Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 301202 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#301202, RRID:AB_314140
- Product name
- Purified anti-human CD11a
- Antibody type
- Monoclonal
- Antigen
- CD11a
- Description
- CD11a is a 170-180 kD type I transmembrane glycoprotein also known as LFA-1α chain and integrin αL subunit. CD11a non-covalently associates with integrin β2 (CD18) to form LFA-1. It is expressed on all leukocytes, including B and T lymphocytes, monocytes, macrophages, neutrophils, basophils and eosinophils. It is absent on non-hematopoietic tissues and platelets. CD11a plays a central role in leukocyte cell-cell interactions and is important in lymphocyte costimulation. CD11a/CD18 binds to ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50). The HI111 antibody blocks cell-cell interaction.
- Reactivity
- Human, Bovine, Canine, Horse, Rabbit, Sheep, Simian
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4° C.
Submitted references Regulation of LFA-1-dependent inflammatory cell recruitment by Cbl-b and 14-3-3 proteins.
Choi EY, Orlova VV, Fagerholm SC, Nurmi SM, Zhang L, Ballantyne CM, Gahmberg CG, Chavakis T
Blood 2008 Apr 1;111(7):3607-14
Blood 2008 Apr 1;111(7):3607-14
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Supportive validation
- Submitted by
- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood lymphocytes stained with purified HI111, followed by anti-mouse IgGs FITC
- Conjugate
- Unconjugated