhou Y, Gao Q, Zhang L, Yan M, Sun Z, Fang D
The Journal of clinical investigation 2023 Dec 1;133(23)
The Journal of clinical investigation 2023 Dec 1;133(23)
The Mechano-Ubiquitinome of Articular Cartilage: Differential Ubiquitination and Activation of a Group of ER-Associated DUBs and ER Stress Regulators.
Kaokhum N, Pinto-Fernández A, Wilkinson M, Kessler BM, Ismail HM
Molecular & cellular proteomics : MCP 2022 Dec;21(12):100419
Molecular & cellular proteomics : MCP 2022 Dec;21(12):100419
Involvement of miR-619-5p in resistance to cisplatin by regulating ATXN3 in oral squamous cell carcinoma.
Song A, Wu Y, Chu W, Yang X, Zhu Z, Yan E, Zhang W, Zhou J, Ding X, Liu J, Zhu H, Ye J, Wu Y, Zheng Y, Song X
International journal of biological sciences 2021;17(2):430-447
International journal of biological sciences 2021;17(2):430-447
DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases.
Zhang N, Bewick B, Schultz J, Tiwari A, Krencik R, Zhang A, Adachi K, Xia G, Yun K, Sarkar P, Ashizawa T
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2021 Jul;18(3):1710-1728
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2021 Jul;18(3):1710-1728
USP15 participates in DBP-induced testicular oxidative stress injury through regulating the Keap1/Nrf2 signaling pathway.
Zhang L, Gao X, Qin Z, Shi X, Xu K, Wang S, Tang M, Wang W, Gao S, Zuo L, Zhang L, Zhang W
The Science of the total environment 2021 Aug 20;783:146898
The Science of the total environment 2021 Aug 20;783:146898
TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling.
Zhu R, Gires O, Zhu L, Liu J, Li J, Yang H, Ju G, Huang J, Ge W, Chen Y, Lu Z, Wang H
Nature communications 2019 Jun 28;10(1):2863
Nature communications 2019 Jun 28;10(1):2863
CRISPR/Cas9-Targeted Deletion of Polyglutamine in Spinocerebellar Ataxia Type 3-Derived Induced Pluripotent Stem Cells.
Ouyang S, Xie Y, Xiong Z, Yang Y, Xian Y, Ou Z, Song B, Chen Y, Xie Y, Li H, Sun X
Stem cells and development 2018 Jun 1;27(11):756-770
Stem cells and development 2018 Jun 1;27(11):756-770
ATXN3 Positively Regulates Type I IFN Antiviral Response by Deubiquitinating and Stabilizing HDAC3.
Feng Q, Miao Y, Ge J, Yuan Y, Zuo Y, Qian L, Liu J, Cheng Q, Guo T, Zhang L, Yu Z, Zheng H
Journal of immunology (Baltimore, Md. : 1950) 2018 Jul 15;201(2):675-687
Journal of immunology (Baltimore, Md. : 1950) 2018 Jul 15;201(2):675-687
An Interaction Landscape of Ubiquitin Signaling.
Zhang X, Smits AH, van Tilburg GB, Jansen PW, Makowski MM, Ovaa H, Vermeulen M
Molecular cell 2017 Mar 2;65(5):941-955.e8
Molecular cell 2017 Mar 2;65(5):941-955.e8
Rescue of ATXN3 neuronal toxicity in Caenorhabditiselegans by chemical modification of endoplasmic reticulum stress.
Fardghassemi Y, Tauffenberger A, Gosselin S, Parker JA
Disease models & mechanisms 2017 Dec 19;10(12):1465-1480
Disease models & mechanisms 2017 Dec 19;10(12):1465-1480
A new humanized ataxin-3 knock-in mouse model combines the genetic features, pathogenesis of neurons and glia and late disease onset of SCA3/MJD.
Switonski PM, Szlachcic WJ, Krzyzosiak WJ, Figiel M
Neurobiology of disease 2015 Jan;73:174-88
Neurobiology of disease 2015 Jan;73:174-88
Inactivation of PNKP by mutant ATXN3 triggers apoptosis by activating the DNA damage-response pathway in SCA3.
Gao R, Liu Y, Silva-Fernandes A, Fang X, Paulucci-Holthauzen A, Chatterjee A, Zhang HL, Matsuura T, Choudhary S, Ashizawa T, Koeppen AH, Maciel P, Hazra TK, Sarkar PS
PLoS genetics 2015 Jan;11(1):e1004834
PLoS genetics 2015 Jan;11(1):e1004834
The role of the mammalian DNA end-processing enzyme polynucleotide kinase 3'-phosphatase in spinocerebellar ataxia type 3 pathogenesis.
Chatterjee A, Saha S, Chakraborty A, Silva-Fernandes A, Mandal SM, Neves-Carvalho A, Liu Y, Pandita RK, Hegde ML, Hegde PM, Boldogh I, Ashizawa T, Koeppen AH, Pandita TK, Maciel P, Sarkar PS, Hazra TK
PLoS genetics 2015 Jan;11(1):e1004749
PLoS genetics 2015 Jan;11(1):e1004749
A deubiquitinase negatively regulates retro-translocation of nonubiquitinated substrates.
Bernardi KM, Williams JM, Inoue T, Schultz A, Tsai B
Molecular biology of the cell 2013 Nov;24(22):3545-56
Molecular biology of the cell 2013 Nov;24(22):3545-56
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse pancreas tissue were subjected to SDS PAGE followed by western blot with 13505-1-AP(ATX3,ATXN3 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ATX3,ATXN3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ATX3,ATXN3. This antibody recognizes human, mouse, rat antigen. The ATX3,ATXN3 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human pancreas cancer using 13505-1-AP(ATX3,ATXN3 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
