Antibody data
- Antibody Data
- Antigen structure
- References [14]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 13442-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13442-2-AP, RRID:AB_2153596
- Product name
- NNT antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated NNT antibody (Cat. #13442-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references G-protein-coupled estrogen receptor 1 promotes peritoneal metastasis of gastric cancer through nicotinamide adenine dinucleotide kinase 1-mediated redox modulation.
Chronic stress hinders sensory axon regeneration via impairing mitochondrial cristae and OXPHOS.
CRISPR-based DNA methylation editing of NNT rescues the cisplatin resistance of lung cancer cells by reducing autophagy.
Ubiquitin-specific peptidase 47 (USP47) regulates cutaneous oxidative injury through nicotinamide nucleotide transhydrogenase (NNT).
Dynamic Mitochondrial Proteome Under Polyamines Treatment in Cardiac Aging.
Nicotinamide nucleotide transhydrogenase mutation analysis in Chinese patients with thyroid dysgenesis.
Inhibiting bridge integrator 2 phosphorylation leads to improved oocyte quality, ovarian health and fertility in aging and after chemotherapy in mice.
Mitochondrial NADP(+) is essential for proline biosynthesis during cell growth.
Nicotinamide nucleotide transhydrogenase acts as a new prognosis biomarker in hepatocellular carcinoma.
Nicotinamide nucleotide transhydrogenase-mediated redox homeostasis promotes tumor growth and metastasis in gastric cancer.
Targeted Metabolomics Reveals Abnormal Hepatic Energy Metabolism by Depletion of β-Carotene Oxygenase 2 in Mice.
Lack of β, β-carotene-9', 10'-oxygenase 2 leads to hepatic mitochondrial dysfunction and cellular oxidative stress in mice.
Effect of Type I Diabetes on the Proteome of Mouse Oocytes.
Impact of a novel homozygous mutation in nicotinamide nucleotide transhydrogenase on mitochondrial DNA integrity in a case of familial glucocorticoid deficiency.
Wu T, Ding K, Wang C, Lin G, Xie C, Chen X, Li Q, Yu F, Mao Y, Hong W, Lu L, Li S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Feb 15;38(3):e23449
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Feb 15;38(3):e23449
Chronic stress hinders sensory axon regeneration via impairing mitochondrial cristae and OXPHOS.
Ruan Y, Cheng J, Dai J, Ma Z, Luo S, Yan R, Wang L, Zhou J, Yu B, Tong X, Shen H, Zhou L, Yuan TF, Han Q
Science advances 2023 Oct 6;9(40):eadh0183
Science advances 2023 Oct 6;9(40):eadh0183
CRISPR-based DNA methylation editing of NNT rescues the cisplatin resistance of lung cancer cells by reducing autophagy.
Xu C, Jiang S, Ma X, Jiang Z, Pan Y, Li X, Zhang L, Zhou H, Chen S, Xing X, Chen L, Fu W, Wang Q, Chen W, Li D
Archives of toxicology 2023 Feb;97(2):441-456
Archives of toxicology 2023 Feb;97(2):441-456
Ubiquitin-specific peptidase 47 (USP47) regulates cutaneous oxidative injury through nicotinamide nucleotide transhydrogenase (NNT).
Li X, Qian K, Zhang Y, Zhang Y, Liu Y, Sun C, Jiao Y, Yu D, Geng F, Cao J, Zhang S
Toxicology and applied pharmacology 2023 Dec 1;480:116734
Toxicology and applied pharmacology 2023 Dec 1;480:116734
Dynamic Mitochondrial Proteome Under Polyamines Treatment in Cardiac Aging.
Zhang H, Yan M, Liu T, Wei P, Chai N, Li L, Wang J, Yu X, Lin Y, Qiu B, Zhao Y
Frontiers in cell and developmental biology 2022;10:840389
Frontiers in cell and developmental biology 2022;10:840389
Nicotinamide nucleotide transhydrogenase mutation analysis in Chinese patients with thyroid dysgenesis.
Li M, Tian W, Wang F, Yang C, Zhang L, Tang Q, Liu S, Wang F
American journal of medical genetics. Part A 2022 Jan;188(1):89-98
American journal of medical genetics. Part A 2022 Jan;188(1):89-98
Inhibiting bridge integrator 2 phosphorylation leads to improved oocyte quality, ovarian health and fertility in aging and after chemotherapy in mice.
Zhu FY, Wang LL, Meng TG, Wang RL, Yang ZX, Cao Y, Zhu GY, Jin Z, Gao LL, Zeng WT, Wang ZB, Sun QY, Zhang D
Nature aging 2021 Nov;1(11):1010-1023
Nature aging 2021 Nov;1(11):1010-1023
Mitochondrial NADP(+) is essential for proline biosynthesis during cell growth.
Tran DH, Kesavan R, Rion H, Soflaee MH, Solmonson A, Bezwada D, Vu HS, Cai F, Phillips JA 3rd, DeBerardinis RJ, Hoxhaj G
Nature metabolism 2021 Apr;3(4):571-585
Nature metabolism 2021 Apr;3(4):571-585
Nicotinamide nucleotide transhydrogenase acts as a new prognosis biomarker in hepatocellular carcinoma.
Duan Z, Song Y, Zou X, Liu S, Zhang W, Liu L
International journal of clinical and experimental pathology 2020;13(5):972-978
International journal of clinical and experimental pathology 2020;13(5):972-978
Nicotinamide nucleotide transhydrogenase-mediated redox homeostasis promotes tumor growth and metastasis in gastric cancer.
Li S, Zhuang Z, Wu T, Lin JC, Liu ZX, Zhou LF, Dai T, Lu L, Ju HQ
Redox biology 2018 Sep;18:246-255
Redox biology 2018 Sep;18:246-255
Targeted Metabolomics Reveals Abnormal Hepatic Energy Metabolism by Depletion of β-Carotene Oxygenase 2 in Mice.
Wu L, Guo X, Lyu Y, Clarke SL, Lucas EA, Smith BJ, Hildebrand D, Wang W, Medeiros DM, Shen X, Lin D
Scientific reports 2017 Nov 7;7(1):14624
Scientific reports 2017 Nov 7;7(1):14624
Lack of β, β-carotene-9', 10'-oxygenase 2 leads to hepatic mitochondrial dysfunction and cellular oxidative stress in mice.
Wu L, Guo X, Hartson SD, Davis MA, He H, Medeiros DM, Wang W, Clarke SL, Lucas EA, Smith BJ, von Lintig J, Lin D
Molecular nutrition & food research 2017 May;61(5)
Molecular nutrition & food research 2017 May;61(5)
Effect of Type I Diabetes on the Proteome of Mouse Oocytes.
Jiang G, Zhang G, An T, He Z, Kang L, Yang X, Gu Y, Zhang D, Wang Y, Gao S
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016;39(6):2320-2330
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016;39(6):2320-2330
Impact of a novel homozygous mutation in nicotinamide nucleotide transhydrogenase on mitochondrial DNA integrity in a case of familial glucocorticoid deficiency.
Fujisawa Y, Napoli E, Wong S, Song G, Yamaguchi R, Matsui T, Nagasaki K, Ogata T, Giulivi C
BBA clinical 2015 Jun 1;3:70-78
BBA clinical 2015 Jun 1;3:70-78
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human adrenal gland tissue were subjected to SDS PAGE followed by western blot with 13442-2-AP(NNT antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 13442-2-AP(NNT antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The NNT antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human NNT. This antibody recognizes human,mouse,rat antigen. The NNT antibody has been validated for the following applications: ELISA, WB, IHC analysis.