Antibody data
- Antibody Data
- Antigen structure
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- Validations
- Western blot [1]
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- Product number
- BS7953 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- HSD17B4 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human HSD17B4.
- Description
- 17ÉÇ-HSD4 (17ÉÇ-hydroxysteroid dehydrogenase type 4) is also known as peroxisomal multifunctional enzyme/protein 2 (MFE-2/MFP-2), D-bifunctional enzyme or 17-ÉÇ Estradiol dehydrogenase type IV. It belongs to the 17ÉÇ-HSD family of proteins that regulate the availability of steroids within various tissues throughout the body. 17ÉÇ-HSD4 inactivates Estradiol through its oxidative activity but it is primarily involved in peroxisomal fatty acid and cholesterol ?-oxidation. It has a multi-domain structure: the dehydrogenase domain is fused to a hydratase and a lipid transfer domain. 17ÉÇ-HSD4 is a target protein of chromeceptin and it is essential for the downstream activation of Stat6. 17ÉÇ-HSD4-deficient patients exhibit Zellweger-like syndrome and die within the first year of life. They display neuronal migration defects, facial dysmorphisms, severe hypotonia and convulsions in the neonatal period.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- WesternBlot (WB) analysis of HSD17B4 polyclonal antibody