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Learn14822-1-AP
antibody from Proteintech Group
Targeting: GIPC1
C19orf3, GIPC, GLUT1CBP, Hs.6454, NIP, RGS19IP1, SEMCAP, SYNECTIN, TIP-2
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [17]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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- Product number
- 14822-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14822-1-AP, RRID:AB_2263269
- Product name
- GIPC1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated GIPC1 antibody (Cat. #14822-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references GIPC1 Restrains the Progression and Chemoresistance of Colorectal Cancer by Regulating TTC7B/mTOR/NF-κB Axis.
GIPC1 governed ferroptosis by regulating DECR1-modulating lipid homeostasis during dilated cardiomyopathy (DCM).
Loss of Dab1 Alters Expression Patterns of Endocytic and Signaling Molecules During Embryonic Lung Development in Mice.
Linking Megalin, Cubilin, Caveolin-1, GIPC1 and Dab2IP Expression to Ocular Tumorigenesis: Profiles in Retinoblastoma, Choroidal Melanoma, and the Normal Human Eye.
The Actin Motor Protein Myosin 6 Contributes to Cell Migration and Expression of GIPC1 and Septins in Breast Cancer Cells.
Overexpressing of the GIPC1 protects against pathological cardiac remodelling.
Immunoexpression Patterns of Megalin, Cubilin, Caveolin-1, Gipc1 and Dab2IP in the Embryonic and Postnatal Development of the Kidneys in Yotari (Dab1(-/-)) Mice.
Exploring the oncogenic role of RGS19 in bladder cancer progression and prognosis.
GIPC1 promotes tumor growth and migration in gastric cancer via activating PDGFR/PI3K/AKT signaling.
GIPC1 CGG Repeat Expansion Is Associated with Movement Disorders.
G-alpha interacting protein interacting protein, C terminus 1 regulates epileptogenesis by increasing the expression of metabotropic glutamate receptor 7.
G protein-coupled receptor GPR151 is involved in trigeminal neuropathic pain through the induction of Gβγ/extracellular signal-regulated kinase-mediated neuroinflammation in the trigeminal ganglion.
SH3BP4 promotes neuropilin-1 and α5-integrin endocytosis and is inhibited by Akt.
Expansion of GGC Repeat in GIPC1 Is Associated with Oculopharyngodistal Myopathy.
Myosin VI maintains the actin-dependent organization of the tubulobulbar complexes required for endocytosis during mouse spermiogenesis†‡.
BMP9 directly induces rapid GSK3-β phosphorylation in a Wnt-independent manner through class I PI3K-Akt axis in osteoblasts.
GIPC proteins negatively modulate Plexind1 signaling during vascular development.
Gan D, Yang C, Shen X, Shi J, Wang R, Zhu L, Li H, Luo J, Zhao T, Li J, Song Y, Su H
International journal of biological sciences 2026;22(2):786-801
International journal of biological sciences 2026;22(2):786-801
GIPC1 governed ferroptosis by regulating DECR1-modulating lipid homeostasis during dilated cardiomyopathy (DCM).
Tang N, Mu R, Wang H, Wu J, Zhang J, Huang D, Han Y, Li W, Chen Y, Li X, Sun Y, Zhang Z, Zuo J, Hu Y, Yin Y, Qu Y, Liu J, Jiao L, Liu X, Liang H, Wang N, Bai Y, Liu Y, Wang B, Zhao D, Liu Y, Yang B
Cell death and differentiation 2026 Mar 5;
Cell death and differentiation 2026 Mar 5;
Loss of Dab1 Alters Expression Patterns of Endocytic and Signaling Molecules During Embryonic Lung Development in Mice.
Todorović P, Maglica M, Kelam N, Filipović N, Rizikalo A, Perutina I, Mišković J, Katsuyama Y, Vukojević K
Life (Basel, Switzerland) 2025 Sep 3;15(9)
Life (Basel, Switzerland) 2025 Sep 3;15(9)
Linking Megalin, Cubilin, Caveolin-1, GIPC1 and Dab2IP Expression to Ocular Tumorigenesis: Profiles in Retinoblastoma, Choroidal Melanoma, and the Normal Human Eye.
Kovačević P, Todorović P, Kelam N, Konjevoda S, Kunac N, Marin Lovrić J, Vukojević K
Cancers 2025 Nov 26;17(23)
Cancers 2025 Nov 26;17(23)
The Actin Motor Protein Myosin 6 Contributes to Cell Migration and Expression of GIPC1 and Septins in Breast Cancer Cells.
Izdebska M, Arendt W, Hałas-Wiśniewska M, Zakrzewski P, Lenartowski R, Lenartowska M
Cancer management and research 2024;16:1445-1462
Cancer management and research 2024;16:1445-1462
Overexpressing of the GIPC1 protects against pathological cardiac remodelling.
Sun X, Han Y, Yu Y, Chen Y, Dong C, Lv Y, Qu H, Fan Z, Yu Y, Sang Y, Tang W, Liu Y, Ju J, Zhao D, Bai Y
European journal of pharmacology 2024 May 15;971:176488
European journal of pharmacology 2024 May 15;971:176488
Immunoexpression Patterns of Megalin, Cubilin, Caveolin-1, Gipc1 and Dab2IP in the Embryonic and Postnatal Development of the Kidneys in Yotari (Dab1(-/-)) Mice.
Žužul S, Kelam N, Racetin A, Kovačević P, Konjevoda S, Filipović N, Pavlović N, Vukojević K
Biomedicines 2024 Jul 11;12(7)
Biomedicines 2024 Jul 11;12(7)
Exploring the oncogenic role of RGS19 in bladder cancer progression and prognosis.
Yan L, Luo G, Han C, Meng J, Liang C
Acta histochemica 2024 Dec;126(8):152212
Acta histochemica 2024 Dec;126(8):152212
GIPC1 promotes tumor growth and migration in gastric cancer via activating PDGFR/PI3K/AKT signaling.
Li T, Zhong W, Yang L, Zhao Z, Wang LI, Liu C, Li W, Lv H, Wang S, Yan J, Wu T, Song G, Luo F
Oncology research 2023;32(2):361-371
Oncology research 2023;32(2):361-371
GIPC1 CGG Repeat Expansion Is Associated with Movement Disorders.
Fan Y, Shen S, Yang J, Yao D, Li M, Mao C, Wang Y, Hao X, Ma D, Li J, Shi J, Guo M, Li S, Yuan Y, Liu F, Yang Z, Zhang S, Hu Z, Fan L, Liu H, Zhang C, Wang Y, Wang Q, Zheng H, He Y, Song B, Xu Y, Shi C
Annals of neurology 2022 May;91(5):704-715
Annals of neurology 2022 May;91(5):704-715
G-alpha interacting protein interacting protein, C terminus 1 regulates epileptogenesis by increasing the expression of metabotropic glutamate receptor 7.
Liu Y, Wang Y, Yang J, Xu T, Tan C, Zhang P, Liu Q, Chen Y
CNS neuroscience & therapeutics 2022 Jan;28(1):126-138
CNS neuroscience & therapeutics 2022 Jan;28(1):126-138
G protein-coupled receptor GPR151 is involved in trigeminal neuropathic pain through the induction of Gβγ/extracellular signal-regulated kinase-mediated neuroinflammation in the trigeminal ganglion.
Jiang BC, Zhang J, Wu B, Jiang M, Cao H, Wu H, Gao YJ
Pain 2021 May 1;162(5):1434-1448
Pain 2021 May 1;162(5):1434-1448
SH3BP4 promotes neuropilin-1 and α5-integrin endocytosis and is inhibited by Akt.
Burckhardt CJ, Minna JD, Danuser G
Developmental cell 2021 Apr 19;56(8):1164-1181.e12
Developmental cell 2021 Apr 19;56(8):1164-1181.e12
Expansion of GGC Repeat in GIPC1 Is Associated with Oculopharyngodistal Myopathy.
Deng J, Yu J, Li P, Luan X, Cao L, Zhao J, Yu M, Zhang W, Lv H, Xie Z, Meng L, Zheng Y, Zhao Y, Gang Q, Wang Q, Liu J, Zhu M, Guo X, Su Y, Liang Y, Liang F, Hayashi T, Maeda MH, Sato T, Ura S, Oya Y, Ogasawara M, Iida A, Nishino I, Zhou C, Yan C, Yuan Y, Hong D, Wang Z
American journal of human genetics 2020 Jun 4;106(6):793-804
American journal of human genetics 2020 Jun 4;106(6):793-804
Myosin VI maintains the actin-dependent organization of the tubulobulbar complexes required for endocytosis during mouse spermiogenesis†‡.
Zakrzewski P, Suwińska A, Lenartowski R, Rędowicz MJ, Buss F, Lenartowska M
Biology of reproduction 2020 Apr 15;102(4):863-875
Biology of reproduction 2020 Apr 15;102(4):863-875
BMP9 directly induces rapid GSK3-β phosphorylation in a Wnt-independent manner through class I PI3K-Akt axis in osteoblasts.
Eiraku N, Chiba N, Nakamura T, Amir MS, Seong CH, Ohnishi T, Kusuyama J, Noguchi K, Matsuguchi T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Nov;33(11):12124-12134
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Nov;33(11):12124-12134
GIPC proteins negatively modulate Plexind1 signaling during vascular development.
Carretero-Ortega J, Chhangawala Z, Hunt S, Narvaez C, Menéndez-González J, Gay CM, Zygmunt T, Li X, Torres-Vázquez J
eLife 2019 May 3;8
eLife 2019 May 3;8
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 14822-1-AP(GIPC1 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of A2780 cells, using 14822-1-AP and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-GIPC1 (IP:14822-1-AP, 4ug; Detection:14822-1-AP 1:500) with mouse brain tissue lysate 9500ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 14822-1-AP(GIPC1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 14822-1-AP(GIPC1 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
