AGTO-G056E

antibody from Creative Biolabs

Targeting: PIK3CA PI3K

Functional assay (Recommended by provider)

Antibody Data

Product number

AGTO-G056E

Provider

Creative Biolabs

Product name

Anti-PIK3CA immunotoxin (scFv)-PE

Antibody type

Monoclonal

Description

This immunotoxin was achieved by conjugating/fusing the Anti-PIK3CA scFv to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to prostate cancer cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating prostate cancer.

Reactivity

Human

Host

Mouse