orb107636

antibody from Biorbyt

Targeting: SMAD6 HsT17432, MADH6, MADH7

Western blot (Recommended by provider)

Antibody Data

Product number

orb107636

Provider

Biorbyt

Product name

SMAD6 antibody

Antibody type

Polyclonal

Description

Rabbit polyclonal to SMAD6. Mothers against decapentaplegic homolog 6, also known as SMAD6, is a protein that in humans is encoded by the SMAD6 gene. It belongs to the SMAD family of proteins, which belongs to the TGF superfamily of modulators. By PCR screening of a somatic cell hybrid panel and YACs, this gene was mapped to 15q22.31. This gene acts as a mediator of TGF-beta and BMP antiflammatory activity. It can suppress 1L 1R-TLR signaling through its direct interaction with PEL1 and prevent NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. SMAD6 may play a role in blocking the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding and binding to regulatory elements in target promoter regions.

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 μg

Storage

Store at -20°C. for one year. After reconstitution, at 4°C. for one month. It can also be aliquotted and stored frozen at -20°C. for a longer time. Avoid repeated freezing and thawing. "