Antibody data
- Antibody Data
- Antigen structure
- References [181]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 15540-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15540-1-AP, RRID:AB_2252506
- Product name
- PPARA antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PPARA antibody (Cat. #15540-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Berberine directly targets AKR1B10 protein to modulate lipid and glucose metabolism disorders in NAFLD.
Dihydromyricetin ameliorates hepatic steatosis and insulin resistance via AMPK/PGC-1α and PPARα-mediated autophagy pathway.
Ketogenic diet time-dependently prevents NAFLD through upregulating the expression of antioxidant protein metallothionein-2.
Oat β-glucan repairs the epidermal barrier by upregulating the levels of epidermal differentiation, cell-cell junctions and lipids via Dectin-1.
Hepatocellular Carcinoma LINC01116 Outcompetes T Cells for Linoleic Acid and Accelerates Tumor Progression.
Postbiotics Prepared Using Lactobacillus reuteri Ameliorates Ethanol-Induced Liver Injury by Regulating the FXR/SHP/SREBP-1c Axis.
The cooperative regulatory effect of the miRNA-130 family on milk fat metabolism in dairy cows.
Tamoxifen upregulates the peroxisomal β-oxidation enzyme Enoyl CoA hydratase and 3-hydroxyacyl CoA hydratase ameliorating hepatic lipid accumulation in mice.
BAP18 acting as a novel peroxisome proliferator-activated receptor α co-regulator contributes to hepatocellular carcinoma progression.
The PPARα/CYP4A14 bile acid pathway is associated with lipid metabolism disorders caused by low birth weight with high-fat diet.
Protective effect of Saussurea involucrata polysaccharide against skin dryness induced by ultraviolet radiation.
Pathological mechanism of heart failure with preserved ejection fraction in rats based on iTRAQ technology.
Bidirectional effect of vitamin D on brown adipogenesis of C3H10T1/2 fibroblast-like cells.
Metabolome combined with gut microbiome revealed the lipid-lowering mechanism of Xuezhiping capsule on hyperlipidemic hamster induced by high fat diet.
Hyodeoxycholic acid ameliorates nonalcoholic fatty liver disease by inhibiting RAN-mediated PPARα nucleus-cytoplasm shuttling.
Down-regulation of Hrd1 protects against myocardial ischemia-reperfusion injury by regulating PPARα to prevent oxidative stress, endoplasmic reticulum stress, and cellular apoptosis.
Deficiency of spns1 exacerbates per- and polyfluoroalkyl substances mediated hepatic toxicity and steatosis in zebrafish (Danio rerio).
L-theanine regulates the immune function of SD rats fed high-protein diets through the FABP5/IL-6/STAT3/PPARα pathway.
Knockdown of repulsive guidance molecule a promotes polarization of microglia into an anti-inflammatory phenotype after oxygen-glucose deprivation-reoxygenation in vitro.
Mechanisms of weight-loss effect in obese mice by the endogenous cannabinoid receptor 2 agonist beta-caryophyllene.
Proanthocyanidin Alleviates Liver Ischemia/Reperfusion Injury by Suppressing Autophagy and Apoptosis via the PPARα/PGC1α Signaling Pathway.
Enhancement of PPARα-Inhibited Leucine Metabolism-Stimulated β-Casein Synthesis and Fatty Acid Synthesis in Primary Bovine Mammary Epithelial Cells.
Combination of canagliflozin and puerarin alleviates the lipotoxicity to diabetic kidney in mice.
MicroRNA-483-5p Inhibits Hepatocellular Carcinoma Cell Proliferation, Cell Steatosis, and Fibrosis by Targeting PPARα and TIMP2.
Intrauterine androgen exposure impairs gonadal adipose tissue functions of adult female rats.
Cyanotoxins Increase Cytotoxicity and Promote Nonalcoholic Fatty Liver Disease Progression by Enhancing Cell Steatosis.
Human umbilical cord mesenchymal stem cell-derived exosomes ameliorate liver steatosis by promoting fatty acid oxidation and reducing fatty acid synthesis.
Di-(2-ethylhexyl) phthalate (DEHP) promoted hepatic lipid accumulation by activating Notch signaling pathway.
A novel small molecule AdipoR2 agonist ameliorates experimental hepatic steatosis in hamsters and mice.
Klf4-Sirt3/Pparα-Lcad pathway contributes to high phosphate-induced lipid degradation.
Exosomal miR-27b-3p secreted by visceral adipocytes contributes to endothelial inflammation and atherogenesis.
PPARγ and C/EBPα response to acute cold stress in brown adipose tissue.
Phosphodiesterase 4B activation exacerbates pulmonary hypertension induced by intermittent hypoxia by regulating mitochondrial injury and cAMP/PKA/p-CREB/PGC-1α signaling.
Mof plays distinct roles in hepatic lipid metabolism under healthy or non-alcoholic fatty liver conditions.
Aloin Attenuates Oxidative Stress, Inflammation, and CCl(4)-Induced Liver Fibrosis in Mice: Possible Role of TGF-β/Smad Signaling.
Air-ventilated normothermic machine perfusion alleviates hepatic injury from DCD rat through CYP1A2.
Therapeutic role of Artemether in the prevention of hepatic steatosis through miR-34a-5p/PPARα pathway.
Sorghum (Sorghum bicolor) Extract-Induced Adipogenesis Is Independent of PPARγ Ser273 Phosphorylation in 3T3-L1 Adipocytes.
Oleoylethanolamide Alleviates Hepatic Ischemia-Reperfusion Injury via Inhibiting Endoplasmic Reticulum Stress-Associated Apoptosis.
Lanzhang Granules Ameliorate Nonalcoholic Fatty Liver Disease by Regulating the PPARα Signaling Pathway.
Gut microbiota and butyrate contribute to nonalcoholic fatty liver disease in premenopause due to estrogen deficiency.
Jiangtang Sanhao formula ameliorates skeletal muscle insulin resistance via regulating GLUT4 translocation in diabetic mice.
D-Mannose Regulates Hepatocyte Lipid Metabolism via PI3K/Akt/mTOR Signaling Pathway and Ameliorates Hepatic Steatosis in Alcoholic Liver Disease.
Fufang Zhenzhu Tiaozhi Capsule Prevents Intestinal Inflammation and Barrier Disruption in Mice With Non-Alcoholic Steatohepatitis.
Sleeve Gastrectomy-Induced AMPK Activation Attenuates Diabetic Cardiomyopathy by Maintaining Mitochondrial Homeostasis via NR4A1 Suppression in Rats.
Atorvastatin Restores PPARα Inhibition of Lipid Metabolism Disorders by Downregulating miR-21 Expression to Improve Mitochondrial Function and Alleviate Diabetic Nephropathy Progression.
Imbalance hepatic metabolism homeostasis in the F1 generation of endometrial DNMT3B conditional knockout female mice.
AKR1C3-dependent lipid droplet formation confers hepatocellular carcinoma cell adaptability to targeted therapy.
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
Limonin stabilises sirtuin 6 (SIRT6) by activating ubiquitin specific peptidase 10 (USP10) in cardiac hypertrophy.
Metabolic Syndrome Ameliorated by 4-Methylesculetin by Reducing Hepatic Lipid Accumulation.
Honokiol alleviates ulcerative colitis by targeting PPAR-γ-TLR4-NF-κB signaling and suppressing gasdermin-D-mediated pyroptosis in vivo and in vitro.
Ginsenoside Rc Modulates SIRT6-NRF2 Interaction to Alleviate Alcoholic Liver Disease.
GDPD5 Related to Lipid Metabolism Is a Potential Prognostic Biomarker in Neuroblastoma.
Dihydroartemisinin alleviates steatosis and inflammation in nonalcoholic steatohepatitis by decreasing endoplasmic reticulum stress and oxidative stress.
Accumulation of polystyrene microplastics induces liver fibrosis by activating cGAS/STING pathway.
Dietary L-arginine supplementation of tilapia (Oreochromis niloticus) alters the microbial population and activates intestinal fatty acid oxidation.
Fat mass and obesity-associated protein promotes liver steatosis by targeting PPARα.
Novel insights for PI3KC3 in mediating lipid accumulation in yellow catfish Pelteobagrus fulvidraco.
Fetal programming by androgen excess impairs liver lipid content and PPARg expression in adult rats.
Amelioration action of gastrodigenin rhamno-pyranoside from Moringa seeds on non-alcoholic fatty liver disease.
PPARα agonist fenofibrate relieves acquired resistance to gefitinib in non-small cell lung cancer by promoting apoptosis via PPARα/AMPK/AKT/FoxO1 pathway.
Steatosis induced by nonylphenol in HepG2 cells and the intervention effect of curcumin.
Prevotellaceae produces butyrate to alleviate PD-1/PD-L1 inhibitor-related cardiotoxicity via PPARα-CYP4X1 axis in colonic macrophages.
Isoliquiritigenin-mediated miR-23a-3p inhibition activates PGC-1α to alleviate alcoholic liver injury.
Activation of PGC-1α via isoliquiritigenin-induced downregulation of miR-138-5p alleviates nonalcoholic fatty liver disease.
Inhibition of high-fat diet-induced obesity via reduction of ER-resident protein Nogo occurs through multiple mechanisms.
Ginsenoside CK ameliorates hepatic lipid accumulation via activating the LKB1/AMPK pathway in vitro and in vivo.
Opuntia dillenii Haw. Polysaccharide Promotes Cholesterol Efflux in THP-1-Derived Foam Cells via the PPARγ-LXRα Signaling Pathway.
m(6)A-Mediated PPARA Translational Suppression Contributes to Corticosterone-Induced Visceral Fat Deposition in Chickens.
Elevated thyroid hormones caused by high concentrate diets participate in hepatic metabolic disorders in dairy cows.
Salvia-Nelumbinis naturalis improves lipid metabolism of NAFLD by regulating the SIRT1/AMPK signaling pathway.
Pdcd4 promotes lipid deposition by attenuating PPARα-mediated fatty acid oxidation in hepatocytes.
L-theanine prevents progression of nonalcoholic hepatic steatosis by regulating hepatocyte lipid metabolic pathways via the CaMKKβ-AMPK signaling pathway.
Gold nanoclusters eliminate obesity induced by antipsychotics.
Lipidomic Alterations and PPARα Activation Induced by Resveratrol Lead to Reduction in Lesion Size in Endometriosis Models.
Fenofibrate Ameliorates Hepatic Ischemia/Reperfusion Injury in Mice: Involvements of Apoptosis, Autophagy, and PPAR-α Activation.
Apigenin Alleviates Liver Fibrosis by Inhibiting Hepatic Stellate Cell Activation and Autophagy via TGF-β1/Smad3 and p38/PPARα Pathways.
Pemafibrate Pretreatment Attenuates Apoptosis and Autophagy during Hepatic Ischemia-Reperfusion Injury by Modulating JAK2/STAT3β/PPARα Pathway.
Recombinant Human Growth Hormone Inhibits Lipotoxicity, Oxidative Stress, and Apoptosis in a Mouse Model of Diabetic Cardiomyopathy.
Exploring the Multi-Tissue Crosstalk Relevant to Insulin Resistance Through Network-Based Analysis.
The Effect of Ellagic Acid on Hepatic Lipid Metabolism and Antioxidant Activity in Mice.
Rubus chingii var. suavissimus alleviates high-fat diet-induced lipid metabolism disorder via modulation of the PPARs/SREBP pathway in Syrian golden hamsters.
Pterostilbene attenuates RIPK3-dependent hepatocyte necroptosis in alcoholic liver disease via SIRT2-mediated NFATc4 deacetylation.
Deficiency of intestinal Bmal1 prevents obesity induced by high-fat feeding.
PPARα agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1.
Human umbilical cord-derived mesenchymal stem cell-exosomal miR-627-5p ameliorates non-alcoholic fatty liver disease by repressing FTO expression.
N(1)-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism.
Danthron ameliorates obesity and MAFLD through activating the interplay between PPARα/RXRα heterodimer and adiponectin receptor 2.
Sildenafil improves right ventricular remodelling in monocrotaline-induced rats by decreasing myocardial apoptosis and activating peroxisome proliferator-activated receptors.
FGF1(ΔHBS) prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK/Nur77 suppression.
Effect of selenium-enriched kiwifruit on body fat reduction and liver protection in hyperlipidaemic mice.
PPARα agonist WY-14,643 enhances ethanol metabolism in mice: Role of catalase.
Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1.
Improvement of hyperlipidemia by aerobic exercise in mice through a regulatory effect of miR-21a-5p on its target genes.
The lipid-lowering drug fenofibrate combined with si-HOTAIR can effectively inhibit the proliferation of gliomas.
Probiotic-fermented black tartary buckwheat alleviates hyperlipidemia and gut microbiota dysbiosis in rats fed with a high-fat diet.
Topotecan induces hepatocellular injury via ASCT2 mediated oxidative stress.
Carbohydrate response element-binding protein regulates lipid metabolism via mTOR complex1 in diabetic nephropathy.
DNA methylation of FTO promotes renal inflammation by enhancing m(6)A of PPAR-α in alcohol-induced kidney injury.
Cordycepin attenuates high-fat diet-induced non-alcoholic fatty liver disease via down-regulation of lipid metabolism and inflammatory responses.
Celastrol inhibits intestinal lipid absorption by reprofiling the gut microbiota to attenuate high-fat diet-induced obesity.
DNMT1-mediated PPARα methylation aggravates damage of retinal tissues in diabetic retinopathy mice.
Mogroside V Protects against Hepatic Steatosis in Mice on a High-Fat Diet and LO2 Cells Treated with Free Fatty Acids via AMPK Activation.
Berberine Suppressed Tumor Growth through Regulating Fatty Acid Metabolism and Triggering Cell Apoptosis via Targeting FABPs.
Empagliflozin Alleviates Hepatic Steatosis by Activating the AMPK-TET2-Autophagy Pathway in vivo and in vitro.
Liraglutide Alleviates Hepatic Steatosis and Liver Injury in T2MD Rats via a GLP-1R Dependent AMPK Pathway.
Investigation of the Lipid-Lowering Mechanisms and Active Ingredients of Danhe Granule on Hyperlipidemia Based on Systems Pharmacology.
Decreased ANGPTL4 impairs endometrial angiogenesis during peri-implantation period in patients with recurrent implantation failure.
TRIB3 destabilizes tumor suppressor PPARα expression through ubiquitin-mediated proteasome degradation in acute myeloid leukemia.
Protective effect of Yi-Qi-Huo-Xue Decoction against ischemic heart disease by regulating cardiac lipid metabolism.
Effect and mechanism of ginsenoside Rg1-regulating hepatic steatosis in HepG2 cells induced by free fatty acid.
Short hairpin RNA attenuates liver fibrosis by regulating the PPAR‑γ and NF‑κB pathways in HBV‑induced liver fibrosis in mice.
Melanoma Persister Cells Are Tolerant to BRAF/MEK Inhibitors via ACOX1-Mediated Fatty Acid Oxidation.
Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment.
Sirt3 modulates fatty acid oxidation and attenuates cisplatin-induced AKI in mice.
Secoisolariciresinol diglucoside alleviates hepatic lipid metabolic misalignment involving the endoplasmic reticulum-mitochondrial axis.
Tectorigenin attenuates diabetic nephropathy by improving vascular endothelium dysfunction through activating AdipoR1/2 pathway.
Auxiliary antitumor effects of fungal proteins from Hericium erinaceus by target on the gut microbiota.
Hepatic HuR modulates lipid homeostasis in response to high-fat diet.
Hypolipidemic effect of pure total flavonoids from peel of Citrus (PTFC) on hamsters of hyperlipidemia and its potential mechanism.
Periostin antisense oligonucleotide prevents hepatic steatosis and fibrosis in a mouse model of non-alcoholic steatohepatitis.
Resveratrol improves meat quality, muscular antioxidant capacity, lipid metabolism and fiber type composition of intrauterine growth retarded pigs.
Caloric restriction alleviates aging-related fibrosis of kidney through downregulation of miR-21 in extracellular vesicles.
Lycopene attenuates body weight gain through induction of browning via regulation of peroxisome proliferator-activated receptor γ in high-fat diet-induced obese mice.
Keratocytes promote corneal neovascularization through VEGFr3 induced by PPARα-inhibition.
MiR-30b-5p regulates the lipid metabolism by targeting PPARGC1A in Huh-7 cell line.
Significant Role of Dicer and miR-223 in Adipose Tissue of Polycystic Ovary Syndrome Patients.
Loquat leaf polysaccharides improve glomerular injury in rats with anti-Thy 1 nephritis via peroxisome proliferator-activated receptor alpha pathway.
Effects of PPARs/20-HETE on the renal impairment under diabetic conditions.
Therapeutic potential of NaoXinTong Capsule on the developed diabetic nephropathy in db/db mice.
Vitamin E Ameliorates Lipid Metabolism in Mice with Nonalcoholic Fatty Liver Disease via Nrf2/CES1 Signaling Pathway.
TIGAR regulates mitochondrial functions through SIRT1-PGC1α pathway and translocation of TIGAR into mitochondria in skeletal muscle.
Formononetin ameliorates cholestasis by regulating hepatic SIRT1 and PPARα.
Chronic treatment with the modified Longdan Xiegan Tang attenuates olanzapine-induced fatty liver in rats by regulating hepatic de novo lipogenesis and fatty acid beta-oxidation-associated gene expression mediated by SREBP-1c, PPAR-alpha and AMPK-alpha.
Bromide alleviates fatty acid-induced lipid accumulation in mouse primary hepatocytes through the activation of PPARα signals.
Loss of Adipose Growth Hormone Receptor in Mice Enhances Local Fatty Acid Trapping and Impairs Brown Adipose Tissue Thermogenesis.
Organophosphorus Flame Retardants Impair Intracellular Lipid Metabolic Function in Human Hepatocellular Cells.
Activation of 20-HETE/PPARs involved in reno-therapeutic effect of naringenin on diabetic nephropathy.
EETs/PPARs activation together mediates the preventive effect of naringenin in high glucose-induced cardiomyocyte hypertrophy.
Therapeutic Effect of Chitooligosaccharide Tablets on Lipids in High-Fat Diets Induced Hyperlipidemic Rats.
Coenzyme Q10 attenuates high-fat diet-induced non-alcoholic fatty liver disease through activation of the AMPK pathway.
High Fat Diet Suppresses Peroxisome Proliferator-Activated Receptors and Reduces Dopaminergic Neurons in the Substantia Nigra.
Fe(3)O(4)@OA@Poloxamer nanoparticles lower triglyceride in hepatocytes through liposuction effect and nano-enzyme effect.
Correction: Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Protective effect of cultured bear bile powder against dimethylnitrosamine-induced hepatic fibrosis in rats.
Cholesterol-lowering effects and potential mechanisms of chitooligosaccharide capsules in hyperlipidemic rats.
Multi-scale, whole-system models of liver metabolic adaptation to fat and sugar in non-alcoholic fatty liver disease.
The Hepatoprotection by Oleanolic Acid Preconditioning: Focusing on PPARα Activation.
GLP-1 receptor agonist ameliorates obesity-induced chronic kidney injury via restoring renal metabolism homeostasis.
Neurotensin contributes to pediatric intestinal failure-associated liver disease via regulating intestinal bile acids uptake.
Functional interplay between liver X receptor and AMP-activated protein kinase α inhibits atherosclerosis in apolipoprotein E-deficient mice - a new anti-atherogenic strategy.
Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-α pathway in mice.
Naringenin exhibits the protective effect on cardiac hypertrophy via EETs-PPARs activation in streptozocin-induced diabetic mice.
Polyacetylene glycoside attenuates ischemic kidney injury by co-inhibiting inflammation, mitochondria dysfunction and lipotoxicity.
Isoquercitrin Attenuated Cardiac Dysfunction Via AMPKα-Dependent Pathways in LPS-Treated Mice.
Effects of mulberry leaf on experimental hyperlipidemia rats induced by high-fat diet.
Protective role of fenofibrate in sepsis-induced acute kidney injury in BALB/c mice.
Metabolomics reveal mitochondrial and fatty acid metabolism disorders that contribute to the development of DKD in T2DM patients.
The effects of di 2-ethyl hexyl phthalate (DEHP) on cellular lipid accumulation in HepG2 cells and its potential mechanisms in the molecular level.
miR-148a and miR-17-5p synergistically regulate milk TAG synthesis via PPARGC1A and PPARA in goat mammary epithelial cells.
The histone methyltransferase Suv39h2 contributes to nonalcoholic steatohepatitis in mice.
Dietary capsaicin and antibiotics act synergistically to reduce non-alcoholic fatty liver disease induced by high fat diet in mice.
Nutritional background changes the hypolipidemic effects of fenofibrate in Nile tilapia (Oreochromis niloticus).
PPARβ/δ activation protects against corticosterone-induced ER stress in astrocytes by inhibiting the CpG hypermethylation of microRNA-181a.
Calycosin attenuates triglyceride accumulation and hepatic fibrosis in murine model of non-alcoholic steatohepatitis via activating farnesoid X receptor.
Mechanisms and metabolic regulation of PPARα activation in Nile tilapia (Oreochromis niloticus).
Polyphenols from hawthorn peels and fleshes differently mitigate dyslipidemia, inflammation and oxidative stress in association with modulation of liver injury in high fructose diet-fed mice.
Jatrorrhizine hydrochloride attenuates hyperlipidemia in a high-fat diet-induced obesity mouse model.
Zinc finger protein 407 overexpression upregulates PPAR target gene expression and improves glucose homeostasis in mice.
Di(2-ethylhexyl) phthalate exacerbates non-alcoholic fatty liver in rats and its potential mechanisms.
Protective effects of heparin on endothelial cells in sepsis.
Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway.
Maternal obesity disrupts circadian rhythms of clock and metabolic genes in the offspring heart and liver.
Potent effects of dioscin against obesity in mice.
I prostanoid receptor-mediated inflammatory pathway promotes hepatic gluconeogenesis through activation of PKA and inhibition of AKT.
Protective effects of dioscin against alcohol-induced liver injury.
Lipoic acid entrains the hepatic circadian clock and lipid metabolic proteins that have been desynchronized with advanced age.
Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Dihydrocapsaicin Attenuates Plaque Formation through a PPARγ/LXRα Pathway in apoE(-/-) Mice Fed a High-Fat/High-Cholesterol Diet.
Effects of flavonoids from Rosa laevigata Michx fruit against high-fat diet-induced non-alcoholic fatty liver disease in rats.
Yang S, Cao SJ, Li CY, Zhang Q, Zhang BL, Qiu F, Kang N
Journal of ethnopharmacology 2024 Oct 5;332:118354
Journal of ethnopharmacology 2024 Oct 5;332:118354
Dihydromyricetin ameliorates hepatic steatosis and insulin resistance via AMPK/PGC-1α and PPARα-mediated autophagy pathway.
Yang Y, Qiu W, Xiao J, Sun J, Ren X, Jiang L
Journal of translational medicine 2024 Mar 26;22(1):309
Journal of translational medicine 2024 Mar 26;22(1):309
Ketogenic diet time-dependently prevents NAFLD through upregulating the expression of antioxidant protein metallothionein-2.
You Y, Huang Y, Wang X, Ni H, Ma Q, Ran H, Cai J, Lin X, Luo T, Wu C, Xiao X, Ma L
Clinical nutrition (Edinburgh, Scotland) 2024 Jun;43(6):1475-1487
Clinical nutrition (Edinburgh, Scotland) 2024 Jun;43(6):1475-1487
Oat β-glucan repairs the epidermal barrier by upregulating the levels of epidermal differentiation, cell-cell junctions and lipids via Dectin-1.
Jing R, Fu M, Huang Y, Zhang K, Ye J, Gong F, Jihea Ali Naji Nasser AB, Xu X, Xiao J, Yu G, Lin S, Zhao W, Xu N, Li X, Li Z, Gao S
British journal of pharmacology 2024 Jun;181(11):1596-1613
British journal of pharmacology 2024 Jun;181(11):1596-1613
Hepatocellular Carcinoma LINC01116 Outcompetes T Cells for Linoleic Acid and Accelerates Tumor Progression.
Ma K, Chu J, Liu Y, Sun L, Zhou S, Li X, Ji C, Zhang N, Guo X, Liang S, Cui T, Hu Q, Wang J, Liu Y, Liu L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jun;11(21):e2400676
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jun;11(21):e2400676
Postbiotics Prepared Using Lactobacillus reuteri Ameliorates Ethanol-Induced Liver Injury by Regulating the FXR/SHP/SREBP-1c Axis.
Liu C, Cai T, Cheng Y, Bai J, Li M, Gu B, Huang M, Fu W
Molecular nutrition & food research 2024 Jul;68(14):e2300927
Molecular nutrition & food research 2024 Jul;68(14):e2300927
The cooperative regulatory effect of the miRNA-130 family on milk fat metabolism in dairy cows.
Li X, Wu Y, Yang X, Gao R, Lu Q, Lv X, Chen Z
Animal bioscience 2024 Jul;37(7):1289-1302
Animal bioscience 2024 Jul;37(7):1289-1302
Tamoxifen upregulates the peroxisomal β-oxidation enzyme Enoyl CoA hydratase and 3-hydroxyacyl CoA hydratase ameliorating hepatic lipid accumulation in mice.
Zhang Z, Yang Q, Jin M, Wang J, Chai Y, Zhang L, Jiang Z, Yu Q
The international journal of biochemistry & cell biology 2024 Jul;172:106585
The international journal of biochemistry & cell biology 2024 Jul;172:106585
BAP18 acting as a novel peroxisome proliferator-activated receptor α co-regulator contributes to hepatocellular carcinoma progression.
Liu W, Wang S, Lin L, Zou R, Sun H, Zeng K, Wu Y, Li Y, Shigeaki K, Wang X, Wang C, Zhao Y
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166974
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166974
The PPARα/CYP4A14 bile acid pathway is associated with lipid metabolism disorders caused by low birth weight with high-fat diet.
Zhou F, Yang L, Sun W, Wang X, Guo N, Ma H, Yang L
Food & nutrition research 2023;67
Food & nutrition research 2023;67
Protective effect of Saussurea involucrata polysaccharide against skin dryness induced by ultraviolet radiation.
Wang L, Yang K, Jing R, Zhao W, Guo K, Hu Z, Liu G, Xu N, Zhao J, Lin L, Gao S
Frontiers in pharmacology 2023;14:1089537
Frontiers in pharmacology 2023;14:1089537
Pathological mechanism of heart failure with preserved ejection fraction in rats based on iTRAQ technology.
Xu H, Gao K, Liu C, Li T, Ding Y, Ma J
PeerJ 2023;11:e15280
PeerJ 2023;11:e15280
Bidirectional effect of vitamin D on brown adipogenesis of C3H10T1/2 fibroblast-like cells.
Mukai T, Kusudo T
PeerJ 2023;11:e14785
PeerJ 2023;11:e14785
Metabolome combined with gut microbiome revealed the lipid-lowering mechanism of Xuezhiping capsule on hyperlipidemic hamster induced by high fat diet.
Wang L, Zhang Z, Luo G, Wang Y, Du K, Gao X
Frontiers in molecular biosciences 2023;10:1147910
Frontiers in molecular biosciences 2023;10:1147910
Hyodeoxycholic acid ameliorates nonalcoholic fatty liver disease by inhibiting RAN-mediated PPARα nucleus-cytoplasm shuttling.
Zhong J, He X, Gao X, Liu Q, Zhao Y, Hong Y, Zhu W, Yan J, Li Y, Li Y, Zheng N, Bao Y, Wang H, Ma J, Huang W, Liu Z, Lyu Y, Ke X, Jia W, Xie C, Hu Y, Sheng L, Li H
Nature communications 2023 Sep 6;14(1):5451
Nature communications 2023 Sep 6;14(1):5451
Down-regulation of Hrd1 protects against myocardial ischemia-reperfusion injury by regulating PPARα to prevent oxidative stress, endoplasmic reticulum stress, and cellular apoptosis.
Xia B, Li Q, Zheng K, Wu J, Huang C, Liu K, You Q, Yuan X
European journal of pharmacology 2023 Sep 5;954:175864
European journal of pharmacology 2023 Sep 5;954:175864
Deficiency of spns1 exacerbates per- and polyfluoroalkyl substances mediated hepatic toxicity and steatosis in zebrafish (Danio rerio).
Gadi S, Niture S, Hoang H, Qi Q, Hatcher C, Huang X, Haider J, Norford DC, Leung T, Levine KE, Kumar D
Toxicology 2023 Nov;499:153641
Toxicology 2023 Nov;499:153641
L-theanine regulates the immune function of SD rats fed high-protein diets through the FABP5/IL-6/STAT3/PPARα pathway.
Zhang Y, Song Y, Zhang J, Li L, He L, Bo J, Gong Z, Xiao W
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Nov;181:114095
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Nov;181:114095
Knockdown of repulsive guidance molecule a promotes polarization of microglia into an anti-inflammatory phenotype after oxygen-glucose deprivation-reoxygenation in vitro.
Shen G, Xiao H, Huang S, Yuan X, Rongrong Z, Ma Y, Qin X
Neurochemistry international 2023 Nov;170:105546
Neurochemistry international 2023 Nov;170:105546
Mechanisms of weight-loss effect in obese mice by the endogenous cannabinoid receptor 2 agonist beta-caryophyllene.
Jiayao C, Jiaoling W, Chengyu H, Guixiang W, Linquan Z
Obesity research & clinical practice 2023 Nov-Dec;17(6):499-510
Obesity research & clinical practice 2023 Nov-Dec;17(6):499-510
Proanthocyanidin Alleviates Liver Ischemia/Reperfusion Injury by Suppressing Autophagy and Apoptosis via the PPARα/PGC1α Signaling Pathway.
Yao Z, Liu N, Lin H, Zhou Y
Journal of clinical and translational hepatology 2023 Nov 28;11(6):1329-1340
Journal of clinical and translational hepatology 2023 Nov 28;11(6):1329-1340
Enhancement of PPARα-Inhibited Leucine Metabolism-Stimulated β-Casein Synthesis and Fatty Acid Synthesis in Primary Bovine Mammary Epithelial Cells.
Huang J, Li J, Ning Y, Ren Y, Shao Y, Zhang H, Zong X, Shi H
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16184-16193
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16184-16193
Combination of canagliflozin and puerarin alleviates the lipotoxicity to diabetic kidney in mice.
Zhu Q, Zhou Q, Luo XL, Zhang XJ, Li SY
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2023 May 1;27(3):221-230
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2023 May 1;27(3):221-230
MicroRNA-483-5p Inhibits Hepatocellular Carcinoma Cell Proliferation, Cell Steatosis, and Fibrosis by Targeting PPARα and TIMP2.
Niture S, Gadi S, Qi Q, Gyamfi MA, Varghese RS, Rios-Colon L, Chimeh U, Vandana, Ressom HW, Kumar D
Cancers 2023 Mar 10;15(6)
Cancers 2023 Mar 10;15(6)
Intrauterine androgen exposure impairs gonadal adipose tissue functions of adult female rats.
Ferrer MJ, Abruzzese GA, Heber MF, Ferreira SR, Campo Verde Arbocco F, Motta AB
Theriogenology 2023 Mar 1;198:131-140
Theriogenology 2023 Mar 1;198:131-140
Cyanotoxins Increase Cytotoxicity and Promote Nonalcoholic Fatty Liver Disease Progression by Enhancing Cell Steatosis.
Niture S, Gadi S, Qi Q, Rios-Colon L, Khatiwada S, Vandana, Fernando RA, Levine KE, Kumar D
Toxins 2023 Jun 25;15(7)
Toxins 2023 Jun 25;15(7)
Human umbilical cord mesenchymal stem cell-derived exosomes ameliorate liver steatosis by promoting fatty acid oxidation and reducing fatty acid synthesis.
Yang F, Wu Y, Chen Y, Xi J, Chu Y, Jin J, Yan Y
JHEP reports : innovation in hepatology 2023 Jul;5(7):100746
JHEP reports : innovation in hepatology 2023 Jul;5(7):100746
Di-(2-ethylhexyl) phthalate (DEHP) promoted hepatic lipid accumulation by activating Notch signaling pathway.
Zhang Y, Qian H, Wang J, Zhu Y, Miao X, Li X, Yin J, Zhang R, Ye J, Huo C, Zhao W, Ye L
Environmental toxicology 2023 Jul;38(7):1628-1640
Environmental toxicology 2023 Jul;38(7):1628-1640
A novel small molecule AdipoR2 agonist ameliorates experimental hepatic steatosis in hamsters and mice.
Zhao Y, Sun N, Song X, Zhu J, Wang T, Wang Z, Yu Y, Ren J, Chen H, Zhan T, Tian J, Ma C, Huang J, Wang J, Zhang Y, Yang B
Free radical biology & medicine 2023 Jul;203:69-85
Free radical biology & medicine 2023 Jul;203:69-85
Klf4-Sirt3/Pparα-Lcad pathway contributes to high phosphate-induced lipid degradation.
Yu A, Xu Y, Hogstrand C, Zhao T, Tan XY, Wei X, Song YF, Luo Z
Cell communication and signaling : CCS 2023 Jan 9;21(1):5
Cell communication and signaling : CCS 2023 Jan 9;21(1):5
Exosomal miR-27b-3p secreted by visceral adipocytes contributes to endothelial inflammation and atherogenesis.
Tang Y, Yang LJ, Liu H, Song YJ, Yang QQ, Liu Y, Qian SW, Tang QQ
Cell reports 2023 Jan 31;42(1):111948
Cell reports 2023 Jan 31;42(1):111948
PPARγ and C/EBPα response to acute cold stress in brown adipose tissue.
Lau KH, Waldhart AN, Dykstra H, Avequin T, Wu N
iScience 2023 Jan 20;26(1):105848
iScience 2023 Jan 20;26(1):105848
Phosphodiesterase 4B activation exacerbates pulmonary hypertension induced by intermittent hypoxia by regulating mitochondrial injury and cAMP/PKA/p-CREB/PGC-1α signaling.
Pan Z, Wu X, Zhang X, Hu K
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Feb;158:114095
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Feb;158:114095
Mof plays distinct roles in hepatic lipid metabolism under healthy or non-alcoholic fatty liver conditions.
Guo X, Liang K, Xia L, Zhang X, Liu J, Wang C, Li J, Li X, Hou X, Chen L
iScience 2023 Dec 15;26(12):108446
iScience 2023 Dec 15;26(12):108446
Aloin Attenuates Oxidative Stress, Inflammation, and CCl(4)-Induced Liver Fibrosis in Mice: Possible Role of TGF-β/Smad Signaling.
Bai J, Qian B, Cai T, Chen Y, Li T, Cheng Y, Wu Z, Liu C, Ye M, Du Y, Fu W
Journal of agricultural and food chemistry 2023 Dec 13;71(49):19475-19487
Journal of agricultural and food chemistry 2023 Dec 13;71(49):19475-19487
Air-ventilated normothermic machine perfusion alleviates hepatic injury from DCD rat through CYP1A2.
Shi JH, Cheng N, Zhang W, Jin Q, Guo WZ, Ge GB, Zhang SJ, Line PD, Wang Y
Heliyon 2023 Aug;9(8):e19150
Heliyon 2023 Aug;9(8):e19150
Therapeutic role of Artemether in the prevention of hepatic steatosis through miR-34a-5p/PPARα pathway.
Chen L, Yu S, Hong S, Lin X, Zhu X, Cao X, Li Y, Xiao H
Drug development research 2023 Apr;84(2):156-171
Drug development research 2023 Apr;84(2):156-171
Sorghum (Sorghum bicolor) Extract-Induced Adipogenesis Is Independent of PPARγ Ser273 Phosphorylation in 3T3-L1 Adipocytes.
Nagaoka A, Sakurai M, Kamiie K, Masumi A
Biological & pharmaceutical bulletin 2022;45(5):659-663
Biological & pharmaceutical bulletin 2022;45(5):659-663
Oleoylethanolamide Alleviates Hepatic Ischemia-Reperfusion Injury via Inhibiting Endoplasmic Reticulum Stress-Associated Apoptosis.
Qi S, Yan Q, Wang Z, Liu D, Zhan M, Du J, Chen L
PPAR research 2022;2022:2212996
PPAR research 2022;2022:2212996
Lanzhang Granules Ameliorate Nonalcoholic Fatty Liver Disease by Regulating the PPARα Signaling Pathway.
Huang P, Yang L, Liu Y, Jiang Y, Li Y, Chen Z, Song H, Zheng P
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1124901
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1124901
Gut microbiota and butyrate contribute to nonalcoholic fatty liver disease in premenopause due to estrogen deficiency.
Liu L, Fu Q, Li T, Shao K, Zhu X, Cong Y, Zhao X
PloS one 2022;17(2):e0262855
PloS one 2022;17(2):e0262855
Jiangtang Sanhao formula ameliorates skeletal muscle insulin resistance via regulating GLUT4 translocation in diabetic mice.
Ye Z, Ma J, Liu Y, Xu B, Dai X, Fu M, Tian T, Sui X, Mo F, Gao S, Zhao D, Zhang D
Frontiers in pharmacology 2022;13:950535
Frontiers in pharmacology 2022;13:950535
D-Mannose Regulates Hepatocyte Lipid Metabolism via PI3K/Akt/mTOR Signaling Pathway and Ameliorates Hepatic Steatosis in Alcoholic Liver Disease.
Hu M, Chen Y, Deng F, Chang B, Luo J, Dong L, Lu X, Zhang Y, Chen Z, Zhou J
Frontiers in immunology 2022;13:877650
Frontiers in immunology 2022;13:877650
Fufang Zhenzhu Tiaozhi Capsule Prevents Intestinal Inflammation and Barrier Disruption in Mice With Non-Alcoholic Steatohepatitis.
Lan T, Xu T, Fu Y, Jiang S, Liang X, Yu Z, Pan L, Rong X, Guo J
Frontiers in endocrinology 2022;13:864703
Frontiers in endocrinology 2022;13:864703
Sleeve Gastrectomy-Induced AMPK Activation Attenuates Diabetic Cardiomyopathy by Maintaining Mitochondrial Homeostasis via NR4A1 Suppression in Rats.
Li S, Dong S, Xu Q, Shi B, Li L, Zhang W, Zhu J, Cheng Y, Zhang G, Zhong M
Frontiers in physiology 2022;13:837798
Frontiers in physiology 2022;13:837798
Atorvastatin Restores PPARα Inhibition of Lipid Metabolism Disorders by Downregulating miR-21 Expression to Improve Mitochondrial Function and Alleviate Diabetic Nephropathy Progression.
Xiang J, Zhang H, Zhou X, Wang D, Chen R, Tan W, Liang L, Shi M, Zhang F, Xiao Y, Zhou Y, Wang Y, Guo B
Frontiers in pharmacology 2022;13:819787
Frontiers in pharmacology 2022;13:819787
Imbalance hepatic metabolism homeostasis in the F1 generation of endometrial DNMT3B conditional knockout female mice.
Li W, Gao R, Ding Y, Chen X, Liu X, He J, Li F, Long J, Lu S, Yang C, Wang Y
Frontiers in physiology 2022;13:1042449
Frontiers in physiology 2022;13:1042449
AKR1C3-dependent lipid droplet formation confers hepatocellular carcinoma cell adaptability to targeted therapy.
Wu C, Dai C, Li X, Sun M, Chu H, Xuan Q, Yin Y, Fang C, Yang F, Jiang Z, Lv Q, He K, Qu Y, Zhao B, Cai K, Zhang S, Sun R, Xu G, Zhang L, Sun S, Liu Y
Theranostics 2022;12(18):7681-7698
Theranostics 2022;12(18):7681-7698
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
Dai W, Xiang W, Han L, Yuan Z, Wang R, Ma Y, Yang Y, Cai S, Xu Y, Mo S, Li Q, Cai G
Cancer communications (London, England) 2022 Sep;42(9):848-867
Cancer communications (London, England) 2022 Sep;42(9):848-867
Limonin stabilises sirtuin 6 (SIRT6) by activating ubiquitin specific peptidase 10 (USP10) in cardiac hypertrophy.
Liu LB, Huang SH, Qiu HL, Cen XF, Guo YY, Li D, Ma YL, Xu M, Tang QZ
British journal of pharmacology 2022 Sep;179(18):4516-4533
British journal of pharmacology 2022 Sep;179(18):4516-4533
Metabolic Syndrome Ameliorated by 4-Methylesculetin by Reducing Hepatic Lipid Accumulation.
Li L, Zhu G, Fu G, Zha W, Li H
International journal of molecular sciences 2022 Sep 9;23(18)
International journal of molecular sciences 2022 Sep 9;23(18)
Honokiol alleviates ulcerative colitis by targeting PPAR-γ-TLR4-NF-κB signaling and suppressing gasdermin-D-mediated pyroptosis in vivo and in vitro.
Wang N, Kong R, Han W, Bao W, Shi Y, Ye L, Lu J
International immunopharmacology 2022 Oct;111:109058
International immunopharmacology 2022 Oct;111:109058
Ginsenoside Rc Modulates SIRT6-NRF2 Interaction to Alleviate Alcoholic Liver Disease.
Pan Z, Guo J, Tang K, Chen Y, Gong X, Chen Y, Zhong Y, Xiao X, Duan S, Cui T, Wu X, Zhong Y, Yang X, Shen C, Gao Y
Journal of agricultural and food chemistry 2022 Nov 9;70(44):14220-14234
Journal of agricultural and food chemistry 2022 Nov 9;70(44):14220-14234
GDPD5 Related to Lipid Metabolism Is a Potential Prognostic Biomarker in Neuroblastoma.
Luo T, Peng J, Li Q, Zhang Y, Huang Y, Xu L, Yang G, Tan D, Zhang Q, Tan Y
International journal of molecular sciences 2022 Nov 8;23(22)
International journal of molecular sciences 2022 Nov 8;23(22)
Dihydroartemisinin alleviates steatosis and inflammation in nonalcoholic steatohepatitis by decreasing endoplasmic reticulum stress and oxidative stress.
Li T, Chen Y, Tan P, Shi H, Huang Z, Cai T, Cheng Y, Du Y, Fu W
Bioorganic chemistry 2022 May;122:105737
Bioorganic chemistry 2022 May;122:105737
Accumulation of polystyrene microplastics induces liver fibrosis by activating cGAS/STING pathway.
Shen R, Yang K, Cheng X, Guo C, Xing X, Sun H, Liu D, Liu X, Wang D
Environmental pollution (Barking, Essex : 1987) 2022 May 1;300:118986
Environmental pollution (Barking, Essex : 1987) 2022 May 1;300:118986
Dietary L-arginine supplementation of tilapia (Oreochromis niloticus) alters the microbial population and activates intestinal fatty acid oxidation.
Li S, Wang C, Wu Z
Amino acids 2022 Mar;54(3):339-351
Amino acids 2022 Mar;54(3):339-351
Fat mass and obesity-associated protein promotes liver steatosis by targeting PPARα.
Wei X, Zhang J, Tang M, Wang X, Fan N, Peng Y
Lipids in health and disease 2022 Mar 13;21(1):29
Lipids in health and disease 2022 Mar 13;21(1):29
Novel insights for PI3KC3 in mediating lipid accumulation in yellow catfish Pelteobagrus fulvidraco.
Zhuo MQ, Chen J, Wu ML, Wang WB
Fish physiology and biochemistry 2022 Jun;48(3):571-583
Fish physiology and biochemistry 2022 Jun;48(3):571-583
Fetal programming by androgen excess impairs liver lipid content and PPARg expression in adult rats.
Silva AF, Abruzzese GA, Ferrer MJ, Heber MF, Ferreira SR, Cerrone GE, Motta AB
Journal of developmental origins of health and disease 2022 Jun;13(3):300-309
Journal of developmental origins of health and disease 2022 Jun;13(3):300-309
Amelioration action of gastrodigenin rhamno-pyranoside from Moringa seeds on non-alcoholic fatty liver disease.
Liao M, Sun C, Li R, Li W, Ge Z, Adu-Frimpong M, Xu X, Yu J
Food chemistry 2022 Jun 15;379:132087
Food chemistry 2022 Jun 15;379:132087
PPARα agonist fenofibrate relieves acquired resistance to gefitinib in non-small cell lung cancer by promoting apoptosis via PPARα/AMPK/AKT/FoxO1 pathway.
Wang MS, Han QS, Jia ZR, Chen CS, Qiao C, Liu QQ, Zhang YM, Wang KW, Wang J, Xiao K, Ding XS
Acta pharmacologica Sinica 2022 Jan;43(1):167-176
Acta pharmacologica Sinica 2022 Jan;43(1):167-176
Steatosis induced by nonylphenol in HepG2 cells and the intervention effect of curcumin.
Shan D, Wang J, Di Q, Jiang Q, Xu Q
Food & function 2022 Jan 4;13(1):327-343
Food & function 2022 Jan 4;13(1):327-343
Prevotellaceae produces butyrate to alleviate PD-1/PD-L1 inhibitor-related cardiotoxicity via PPARα-CYP4X1 axis in colonic macrophages.
Chen Y, Liu Y, Wang Y, Chen X, Wang C, Chen X, Yuan X, Liu L, Yang J, Zhou X
Journal of experimental & clinical cancer research : CR 2022 Jan 3;41(1):1
Journal of experimental & clinical cancer research : CR 2022 Jan 3;41(1):1
Isoliquiritigenin-mediated miR-23a-3p inhibition activates PGC-1α to alleviate alcoholic liver injury.
Wang L, Kong L, Xu S, Wang X, Huang K, Wang S, Wu J, Wang C, Sun H, Liu K, Meng Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Feb;96:153845
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Feb;96:153845
Activation of PGC-1α via isoliquiritigenin-induced downregulation of miR-138-5p alleviates nonalcoholic fatty liver disease.
Wang L, Wang X, Kong L, Li Y, Huang K, Wu J, Wang C, Sun H, Sun P, Gu J, Luo H, Liu K, Meng Q
Phytotherapy research : PTR 2022 Feb;36(2):899-913
Phytotherapy research : PTR 2022 Feb;36(2):899-913
Inhibition of high-fat diet-induced obesity via reduction of ER-resident protein Nogo occurs through multiple mechanisms.
Wang X, Yang Y, Zhao D, Zhang S, Chen Y, Chen Y, Feng K, Li X, Han J, Iwakiri Y, Duan Y, Yang X
The Journal of biological chemistry 2022 Feb;298(2):101561
The Journal of biological chemistry 2022 Feb;298(2):101561
Ginsenoside CK ameliorates hepatic lipid accumulation via activating the LKB1/AMPK pathway in vitro and in vivo.
Zhang J, Ma X, Fan D
Food & function 2022 Feb 7;13(3):1153-1167
Food & function 2022 Feb 7;13(3):1153-1167
Opuntia dillenii Haw. Polysaccharide Promotes Cholesterol Efflux in THP-1-Derived Foam Cells via the PPARγ-LXRα Signaling Pathway.
Li H, Huang Z, Zeng F
Molecules (Basel, Switzerland) 2022 Dec 7;27(24)
Molecules (Basel, Switzerland) 2022 Dec 7;27(24)
m(6)A-Mediated PPARA Translational Suppression Contributes to Corticosterone-Induced Visceral Fat Deposition in Chickens.
Zhou Z, Zhang A, Liu X, Yang Y, Zhao R, Jia Y
International journal of molecular sciences 2022 Dec 12;23(24)
International journal of molecular sciences 2022 Dec 12;23(24)
Elevated thyroid hormones caused by high concentrate diets participate in hepatic metabolic disorders in dairy cows.
Chen Q, Wu C, Yao Z, Cai L, Ni Y, Mao S
Animal bioscience 2022 Aug;35(8):1184-1194
Animal bioscience 2022 Aug;35(8):1184-1194
Salvia-Nelumbinis naturalis improves lipid metabolism of NAFLD by regulating the SIRT1/AMPK signaling pathway.
Liu Y, Li Y, Wang J, Yang L, Yu X, Huang P, Song H, Zheng P
BMC complementary medicine and therapies 2022 Aug 9;22(1):213
BMC complementary medicine and therapies 2022 Aug 9;22(1):213
Pdcd4 promotes lipid deposition by attenuating PPARα-mediated fatty acid oxidation in hepatocytes.
Du X, Osoro EK, Chen Q, Yan X, Gao D, Wu L, Ren J, Feng L, Wu N, Lu K, Yang X, Zhong B, Han Y, Zhang F, Li D, Lan X, Lu S
Molecular and cellular endocrinology 2022 Apr 5;545:111562
Molecular and cellular endocrinology 2022 Apr 5;545:111562
L-theanine prevents progression of nonalcoholic hepatic steatosis by regulating hepatocyte lipid metabolic pathways via the CaMKKβ-AMPK signaling pathway.
Liang J, Gu L, Liu X, Yan X, Bi X, Fan X, Zhou J, Lu S, Luo L, Yin Z
Nutrition & metabolism 2022 Apr 15;19(1):29
Nutrition & metabolism 2022 Apr 15;19(1):29
Gold nanoclusters eliminate obesity induced by antipsychotics.
He M, Yao J, Zhang Z, Zhang Y, Chen R, Gu Z, Huang X, Deng C, Zhou R, Fan J, Zhang B, Xie Y, Gao G, Sun T
Scientific reports 2022 Apr 1;12(1):5502
Scientific reports 2022 Apr 1;12(1):5502
Lipidomic Alterations and PPARα Activation Induced by Resveratrol Lead to Reduction in Lesion Size in Endometriosis Models.
Chen Z, Wang C, Lin C, Zhang L, Zheng H, Zhou Y, Li X, Li C, Zhang X, Yang X, Guan M, Xi Y
Oxidative medicine and cellular longevity 2021;2021:9979953
Oxidative medicine and cellular longevity 2021;2021:9979953
Fenofibrate Ameliorates Hepatic Ischemia/Reperfusion Injury in Mice: Involvements of Apoptosis, Autophagy, and PPAR-α Activation.
Zhang J, Cheng P, Dai W, Ji J, Wu L, Feng J, Wu J, Yu Q, Li J, Guo C
PPAR research 2021;2021:6658944
PPAR research 2021;2021:6658944
Apigenin Alleviates Liver Fibrosis by Inhibiting Hepatic Stellate Cell Activation and Autophagy via TGF-β1/Smad3 and p38/PPARα Pathways.
Ji J, Yu Q, Dai W, Wu L, Feng J, Zheng Y, Li Y, Guo C
PPAR research 2021;2021:6651839
PPAR research 2021;2021:6651839
Pemafibrate Pretreatment Attenuates Apoptosis and Autophagy during Hepatic Ischemia-Reperfusion Injury by Modulating JAK2/STAT3β/PPARα Pathway.
Cheng Z, Guo C
PPAR research 2021;2021:6632137
PPAR research 2021;2021:6632137
Recombinant Human Growth Hormone Inhibits Lipotoxicity, Oxidative Stress, and Apoptosis in a Mouse Model of Diabetic Cardiomyopathy.
Pei Z, Wang X, Yang C, Dong M, Wang F
Oxidative medicine and cellular longevity 2021;2021:3899356
Oxidative medicine and cellular longevity 2021;2021:3899356
Exploring the Multi-Tissue Crosstalk Relevant to Insulin Resistance Through Network-Based Analysis.
Yang L, Yang L, Wang X, Xing H, Zhao H, Xing Y, Zhou F, Wang C, Song G, Ma H
Frontiers in endocrinology 2021;12:756785
Frontiers in endocrinology 2021;12:756785
The Effect of Ellagic Acid on Hepatic Lipid Metabolism and Antioxidant Activity in Mice.
Xu Q, Li S, Tang W, Yan J, Wei X, Zhou M, Diao H
Frontiers in physiology 2021;12:751501
Frontiers in physiology 2021;12:751501
Rubus chingii var. suavissimus alleviates high-fat diet-induced lipid metabolism disorder via modulation of the PPARs/SREBP pathway in Syrian golden hamsters.
Jiang MJ, Li L, Huang WF, Su J, Li YH, Qu XS, Fan LL
Journal of natural medicines 2021 Sep;75(4):884-892
Journal of natural medicines 2021 Sep;75(4):884-892
Pterostilbene attenuates RIPK3-dependent hepatocyte necroptosis in alcoholic liver disease via SIRT2-mediated NFATc4 deacetylation.
Shao Y, Wang X, Zhou Y, Jiang Y, Wu R, Lu C
Toxicology 2021 Sep;461:152923
Toxicology 2021 Sep;461:152923
Deficiency of intestinal Bmal1 prevents obesity induced by high-fat feeding.
Yu F, Wang Z, Zhang T, Chen X, Xu H, Wang F, Guo L, Chen M, Liu K, Wu B
Nature communications 2021 Sep 7;12(1):5323
Nature communications 2021 Sep 7;12(1):5323
PPARα agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1.
Xu Y, Denning KL, Lu Y
Biochemical pharmacology 2021 Oct;192:114678
Biochemical pharmacology 2021 Oct;192:114678
Human umbilical cord-derived mesenchymal stem cell-exosomal miR-627-5p ameliorates non-alcoholic fatty liver disease by repressing FTO expression.
Cheng L, Yu P, Li F, Jiang X, Jiao X, Shen Y, Lai X
Human cell 2021 Nov;34(6):1697-1708
Human cell 2021 Nov;34(6):1697-1708
N(1)-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism.
Wang Y, Wang J, Li X, Xiong X, Wang J, Zhou Z, Zhu X, Gu Y, Dominissini D, He L, Tian Y, Yi C, Fan Z
Nature communications 2021 Nov 2;12(1):6314
Nature communications 2021 Nov 2;12(1):6314
Danthron ameliorates obesity and MAFLD through activating the interplay between PPARα/RXRα heterodimer and adiponectin receptor 2.
Ma C, Wang Z, Xia R, Wei L, Zhang C, Zhang J, Zhao L, Wu H, Kang L, Yang S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 May;137:111344
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 May;137:111344
Sildenafil improves right ventricular remodelling in monocrotaline-induced rats by decreasing myocardial apoptosis and activating peroxisome proliferator-activated receptors.
Li YL, Li YQ, Zeng FQ, Lin XY, Li XT, Ren XQ, Yang DL
The Journal of pharmacy and pharmacology 2021 Mar 4;73(2):145-151
The Journal of pharmacy and pharmacology 2021 Mar 4;73(2):145-151
FGF1(ΔHBS) prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK/Nur77 suppression.
Wang D, Yin Y, Wang S, Zhao T, Gong F, Zhao Y, Wang B, Huang Y, Cheng Z, Zhu G, Wang Z, Wang Y, Ren J, Liang G, Li X, Huang Z
Signal transduction and targeted therapy 2021 Mar 24;6(1):133
Signal transduction and targeted therapy 2021 Mar 24;6(1):133
Effect of selenium-enriched kiwifruit on body fat reduction and liver protection in hyperlipidaemic mice.
Zhang X, Xia H, Wang J, Leng R, Zhou X, Gao Q, He K, Liu D, Huang B
Food & function 2021 Mar 15;12(5):2044-2057
Food & function 2021 Mar 15;12(5):2044-2057
PPARα agonist WY-14,643 enhances ethanol metabolism in mice: Role of catalase.
Chen X, Xu Y, Denning KL, Grigore A, Lu Y
Free radical biology & medicine 2021 Jun;169:283-293
Free radical biology & medicine 2021 Jun;169:283-293
Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1.
Zhou L, Zhang C, Yang X, Liu L, Hu J, Hou Y, Tao H, Sugimura H, Chen Z, Wang L, Chen K
Clinical and translational medicine 2021 Jun;11(6):e449
Clinical and translational medicine 2021 Jun;11(6):e449
Improvement of hyperlipidemia by aerobic exercise in mice through a regulatory effect of miR-21a-5p on its target genes.
Zhao J, Song Y, Zeng Y, Chen L, Yan F, Chen A, Wu B, Wang Y
Scientific reports 2021 Jun 7;11(1):11966
Scientific reports 2021 Jun 7;11(1):11966
The lipid-lowering drug fenofibrate combined with si-HOTAIR can effectively inhibit the proliferation of gliomas.
Zhu W, Zhao H, Xu F, Huang B, Dai X, Sun J, Nyalali AMK, Zhang K, Ni S
BMC cancer 2021 Jun 3;21(1):664
BMC cancer 2021 Jun 3;21(1):664
Probiotic-fermented black tartary buckwheat alleviates hyperlipidemia and gut microbiota dysbiosis in rats fed with a high-fat diet.
Ren Y, Wu S, Xia Y, Huang J, Ye J, Xuan Z, Li P, Du B
Food & function 2021 Jul 5;12(13):6045-6057
Food & function 2021 Jul 5;12(13):6045-6057
Topotecan induces hepatocellular injury via ASCT2 mediated oxidative stress.
Zhou G, Qin M, Zhang X, Yang J, Yu H
Gastroenterologia y hepatologia 2021 Jan;44(1):1-12
Gastroenterologia y hepatologia 2021 Jan;44(1):1-12
Carbohydrate response element-binding protein regulates lipid metabolism via mTOR complex1 in diabetic nephropathy.
Chen N, Mu L, Yang Z, Du C, Wu M, Song S, Yuan C, Shi Y
Journal of cellular physiology 2021 Jan;236(1):625-640
Journal of cellular physiology 2021 Jan;236(1):625-640
DNA methylation of FTO promotes renal inflammation by enhancing m(6)A of PPAR-α in alcohol-induced kidney injury.
Yu JT, Hu XW, Chen HY, Yang Q, Li HD, Dong YH, Zhang Y, Wang JN, Jin J, Wu YG, Li J, Ge JF, Meng XM
Pharmacological research 2021 Jan;163:105286
Pharmacological research 2021 Jan;163:105286
Cordycepin attenuates high-fat diet-induced non-alcoholic fatty liver disease via down-regulation of lipid metabolism and inflammatory responses.
Gong X, Li T, Wan R, Sha L
International immunopharmacology 2021 Feb;91:107173
International immunopharmacology 2021 Feb;91:107173
Celastrol inhibits intestinal lipid absorption by reprofiling the gut microbiota to attenuate high-fat diet-induced obesity.
Hua H, Zhang Y, Zhao F, Chen K, Wu T, Liu Q, Huang S, Zhang A, Jia Z
iScience 2021 Feb 19;24(2):102077
iScience 2021 Feb 19;24(2):102077
DNMT1-mediated PPARα methylation aggravates damage of retinal tissues in diabetic retinopathy mice.
Zhu Y, Wang X, Zhou X, Ding L, Liu D, Xu H
Biological research 2021 Aug 6;54(1):25
Biological research 2021 Aug 6;54(1):25
Mogroside V Protects against Hepatic Steatosis in Mice on a High-Fat Diet and LO2 Cells Treated with Free Fatty Acids via AMPK Activation.
Li L, Zheng W, Wang C, Qi J, Li H
Evidence-based complementary and alternative medicine : eCAM 2020;2020:7826874
Evidence-based complementary and alternative medicine : eCAM 2020;2020:7826874
Berberine Suppressed Tumor Growth through Regulating Fatty Acid Metabolism and Triggering Cell Apoptosis via Targeting FABPs.
Li L, Peng Z, Hu Q, Xu L, Zou X, Yu Y, Huang D, Yi P
Evidence-based complementary and alternative medicine : eCAM 2020;2020:6195050
Evidence-based complementary and alternative medicine : eCAM 2020;2020:6195050
Empagliflozin Alleviates Hepatic Steatosis by Activating the AMPK-TET2-Autophagy Pathway in vivo and in vitro.
Li T, Fang T, Xu L, Liu X, Li X, Xue M, Yu X, Sun B, Chen L
Frontiers in pharmacology 2020;11:622153
Frontiers in pharmacology 2020;11:622153
Liraglutide Alleviates Hepatic Steatosis and Liver Injury in T2MD Rats via a GLP-1R Dependent AMPK Pathway.
Zhou R, Lin C, Cheng Y, Zhuo X, Li Q, Xu W, Zhao L, Yang L
Frontiers in pharmacology 2020;11:600175
Frontiers in pharmacology 2020;11:600175
Investigation of the Lipid-Lowering Mechanisms and Active Ingredients of Danhe Granule on Hyperlipidemia Based on Systems Pharmacology.
Chen K, Ma Z, Yan X, Liu J, Xu W, Li Y, Dai Y, Zhang Y, Xiao H
Frontiers in pharmacology 2020;11:528
Frontiers in pharmacology 2020;11:528
Decreased ANGPTL4 impairs endometrial angiogenesis during peri-implantation period in patients with recurrent implantation failure.
Li M, Hu J, Yao L, Gao M
Journal of cellular and molecular medicine 2020 Sep;24(18):10730-10743
Journal of cellular and molecular medicine 2020 Sep;24(18):10730-10743
TRIB3 destabilizes tumor suppressor PPARα expression through ubiquitin-mediated proteasome degradation in acute myeloid leukemia.
Luo X, Zhong L, Yu L, Xiong L, Dan W, Li J, Ye J, Chu X, Liu C, Liu B
Life sciences 2020 Sep 15;257:118021
Life sciences 2020 Sep 15;257:118021
Protective effect of Yi-Qi-Huo-Xue Decoction against ischemic heart disease by regulating cardiac lipid metabolism.
Li FH, Huang XL, Wang H, Guo SW, Li P
Chinese journal of natural medicines 2020 Oct;18(10):779-792
Chinese journal of natural medicines 2020 Oct;18(10):779-792
Effect and mechanism of ginsenoside Rg1-regulating hepatic steatosis in HepG2 cells induced by free fatty acid.
Gao Y, Zhang S, Li J, Zhao J, Xiao Q, Zhu Y, Zhang J, Huang W
Bioscience, biotechnology, and biochemistry 2020 Nov;84(11):2228-2240
Bioscience, biotechnology, and biochemistry 2020 Nov;84(11):2228-2240
Short hairpin RNA attenuates liver fibrosis by regulating the PPAR‑γ and NF‑κB pathways in HBV‑induced liver fibrosis in mice.
Ye L, Chen T, Cao J, Sun L, Li W, Zhang C
International journal of oncology 2020 Nov;57(5):1116-1128
International journal of oncology 2020 Nov;57(5):1116-1128
Melanoma Persister Cells Are Tolerant to BRAF/MEK Inhibitors via ACOX1-Mediated Fatty Acid Oxidation.
Shen S, Faouzi S, Souquere S, Roy S, Routier E, Libenciuc C, André F, Pierron G, Scoazec JY, Robert C
Cell reports 2020 Nov 24;33(8):108421
Cell reports 2020 Nov 24;33(8):108421
Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment.
Wang L, Cheng CM, Qin J, Xu M, Kao CY, Shi J, You E, Gong W, Rosa LP, Chase P, Scampavia L, Madoux F, Spicer T, Hodder P, Xu HE, Tsai SY, Tsai MJ
Science advances 2020 May;6(18):eaaz8031
Science advances 2020 May;6(18):eaaz8031
Sirt3 modulates fatty acid oxidation and attenuates cisplatin-induced AKI in mice.
Li M, Li CM, Ye ZC, Huang J, Li Y, Lai W, Peng H, Lou TQ
Journal of cellular and molecular medicine 2020 May;24(9):5109-5121
Journal of cellular and molecular medicine 2020 May;24(9):5109-5121
Secoisolariciresinol diglucoside alleviates hepatic lipid metabolic misalignment involving the endoplasmic reticulum-mitochondrial axis.
Wei L, Zhao C, Dong S, Yao S, Ji B, Zhao B, Liu Z, Liu X, Wang Y
Food & function 2020 May 1;11(5):3952-3963
Food & function 2020 May 1;11(5):3952-3963
Tectorigenin attenuates diabetic nephropathy by improving vascular endothelium dysfunction through activating AdipoR1/2 pathway.
Yang S, Ma C, Wu H, Zhang H, Yuan F, Yang G, Yang Q, Jia L, Liang Z, Kang L
Pharmacological research 2020 Mar;153:104678
Pharmacological research 2020 Mar;153:104678
Auxiliary antitumor effects of fungal proteins from Hericium erinaceus by target on the gut microbiota.
Wang D, Zhu X, Tang X, Li H, Yizhen X, Chen D
Journal of food science 2020 Jun;85(6):1872-1890
Journal of food science 2020 Jun;85(6):1872-1890
Hepatic HuR modulates lipid homeostasis in response to high-fat diet.
Zhang Z, Zong C, Jiang M, Hu H, Cheng X, Ni J, Yi X, Jiang B, Tian F, Chang MW, Su W, Zhu L, Li J, Xiang X, Miao C, Gorospe M, de Cabo R, Dou Y, Ju Z, Yang J, Jiang C, Yang Z, Wang W
Nature communications 2020 Jun 16;11(1):3067
Nature communications 2020 Jun 16;11(1):3067
Hypolipidemic effect of pure total flavonoids from peel of Citrus (PTFC) on hamsters of hyperlipidemia and its potential mechanism.
Ling Y, Shi Z, Yang X, Cai Z, Wang L, Wu X, Ye A, Jiang J
Experimental gerontology 2020 Feb;130:110786
Experimental gerontology 2020 Feb;130:110786
Periostin antisense oligonucleotide prevents hepatic steatosis and fibrosis in a mouse model of non-alcoholic steatohepatitis.
Kobayashi T, Kanno K, Nguyen PT, Sugiyama A, Kawahara A, Otani Y, Kishikawa N, Ito M, Tazuma S
Journal of gastroenterology and hepatology 2020 Dec;35(12):2140-2150
Journal of gastroenterology and hepatology 2020 Dec;35(12):2140-2150
Resveratrol improves meat quality, muscular antioxidant capacity, lipid metabolism and fiber type composition of intrauterine growth retarded pigs.
Cheng K, Yu C, Li Z, Li S, Yan E, Song Z, Zhang H, Zhang L, Wang T
Meat science 2020 Dec;170:108237
Meat science 2020 Dec;170:108237
Caloric restriction alleviates aging-related fibrosis of kidney through downregulation of miR-21 in extracellular vesicles.
Liu JR, Cai GY, Ning YC, Wang JC, Lv Y, Guo YN, Fu B, Hong Q, Sun XF, Chen XM
Aging 2020 Aug 27;12(18):18052-18072
Aging 2020 Aug 27;12(18):18052-18072
Lycopene attenuates body weight gain through induction of browning via regulation of peroxisome proliferator-activated receptor γ in high-fat diet-induced obese mice.
Zhu R, Wei J, Liu H, Liu C, Wang L, Chen B, Li L, Jia Q, Tian Y, Li R, Zhao D, Mo F, Li Y, Gao S, Wang XD, Zhang D
The Journal of nutritional biochemistry 2020 Apr;78:108335
The Journal of nutritional biochemistry 2020 Apr;78:108335
Keratocytes promote corneal neovascularization through VEGFr3 induced by PPARα-inhibition.
Wang X, Tang L, Zhang Z, Li W, Chen Y
Experimental eye research 2020 Apr;193:107982
Experimental eye research 2020 Apr;193:107982
MiR-30b-5p regulates the lipid metabolism by targeting PPARGC1A in Huh-7 cell line.
Zhang Q, Ma XF, Dong MZ, Tan J, Zhang J, Zhuang LK, Liu SS, Xin YN
Lipids in health and disease 2020 Apr 16;19(1):76
Lipids in health and disease 2020 Apr 16;19(1):76
Significant Role of Dicer and miR-223 in Adipose Tissue of Polycystic Ovary Syndrome Patients.
Qin L, Chen J, Tang L, Zuo T, Chen H, Gao R, Xu W
BioMed research international 2019;2019:9193236
BioMed research international 2019;2019:9193236
Loquat leaf polysaccharides improve glomerular injury in rats with anti-Thy 1 nephritis via peroxisome proliferator-activated receptor alpha pathway.
Lu T, Fan Z, Hou J, Qi X, Guo M, Ju J, Yang Y, Gu C
American journal of translational research 2019;11(6):3531-3542
American journal of translational research 2019;11(6):3531-3542
Effects of PPARs/20-HETE on the renal impairment under diabetic conditions.
Ding S, Huang J, Qiu H, Chen R, Zhang J, Huang B, Cheng O, Jiang Q
Experimental cell research 2019 Sep 1;382(1):111455
Experimental cell research 2019 Sep 1;382(1):111455
Therapeutic potential of NaoXinTong Capsule on the developed diabetic nephropathy in db/db mice.
Yang S, Chen Y, Duan Y, Ma C, Liu L, Li Q, Yang J, Li X, Zhao B, Wang Y, Qian K, Liu M, Zhu Y, Yang X, Han J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109389
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109389
Vitamin E Ameliorates Lipid Metabolism in Mice with Nonalcoholic Fatty Liver Disease via Nrf2/CES1 Signaling Pathway.
He W, Xu Y, Ren X, Xiang D, Lei K, Zhang C, Liu D
Digestive diseases and sciences 2019 Nov;64(11):3182-3191
Digestive diseases and sciences 2019 Nov;64(11):3182-3191
TIGAR regulates mitochondrial functions through SIRT1-PGC1α pathway and translocation of TIGAR into mitochondria in skeletal muscle.
Geng J, Wei M, Yuan X, Liu Z, Wang X, Zhang D, Luo L, Wu J, Guo W, Qin ZH
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 May;33(5):6082-6098
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 May;33(5):6082-6098
Formononetin ameliorates cholestasis by regulating hepatic SIRT1 and PPARα.
Yang S, Wei L, Xia R, Liu L, Chen Y, Zhang W, Li Q, Feng K, Yu M, Zhang W, Qu J, Xu S, Mao J, Fan G, Ma C
Biochemical and biophysical research communications 2019 May 14;512(4):770-778
Biochemical and biophysical research communications 2019 May 14;512(4):770-778
Chronic treatment with the modified Longdan Xiegan Tang attenuates olanzapine-induced fatty liver in rats by regulating hepatic de novo lipogenesis and fatty acid beta-oxidation-associated gene expression mediated by SREBP-1c, PPAR-alpha and AMPK-alpha.
Ren L, Sun D, Zhou X, Yang Y, Huang X, Li Y, Wang C, Li Y
Journal of ethnopharmacology 2019 Mar 25;232:176-187
Journal of ethnopharmacology 2019 Mar 25;232:176-187
Bromide alleviates fatty acid-induced lipid accumulation in mouse primary hepatocytes through the activation of PPARα signals.
Shi Y, Zhang W, Cheng Y, Liu C, Chen S
Journal of cellular and molecular medicine 2019 Jun;23(6):4464-4474
Journal of cellular and molecular medicine 2019 Jun;23(6):4464-4474
Loss of Adipose Growth Hormone Receptor in Mice Enhances Local Fatty Acid Trapping and Impairs Brown Adipose Tissue Thermogenesis.
Ran L, Wang X, Mi A, Liu Y, Wu J, Wang H, Guo M, Sun J, Liu B, Li Y, Wang D, Jiang R, Wang N, Gao W, Zeng L, Huang L, Chen X, LeRoith D, Liang B, Li X, Wu Y
iScience 2019 Jun 28;16:106-121
iScience 2019 Jun 28;16:106-121
Organophosphorus Flame Retardants Impair Intracellular Lipid Metabolic Function in Human Hepatocellular Cells.
Hao Z, Zhang Z, Lu D, Ding B, Shu L, Zhang Q, Wang C
Chemical research in toxicology 2019 Jun 17;32(6):1250-1258
Chemical research in toxicology 2019 Jun 17;32(6):1250-1258
Activation of 20-HETE/PPARs involved in reno-therapeutic effect of naringenin on diabetic nephropathy.
Ding S, Qiu H, Huang J, Chen R, Zhang J, Huang B, Zou X, Cheng O, Jiang Q
Chemico-biological interactions 2019 Jul 1;307:116-124
Chemico-biological interactions 2019 Jul 1;307:116-124
EETs/PPARs activation together mediates the preventive effect of naringenin in high glucose-induced cardiomyocyte hypertrophy.
Zhang J, Qiu H, Huang J, Ding S, Huang B, Zhou P, Jiang Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jan;109:1498-1505
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jan;109:1498-1505
Therapeutic Effect of Chitooligosaccharide Tablets on Lipids in High-Fat Diets Induced Hyperlipidemic Rats.
Yang D, Hu C, Deng X, Bai Y, Cao H, Guo J, Su Z
Molecules (Basel, Switzerland) 2019 Jan 31;24(3)
Molecules (Basel, Switzerland) 2019 Jan 31;24(3)
Coenzyme Q10 attenuates high-fat diet-induced non-alcoholic fatty liver disease through activation of the AMPK pathway.
Chen K, Chen X, Xue H, Zhang P, Fang W, Chen X, Ling W
Food & function 2019 Feb 20;10(2):814-823
Food & function 2019 Feb 20;10(2):814-823
High Fat Diet Suppresses Peroxisome Proliferator-Activated Receptors and Reduces Dopaminergic Neurons in the Substantia Nigra.
Kao YC, Wei WY, Tsai KJ, Wang LC
International journal of molecular sciences 2019 Dec 27;21(1)
International journal of molecular sciences 2019 Dec 27;21(1)
Fe(3)O(4)@OA@Poloxamer nanoparticles lower triglyceride in hepatocytes through liposuction effect and nano-enzyme effect.
Sun Y, Shi F, Niu Y, Zhang Y, Xiong F
Colloids and surfaces. B, Biointerfaces 2019 Dec 1;184:110528
Colloids and surfaces. B, Biointerfaces 2019 Dec 1;184:110528
Correction: Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Dong D, Qi Y, Xu L, Yin L, Xu Y, Han X, Zhao Y, Peng J
Food & function 2019 Aug 1;10(8):5240-5241
Food & function 2019 Aug 1;10(8):5240-5241
Protective effect of cultured bear bile powder against dimethylnitrosamine-induced hepatic fibrosis in rats.
Zheng M, Li YY, Wang GF, Jin JY, Wang YH, Wang TM, Yang L, Liu SY, Wu JS, Wang ZT, Ma YM
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108701
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108701
Cholesterol-lowering effects and potential mechanisms of chitooligosaccharide capsules in hyperlipidemic rats.
Jiang Y, Fu C, Liu G, Guo J, Su Z
Food & nutrition research 2018;62
Food & nutrition research 2018;62
Multi-scale, whole-system models of liver metabolic adaptation to fat and sugar in non-alcoholic fatty liver disease.
Maldonado EM, Fisher CP, Mazzatti DJ, Barber AL, Tindall MJ, Plant NJ, Kierzek AM, Moore JB
NPJ systems biology and applications 2018;4:33
NPJ systems biology and applications 2018;4:33
The Hepatoprotection by Oleanolic Acid Preconditioning: Focusing on PPARα Activation.
Wang W, Chen K, Xia Y, Mo W, Wang F, Dai W, Niu P
PPAR research 2018;2018:3180396
PPAR research 2018;2018:3180396
GLP-1 receptor agonist ameliorates obesity-induced chronic kidney injury via restoring renal metabolism homeostasis.
Wang C, Li L, Liu S, Liao G, Li L, Chen Y, Cheng J, Lu Y, Liu J
PloS one 2018;13(3):e0193473
PloS one 2018;13(3):e0193473
Neurotensin contributes to pediatric intestinal failure-associated liver disease via regulating intestinal bile acids uptake.
Xiao Y, Yan W, Lu Y, Zhou K, Cai W
EBioMedicine 2018 Sep;35:133-141
EBioMedicine 2018 Sep;35:133-141
Functional interplay between liver X receptor and AMP-activated protein kinase α inhibits atherosclerosis in apolipoprotein E-deficient mice - a new anti-atherogenic strategy.
Ma C, Zhang W, Yang X, Liu Y, Liu L, Feng K, Zhang X, Yang S, Sun L, Yu M, Yang J, Li X, Hu W, Miao RQ, Zhu Y, Li L, Han J, Chen Y, Duan Y
British journal of pharmacology 2018 May;175(9):1486-1503
British journal of pharmacology 2018 May;175(9):1486-1503
Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-α pathway in mice.
Lu X, Liu T, Chen K, Xia Y, Dai W, Xu S, Xu L, Wang F, Wu L, Li J, Li S, Wang W, Yu Q, Feng J, Fan X, Zhou Y, Niu P, Guo C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:800-811
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:800-811
Naringenin exhibits the protective effect on cardiac hypertrophy via EETs-PPARs activation in streptozocin-induced diabetic mice.
Zhang J, Qiu H, Huang J, Ding S, Huang B, Wu Q, Jiang Q
Biochemical and biophysical research communications 2018 Jul 7;502(1):55-61
Biochemical and biophysical research communications 2018 Jul 7;502(1):55-61
Polyacetylene glycoside attenuates ischemic kidney injury by co-inhibiting inflammation, mitochondria dysfunction and lipotoxicity.
Zhou Y, Du D, Liu S, Zhao M, Yuan Y, Li L, Chen Y, Lu Y, Cheng J, Liu J
Life sciences 2018 Jul 1;204:55-64
Life sciences 2018 Jul 1;204:55-64
Isoquercitrin Attenuated Cardiac Dysfunction Via AMPKα-Dependent Pathways in LPS-Treated Mice.
Huang SH, Xu M, Wu HM, Wan CX, Wang HB, Wu QQ, Liao HH, Deng W, Tang QZ
Molecular nutrition & food research 2018 Dec;62(24):e1800955
Molecular nutrition & food research 2018 Dec;62(24):e1800955
Effects of mulberry leaf on experimental hyperlipidemia rats induced by high-fat diet.
Huang J, Wang Y, Ying C, Liu L, Lou Z
Experimental and therapeutic medicine 2018 Aug;16(2):547-556
Experimental and therapeutic medicine 2018 Aug;16(2):547-556
Protective role of fenofibrate in sepsis-induced acute kidney injury in BALB/c mice.
Pei Z, Deng S, Xie D, Lv M, Guo W, Liu D, Zheng Z, Long X
RSC advances 2018 Aug 7;8(50):28510-28517
RSC advances 2018 Aug 7;8(50):28510-28517
Metabolomics reveal mitochondrial and fatty acid metabolism disorders that contribute to the development of DKD in T2DM patients.
Li L, Wang C, Yang H, Liu S, Lu Y, Fu P, Liu J
Molecular bioSystems 2017 Oct 24;13(11):2392-2400
Molecular bioSystems 2017 Oct 24;13(11):2392-2400
The effects of di 2-ethyl hexyl phthalate (DEHP) on cellular lipid accumulation in HepG2 cells and its potential mechanisms in the molecular level.
Zhang W, Shen XY, Zhang WW, Chen H, Xu WP, Wei W
Toxicology mechanisms and methods 2017 May;27(4):245-252
Toxicology mechanisms and methods 2017 May;27(4):245-252
miR-148a and miR-17-5p synergistically regulate milk TAG synthesis via PPARGC1A and PPARA in goat mammary epithelial cells.
Chen Z, Luo J, Sun S, Cao D, Shi H, Loor JJ
RNA biology 2017 Mar 4;14(3):326-338
RNA biology 2017 Mar 4;14(3):326-338
The histone methyltransferase Suv39h2 contributes to nonalcoholic steatohepatitis in mice.
Fan Z, Li L, Li M, Zhang X, Hao C, Yu L, Zeng S, Xu H, Fang M, Shen A, Jenuwein T, Xu Y
Hepatology (Baltimore, Md.) 2017 Jun;65(6):1904-1919
Hepatology (Baltimore, Md.) 2017 Jun;65(6):1904-1919
Dietary capsaicin and antibiotics act synergistically to reduce non-alcoholic fatty liver disease induced by high fat diet in mice.
Hu J, Luo H, Jiang Y, Chen P
Oncotarget 2017 Jun 13;8(24):38161-38175
Oncotarget 2017 Jun 13;8(24):38161-38175
Nutritional background changes the hypolipidemic effects of fenofibrate in Nile tilapia (Oreochromis niloticus).
Ning LJ, He AY, Lu DL, Li JM, Qiao F, Li DL, Zhang ML, Chen LQ, Du ZY
Scientific reports 2017 Jan 31;7:41706
Scientific reports 2017 Jan 31;7:41706
PPARβ/δ activation protects against corticosterone-induced ER stress in astrocytes by inhibiting the CpG hypermethylation of microRNA-181a.
Ji J, Zeng XN, Cao LL, Zhang L, Zhao Z, Yang DD, Sun XL
Neuropharmacology 2017 Feb;113(Pt A):396-406
Neuropharmacology 2017 Feb;113(Pt A):396-406
Calycosin attenuates triglyceride accumulation and hepatic fibrosis in murine model of non-alcoholic steatohepatitis via activating farnesoid X receptor.
Duan X, Meng Q, Wang C, Liu Z, Liu Q, Sun H, Sun P, Yang X, Huo X, Peng J, Liu K
Phytomedicine : international journal of phytotherapy and phytopharmacology 2017 Feb 15;25:83-92
Phytomedicine : international journal of phytotherapy and phytopharmacology 2017 Feb 15;25:83-92
Mechanisms and metabolic regulation of PPARα activation in Nile tilapia (Oreochromis niloticus).
Ning LJ, He AY, Li JM, Lu DL, Jiao JG, Li LY, Li DL, Zhang ML, Chen LQ, Du ZY
Biochimica et biophysica acta 2016 Sep;1861(9 Pt A):1036-1048
Biochimica et biophysica acta 2016 Sep;1861(9 Pt A):1036-1048
Polyphenols from hawthorn peels and fleshes differently mitigate dyslipidemia, inflammation and oxidative stress in association with modulation of liver injury in high fructose diet-fed mice.
Han X, Li W, Huang D, Yang X
Chemico-biological interactions 2016 Sep 25;257:132-40
Chemico-biological interactions 2016 Sep 25;257:132-40
Jatrorrhizine hydrochloride attenuates hyperlipidemia in a high-fat diet-induced obesity mouse model.
Yang W, She L, Yu K, Yan S, Zhang X, Tian X, Ma S, Zhang X
Molecular medicine reports 2016 Oct;14(4):3277-84
Molecular medicine reports 2016 Oct;14(4):3277-84
Zinc finger protein 407 overexpression upregulates PPAR target gene expression and improves glucose homeostasis in mice.
Charrier A, Wang L, Stephenson EJ, Ghanta SV, Ko CW, Croniger CM, Bridges D, Buchner DA
American journal of physiology. Endocrinology and metabolism 2016 Nov 1;311(5):E869-E880
American journal of physiology. Endocrinology and metabolism 2016 Nov 1;311(5):E869-E880
Di(2-ethylhexyl) phthalate exacerbates non-alcoholic fatty liver in rats and its potential mechanisms.
Chen H, Zhang W, Rui BB, Yang SM, Xu WP, Wei W
Environmental toxicology and pharmacology 2016 Mar;42:38-44
Environmental toxicology and pharmacology 2016 Mar;42:38-44
Protective effects of heparin on endothelial cells in sepsis.
Ma J, Bai J
International journal of clinical and experimental medicine 2015;8(4):5547-52
International journal of clinical and experimental medicine 2015;8(4):5547-52
Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway.
Cui M, Xiao Z, Wang Y, Zheng M, Song T, Cai X, Sun B, Ye L, Zhang X
Cancer research 2015 Mar 1;75(5):846-57
Cancer research 2015 Mar 1;75(5):846-57
Maternal obesity disrupts circadian rhythms of clock and metabolic genes in the offspring heart and liver.
Wang D, Chen S, Liu M, Liu C
Chronobiology international 2015 Jun;32(5):615-26
Chronobiology international 2015 Jun;32(5):615-26
Potent effects of dioscin against obesity in mice.
Liu M, Xu L, Yin L, Qi Y, Xu Y, Han X, Zhao Y, Sun H, Yao J, Lin Y, Liu K, Peng J
Scientific reports 2015 Jan 22;5:7973
Scientific reports 2015 Jan 22;5:7973
I prostanoid receptor-mediated inflammatory pathway promotes hepatic gluconeogenesis through activation of PKA and inhibition of AKT.
Yan S, Zhang Q, Zhong X, Tang J, Wang Y, Yu J, Zhou Y, Zhang J, Guo F, Liu Y, FitzGerald GA, Yu Y
Diabetes 2014 Sep;63(9):2911-23
Diabetes 2014 Sep;63(9):2911-23
Protective effects of dioscin against alcohol-induced liver injury.
Xu T, Zheng L, Xu L, Yin L, Qi Y, Xu Y, Han X, Peng J
Archives of toxicology 2014 Mar;88(3):739-53
Archives of toxicology 2014 Mar;88(3):739-53
Lipoic acid entrains the hepatic circadian clock and lipid metabolic proteins that have been desynchronized with advanced age.
Keith D, Finlay L, Butler J, Gómez L, Smith E, Moreau R, Hagen T
Biochemical and biophysical research communications 2014 Jul 18;450(1):324-9
Biochemical and biophysical research communications 2014 Jul 18;450(1):324-9
Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Dong D, Qi Y, Xu L, Yin L, Xu Y, Han X, Zhao Y, Peng J
Food & function 2014 Dec;5(12):3065-3075
Food & function 2014 Dec;5(12):3065-3075
Dihydrocapsaicin Attenuates Plaque Formation through a PPARγ/LXRα Pathway in apoE(-/-) Mice Fed a High-Fat/High-Cholesterol Diet.
Hu YW, Ma X, Huang JL, Mao XR, Yang JY, Zhao JY, Li SF, Qiu YR, Yang J, Zheng L, Wang Q
PloS one 2013;8(6):e66876
PloS one 2013;8(6):e66876
Effects of flavonoids from Rosa laevigata Michx fruit against high-fat diet-induced non-alcoholic fatty liver disease in rats.
Zhang S, Zheng L, Dong D, Xu L, Yin L, Qi Y, Han X, Lin Y, Liu K, Peng J
Food chemistry 2013 Dec 1;141(3):2108-16
Food chemistry 2013 Dec 1;141(3):2108-16
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- U-937 cells were subjected to SDS PAGE followed by western blot with 15540-1-AP(PPARA antibody) at dilution of 1:100
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PPARA antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PPARA. This antibody recognizes human,mouse,rat antigen. The PPARA antibody has been validated for the following applications: ELISA, WB, IHC analysis.