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- References [19]
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- Product number
- 19858-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#19858-1-AP, RRID:AB_10665555
- Product name
- Spermidine synthase antibody
- Antibody type
- Polyclonal
- Description
- Spermidine synthase antibody (Cat. #19858-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Assessing the Role of Polyamine Metabolites in Blood and the DNA Methylation of Mycobacterium Tuberculosis in Patients with Multidrug-Resistant Tuberculosis.
Oleanolic acid alleviates ulcerative colitis by remodeling Th17 cells via targeting HSP90β-ODC1 pathway-mediated polyamine synthesis.
A Genome-Wide Synthetic Lethal Screen Identifies Spermidine Synthase as a Target to Enhance Erdafitinib Efficacy in FGFR-Mutant Bladder Cancer.
Polyamines buffer labile iron to suppress ferroptosis.
Arachidonic acid triggers spermidine synthase secretion from primary tumor to induce skeletal muscle weakness upon irradiation.
Secreted spermidine synthase reveals a paracrine role for PGC1α-induced growth suppression in prostate cancer.
Development of a novel centrosome-related risk signature to predict prognosis and treatment response in lung adenocarcinoma.
Acidic extracellular pH drives accumulation of N1-acetylspermidine and recruitment of protumor neutrophils.
The upregulation of peripheral blood polyamine metabolites spermidine and spermine in children with hand, foot, mouth disease is related to enterovirus 71 capsid protein VP1, but not VP4.
Inhibition of Polyamine Catabolism Reduces Cellular Senescence.
A search for acrolein scavengers among food components.
Progesterone and interferon tau regulate expression of polyamine enzymes during the ovine peri-implantation period†.
The regulation of polyamine pathway proteins in models of skeletal muscle hypertrophy and atrophy: a potential role for mTORC1.
Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology.
Correlation of polyamines, acrolein-conjugated lysine and polyamine metabolic enzyme levels with age in human liver.
The miR-1908/SRM regulatory axis contributes to extracellular vesicle secretion in prostate cancer.
Proteomic analysis revealed different responses to hypergravity of soleus and extensor digitorum longus muscles in mice.
Polyamine Homeostasis in Snyder-Robinson Syndrome.
Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM.
Yan L, Niu X, Liang K, Guan F, Yu X, Ye Z, Huang M, Liang H, Zhong X, Zeng J
International journal of medical sciences 2025;22(8):1762-1772
International journal of medical sciences 2025;22(8):1762-1772
Oleanolic acid alleviates ulcerative colitis by remodeling Th17 cells via targeting HSP90β-ODC1 pathway-mediated polyamine synthesis.
Yuan Y, Tian Y, Zhao Z, Gui Y, Wang J, Zhu F, Xue G, Gao F, Liu Y, Fan H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157441
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157441
A Genome-Wide Synthetic Lethal Screen Identifies Spermidine Synthase as a Target to Enhance Erdafitinib Efficacy in FGFR-Mutant Bladder Cancer.
Yu Y, Gao X, Zhao H, Sun J, Wang M, Xiong X, Li J, Huang C, Zhang H, Jiang G, Xiao X
Cancer research 2025 Jun 16;85(12):2288-2301
Cancer research 2025 Jun 16;85(12):2288-2301
Polyamines buffer labile iron to suppress ferroptosis.
Sharma P, Keys HR, Müller S, Pires IS, Mansell R, Imada S, Kunchok T, Waite M, Ausler C, Yuan B, Deik A, Hammond PT, Rodriguez R, Henry W, Jain A
bioRxiv : the preprint server for biology 2025 Jul 2;
bioRxiv : the preprint server for biology 2025 Jul 2;
Arachidonic acid triggers spermidine synthase secretion from primary tumor to induce skeletal muscle weakness upon irradiation.
Zhang X, Nie Z, Wang S, Ma Y, Han D, Hu T, Liu L, Men L, Zhang T, Wu X, Li X, Hu S, Yuan M, Liu L, Wang C, Xu P, Xiang L, Liu J, Zhang Y, Zhu D, Lei H, Zhang L, Li X, Zhao Y, Yan W
Cell metabolism 2025 Aug 5;37(8):1766-1782.e12
Cell metabolism 2025 Aug 5;37(8):1766-1782.e12
Secreted spermidine synthase reveals a paracrine role for PGC1α-induced growth suppression in prostate cancer.
Schaub-Clerigué A, Hermanova I, Pintor-Rial A, Sydorenko M, Valcarcel-Jimenez L, Macchia A, Lectez B, Garcia-Longarte S, Fagoaga-Eugui M, Astobiza I, Martín-Martín N, Zabala-Letona A, Pujana-Vaquerizo M, Royo F, Azkargorta M, Berra E, Sutherland JD, Peinado H, Falcón-Perez JM, Elortza F, Carracedo A, Torrano V
Cell death & disease 2025 Apr 23;16(1):330
Cell death & disease 2025 Apr 23;16(1):330
Development of a novel centrosome-related risk signature to predict prognosis and treatment response in lung adenocarcinoma.
Wang Z, Zuo C, Fei J, Chen H, Wang L, Xie Y, Zhang J, Min S, Wang X, Lian C
Discover oncology 2024 Nov 26;15(1):717
Discover oncology 2024 Nov 26;15(1):717
Acidic extracellular pH drives accumulation of N1-acetylspermidine and recruitment of protumor neutrophils.
Kato M, Maeda K, Nakahara R, Hirose H, Kondo A, Aki S, Sugaya M, Hibino S, Nishida M, Hasegawa M, Morita H, Ando R, Tsuchida R, Yoshida M, Kodama T, Yanai H, Shimamura T, Osawa T
PNAS nexus 2023 Oct;2(10):pgad306
PNAS nexus 2023 Oct;2(10):pgad306
The upregulation of peripheral blood polyamine metabolites spermidine and spermine in children with hand, foot, mouth disease is related to enterovirus 71 capsid protein VP1, but not VP4.
Li C, Zhang W, Chang X, Di X, Xie Q, Lin B, Zhang H, Ye Z, Lan M, Lian J, Zhang H, Qiu X, Zeng J, Huang M
Translational pediatrics 2023 Feb 28;12(2):194-207
Translational pediatrics 2023 Feb 28;12(2):194-207
Inhibition of Polyamine Catabolism Reduces Cellular Senescence.
Uemura T, Matsunaga M, Yokota Y, Takao K, Furuchi T
International journal of molecular sciences 2023 Aug 29;24(17)
International journal of molecular sciences 2023 Aug 29;24(17)
A search for acrolein scavengers among food components.
Uemura T, Uchida M, Nakamura M, Shimekake M, Sakamoto A, Terui Y, Higashi K, Ishii I, Kashiwagi K, Igarashi K
Amino acids 2023 Apr;55(4):509-518
Amino acids 2023 Apr;55(4):509-518
Progesterone and interferon tau regulate expression of polyamine enzymes during the ovine peri-implantation period†.
Halloran KM, Stenhouse C, Moses RM, Seo H, Johnson GA, Wu G, Bazer FW
Biology of reproduction 2022 May 17;106(5):865-878
Biology of reproduction 2022 May 17;106(5):865-878
The regulation of polyamine pathway proteins in models of skeletal muscle hypertrophy and atrophy: a potential role for mTORC1.
Tabbaa M, Ruz Gomez T, Campelj DG, Gregorevic P, Hayes A, Goodman CA
American journal of physiology. Cell physiology 2021 Jun 1;320(6):C987-C999
American journal of physiology. Cell physiology 2021 Jun 1;320(6):C987-C999
Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology.
Sandusky-Beltran LA, Kovalenko A, Placides DS, Ratnasamy K, Ma C, Hunt JB Jr, Liang H, Calahatian JIT, Michalski C, Fahnestock M, Blair LJ, Darling AL, Baker JD, Fontaine SN, Dickey CA, Gamsby JJ, Nash KR, Abner E, Selenica MB, Lee DC
The Journal of clinical investigation 2021 Feb 15;131(4)
The Journal of clinical investigation 2021 Feb 15;131(4)
Correlation of polyamines, acrolein-conjugated lysine and polyamine metabolic enzyme levels with age in human liver.
Uemura T, Akasaka Y, Ikegaya H
Heliyon 2020 Sep;6(9):e05031
Heliyon 2020 Sep;6(9):e05031
The miR-1908/SRM regulatory axis contributes to extracellular vesicle secretion in prostate cancer.
Urabe F, Kosaka N, Sawa Y, Ito K, Kimura T, Egawa S, Ochiya T, Yamamoto Y
Cancer science 2020 Sep;111(9):3258-3267
Cancer science 2020 Sep;111(9):3258-3267
Proteomic analysis revealed different responses to hypergravity of soleus and extensor digitorum longus muscles in mice.
Ohira T, Ino Y, Nakai Y, Morita H, Kimura A, Kurata Y, Kagawa H, Kimura M, Egashira K, Moriya S, Hiramatsu K, Kawakita M, Kimura Y, Hirano H
Journal of proteomics 2020 Apr 15;217:103686
Journal of proteomics 2020 Apr 15;217:103686
Polyamine Homeostasis in Snyder-Robinson Syndrome.
Murray-Stewart T, Dunworth M, Foley JR, Schwartz CE, Casero RA Jr
Medical sciences (Basel, Switzerland) 2018 Dec 7;6(4)
Medical sciences (Basel, Switzerland) 2018 Dec 7;6(4)
Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM.
Miao H, Ou J, Peng Y, Zhang X, Chen Y, Hao L, Xie G, Wang Z, Pang X, Ruan Z, Li J, Yu L, Xue B, Shi H, Shi C, Liang H
Nature communications 2016 May 18;7:11716
Nature communications 2016 May 18;7:11716
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- PC-3 cells were subjected to SDS PAGE followed by western blot with 19858-1-AP(SRM antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using SRM antibody 19858-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
