AMM01919G

antibody from Leading Biology

Targeting: SMAD6 HsT17432, MADH6, MADH7

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

AMM01919G

Provider

Leading Biology

Product name

SMAD6 Antibody (clone 4C8)

Antibody type

Monoclonal

Description

Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.

Reactivity

Human

Host

Mouse

Antibody clone number

4C8

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.