Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [16]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 16898-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16898-1-AP, RRID:AB_2295304
- Product name
- HMGCL antibody
- Antibody type
- Polyclonal
- Description
- HMGCL antibody (Cat. #16898-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references TIGAR maintains intestinal epithelial regeneration by stabilizing HMGCL and promoting β-catenin β-hydroxybutyrylation in burn-induced sepsis.
Artesunate promotes intestinal epithelial barrier repair by facilitating HMGCS2-dependent ketogenesis in experimental ulcerative colitis model mice.
Aryl Hydrocarbon Receptor-Dependent miRNA-382-5p Mediates the Classical Pyroptosis Induced by Foodborne Benzo(a)pyrene through Targeting IκB in Liver.
Activation of GPER1 alleviates white matter injury by promoting microglia M2 polarization through EGFR/Stat3 pathway in intracerebral hemorrhage mice.
Impact of Dapagliflozin on Hepatic Lipid Metabolism and a Dynamic Model of Ketone Body Levels.
Identification of potential biomarkers associated with mitochondrial oxidative stress in idiopathic pulmonary arterial hypertension via bioinformatic and experimental analysis.
PCK1 attenuates intrahepatic cholangiocarcinoma progression by suppressing lactate accumulation and PI3K-AKT signaling.
The Impact of a Ketogenic Diet on Late-Stage Pancreatic Carcinogenesis in Mice: Efficacy and Safety Studies.
Phosphorylation by IKKβ Promotes the Degradation of HMGCL via NEDD4 in Lung Cancer.
Hepatic safety profile of pancreatic cancer‑bearing mice fed a ketogenic diet in combination with gemcitabine.
Hepatic palmitoyl-proteomes and acyl-protein thioesterase protein proximity networks link lipid modification and mitochondria.
Innate immune cell-intrinsic ketogenesis is dispensable for organismal metabolism and age-related inflammation.
HMGCL-induced β-hydroxybutyrate production attenuates hepatocellular carcinoma via DPP4-mediated ferroptosis susceptibility.
AMPK induces degradation of the transcriptional repressor PROX1 impairing branched amino acid metabolism and tumourigenesis.
BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma.
Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress.
Zhang P, Wu D, Wei Y, Su S, Zha X, Liu X, Zhang T, Huang Q, Chen Q, Bao Z, Fan S, Xia L, Peng X
Cell death & disease 2026 Feb 19;17(1)
Cell death & disease 2026 Feb 19;17(1)
Artesunate promotes intestinal epithelial barrier repair by facilitating HMGCS2-dependent ketogenesis in experimental ulcerative colitis model mice.
Wang G, Han L, Sun H, Sun T, Wu B, Cheng X, Yang S, Zhou D
International immunopharmacology 2025 Sep 23;162:115152
International immunopharmacology 2025 Sep 23;162:115152
Aryl Hydrocarbon Receptor-Dependent miRNA-382-5p Mediates the Classical Pyroptosis Induced by Foodborne Benzo(a)pyrene through Targeting IκB in Liver.
Meng Y, Jia Y, He Z, Li J, Yuan L
Journal of agricultural and food chemistry 2025 May 28;73(21):12978-12992
Journal of agricultural and food chemistry 2025 May 28;73(21):12978-12992
Activation of GPER1 alleviates white matter injury by promoting microglia M2 polarization through EGFR/Stat3 pathway in intracerebral hemorrhage mice.
Zhang X, Mao J, Li H, Zhang C, Ge H, Zhong J
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2025 Jun;34(6):108315
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2025 Jun;34(6):108315
Impact of Dapagliflozin on Hepatic Lipid Metabolism and a Dynamic Model of Ketone Body Levels.
Wan Z, Yuan M, Liu Z, Cai Y, He H, Hao K
The AAPS journal 2025 Feb 3;27(1):38
The AAPS journal 2025 Feb 3;27(1):38
Identification of potential biomarkers associated with mitochondrial oxidative stress in idiopathic pulmonary arterial hypertension via bioinformatic and experimental analysis.
Zhu Y, Wang X, Yan X, Sun Y, Wang Q, Zhai C
Scientific reports 2025 Dec 9;16(1):1647
Scientific reports 2025 Dec 9;16(1):1647
PCK1 attenuates intrahepatic cholangiocarcinoma progression by suppressing lactate accumulation and PI3K-AKT signaling.
Pei Y, Wu W, Wang J, Yu X, Xu B, Li Z, Li Q, Chen X, Zhan D, Li Y, Wang R, Liu J, He M, Chen W
Functional & integrative genomics 2025 Dec 26;26(1):12
Functional & integrative genomics 2025 Dec 26;26(1):12
The Impact of a Ketogenic Diet on Late-Stage Pancreatic Carcinogenesis in Mice: Efficacy and Safety Studies.
Cortez NE, Bacha TA, Ead AS, Rodriguez Lanzi C, Lacroix C, Franceschetti A, Hong BV, Matsukuma K, Mackenzie GG
Nutrients 2024 Nov 16;16(22)
Nutrients 2024 Nov 16;16(22)
Phosphorylation by IKKβ Promotes the Degradation of HMGCL via NEDD4 in Lung Cancer.
Zhong C, Xiong G, Yang H, Du X, Du J, Yao F, Fang W, Deng Y
International journal of biological sciences 2023;19(4):1110-1122
International journal of biological sciences 2023;19(4):1110-1122
Hepatic safety profile of pancreatic cancer‑bearing mice fed a ketogenic diet in combination with gemcitabine.
Cortez NE, Lanzi CR, Vahmani P, Matsukuma K, Mackenzie GG
Oncology letters 2023 Nov;26(5):479
Oncology letters 2023 Nov;26(5):479
Hepatic palmitoyl-proteomes and acyl-protein thioesterase protein proximity networks link lipid modification and mitochondria.
Speck SL, Bhatt DP, Zhang Q, Adak S, Yin L, Dong G, Feng C, Zhang W, Ben Major M, Wei X, Semenkovich CF
Cell reports 2023 Nov 28;42(11):113389
Cell reports 2023 Nov 28;42(11):113389
Innate immune cell-intrinsic ketogenesis is dispensable for organismal metabolism and age-related inflammation.
Goldberg EL, Letian A, Dlugos T, Leveau C, Dixit VD
The Journal of biological chemistry 2023 Mar;299(3):103005
The Journal of biological chemistry 2023 Mar;299(3):103005
HMGCL-induced β-hydroxybutyrate production attenuates hepatocellular carcinoma via DPP4-mediated ferroptosis susceptibility.
Cui X, Yun X, Sun M, Li R, Lyu X, Lao Y, Qin X, Yu W
Hepatology international 2023 Apr;17(2):377-392
Hepatology international 2023 Apr;17(2):377-392
AMPK induces degradation of the transcriptional repressor PROX1 impairing branched amino acid metabolism and tumourigenesis.
Wang Y, Luo M, Wang F, Tong Y, Li L, Shu Y, Qiao K, Zhang L, Yan G, Liu J, Ji H, Xie Y, Zhang Y, Gao WQ, Liu Y
Nature communications 2022 Nov 24;13(1):7215
Nature communications 2022 Nov 24;13(1):7215
BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma.
Li JT, Yin M, Wang D, Wang J, Lei MZ, Zhang Y, Liu Y, Zhang L, Zou SW, Hu LP, Zhang ZG, Wang YP, Wen WY, Lu HJ, Chen ZJ, Su D, Lei QY
Nature cell biology 2020 Feb;22(2):167-174
Nature cell biology 2020 Feb;22(2):167-174
Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress.
Huang D, Li T, Wang L, Zhang L, Yan R, Li K, Xing S, Wu G, Hu L, Jia W, Lin SC, Dang CV, Song L, Gao P, Zhang H
Cell research 2016 Oct;26(10):1112-1130
Cell research 2016 Oct;26(10):1112-1130
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse liver tissue were subjected to SDS PAGE followed by western blot with 16898-1-AP(HMGCL antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 16898-1-AP(HMGCL antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HMGCL antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human HMGCL. This antibody recognizes human, mouse, rat antigen. The HMGCL antibody has been validated for the following applications: ELISA, WB, IHC analysis.
