13505-1-AP

antibody from Proteintech Group

Targeting: ATXN3 ATX3, JOS, MJD, SCA3

Provider product page for 13505-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [29]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 13505-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#13505-1-AP, RRID:AB_2061192
Product name: ATX3,ATXN3 antibody
Antibody type: Polyclonal
Description: KD/KO validated ATX3,ATXN3 antibody (Cat. #13505-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ATXN3 protein structure - 13505-1-AP shown in red.

Submitted references ATI-1 mediated disruption of the VCP-UFL1-Beclin1 axis thwarts autophagy initiation to trigger metabolic catastrophe in autophagy-addicted cancers.

Liu T, Zhao M, Gao J, Liu J, Zhang J
Bioorganic chemistry 2026 Aug 5;177:109923

Nomogram Based on A-To-I RNA Editing for Predicting Overall Survival in Patients With Breast Cancer.

Zhang Y, Zhou J, Li H, Chai D, Lian B, Liu Y, Guo L, Li J
Journal of cellular and molecular medicine 2025 Sep;29(18):e70781

CAG-targeted brain-permeable therapy tested in biallelic humanized polyQ mouse models.

Surdyka M, Kalinowska-Pośka Ż, Niewiadomska-Cimicka A, Jesion E, Fiszer A, Singer-Mikosch E, Fievet L, Przybyl L, Caron NS, Hayden MR, Nguyen HP, Trottier Y, Figiel M
Molecular therapy. Nucleic acids 2025 Jun 10;36(2):102496

The deubiquitinating enzyme ATXN3 promotes hepatocellular carcinoma progression by stabilizing TAZ.

Peng Y, Nie H, Kang K, Li X, Tao Y, Zhou Y
Cancer gene therapy 2025 Jan;32(1):136-145

Genome editing in spinocerebellar ataxia type 3 cells improves Golgi apparatus structure.

Wang Y, Cheng Y, Sun H, Wang Z, Chen N, Shi C, Liu H, Yang J, Xu Y
Scientific reports 2025 Apr 9;15(1):12106

Fructose-2,6-bisphosphate restores DNA repair activity of PNKP and ameliorates neurodegenerative symptoms in Huntington's disease.

Chakraborty A, Sreenivasmurthy SG, Miller W, Huai W, Biswas T, Mandal SM, Boscá L, Krishnan B, Ghosh G, Hazra T
Proceedings of the National Academy of Sciences of the United States of America 2024 Sep 24;121(39):e2406308121

ATXN3 functions as a tumor suppressor through potentiating galectin-9-mediated apoptosis in human colon adenocarcinoma.

Cheng Y, Wang S, Gao Q, Fang D
The Journal of biological chemistry 2024 Jul;300(7):107415

Fructose-2,6-bisphosphate restores DNA repair activity of PNKP and ameliorates neurodegenerative symptoms in Huntington's disease.

Chakraborty A, Sreenivasmurthy SG, Miller W, Huai W, Biswas T, Mandal SM, Boscá L, Krishnan B, Ghosh G, Hazra T
bioRxiv : the preprint server for biology 2024 Jul 16;

XAF1 promotes colorectal cancer metastasis via VCP-RNF114-JUP axis.

Xia J, Ma N, Shi Q, Liu QC, Zhang W, Cao HJ, Wang YK, Zheng QW, Ni QZ, Xu S, Zhu B, Qiu XS, Ding K, Huang JY, Liang X, Chen Y, Xiang YJ, Zhang XR, Qiu L, Chen W, Xie D, Wang X, Long L, Li JJ
The Journal of cell biology 2024 Feb 5;223(2)

VCP/p97-associated proteins are binders and debranching enzymes of K48-K63-branched ubiquitin chains.

Lange SM, McFarland MR, Lamoliatte F, Carroll T, Krshnan L, Pérez-Ràfols A, Kwasna D, Shen L, Wallace I, Cole I, Armstrong LA, Knebel A, Johnson C, De Cesare V, Kulathu Y
Nature structural & molecular biology 2024 Dec;31(12):1872-1887

Impaired interactions of ataxin-3 with protein complexes reveals their specific structure and functions in SCA3 Ki150 model.

Piasecki P, Wiatr K, Ruszkowski M, Marczak Ł, Trottier Y, Figiel M
Frontiers in molecular neuroscience 2023;16:1122308

ATXN3 deubiquitinates YAP1 to promote tumor growth.

Wang S, Liu K, Han X, Cheng Y, Zhao E, Brat DJ, Sun Z, Fang D
American journal of cancer research 2023;13(9):4222-4234

Human DNA polymerase η promotes RNA-templated error-free repair of DNA double-strand breaks.

Chakraborty A, Tapryal N, Islam A, Sarker AH, Manohar K, Mitra J, Hegde ML, Hazra T
The Journal of biological chemistry 2023 Mar;299(3):102991

CircHIPK3 negatively regulates autophagy by blocking VCP binding to the Beclin 1 complex in bladder cancer.

Wang C, Liu T, Wang J, Cheng C, Zhang Z, Zhang J, Huang H, Li Y
Discover oncology 2023 Jun 3;14(1):86

ATXN3 promotes prostate cancer progression by stabilizing YAP.

Wu L, Ou Z, Liu P, Zhao C, Tong S, Wang R, Li Y, Yuan J, Chen M, Fan B, Zu X, Wang Y, Tang J
Cell communication and signaling : CCS 2023 Jun 22;21(1):152

CRISPR screening identifies the deubiquitylase ATXN3 as a PD-L1-positive regulator for tumor immune evasion.

Wang S, Iyer R, Han X, Wei J, Li N, Cheng Y, Zhou Y, Gao Q, Zhang L, Yan M, Sun Z, Fang D
The Journal of clinical investigation 2023 Dec 1;133(23)

The Mechano-Ubiquitinome of Articular Cartilage: Differential Ubiquitination and Activation of a Group of ER-Associated DUBs and ER Stress Regulators.

Kaokhum N, Pinto-Fernández A, Wilkinson M, Kessler BM, Ismail HM
Molecular & cellular proteomics : MCP 2022 Dec;21(12):100419

Involvement of miR-619-5p in resistance to cisplatin by regulating ATXN3 in oral squamous cell carcinoma.

Song A, Wu Y, Chu W, Yang X, Zhu Z, Yan E, Zhang W, Zhou J, Ding X, Liu J, Zhu H, Ye J, Wu Y, Zheng Y, Song X
International journal of biological sciences 2021;17(2):430-447

DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases.

Zhang N, Bewick B, Schultz J, Tiwari A, Krencik R, Zhang A, Adachi K, Xia G, Yun K, Sarkar P, Ashizawa T
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2021 Jul;18(3):1710-1728

USP15 participates in DBP-induced testicular oxidative stress injury through regulating the Keap1/Nrf2 signaling pathway.

Zhang L, Gao X, Qin Z, Shi X, Xu K, Wang S, Tang M, Wang W, Gao S, Zuo L, Zhang L, Zhang W
The Science of the total environment 2021 Aug 20;783:146898

TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling.

Zhu R, Gires O, Zhu L, Liu J, Li J, Yang H, Ju G, Huang J, Ge W, Chen Y, Lu Z, Wang H
Nature communications 2019 Jun 28;10(1):2863

CRISPR/Cas9-Targeted Deletion of Polyglutamine in Spinocerebellar Ataxia Type 3-Derived Induced Pluripotent Stem Cells.

Ouyang S, Xie Y, Xiong Z, Yang Y, Xian Y, Ou Z, Song B, Chen Y, Xie Y, Li H, Sun X
Stem cells and development 2018 Jun 1;27(11):756-770

ATXN3 Positively Regulates Type I IFN Antiviral Response by Deubiquitinating and Stabilizing HDAC3.

Feng Q, Miao Y, Ge J, Yuan Y, Zuo Y, Qian L, Liu J, Cheng Q, Guo T, Zhang L, Yu Z, Zheng H
Journal of immunology (Baltimore, Md. : 1950) 2018 Jul 15;201(2):675-687

An Interaction Landscape of Ubiquitin Signaling.

Zhang X, Smits AH, van Tilburg GB, Jansen PW, Makowski MM, Ovaa H, Vermeulen M
Molecular cell 2017 Mar 2;65(5):941-955.e8

Rescue of ATXN3 neuronal toxicity in Caenorhabditiselegans by chemical modification of endoplasmic reticulum stress.

Fardghassemi Y, Tauffenberger A, Gosselin S, Parker JA
Disease models & mechanisms 2017 Dec 19;10(12):1465-1480

A new humanized ataxin-3 knock-in mouse model combines the genetic features, pathogenesis of neurons and glia and late disease onset of SCA3/MJD.

Switonski PM, Szlachcic WJ, Krzyzosiak WJ, Figiel M
Neurobiology of disease 2015 Jan;73:174-88

Inactivation of PNKP by mutant ATXN3 triggers apoptosis by activating the DNA damage-response pathway in SCA3.

Gao R, Liu Y, Silva-Fernandes A, Fang X, Paulucci-Holthauzen A, Chatterjee A, Zhang HL, Matsuura T, Choudhary S, Ashizawa T, Koeppen AH, Maciel P, Hazra TK, Sarkar PS
PLoS genetics 2015 Jan;11(1):e1004834

The role of the mammalian DNA end-processing enzyme polynucleotide kinase 3'-phosphatase in spinocerebellar ataxia type 3 pathogenesis.

Chatterjee A, Saha S, Chakraborty A, Silva-Fernandes A, Mandal SM, Neves-Carvalho A, Liu Y, Pandita RK, Hegde ML, Hegde PM, Boldogh I, Ashizawa T, Koeppen AH, Pandita TK, Maciel P, Sarkar PS, Hazra TK
PLoS genetics 2015 Jan;11(1):e1004749

A deubiquitinase negatively regulates retro-translocation of nonubiquitinated substrates.

Bernardi KM, Williams JM, Inoue T, Schultz A, Tsai B
Molecular biology of the cell 2013 Nov;24(22):3545-56

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse pancreas tissue were subjected to SDS PAGE followed by western blot with 13505-1-AP(ATX3,ATXN3 antibody) at dilution of 1:500
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The ATX3,ATXN3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ATX3,ATXN3. This antibody recognizes human, mouse, rat antigen. The ATX3,ATXN3 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 13505-1-AP.pdf

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human pancreas cancer using 13505-1-AP(ATX3,ATXN3 antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue