BS8379

antibody from Bioworld Technology, Inc
Targeting: RAPSN CMS1D, CMS1E, RNF205
Provider product page for BS8379
Western blot
Immunohistochemistry

Antibody data

Product number
BS8379 - Provider product page
Provider
Bioworld Technology, Inc
Product name
RAPSN polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human RAPSN.
Description
The RAPSN gene locus is located on chromosome 11p11.1-p11.2 and encodes a peripheral membrane protein. Rapsyn (receptor-associated protein of the synapse) is expressed in the postsynaptic membrane of skeletal muscle. Rap-syn is required for the clustering of nicotinic acetylcholine receptors (nAChR). Rapsyn self-associates through at least two of its seven tetra-tricopeptide repeats (TPRs). Rapsyn interacts with the large intracellular domain of the nAChR a subunit through the hydrophobic surface of the coiled-coil domain. Rapsyn modifies trafficking of AChR within the cell. Expression is essential for agrin-induced AChR clustering. Overexpression inhibits agrin-induced AChR clustering pathway. Absence of rapsyn causes deficit in the formation of postsynaptic specializations at neuromuscular synapse, which increases axonal branching and motonueron survival. Rapsyn plays a role in selective targeting of newly synthesized intracellular AChR to postsynaptic membrane.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
RAPSN protein structure - BS8379 shown in red.