604901

antibody from BioLegend

Targeting: PIK3CA PI3K

Western blot (Data presented on provider website)

Antibody Data

Product number

604901

Provider

BioLegend

Product name

Purified anti-PI3K p110 Š

Antibody type

Polyclonal

Antigen

Recombinant (partial) Amino acid residues 450-550

Description

PI3K p110 delta (phosphatidylinositol-4,5-biphosphate 3-kinase catalytic subunit delta isoform) is a member of the PI3/PI4 kinase family containing a B-Zip domain. This 110 kD protein autophosphorylates, but does not phosphorylate p85 like PI3K p110 δ. PI3K p110 delta exhibits a broad phosphoinositide lipid substrate specificity and is required for directional movement in neutrophils, and is involved in B and T cell receptor complex signaling. This isoform interacts with SH2/SH3 domain-containing p85 adaptor proteins and GTP-bound Ras and consists of catalytic p110 and regulatory p85 subunits and is activated by IL-3, IL-4 and SCF. PI3K is modified by phosphorylation. The Poly6049 antibody recognizes human PI3K p100 delta and has been shown to be useful for Western blotting.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Vial size

50 µl

Storage

Upon receipt, store frozen at -20° C.