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- Antibody Data
- Antigen structure
- References [210]
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- Product number
- 66826-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- PPARA antibody
- Antibody type
- Monoclonal
- Description
- PPARA antibody (Cat. #66826-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, rat and has been validated for the following applications: WB,ELISA.
- Reactivity
- Human, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 1G1E10
- Vial size
- 20ul, 150ul
Submitted references Porphyromonas gingivalis Promotes Neuroinflammation by Microglial Ferroptosis via NOX4/PPAR-α/PGC-1α Pathway.
The Bioinformatics Analysis of Publicly Available Datasets and Validation in a Mouse Model of Myocardial Infarction Through Coronary Artery Ligation.
Qingyi Decoction Alleviates Alcoholic Pancreatitis by Improving Glycerolipid Homeostasis via the AMPK/SREBP-1c/PPARα Pathway.
PPAR-gamma regulates PFAS-mediated proinflammatory cytokines in lung epithelial cells.
Physiological safety and Multi-Tissue metabolic adaptation under a novel intermittent prolonged fasting regimen.
Polydatin Targets ACADVL to Combat Obesity by Promoting Adipocyte Browning and Activating Fatty Acid Oxidation.
Multi-omics reveals that 4'-O-β-D-glucosyl-5-O-methylvisamminol ameliorates acute liver injury by modulating the miR-30e-3p/Tfrc axis and a multi-dimensional network of ferroptosis, inflammation, metabolism, and gut microbiota.
HMGCS2-dependent β-OHB/H3K9bhb ameliorates synaptic plasticity and cognition in Alzheimer's disease.
USP2 promotes metabolic dysfunction-associated steatotic liver disease progression via stabilization of PPARγ.
Salvianolic Acid B Alleviates MAFLD by Targeting PPAR-α: Mechanistic Insights From Network Pharmacology and Lipidomics.
Integrated Proteomics and Metabolomics Reveal the Direct Hepatic Protection of Propionate Against Alcoholic Liver Disease via the RGN-PPARα Pathway.
β-catenin mutation reprograms ketone body metabolism to drive hepatocellular carcinoma metastasis and resistance to ketogenic therapy via transcriptional activation of OXCT1.
Unraveling the potential mechanisms of Bupleuri Radix-Scutellariae Radix herb pair on non-alcoholic fatty liver disease by integrated transcriptomics, metabolomics and network pharmacology.
Exercise attenuates polycystic ovary syndrome development via improved mitochondrial proteostasis.
Hexafluoropropylene oxide trimer acid (HFPO-TA) exposure predisposes to MASLD through reprogramming hepatic epigenome and transcriptome.
Single-nucleus RNA Sequencing and multi-omics reveal Uncaria-derived indole alkaloids induce hepatocyte injury by mediating CAR/PPARα axis.
Ferulic acid improves growth performance and lipid metabolism and bile acid level partially by activating the PPAR and CYP7A1 pathways in broilers.
Xiaoyaosan ameliorates stress-induced MASH via modulating IL-1R1/RXRα-mediated liver-brain crosstalk.
Buyanghuanwu decoction (BYHWD) attenuates hepatic fibrosis in CCl(4)-induced mice by regulating bile acid metabolism through activating PPARα.
A foam cell-targeted lipophagy restoration strategy stabilizes vulnerable atherosclerotic plaques.
Caveolin-1 deficiency exacerbates liver fibrosis by driving lipid metabolic reprogramming in hepatic stellate cells via DRP1-mediated mitochondrial fission.
Monascus pilosus SWM-008-Fermented Red Mold Rice and Its Monascinol Ameliorate Non-Alcoholic Fatty Liver Disease via Activation of the AMPK-ATGL Pathway and Enrichment of Butyrate-Producing Bacteria.
Endothelial CEPT1 Promotes Angiogenesis Through PPARα and VEGF-A Signaling.
Combination of GLP-1 receptor agonist and Akkermansia muciniphila Akk11 reduces adiposity and ameliorates MASLD in T2D mice.
Environmentally relevant lanthanum chloride exposure induces hepatic steatosis in zebrafish larvae via PPARα-dependent ApoB suppression.
Loss of HuD Sensitizes Neuroblastoma Cells to Palmitate-Driven Stress-Induced Premature Senescence via PPARα Downregulation and FAO Impairment.
Capsaicin Improves Lipid Metabolism Disorders Caused by LPS-Induced Immune Stress in Weaned Piglets.
Bidens biternata (Lour.) Merr. & Sherff improves liver lipid metabolism disorders in type 2 diabetic mice by activating mitophagy.
Environmental PET-microplastic exposure and risk of non-alcoholic fatty liver disease: An integrated computational toxicology and multi-omics study.
Targeted inhibition of M2 macrophages polarization via a PDC attenuates chronic pancreatitis through the PPARα pathway.
Metagenomics and Machine Learning Identify TMA-Producing Serratia Induced by High-Fat/Choline Diet: A Novel Obesity Target for TMA.
Annexin A1 exacerbates islet stellate cell activation by regulating triglyceride catabolism via the PPARα/ACOX1/CYP4a pathway.
MCL1 promotes porcine epidemic diarrhea virus replication by modulating arachidonic acid metabolic pathway.
Pedunculoside ameliorates metabolic dysfunction-associated steatotic liver disease by targeting HNRNPA1 and modulating PPARα signaling pathway to enhance Mitochondrial Fatty Acid β-Oxidation.
Structural characterization, physicochemical properties and hypolipidemic activity of hemp (Cannabis sativa L.) protein hydrolysates prepared via enzyme-microbial synergy.
METTL3/miR-192-5p/SCD1 Axis Regulates Lipid Metabolism to Affect T Cell Differentiation in Asthma.
A new investigation of nonalcoholic fatty liver disease: Effects of hypoxia on mitochondrial function and lipid droplet autophagy.
Aerobic exercise improved liver steatosis by modulating miR-34a-mediated PPARα/SIRT1-AMPK signaling pathway.
Hyodeoxycholic Acid Ameliorates Metabolic Syndrome Through Pathways of Primary Bile Acid Synthesis and Fatty Acid Degradation: Insights From a Rat Model.
PEDF Overexpression Ameliorates Cardiac Lipotoxicity in Diabetic Cardiomyopathy via Regulation of Energy Metabolism.
Study on the effect and mechanism of Ershiyiwei Lvronghao concentrated Pills in the treatment of nonalcoholic fatty liver disease.
Nobiletin protected against hypertrophic cardiomyopathy via targeting PPARα.
Jianpi-Huayu-Jiedu formula improves metabolic dysfunction-associated steatohepatitis through ameliorateing hepatic oxidative stress and lipid accumulation in vivo and in vitro.
α-Mangostin prevents diabetic cardiomyopathy by inhibiting oxidative damage and lipotoxicity through the AKT-FOXO1-CD36 pathway.
Short-term exposure to a high-humidity environment triggers intestinal inflammation via AQP3.
Gallic acid mitigates high-fat and high-carbohydrate diet-induced steatohepatitis by modulating the IRF6/PPARγ signaling pathway.
HPV11 targeting PPARA regulates the autophagy to inhibit the occurrence and development of nasal inverted papilloma.
Cigarette smoke-induced PPAR signaling dysregulation accelerates Alzheimer's disease pathogenesis and cognitive decline in 5xFAD mice.
Mechanisms of metabolic-associated fatty liver disease induced by 48-week PCB138 exposure and theabrownin intervention.
Calycosin alleviates myocardial fibrosis after myocardial infarction by restoring fatty acid metabolism homeostasis through inhibiting FAP.
Betaine decreases hepatic lipid deposition through DNA 5 mC and RNA m(6)A methylation-mediated regulation of fatty acid metabolic genes expression in laying hens.
Long-term low-dose exposure to 9-chlorophenanthrene induces liver lipid accumulation via disrupting circadian rhythm.
Mechanism of Bao Gan Ning decoction in attenuating hepatic fibrosis via modulation of the gut microbiome and PPAR/CYP7A1-mediated bile acid metabolism.
Artesunate promotes intestinal epithelial barrier repair by facilitating HMGCS2-dependent ketogenesis in experimental ulcerative colitis model mice.
Breviscapine regulates lipid metabolism of microglia via the ADORA1/PPARα/ACOX1 pathway to promote spinal cord injury recovery.
Liquid-liquid phase separation of GPS2-LATS1 promotes colorectal cancer progression by reprogramming lipid metabolism.
A distal enhancer of Pparα regulates thermogenesis and mitochondrial function in brown fat.
ILF3 mediates lipid metabolism to promote pancreatic cancer development by regulating CPT1A-activated PPARa signaling pathway.
Capsaicin Alleviates Autophagy-Lysosomal Dysfunction via PPARA-Mediated V-ATPase Subunit ATP6V0E1 Signaling in 3xTg-AD Mice.
Geniposide alleviates kidney fibrosis by targeting STAT3-HK2-mediated glycolysis.
Fenofibrate alleviates sepsis-associated acute kidney injury by enhancing renal fatty acid oxidation.
CRLS1 influences liver metastasis in colon cancer by regulating lipid metabolism pathways.
One day of environment-induced heat stress causes injury to the murine kidney.
Harnessing TP73‑targeted nintedanib: A novel strategy to halt triple‑negative breast cancer via p53‑PPARα/PI3K‑Akt pathway suppression.
Macrophage-derived VISTA engages with LRIG1 and hinders gut epithelial repair in colitis.
Heterozygous Kctd5 knockout mice exhibit abnormal lipid metabolism.
Quercetin ameliorates renal injury by promoting UCP1-mediated alleviation of lipid accumulation in diabetic kidney disease.
Dual targeting of lipogenesis and PUFAs homeostasis by compound kushen injection suppresses breast cancer bone metastasis.
3-O-Acetyloleanolic acid alleviates autoimmune liver injury by targeting FXR.
Eriocalyxin B induces ferroptosis through SIRT3 inhibition in triple-negative breast cancer.
Adiponectin Signaling Ameliorates Cognitive Dysfunction in Type 2 Diabetic Mice by Activating the Hippocampal AdipoR2-PPARα/CREB Pathway.
Sodium hexametaphosphate mitigates calcium oxalate stone formation by modulating crystallization and maintaining PPARα signaling.
Ferulic acid protects against stress-induced myocardial injury in mice.
CILP1 interacting with YBX1 promotes hypertrophic scar formation by suppressing PPARs transcription.
Effects of extreme heat exposure on heatstroke and liver injury in mice: The role of PPARα.
The Splice Variant of the NCOR2 Gene BQ323636.1 Modulates ACSL4 Expression to Enhance Fatty Acid Metabolism and Support of Tumor Growth in Breast Cancer.
Isorhamnetin Attenuates Isoproterenol-Induced Myocardial Injury by Reducing ENO1 (Alpha-Enolase) in Cardiomyocytes.
Environmental Chemical-Induced Cardiometabolic Disorders: Combined Epidemiological and Experimental Evidence.
Ginsenoside Rb(1) Ameliorates Heart Failure Ventricular Remodeling by Regulating the Twist1/PGC-1α/PPARα Signaling Pathway.
Structure characteristics of a novel pectic polysaccharide from Fructus Corni and its protective effect on alcoholic fatty liver.
Lipid-lowering effects of bile Arisaema polysaccharides on high-fat diet-induced hyperlipidemia: An integrated analysis of metabolomics, lipidomics and microbiome.
Cardioprotective effects of the jiming formula on myocardial metabolism in Mice with myocardial infarction via the AMPK/SIRT1/PGC-1α pathway.
Asprosin-FABP5 Interaction Modulates Mitochondrial Fatty Acid Oxidation through PPARα Contributing to MASLD Development.
OTUB1 enhances fatty acid oxidation in APAP-induced liver injury by mediating ACSL5 deubiquitination.
Melatonin modulates mitochondrial function and inhibits atherosclerosis progression through NRF2 activation and OPA1 inhibition.
18β-glycyrrhetinic acid mitigates lipotoxicity-induced premature senescence of tubular epithelial cells by activating SIRT1-TFEB signaling.
Exploring the Mechanism of Kidney Injury in Mice Induced by High-Fat Diet and Polystyrene Nanoplastics Co-Exposure Through the Kidney-Gut Axis.
Clinical and Experimental Insights into the Role of NETosis in IgA Nephropathy Pathogenesis.
Precise Carrier-Free Pt(IV)-Nanobombs for Apoptosis/Ferroptosis Synergistic Tumor Therapy: A New Effective Method to Obtain Good Chemotherapy and Low Toxicity.
Network pharmacology, transcriptomics, and biological validation reveal a lipid secretion inhibitory and anti-inflammatory mechanism of tanreqing gel in the treatment of acne.
Cassia mimosoides L. decoction improves non-alcoholic fatty liver disease by modulating the pregnane X receptor.
Hericium erinaceus Protein Alleviates High-Fat Diet-Induced Hepatic Lipid Accumulation and Oxidative Stress In Vivo.
Targeting Catenibacterium mitsuokai with icariin modulates gut microbiota and improves hepatic lipid metabolism in intrauterine growth restriction.
Integration of network pharmacology, UHPLC-Q exactive orbitrap HRMS technique and metabolomics to elucidate the active ingredients and mechanisms of compound danshen pills in treating hypercholesterolemic rats.
Identification of Senkyunolide I as a novel modulator of hepatic steatosis and PPARα signaling in zebrafish and hamster models.
Inhalation exposure to airborne PM(2.5) attenuates hepatic metabolic pathways through S-nitrosylation of the primary ER stress sensor.
1-Bromopropane induces mitochondrial damage and lipid metabolism imbalance in respiratory epithelial cells through the PGC-1α/PPARα pathway.
Natural molecule isoliquiritigenin mitigates MASH and liver fibrosis in mice by promoting autophagy through the PI3K/Akt signaling pathway.
Boeravinone C ameliorates lipid accumulation and inflammation in diabetic kidney disease by activating PPARα signaling.
Axin formation inhibitor 1 aggravates hepatic ischemia‒reperfusion injury by promoting the ubiquitination and degradation of PPARβ.
Qihuang Zhuyu formula modulates mitochondrial function to inhibit platelet activation via endocannabinoid signaling mediated by the SIRT1/PPARα pathway.
Neoagarotetraose Attenuates Hyperglycemia Through Inflammation Amelioration and Glucose Metabolism Improvement.
High-throughput screening reveals paeoniflorin's efficacy against Apoc2-deficient hypertriglyceridemia via HNF4A/PPARA/LDLR.
Mdivi-1 promotes lipid droplets-mitochondria contact and ameliorates cardiac lipotoxicity in high-fat diet-fed mice.
Gut-liver axis mechanisms of Hippophae rhamnoides L. in non-alcoholic fatty liver disease prevention.
Revealing the Causal Relationship of the Gut-Liver Axis in MASH: A Study Based on Mendelian Randomization and Multi-Omics.
Smilax china L. Extract Alleviates Metabolic-Associated Fatty Liver Disease by Regulating Gut Microbiota and Bile Acid Metabolism.
The protective effect of probiotic therapy on gut microbiota and the activation of ω-oxidation after ovarian cancer surgery.
An Enhanced Cancer Immunogenic Cell Death Strategy: Fibrate-Oxaliplatin(IV) Conjugates with Modulating Tumor Immune Microenvironment.
B-Cell Receptor-Associated Protein 31 Deficiency Aggravates Ethanol-Induced Liver Steatosis and Liver Injury via Attenuating Fatty Acid Oxidation and Glycogen Synthesis.
Limitations in PPARα-dependent mitochondrial programming restrain the differentiation of human stem cell-derived β cells.
Exposure to submicroplastics promotes the progression of nonalcoholic fatty liver disease in ApoE-deficient mice.
Andrographolide Attenuates Myocardial Ischemia-Reperfusion Injury in Mice by Up-Regulating PPAR-α.
EGCG and Taurine Synergistically Ameliorate Lipid Metabolism Disorder by Modulating Gut Microbiota and PPARα/FAS Signaling Pathway.
Fenofibrate Differently Affects the Heart's Morphology and Metabolism in Young and Old Rats.
Oxybaphus himalaicus alleviates diabetic kidney disease by suppressing the lipid metabolism and inflammation via PPARα signaling.
Distinct Hepatic Metabolic Reprogramming in Acute and Chronic Sleep Deprivation and the Protective Effects of the Chalcone Analogue TAK.
Anthocyanins prevent the development and progression of urethane-induced lung cancer by regulating energy metabolism in mice.
Salidroside may target PPARα to exert preventive and therapeutic activities on NASH.
Palmitoylation of PKCδ by ZDHHC5 in hypothalamic microglia presents as a therapeutic target for fatty liver disease.
Inactivation of mitochondrial MUL1 E3 ubiquitin ligase deregulates mitophagy and prevents diet-induced obesity in mice.
Ethanol Extract of Propolis Attenuates Liver Lipid Metabolism Disorder in High-Fat Diet-Fed SAMP8 Mice.
Counteracting TGM2 by a Fibroin peptide ameliorated Adriamycin-induced nephropathy via regulation of lipid metabolism through PANX1-PPAR α/PANK1 pathway.
Beneficial effects of Dendrobium officinale National Herbal Drink on metabolic immune crosstalk via regulate SCFAs-Th17/Treg.
Exposure to Succinate Leads to Steatosis in Non-Obese Non-Alcoholic Fatty Liver Disease by Inhibiting AMPK/PPARα/FGF21-Dependent Fatty Acid Oxidation.
FABP4 deficiency ameliorates alcoholic steatohepatitis in mice via inhibition of p53 signaling pathway.
Epicatechin and β-glucan from whole highland barley grain ameliorates hyperlipidemia associated with attenuating intestinal barrier dysfunction and modulating gut microbiota in high-fat-diet-fed mice.
Mitochondria-related HSDL2 is a potential biomarker in temporal lobe epilepsy by modulating astrocytic lipid metabolism.
SMYD2 Promotes Calcium Oxalate-Induced Glycolysis in Renal Tubular Epithelial Cells via PTEN Methylation.
Activation of NOD1 on tumor-associated macrophages augments CD8(+) T cell-mediated antitumor immunity in hepatocellular carcinoma.
The transcription factor PPARA mediates SIRT1 regulation of NCOR1 to protect damaged heart cells.
IGFBP1 promotes the proliferation and migration of lung adenocarcinoma cells through the PPARα pathway.
Non-Sugar Sweetener Rubusoside Alleviates Lipid Metabolism Disorder In Vivo and In Vitro by Targeting PPARγ/α, Lgals3, and Mknk2.
Resistance Exercise Improves Glycolipid Metabolism and Mitochondrial Biogenesis in Skeletal Muscle of T2DM Mice via miR-30d-5p/SIRT1/PGC-1α Axis.
Gemfibrozil-Platinum(IV) Precursors for New Enhanced-Starvation and Chemotherapy In Vitro and In Vivo.
Probiotic-fermented tomato with hepatic lipid metabolism modulation effects: analysis of physicochemical properties, bioactivities, and potential bioactive compounds.
Effects of replacing fishmeal with different proportions of mixed protein source in the diet of largemouth bass (Micropterus salmoides).
f25, a novel synthetic quinoline derivative, inhibits tongue cancer cell invasion and survival by the PPAR pathway in vitro and vivo.
Mechanistic of AMPK/ACC2 regulating myoblast differentiation by fatty acid oxidation of goat.
Procyanidin B1 and Coumaric Acid from Highland Barley Alleviated High-Fat-Diet-Induced Hyperlipidemia by Regulating PPARα-Mediated Hepatic Lipid Metabolism and Gut Microbiota in Diabetic C57BL/6J Mice.
PPARα phosphorylation regulates colorectal tumor immune escape.
Luteolin alleviates cadmium-induced metabolism disorder through antioxidant and anti-inflammatory mechanisms in chicken kidney.
Chrysanthemum morifolium attenuates metabolic and alcohol-associated liver disease via gut microbiota and PPARα/γ activation.
Podophyllotoxin via SIRT1/PPAR /NF-κB axis induced cardiac injury in rats based on the toxicological evidence chain (TEC) concept.
Intermittent hypoxia exacerbates metabolic dysfunction-associated fatty liver disease by aggravating hepatic copper deficiency-induced ferroptosis.
Liver Lipidomics Analysis Revealed the Protective mechanism of Zuogui Jiangtang Qinggan Formula in type 2 diabetes mellitus with non-alcoholic fatty liver disease.
Hydrangea paniculata coumarins alleviate adriamycin-induced renal lipotoxicity through activating AMPK and inhibiting C/EBPβ.
Metabolomics analyses reveal the liver-protective mechanism of Wang's metabolic formula on metabolic-associated fatty liver disease.
A mixed animal and plant protein source replacing fishmeal affects bile acid metabolism and apoptosis in largemouth bass (Micropterus salmoides).
Muscular lipidomics and transcriptomics reveal the effects of bile acids on lipid metabolism in high-fat diet-fed grouper.
Efficacy of DHA-enriched phosphatidylserine and its underlying mechanism in alleviating polystyrene nanoplastics-induced hepatotoxicity in mice.
Therapeutic potential of palmitoleic acid in non-alcoholic fatty liver disease: Targeting ferroptosis and lipid metabolism disorders.
High-iron diet damages brown adipose tissue mitochondria and exacerbates metabolic hazards of a high-fat diet.
mTORC2 knockdown mediates lipid metabolism to alleviate hyperlipidemic pancreatitis through PPARα.
PFDA promotes cancer metastasis through macrophage M2 polarization mediated by Wnt/β-catenin signaling.
Permethrin exposure impacts zebrafish lipid metabolism via the KRAS-PPAR-GLUT signaling pathway, which is mediated by oxidative stress.
CD9 Counteracts Liver Steatosis and Mediates GCGR Agonist Hepatic Effects.
Berberine alleviates high-energy and low-protein diet-induced fatty liver hemorrhagic syndrome in laying hens: insights from microbiome and metabolomics.
Polypeptide N-acetylgalactosaminyltransferase-15 regulates adipogenesis in human SGBS cells.
Diosgenin attenuates nonalcoholic hepatic steatosis through the hepatic SIRT1/PGC-1α pathway.
Sodium butyrate alleviates free fatty acid-induced steatosis in primary chicken hepatocytes via the AMPK/PPARα pathway.
Klotho exerts protection in chronic kidney disease associated with regulating inflammatory response and lipid metabolism.
Targeting hepatic ceruloplasmin mitigates nonalcoholic steatohepatitis by modulating bile acid metabolism.
The natural compounds, Magnolol or Honokiol, promote adipose tissue browning and resist obesity through modulating PPARα/γ activity.
Corn peptides attenuate non-alcoholic fatty liver disease via PINK1/Parkin-mediated mitochondrial autophagy.
Herpetrione, a New Type of PPARα Ligand as a Therapeutic Strategy Against Nonalcoholic Steatohepatitis.
Replacement of Dietary Fishmeal with Clostridium autoethanogenum Protein on Lipidomics and Lipid Metabolism in Muscle of Pearl Gentian Grouper.
Deep Sea Water Inhibited Pancreatic β-Cell Apoptosis and Regulated Glucose Homeostasis by Affecting Lipid Metabolism in Db/Db Mice.
A novel risk model of three SUMOylation genes based on RNA expression for potential prognosis and treatment sensitivity prediction in kidney cancer.
Puerarin inhibits inflammation and lipid accumulation in alcoholic liver disease through regulating MMP8.
Xianlinglianxiafang Inhibited the growth and metastasis of triple-negative breast cancer via activating PPARγ/AMPK signaling pathway.
γ-glutamylcysteine alleviates insulin resistance and hepatic steatosis by regulating adenylate cyclase and IGF-1R/IRS1/PI3K/Akt signaling pathways.
HMGCS2 serves as a potential biomarker for inhibition of renal clear cell carcinoma growth.
Metabolic characteristics of voriconazole - Induced liver injury in rats.
Bo's abdominal acupuncture improves disordered metabolism in obese type 2 diabetic rats through regulating fibroblast growth factor 21 and its related adipokines.
Investigation of the potential ameliorative effects of DHA-enriched phosphatidylserine on bisphenol A-induced murine nephrotoxicity.
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
RAE1 promotes nitrosamine-induced malignant transformation of human esophageal epithelial cells through PPARα-mediated lipid metabolism.
Green Pea (Pisum sativum L.) Hull Polyphenol Extract Alleviates NAFLD through VB6/TLR4/NF-κB and PPAR Pathways.
Butyrate mitigates metabolic dysfunctions via the ERα-AMPK pathway in muscle in OVX mice with diet-induced obesity.
Insoluble Dietary Fiber from Soybean Residue (Okara) Exerts Anti-Obesity Effects by Promoting Hepatic Mitochondrial Fatty Acid Oxidation.
Local glucose elevation activates pyroptosis via NLRP3 inflammasome in ovarian granulosa cells of overweight patients.
Supplemental Clostridium butyricum modulates lipid metabolism by reshaping the gut microbiota composition and bile acid profile in IUGR suckling piglets.
Hepatocyte-derived extracellular vesicles miR-122-5p promotes hepatic ischemia reperfusion injury by regulating Kupffer cell polarization.
Modulation of the Microbiome-Fat-Liver Axis by Lactic Acid Bacteria: A Potential Alleviated Role in High-Fat-Diet-Induced Obese Mice.
PPARα agonist fenofibrate prevents postoperative cognitive dysfunction by enhancing fatty acid oxidation in mice.
STAT6 promoting oxalate crystal deposition-induced renal fibrosis by mediating macrophage-to-myofibroblast transition via inhibiting fatty acid oxidation.
Nobiletin Ameliorates Hepatic Lipid Deposition, Oxidative Stress, and Inflammation by Mechanisms That Involve the Nrf2/NF-κB Axis in Nonalcoholic Fatty Liver Disease.
Therapeutic Potential of Ginsenoside Rb1-PLGA Nanoparticles for Heart Failure Treatment via the ROS/PPARα/PGC1α Pathway.
Theabrownin of raw and ripened pu-erh tea varies in the alleviation of HFD-induced obesity via the regulation of gut microbiota.
Melatonin alleviates cadmium-induced nonalcoholic fatty liver disease in ducks by alleviating autophagic flow arrest via PPAR-α and reducing oxidative stress.
Diosgenin attenuates nonalcoholic hepatic steatosis through the hepatic FXR-SHP-SREBP1C/PPARα/CD36 pathway.
Derivation and comprehensive analysis of ageing-related genes in intervertebral disc degeneration for prediction and immunology.
Anti-inflammatory effect of Irisin on LPS-stimulated macrophages through inhibition of MAPK pathway.
Berberrubine, a Main Metabolite of Berberine, Alleviates Non-Alcoholic Fatty Liver Disease via Modulating Glucose and Lipid Metabolism and Restoring Gut Microbiota.
Dynein light chain LC8 alleviates nonalcoholic steatohepatitis by inhibiting NF-κB signaling and reducing oxidative stress.
Ban-xia-xie-xin-tang ameliorates hepatic steatosis by regulating Cidea and Cidec expression in HFD-fed mice.
RUNX2 recruits the NuRD(MTA1)/CRL4B complex to promote breast cancer progression and bone metastasis.
Recombinant Humanized IgG1 Antibody Promotes Reverse Cholesterol Transport through FcRn-ERK1/2-PPARα Pathway in Hepatocytes.
Probiotic-fermented rice buckwheat alleviates high-fat diet-induced hyperlipidemia in mice by suppressing lipid accumulation and modulating gut microbiota.
Loss of mitochondrial ATPase ATAD3A contributes to nonalcoholic fatty liver disease through accumulation of lipids and damaged mitochondria.
Bifidobacterium animalis subsp. lactis A6 Enhances Fatty Acid β-Oxidation of Adipose Tissue to Ameliorate the Development of Obesity in Mice.
Farnesoid X receptor regulates PI(3)K/AKT/mTOR signaling pathway, lipid metabolism, and immune response in hybrid grouper.
Pharmacological inhibition of Lin28 promotes ketogenesis and restores lipid homeostasis in models of non-alcoholic fatty liver disease.
Effects of heat-processed Gynostemma pentaphyllum on high-fat diet-fed mice of obesity and functional analysis on network pharmacology and molecular docking strategy.
Pterostilbene and Its Derivative 3'-Hydroxypterostilbene Ameliorated Nonalcoholic Fatty Liver Disease Through Synergistic Modulation of the Gut Microbiota and SIRT1/AMPK Signaling Pathway.
Hepatic COX-2 expression protects mice from an alcohol-high fat diet-induced metabolic disorder by involving protein acetylation related energy metabolism.
Effects of dibutyl phthalate on lipid metabolism in liver and hepatocytes based on PPARα/SREBP-1c/FAS/GPAT/AMPK signal pathway.
Effect of fenofibrate on proliferation of SMMC-7721 cells via regulating cell cycle.
Chrysanthemi Flos extract alleviated acetaminophen-induced rat liver injury via inhibiting oxidative stress and apoptosis based on network pharmacology analysis.
Li X, Wu Z, Yao C, Zhang P, Zhu Q, Nan S, Xiao L, Qi S
Research (Washington, D.C.) 2026;9:1163
Research (Washington, D.C.) 2026;9:1163
The Bioinformatics Analysis of Publicly Available Datasets and Validation in a Mouse Model of Myocardial Infarction Through Coronary Artery Ligation.
Sun H, Liu F, Sun M, Wang W, Wang J, Wang H, Jiang X, Ding X, Wang C, Zhong L
Journal of inflammation research 2026;19:558274
Journal of inflammation research 2026;19:558274
Qingyi Decoction Alleviates Alcoholic Pancreatitis by Improving Glycerolipid Homeostasis via the AMPK/SREBP-1c/PPARα Pathway.
Zhang J, Qi Y, Jiang Y, Wei T, Ma S, Fu K, Shen J, Chen C, Li X, Wang G, Leng A, Shang D, Qu J
Journal of inflammation research 2026;19:537259
Journal of inflammation research 2026;19:537259
PPAR-gamma regulates PFAS-mediated proinflammatory cytokines in lung epithelial cells.
Shaikh SB, Faizan MI, Islam KU, Rehan VK, Rahman I
Frontiers in pharmacology 2026;17:1779345
Frontiers in pharmacology 2026;17:1779345
Physiological safety and Multi-Tissue metabolic adaptation under a novel intermittent prolonged fasting regimen.
Sui X, Guo Y, Wu F, Wang H, Yang C, Zhang H, Jiang S, Dai Z
Life sciences in space research 2026 May;50:113-123
Life sciences in space research 2026 May;50:113-123
Polydatin Targets ACADVL to Combat Obesity by Promoting Adipocyte Browning and Activating Fatty Acid Oxidation.
He W, Gu Y, Zhang F, Xiang Y, Fang Y, Cai J, Li W, Wang Z, Qin G, Li K, Gu X, Lin X, Ma L, Hou Y, Xiao X, Luo T
Phytotherapy research : PTR 2026 May;40(5):2417-2436
Phytotherapy research : PTR 2026 May;40(5):2417-2436
Multi-omics reveals that 4'-O-β-D-glucosyl-5-O-methylvisamminol ameliorates acute liver injury by modulating the miR-30e-3p/Tfrc axis and a multi-dimensional network of ferroptosis, inflammation, metabolism, and gut microbiota.
Zhang T, Zou R, Chen Z, Li Y, Sun X, Sun X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158022
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158022
HMGCS2-dependent β-OHB/H3K9bhb ameliorates synaptic plasticity and cognition in Alzheimer's disease.
Yu H, Wang F, Yuan JQ, Chen J, Zhang KY, Jia D, Gong J, Mao Y, Bi S, Zhang YQ, Lan ZC, Yu HY, Chai GS
Experimental & molecular medicine 2026 Mar;58(3):813-831
Experimental & molecular medicine 2026 Mar;58(3):813-831
USP2 promotes metabolic dysfunction-associated steatotic liver disease progression via stabilization of PPARγ.
Luo H, Zhu C, Wang Y, Dai Y, Hao P, Cai H, Bai W, Zhang Z, Wan J, Zhang Y, Sun Y, Zhang Z, Wu Y, Zhai Y, Wu W, Lei H, Xu H, He M, Wu Y
Cell death and differentiation 2026 Mar;33(3):525-538
Cell death and differentiation 2026 Mar;33(3):525-538
Salvianolic Acid B Alleviates MAFLD by Targeting PPAR-α: Mechanistic Insights From Network Pharmacology and Lipidomics.
Huang F, Qiu C, Wang D, Ni Y, Fu Z, Fu L, Liang C, Huang S, Deng Z
Food science & nutrition 2026 Mar;14(3):e71646
Food science & nutrition 2026 Mar;14(3):e71646
Integrated Proteomics and Metabolomics Reveal the Direct Hepatic Protection of Propionate Against Alcoholic Liver Disease via the RGN-PPARα Pathway.
Wang H, Liu H, Wang M, Chi T, Liu F, Qu X, Mu Y, Xu Q, Wang Q
Nutrients 2026 Mar 9;18(5)
Nutrients 2026 Mar 9;18(5)
β-catenin mutation reprograms ketone body metabolism to drive hepatocellular carcinoma metastasis and resistance to ketogenic therapy via transcriptional activation of OXCT1.
Li H, Qian L, Ji Y, Geng Y, Lu Y, Zhang L, Xu Y, Zong W, Jiang X, Zhou X, Wen J, Liu D, Wang Y, Li Y, Li B, Ma H, Yu D
Cell death & disease 2026 Mar 9;17(1)
Cell death & disease 2026 Mar 9;17(1)
Unraveling the potential mechanisms of Bupleuri Radix-Scutellariae Radix herb pair on non-alcoholic fatty liver disease by integrated transcriptomics, metabolomics and network pharmacology.
Zhong Y, Zhu X, Li J, Du H, Sheng L, Huang N, Liu R, Sun R
Journal of ethnopharmacology 2026 Mar 1;358:120963
Journal of ethnopharmacology 2026 Mar 1;358:120963
Exercise attenuates polycystic ovary syndrome development via improved mitochondrial proteostasis.
Shin C, Chen LW, Hossain MN, Li X, Islam S, Kou Z, Cui Q, de Avila JM, Zhu MJ, Du M
American journal of physiology. Endocrinology and metabolism 2026 Mar 1;330(3):E390-E400
American journal of physiology. Endocrinology and metabolism 2026 Mar 1;330(3):E390-E400
Hexafluoropropylene oxide trimer acid (HFPO-TA) exposure predisposes to MASLD through reprogramming hepatic epigenome and transcriptome.
Yu J, Guo M, Zhou Q, Xue L, Wang W, Wu X, Qin Y, Gu W, Du G
Ecotoxicology and environmental safety 2026 Mar 1;312:119940
Ecotoxicology and environmental safety 2026 Mar 1;312:119940
Single-nucleus RNA Sequencing and multi-omics reveal Uncaria-derived indole alkaloids induce hepatocyte injury by mediating CAR/PPARα axis.
Yang B, Sun X, Zhang X, Wang S, Wang Y, Wang Y, Yang S, Shu L, Li Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158162
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158162
Ferulic acid improves growth performance and lipid metabolism and bile acid level partially by activating the PPAR and CYP7A1 pathways in broilers.
Long F, Lou Z, Qi J, Li W, Liang Y, Yu D, Zhuang S, Han Y, Chen Q, Zhong X
Journal of the science of food and agriculture 2026 Jun;106(8):4600-4612
Journal of the science of food and agriculture 2026 Jun;106(8):4600-4612
Xiaoyaosan ameliorates stress-induced MASH via modulating IL-1R1/RXRα-mediated liver-brain crosstalk.
Zhang Y, Luo X, Wu S, Qin Y, Xue Q, Ye W, Hou S, Liu B, Huang D, Yuan W, Ao H, Tong G, Liao M
Journal of ethnopharmacology 2026 Jun 28;365:121585
Journal of ethnopharmacology 2026 Jun 28;365:121585
Buyanghuanwu decoction (BYHWD) attenuates hepatic fibrosis in CCl(4)-induced mice by regulating bile acid metabolism through activating PPARα.
Wei X, Wang Z, Wang J, Yang H, Zhou F, Qi S, Zhang J, Shi X, Xu G, Li Z, Xu Y, Zhang D
Journal of ethnopharmacology 2026 Jun 12;364:121476
Journal of ethnopharmacology 2026 Jun 12;364:121476
A foam cell-targeted lipophagy restoration strategy stabilizes vulnerable atherosclerotic plaques.
Li H, Qin Y, Zhang J, Guo X, Hu X, Sun D, Zhao Y, Bernardini S, Xu D, Jiang P, Zhang H, Luo Y
Bioactive materials 2026 Jul;61:879-899
Bioactive materials 2026 Jul;61:879-899
Caveolin-1 deficiency exacerbates liver fibrosis by driving lipid metabolic reprogramming in hepatic stellate cells via DRP1-mediated mitochondrial fission.
Wang Y, Wang X, Lin J, Zhang W, Sun Y, Geng Q, Chen S, Zhang C, Jin L, Hu C
Free radical biology & medicine 2026 Jul;250:203-215
Free radical biology & medicine 2026 Jul;250:203-215
Monascus pilosus SWM-008-Fermented Red Mold Rice and Its Monascinol Ameliorate Non-Alcoholic Fatty Liver Disease via Activation of the AMPK-ATGL Pathway and Enrichment of Butyrate-Producing Bacteria.
Hsieh CP, Hsu YW, Pan TM, Lee CL
Molecular nutrition & food research 2026 Jan;70(1):e70342
Molecular nutrition & food research 2026 Jan;70(1):e70342
Endothelial CEPT1 Promotes Angiogenesis Through PPARα and VEGF-A Signaling.
Khan TJ, Meade R, Elizondo-Benedetto S, Belaygorod L, Saffaf O, Rusconi B, Hsu FF, Adak S, Arif B, Zaghloul MS, Li T, Zhang B, Semenkovich CF, Zayed MA
Arteriosclerosis, thrombosis, and vascular biology 2026 Jan;46(1):195-209
Arteriosclerosis, thrombosis, and vascular biology 2026 Jan;46(1):195-209
Combination of GLP-1 receptor agonist and Akkermansia muciniphila Akk11 reduces adiposity and ameliorates MASLD in T2D mice.
Gao K, Yin Z, Zhang C, Dong Z, Wang R, Chen Q, Liu X, Jiang C, Wang Y, Guo B, Zhou Z, Jia Z, Sun H, Feng Y
Cell & bioscience 2026 Jan 12;16(1):18
Cell & bioscience 2026 Jan 12;16(1):18
Environmentally relevant lanthanum chloride exposure induces hepatic steatosis in zebrafish larvae via PPARα-dependent ApoB suppression.
Li K, Zhao X, Xie Z, Wu Q, Jia W, Zhou X, Gao X, Zeng P, Li J, Niu Q, Qi Z, Cui M, Song W
Communications biology 2026 Feb 9;9(1)
Communications biology 2026 Feb 9;9(1)
Loss of HuD Sensitizes Neuroblastoma Cells to Palmitate-Driven Stress-Induced Premature Senescence via PPARα Downregulation and FAO Impairment.
Ryu S, Seo J, Sim YE, Jung SH, Zhang W, Jeong SM, Lee EK
Cells 2026 Feb 7;15(4)
Cells 2026 Feb 7;15(4)
Capsaicin Improves Lipid Metabolism Disorders Caused by LPS-Induced Immune Stress in Weaned Piglets.
Zhao J, Liu W, Zhang X, Xie Z, Liu S, Zhou W, Zhang L
Veterinary sciences 2026 Feb 5;13(2)
Veterinary sciences 2026 Feb 5;13(2)
Bidens biternata (Lour.) Merr. & Sherff improves liver lipid metabolism disorders in type 2 diabetic mice by activating mitophagy.
Li Y, Kang S, Wang Q, Zeng C, Dong G
Journal of ethnopharmacology 2026 Feb 28;357:120877
Journal of ethnopharmacology 2026 Feb 28;357:120877
Environmental PET-microplastic exposure and risk of non-alcoholic fatty liver disease: An integrated computational toxicology and multi-omics study.
Yuan Y, Lin C, Zhang T, Song C, Sun Y, Tang H
Naunyn-Schmiedeberg's archives of pharmacology 2026 Feb 24;
Naunyn-Schmiedeberg's archives of pharmacology 2026 Feb 24;
Targeted inhibition of M2 macrophages polarization via a PDC attenuates chronic pancreatitis through the PPARα pathway.
Kong X, Tao X, Xiang H, Guo F, Wu Y, Lv J, Zhao X, Zhang X, Zhai Z, Dong D
iScience 2026 Feb 20;29(2):114839
iScience 2026 Feb 20;29(2):114839
Metagenomics and Machine Learning Identify TMA-Producing Serratia Induced by High-Fat/Choline Diet: A Novel Obesity Target for TMA.
Wang Z, Wei J, Huang Z, Liu X, Li S, Fang Z, Hu L, Li R, Tao L, Li C, Chen H
Nutrients 2026 Feb 17;18(4)
Nutrients 2026 Feb 17;18(4)
Annexin A1 exacerbates islet stellate cell activation by regulating triglyceride catabolism via the PPARα/ACOX1/CYP4a pathway.
Li Q, Zhang Y, Yu T, Shi L, Qiu Q, Wang B, Sang Y, Li R, Lv Q, Wang J, Liu X, Geng H, Jones PM, Liang J, Xu W
Islets 2026 Dec 31;18(1):2633793
Islets 2026 Dec 31;18(1):2633793
MCL1 promotes porcine epidemic diarrhea virus replication by modulating arachidonic acid metabolic pathway.
Shang H, Yang S, Sun M, Zhao Y, Guo R, Wang W, Qian B, Li Y, Hu M, Bian X, Cao Q, Li C, Fan B, Li B
PLoS pathogens 2026 Apr;22(4):e1014170
PLoS pathogens 2026 Apr;22(4):e1014170
Pedunculoside ameliorates metabolic dysfunction-associated steatotic liver disease by targeting HNRNPA1 and modulating PPARα signaling pathway to enhance Mitochondrial Fatty Acid β-Oxidation.
Zhou Y, Chi J, Xu X, Zhu R, Wang T, Zhang T, Hong D, Fu H, Zhou X, Zhao K
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157910
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157910
Structural characterization, physicochemical properties and hypolipidemic activity of hemp (Cannabis sativa L.) protein hydrolysates prepared via enzyme-microbial synergy.
Zhao Y, Liu M, Zang X, Li J, Zhang G, Du P, Zhang T, Sun X, Li C, Liu L
Food research international (Ottawa, Ont.) 2026 Apr 1;229:118355
Food research international (Ottawa, Ont.) 2026 Apr 1;229:118355
METTL3/miR-192-5p/SCD1 Axis Regulates Lipid Metabolism to Affect T Cell Differentiation in Asthma.
Chen Z, Yan D, Guo S, Song Y, Zhang X, Gu W, Dong H, Huang L
Mediators of inflammation 2025;2025:4955849
Mediators of inflammation 2025;2025:4955849
A new investigation of nonalcoholic fatty liver disease: Effects of hypoxia on mitochondrial function and lipid droplet autophagy.
Tian M, Zhang Y, Liu Z, Zhao N, Huang D, Hou J, Sun L, Jiang Y, Zhang G, Ma Y
PloS one 2025;20(9):e0331305
PloS one 2025;20(9):e0331305
Aerobic exercise improved liver steatosis by modulating miR-34a-mediated PPARα/SIRT1-AMPK signaling pathway.
Wu B, Zhang Z, Xu C, Zhao J
PloS one 2025;20(11):e0333872
PloS one 2025;20(11):e0333872
Hyodeoxycholic Acid Ameliorates Metabolic Syndrome Through Pathways of Primary Bile Acid Synthesis and Fatty Acid Degradation: Insights From a Rat Model.
Chen M, Huang K, Luo W, Zhang F, Gan H, Yang Z
Drug design, development and therapy 2025;19:3611-3630
Drug design, development and therapy 2025;19:3611-3630
PEDF Overexpression Ameliorates Cardiac Lipotoxicity in Diabetic Cardiomyopathy via Regulation of Energy Metabolism.
Mao T, Wang Y
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:217-231
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:217-231
Study on the effect and mechanism of Ershiyiwei Lvronghao concentrated Pills in the treatment of nonalcoholic fatty liver disease.
Wu Y, Chen B, Long J, Pai M, Xiao Z, Huang Q, Li K, Ye B
Frontiers in pharmacology 2025;16:1725610
Frontiers in pharmacology 2025;16:1725610
Nobiletin protected against hypertrophic cardiomyopathy via targeting PPARα.
Zhou K, Chen C, Cai H, Lian Z, Wang L, Li Q, Wang C, Wu X, Wang P
Frontiers in pharmacology 2025;16:1628625
Frontiers in pharmacology 2025;16:1628625
Jianpi-Huayu-Jiedu formula improves metabolic dysfunction-associated steatohepatitis through ameliorateing hepatic oxidative stress and lipid accumulation in vivo and in vitro.
Wu X, Chen T, Zhang Z, Wang D, Zhou K, Li J, Xu L, Meng C, Pan H, Huang J, Gao Y, Li S
Frontiers in pharmacology 2025;16:1612726
Frontiers in pharmacology 2025;16:1612726
α-Mangostin prevents diabetic cardiomyopathy by inhibiting oxidative damage and lipotoxicity through the AKT-FOXO1-CD36 pathway.
Bai X, Zhang Z, Zhang M, Xu J, Dong K, Du Q, Chen L, Ma P, Yang J
Frontiers in pharmacology 2025;16:1566311
Frontiers in pharmacology 2025;16:1566311
Short-term exposure to a high-humidity environment triggers intestinal inflammation via AQP3.
Song J, Huang X, Luo Y, Li M, Ouyang Y, Liu W, Pan H, Luo H
Frontiers in immunology 2025;16:1563602
Frontiers in immunology 2025;16:1563602
Gallic acid mitigates high-fat and high-carbohydrate diet-induced steatohepatitis by modulating the IRF6/PPARγ signaling pathway.
Qiu J, Fu L, Xue Y, Yang Y, Qiao F, Zhu W, Gao Y, Fang M, Liu Y, Gao Z, Guan Y, Gao Y, Zhang X, Shang Z
Frontiers in pharmacology 2025;16:1563561
Frontiers in pharmacology 2025;16:1563561
HPV11 targeting PPARA regulates the autophagy to inhibit the occurrence and development of nasal inverted papilloma.
Zhu G, Zheng L, He W, Chen X, Huang S, Jin M, Zhang Y
Frontiers in oncology 2025;15:1743808
Frontiers in oncology 2025;15:1743808
Cigarette smoke-induced PPAR signaling dysregulation accelerates Alzheimer's disease pathogenesis and cognitive decline in 5xFAD mice.
Xie Y, Wang H, Zhang Y, Lin B, Chen Y, Li K, Tang H, Sun Q
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Sep;203:115596
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Sep;203:115596
Mechanisms of metabolic-associated fatty liver disease induced by 48-week PCB138 exposure and theabrownin intervention.
Han J, Liu C, Chen Z, Ruan F, Xue F, Ye L, Yu Y, Zuo Z, He C
Environment international 2025 Sep;203:109780
Environment international 2025 Sep;203:109780
Calycosin alleviates myocardial fibrosis after myocardial infarction by restoring fatty acid metabolism homeostasis through inhibiting FAP.
Sun SN, Liu X, Chen XL, Liang SL, Li J, Liao HL, Fang HC, Ni SH, Li Y, Lu L, Yang ZQ, Wu H, Wang LJ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157045
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157045
Betaine decreases hepatic lipid deposition through DNA 5 mC and RNA m(6)A methylation-mediated regulation of fatty acid metabolic genes expression in laying hens.
Yang Y, Jin X, Lu D, Wu Y, Meng F, Zhang M, Wang J, Cui X, Li T, Wang S, Luo X, Hu Y
Poultry science 2025 Sep;104(9):105496
Poultry science 2025 Sep;104(9):105496
Long-term low-dose exposure to 9-chlorophenanthrene induces liver lipid accumulation via disrupting circadian rhythm.
Liu M, Lu Y, Zhou H, Chen Y, Li Y, Zhang T
Journal of hazardous materials 2025 Sep 5;495:139145
Journal of hazardous materials 2025 Sep 5;495:139145
Mechanism of Bao Gan Ning decoction in attenuating hepatic fibrosis via modulation of the gut microbiome and PPAR/CYP7A1-mediated bile acid metabolism.
Li M, Deng K, Zheng R, Li Y, Xiang L, Cheng J, Wang Y, Kuang S, Huang S, Lv Z
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120488
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120488
Artesunate promotes intestinal epithelial barrier repair by facilitating HMGCS2-dependent ketogenesis in experimental ulcerative colitis model mice.
Wang G, Han L, Sun H, Sun T, Wu B, Cheng X, Yang S, Zhou D
International immunopharmacology 2025 Sep 23;162:115152
International immunopharmacology 2025 Sep 23;162:115152
Breviscapine regulates lipid metabolism of microglia via the ADORA1/PPARα/ACOX1 pathway to promote spinal cord injury recovery.
Shi F, Wang S, Wu C, Wen H, Zhou W
International immunopharmacology 2025 Sep 23;162:115145
International immunopharmacology 2025 Sep 23;162:115145
Liquid-liquid phase separation of GPS2-LATS1 promotes colorectal cancer progression by reprogramming lipid metabolism.
Ren Y, Chen J, Zhan X, Sheng S, Zhong Y, Gu M, Liu X, Zhang L, Bao L, Si Y, Liu Y
Oncogene 2025 Oct;44(39):3741-3754
Oncogene 2025 Oct;44(39):3741-3754
A distal enhancer of Pparα regulates thermogenesis and mitochondrial function in brown fat.
Jiang T, Su D, Ke J, Dai X, Wang M, Wang Y, Zhan S, Zhong T, Guo J, Li L, Zhang H, Wang L
PLoS genetics 2025 Oct;21(10):e1011915
PLoS genetics 2025 Oct;21(10):e1011915
ILF3 mediates lipid metabolism to promote pancreatic cancer development by regulating CPT1A-activated PPARa signaling pathway.
Zhan T, Chen M, Zhu Q, Liu M, Tan J, Chen X, Liu J, Han Z, Zou Y, Tian X, Huang X
Biochimica et biophysica acta. Molecular basis of disease 2025 Oct;1871(7):167919
Biochimica et biophysica acta. Molecular basis of disease 2025 Oct;1871(7):167919
Capsaicin Alleviates Autophagy-Lysosomal Dysfunction via PPARA-Mediated V-ATPase Subunit ATP6V0E1 Signaling in 3xTg-AD Mice.
Yu H, Chen J, Wang F, Jia D, Bi S, Mao Y, Zhang YQ, Gao TL, Yang L, Du JX, Zhou ZH, Zhu XC, Chai GS
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e02707
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e02707
Geniposide alleviates kidney fibrosis by targeting STAT3-HK2-mediated glycolysis.
Shi R, Liu MQ, Xiao JP, Zhu YK, Zhu JX, Zhao WM, Wang ZJ, Zhu YY, Li XL, Wang XR, Wang RF, Wang DG
BMC complementary medicine and therapies 2025 Oct 9;25(1):365
BMC complementary medicine and therapies 2025 Oct 9;25(1):365
Fenofibrate alleviates sepsis-associated acute kidney injury by enhancing renal fatty acid oxidation.
Zeng S, Wang J, Guan C, Yao Z, Zhang Y, Li Y, Zheng J, Wang H
BMC pharmacology & toxicology 2025 Oct 7;26(1):160
BMC pharmacology & toxicology 2025 Oct 7;26(1):160
CRLS1 influences liver metastasis in colon cancer by regulating lipid metabolism pathways.
Mu J, Li D, Shen H, Cao M, Zhang L, Wang C, Sun K, Wang H, He Y, Liu K, Huang X, Liang Q, Tang W, Kong X
Functional & integrative genomics 2025 Oct 21;25(1):216
Functional & integrative genomics 2025 Oct 21;25(1):216
One day of environment-induced heat stress causes injury to the murine kidney.
Roths M, Michael A, Schlader ZJ, Selsby JT
Experimental physiology 2025 Oct 2;
Experimental physiology 2025 Oct 2;
Harnessing TP73‑targeted nintedanib: A novel strategy to halt triple‑negative breast cancer via p53‑PPARα/PI3K‑Akt pathway suppression.
Zou X, Li S, Huang S, Niu R, Liu G, Wang Z
International journal of oncology 2025 Nov;67(5)
International journal of oncology 2025 Nov;67(5)
Macrophage-derived VISTA engages with LRIG1 and hinders gut epithelial repair in colitis.
Li M, Chen B, Wang Z, Guo R, Xiong N, Qian Y, Ye B, Lai Y, Wang S, Zhu Y, Yang N, Zhang H
Cellular & molecular immunology 2025 Nov;22(11):1379-1397
Cellular & molecular immunology 2025 Nov;22(11):1379-1397
Heterozygous Kctd5 knockout mice exhibit abnormal lipid metabolism.
Ling Q, Cao M, Zhang HA, Li X, Wang W, Wang Z, Sun Q, Liang Z, Huang W, Wang M, Li X, Lin C, Jiang X, Pan JA, Peng X
The international journal of biochemistry & cell biology 2025 Nov;188:106851
The international journal of biochemistry & cell biology 2025 Nov;188:106851
Quercetin ameliorates renal injury by promoting UCP1-mediated alleviation of lipid accumulation in diabetic kidney disease.
Yong W, Li Z, Xu W, Gao D, Sha B, Jin Y, Shen Y, Zhang Y, Pan Y, Liu J, Zhang F, Yu J, Jin L, Yang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157213
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157213
Dual targeting of lipogenesis and PUFAs homeostasis by compound kushen injection suppresses breast cancer bone metastasis.
Dai CL, Qiu ZY, Guo X, Yan S, Wang AQ, Zhao J, Le WQ, Jiang YX, Lin JY, Zhang LJ, Zhang WD, Luan X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157323
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157323
3-O-Acetyloleanolic acid alleviates autoimmune liver injury by targeting FXR.
Wang Y, Li Z, Xiao W, Yongbo X, Li Y, Li Z, Chen D, Feng Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157273
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157273
Eriocalyxin B induces ferroptosis through SIRT3 inhibition in triple-negative breast cancer.
Chen X, He J, Ge G, Ma S, Chen Z, Zhang L, Gao F, Zhang J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157257
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157257
Adiponectin Signaling Ameliorates Cognitive Dysfunction in Type 2 Diabetic Mice by Activating the Hippocampal AdipoR2-PPARα/CREB Pathway.
Gong H, Liu Y, Xia L, Niu B, Kong J, Wang B, Lin X, Lin L, Bi Y
Molecular neurobiology 2025 Nov 19;63(1):68
Molecular neurobiology 2025 Nov 19;63(1):68
Sodium hexametaphosphate mitigates calcium oxalate stone formation by modulating crystallization and maintaining PPARα signaling.
Xian JY, Peng L, Long J, Chen XW, Huang LH, Sun XY
Urolithiasis 2025 Nov 18;53(1):222
Urolithiasis 2025 Nov 18;53(1):222
Ferulic acid protects against stress-induced myocardial injury in mice.
Li S, He P, Liu J, Zang S, Luo J, Luo Y, Zhu S, Zang L
Toxicology and applied pharmacology 2025 May;498:117309
Toxicology and applied pharmacology 2025 May;498:117309
CILP1 interacting with YBX1 promotes hypertrophic scar formation by suppressing PPARs transcription.
Wang J, Du J, Song Y, Tan X, Wu J, Wang T, Shi Y, Xu X, Yu Z, Song B
Cell death & disease 2025 May 9;16(1):371
Cell death & disease 2025 May 9;16(1):371
Effects of extreme heat exposure on heatstroke and liver injury in mice: The role of PPARα.
Zhang G, Zhao L, Wang J, Wang K, Ji X, Hu R, Hou T, Zhang L, Li R, Sun Q, Zhang K, Liu C
Environmental health perspectives 2025 May 30;
Environmental health perspectives 2025 May 30;
The Splice Variant of the NCOR2 Gene BQ323636.1 Modulates ACSL4 Expression to Enhance Fatty Acid Metabolism and Support of Tumor Growth in Breast Cancer.
Tsoi H, You CP, Cheung KH, Tse YS, Khoo US
International journal of molecular sciences 2025 May 22;26(11)
International journal of molecular sciences 2025 May 22;26(11)
Isorhamnetin Attenuates Isoproterenol-Induced Myocardial Injury by Reducing ENO1 (Alpha-Enolase) in Cardiomyocytes.
Guo Z, Liu S, Hou X, Zhou X, Wang Y, Rong Y, Li X, Yang R, Ma K
Antioxidants (Basel, Switzerland) 2025 May 11;14(5)
Antioxidants (Basel, Switzerland) 2025 May 11;14(5)
Environmental Chemical-Induced Cardiometabolic Disorders: Combined Epidemiological and Experimental Evidence.
Jiang Q, Zhang D, Hu N, Ma Y, Jin H, Zhao Y, Zhang M, Li B, Huang Z, Yuan B, Zhu Y, Tian J, Miao X
Environmental science & technology 2025 Mar 4;59(8):3853-3868
Environmental science & technology 2025 Mar 4;59(8):3853-3868
Ginsenoside Rb(1) Ameliorates Heart Failure Ventricular Remodeling by Regulating the Twist1/PGC-1α/PPARα Signaling Pathway.
Zhou Z, Song Z, Guo X, Wang Q, Li M, Zhang M, Gong M
Pharmaceuticals (Basel, Switzerland) 2025 Mar 30;18(4)
Pharmaceuticals (Basel, Switzerland) 2025 Mar 30;18(4)
Structure characteristics of a novel pectic polysaccharide from Fructus Corni and its protective effect on alcoholic fatty liver.
Bai HX, Gao YX, Wang S, Ma GY, Zhao W, Li XQ, Wang YF, Nong QN, Wang YB, Tan J, Duan Q, Cao W
Carbohydrate polymers 2025 Mar 15;352:123153
Carbohydrate polymers 2025 Mar 15;352:123153
Lipid-lowering effects of bile Arisaema polysaccharides on high-fat diet-induced hyperlipidemia: An integrated analysis of metabolomics, lipidomics and microbiome.
Su FZ, Bai CX, Zhang WS, Liu M, Li B, Sun MH, He YJ, Zeng YN, Sun YP, Yang BY, Kuang HX, Wang QH
International journal of biological macromolecules 2025 Jun;311(Pt 4):143932
International journal of biological macromolecules 2025 Jun;311(Pt 4):143932
Cardioprotective effects of the jiming formula on myocardial metabolism in Mice with myocardial infarction via the AMPK/SIRT1/PGC-1α pathway.
Fan X, Wei X, Wang W, Chai W, Xiao J, Han J, Li F, Guo S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156727
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156727
Asprosin-FABP5 Interaction Modulates Mitochondrial Fatty Acid Oxidation through PPARα Contributing to MASLD Development.
Yu YY, Feng M, Chen Y, Jia HL, Zhang Q, Tong M, Li YX, Zhao Y, Liu XX, Cao SF, Wang ZK, Li HW, Liu X, Zhang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(21):e2415846
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(21):e2415846
OTUB1 enhances fatty acid oxidation in APAP-induced liver injury by mediating ACSL5 deubiquitination.
Guo S, Zhao Y, Wang Y, Lin M, Luan Q, Hu Z, Zhao X, Tian X, Wang Z, Yao J
Biochemical pharmacology 2025 Jul;237:116957
Biochemical pharmacology 2025 Jul;237:116957
Melatonin modulates mitochondrial function and inhibits atherosclerosis progression through NRF2 activation and OPA1 inhibition.
Lu C, Lin Q, Guo X, Luo T, Zhou H, Cai Z, Peng C, Yang G, Wang W
International immunopharmacology 2025 Jul 28;160:114960
International immunopharmacology 2025 Jul 28;160:114960
18β-glycyrrhetinic acid mitigates lipotoxicity-induced premature senescence of tubular epithelial cells by activating SIRT1-TFEB signaling.
Yang M, Qin W, Dai Q, Wu S, Chen Y, Xie W, Jiang X, Song H, Lei Y, Zheng T, Wang Y, Ouyang S, Guan M, Huang G, Liu X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156846
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156846
Exploring the Mechanism of Kidney Injury in Mice Induced by High-Fat Diet and Polystyrene Nanoplastics Co-Exposure Through the Kidney-Gut Axis.
Dong J, Yang F, Xu Y, Zhao Q, Li X, Liu T, Tang Y
Journal of agricultural and food chemistry 2025 Jul 16;73(28):17956-17966
Journal of agricultural and food chemistry 2025 Jul 16;73(28):17956-17966
Clinical and Experimental Insights into the Role of NETosis in IgA Nephropathy Pathogenesis.
Wang G, Dong Y, Qiao X, Jia C, Wang J, Chen G, Zheng K, Jiang C, Li X
Kidney diseases (Basel, Switzerland) 2025 Jan-Dec;11(1):450-468
Kidney diseases (Basel, Switzerland) 2025 Jan-Dec;11(1):450-468
Precise Carrier-Free Pt(IV)-Nanobombs for Apoptosis/Ferroptosis Synergistic Tumor Therapy: A New Effective Method to Obtain Good Chemotherapy and Low Toxicity.
Guo X, Liang XJ, Liu JL, Li ZH, You Z, Zhao D, Song Y, Li L, Song XQ
Journal of medicinal chemistry 2025 Jan 9;68(1):387-404
Journal of medicinal chemistry 2025 Jan 9;68(1):387-404
Network pharmacology, transcriptomics, and biological validation reveal a lipid secretion inhibitory and anti-inflammatory mechanism of tanreqing gel in the treatment of acne.
Ren X, Zhou N, Li D, Li L, Wang Y, Li L, Ma Y, Gao X, Zhao Y, Sun Y, Wang Y
Journal of ethnopharmacology 2025 Jan 31;340:119278
Journal of ethnopharmacology 2025 Jan 31;340:119278
Cassia mimosoides L. decoction improves non-alcoholic fatty liver disease by modulating the pregnane X receptor.
Zhao J, Zhong Y, Huang Q, Pan Z, Zheng Y, Miao D, Liu S, Chen P, Liu C, Liu M, Shen C
Journal of ethnopharmacology 2025 Jan 31;340:119199
Journal of ethnopharmacology 2025 Jan 31;340:119199
Hericium erinaceus Protein Alleviates High-Fat Diet-Induced Hepatic Lipid Accumulation and Oxidative Stress In Vivo.
Lu H, Yang S, Li W, Zheng B, Zeng S, Chen H
Foods (Basel, Switzerland) 2025 Jan 31;14(3)
Foods (Basel, Switzerland) 2025 Jan 31;14(3)
Targeting Catenibacterium mitsuokai with icariin modulates gut microbiota and improves hepatic lipid metabolism in intrauterine growth restriction.
Wei Y, Mao J, Tang W, Ma Y, Li J, Su S, Ni Z, Wu J, Liu D, Wang H
The ISME journal 2025 Jan 2;19(1)
The ISME journal 2025 Jan 2;19(1)
Integration of network pharmacology, UHPLC-Q exactive orbitrap HRMS technique and metabolomics to elucidate the active ingredients and mechanisms of compound danshen pills in treating hypercholesterolemic rats.
Li S, An J, Zhang T, Chen G, Zhang Z, Guo Z, Dai Z, Cheng X, Cheng S, Xiong X, Wang N, Jiang G, Xu B, Lei H
Journal of ethnopharmacology 2025 Jan 10;336:118759
Journal of ethnopharmacology 2025 Jan 10;336:118759
Identification of Senkyunolide I as a novel modulator of hepatic steatosis and PPARα signaling in zebrafish and hamster models.
Li Q, Sheng J, Baruscotti M, Liu Z, Wang Y, Zhao L
Journal of ethnopharmacology 2025 Jan 10;336:118743
Journal of ethnopharmacology 2025 Jan 10;336:118743
Inhalation exposure to airborne PM(2.5) attenuates hepatic metabolic pathways through S-nitrosylation of the primary ER stress sensor.
Yang Z, Chen Q, Wang J, Qiu Y, Thepsuwan P, Yi Z, Heng HH, Sun Q, Chen X, Li L, He P, Zhang R, Zhang K
American journal of physiology. Cell physiology 2025 Jan 1;328(1):C212-C226
American journal of physiology. Cell physiology 2025 Jan 1;328(1):C212-C226
1-Bromopropane induces mitochondrial damage and lipid metabolism imbalance in respiratory epithelial cells through the PGC-1α/PPARα pathway.
Wu Q, Jin C, Liu X, Zhang Q, Jiao B, Yu H
Ecotoxicology and environmental safety 2025 Jan 1;289:117492
Ecotoxicology and environmental safety 2025 Jan 1;289:117492
Natural molecule isoliquiritigenin mitigates MASH and liver fibrosis in mice by promoting autophagy through the PI3K/Akt signaling pathway.
Liu R, Zhang Y, Liu M, Shang Z, Song S, Zhang Y, Zhou Y, Tu C
The Journal of nutritional biochemistry 2025 Feb;136:109808
The Journal of nutritional biochemistry 2025 Feb;136:109808
Boeravinone C ameliorates lipid accumulation and inflammation in diabetic kidney disease by activating PPARα signaling.
Cheng Z, Zhan H, Yuan H, Wang N, Lan Y, Qu W, Lan X, Liao Z, Wang G, Chen M
Journal of ethnopharmacology 2025 Feb 27;342:119398
Journal of ethnopharmacology 2025 Feb 27;342:119398
Axin formation inhibitor 1 aggravates hepatic ischemia‒reperfusion injury by promoting the ubiquitination and degradation of PPARβ.
Qian B, Yin B, Yu H, Wang C, Lu S, Ke S, Li Z, Li X, Hua Y, Li Z, Zhou Y, Meng Z, Fu Y, Tang W, Ma Y
Nature communications 2025 Feb 19;16(1):1776
Nature communications 2025 Feb 19;16(1):1776
Qihuang Zhuyu formula modulates mitochondrial function to inhibit platelet activation via endocannabinoid signaling mediated by the SIRT1/PPARα pathway.
Shi R, Sun W, Yin S, Sun T, Yang N, Zhang H, Yao Y, Lai K, Chen X, Yu P
Journal of ethnopharmacology 2025 Feb 10;338(Pt 1):119006
Journal of ethnopharmacology 2025 Feb 10;338(Pt 1):119006
Neoagarotetraose Attenuates Hyperglycemia Through Inflammation Amelioration and Glucose Metabolism Improvement.
Cheng J, Yan Q, Liu D, Wu C, Li Y, Jiang Z
Molecular nutrition & food research 2025 Dec;69(24):e70323
Molecular nutrition & food research 2025 Dec;69(24):e70323
High-throughput screening reveals paeoniflorin's efficacy against Apoc2-deficient hypertriglyceridemia via HNF4A/PPARA/LDLR.
Li Q, Qi K, Wu S, Shen A, Zhao L
Biochemical pharmacology 2025 Dec;242(Pt 2):117351
Biochemical pharmacology 2025 Dec;242(Pt 2):117351
Mdivi-1 promotes lipid droplets-mitochondria contact and ameliorates cardiac lipotoxicity in high-fat diet-fed mice.
Xu Z, Ma Z, Ren H, Yang Y, Zhao X, Zhang B
Pharmacological research 2025 Dec;222:108028
Pharmacological research 2025 Dec;222:108028
Gut-liver axis mechanisms of Hippophae rhamnoides L. in non-alcoholic fatty liver disease prevention.
Ma J, Li Y, Yang Y, Zhao L, Jiang Y, Wong TW, Zhang D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Dec;149:157517
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Dec;149:157517
Revealing the Causal Relationship of the Gut-Liver Axis in MASH: A Study Based on Mendelian Randomization and Multi-Omics.
Yin D, Cheng J, Cao H, Wang X, He J, Zhu Y, Li J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Dec 31;39(24):e71355
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Dec 31;39(24):e71355
Smilax china L. Extract Alleviates Metabolic-Associated Fatty Liver Disease by Regulating Gut Microbiota and Bile Acid Metabolism.
Cheng S, Li H, Sun Z, Xiong Y, Li J, Tian J, Shen Y, Shen L, Yang J, Yang Y, Liu D, Wei Q, Huang C, Ye X
Metabolites 2025 Dec 26;16(1)
Metabolites 2025 Dec 26;16(1)
The protective effect of probiotic therapy on gut microbiota and the activation of ω-oxidation after ovarian cancer surgery.
Geng C, Cao Q, Chen Z, Song X, Shi X
Journal of cancer research and clinical oncology 2025 Dec 26;152(1):23
Journal of cancer research and clinical oncology 2025 Dec 26;152(1):23
An Enhanced Cancer Immunogenic Cell Death Strategy: Fibrate-Oxaliplatin(IV) Conjugates with Modulating Tumor Immune Microenvironment.
Liang XJ, Guo X, Zhu PH, Zhao ZH, You Z, Yang K, Song Y, Li L, Song XQ
Journal of medicinal chemistry 2025 Dec 25;68(24):26328-26347
Journal of medicinal chemistry 2025 Dec 25;68(24):26328-26347
B-Cell Receptor-Associated Protein 31 Deficiency Aggravates Ethanol-Induced Liver Steatosis and Liver Injury via Attenuating Fatty Acid Oxidation and Glycogen Synthesis.
Yu S, Xia Y, Zhang C, Han X, Feng X, Li L, Ma H, Xu J
International journal of molecular sciences 2025 Dec 18;26(24)
International journal of molecular sciences 2025 Dec 18;26(24)
Limitations in PPARα-dependent mitochondrial programming restrain the differentiation of human stem cell-derived β cells.
Lietzke AC, Walker EM, Bealer E, Crumley K, King J, Stendahl AM, Zhu J, Pearson GL, Levi-D'Ancona E, Henry-Kanarek B, Davidson RK, Li J, Reck EC, Wu Y, Arnipalli M, Pham JP, Mundada L, Sidarala V, Herron TJ, Coronel MM, Pennathur S, Madsen JGS, Shea LD, Soleimanpour SA
Nature communications 2025 Dec 10;16(1):11037
Nature communications 2025 Dec 10;16(1):11037
Exposure to submicroplastics promotes the progression of nonalcoholic fatty liver disease in ApoE-deficient mice.
Li Q, Niu X, Cai Y, Li L, Xia Z
Toxicology 2025 Aug;515:154137
Toxicology 2025 Aug;515:154137
Andrographolide Attenuates Myocardial Ischemia-Reperfusion Injury in Mice by Up-Regulating PPAR-α.
Zhang S, Ye Y, Li Q, Zhao J, Song R, Huang C, Lu X, Huang C, Yin L, You Q
Inflammation 2025 Aug;48(4):2341-2354
Inflammation 2025 Aug;48(4):2341-2354
EGCG and Taurine Synergistically Ameliorate Lipid Metabolism Disorder by Modulating Gut Microbiota and PPARα/FAS Signaling Pathway.
Xiao Y, Yang M, Cai M, Zhang H, Hu K, Duan Y
Nutrients 2025 Aug 9;17(16)
Nutrients 2025 Aug 9;17(16)
Fenofibrate Differently Affects the Heart's Morphology and Metabolism in Young and Old Rats.
Wrońska A, Kieżun J, Kmieć Z
International journal of molecular sciences 2025 Aug 20;26(16)
International journal of molecular sciences 2025 Aug 20;26(16)
Oxybaphus himalaicus alleviates diabetic kidney disease by suppressing the lipid metabolism and inflammation via PPARα signaling.
Qu W, Lan Y, Cheng Z, Yuan H, Zhan H, Lan X, Liao Z, Wang G, Chen M
Fitoterapia 2025 Apr;182:106474
Fitoterapia 2025 Apr;182:106474
Distinct Hepatic Metabolic Reprogramming in Acute and Chronic Sleep Deprivation and the Protective Effects of the Chalcone Analogue TAK.
Wang Y, Hu Y, Wang P, Hu R, Chen Z, Zhang T, Liu J, Noda M, Long J, Peng Y
International journal of molecular sciences 2025 Apr 8;26(8)
International journal of molecular sciences 2025 Apr 8;26(8)
Anthocyanins prevent the development and progression of urethane-induced lung cancer by regulating energy metabolism in mice.
Luo H, Gao M, Lu H, Chen Q, Lian X
Food & nutrition research 2024;68
Food & nutrition research 2024;68
Salidroside may target PPARα to exert preventive and therapeutic activities on NASH.
Chu X, Liu S, Qu B, Xin Y, Lu L
Frontiers in pharmacology 2024;15:1433076
Frontiers in pharmacology 2024;15:1433076
Palmitoylation of PKCδ by ZDHHC5 in hypothalamic microglia presents as a therapeutic target for fatty liver disease.
Wang YH, Chen X, Bai YZ, Gao P, Yang Z, Guo Q, Lu YY, Zheng J, Liu D, Yang J, Tu PF, Zeng KW
Theranostics 2024;14(3):988-1009
Theranostics 2024;14(3):988-1009
Inactivation of mitochondrial MUL1 E3 ubiquitin ligase deregulates mitophagy and prevents diet-induced obesity in mice.
Cilenti L, Di Gregorio J, Mahar R, Liu F, Ambivero CT, Periasamy M, Merritt ME, Zervos AS
Frontiers in molecular biosciences 2024;11:1397565
Frontiers in molecular biosciences 2024;11:1397565
Ethanol Extract of Propolis Attenuates Liver Lipid Metabolism Disorder in High-Fat Diet-Fed SAMP8 Mice.
Xie QY, Shu X, Liu T, Chen LL, Luo LP
Molecular nutrition & food research 2024 Sep;68(17):e2400297
Molecular nutrition & food research 2024 Sep;68(17):e2400297
Counteracting TGM2 by a Fibroin peptide ameliorated Adriamycin-induced nephropathy via regulation of lipid metabolism through PANX1-PPAR α/PANK1 pathway.
Li SS, Liu QJ, Bao JX, Lu MT, Deng BQ, Li WW, Cao CC
Translational research : the journal of laboratory and clinical medicine 2024 Sep;271:26-39
Translational research : the journal of laboratory and clinical medicine 2024 Sep;271:26-39
Beneficial effects of Dendrobium officinale National Herbal Drink on metabolic immune crosstalk via regulate SCFAs-Th17/Treg.
Dong YJ, Zhang YP, Jiang XF, Xie ZY, Li B, Jiang NH, Chen SH, Lv GY
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155816
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155816
Exposure to Succinate Leads to Steatosis in Non-Obese Non-Alcoholic Fatty Liver Disease by Inhibiting AMPK/PPARα/FGF21-Dependent Fatty Acid Oxidation.
Yang H, Ran S, Zhou Y, Shi Q, Yu J, Wang W, Sun C, Li D, Hu Y, Pan C, Yuan Q, Zhen Y, Liu Q, Song L
Journal of agricultural and food chemistry 2024 Sep 25;72(38):21052-21064
Journal of agricultural and food chemistry 2024 Sep 25;72(38):21052-21064
FABP4 deficiency ameliorates alcoholic steatohepatitis in mice via inhibition of p53 signaling pathway.
Xing H, Wu Z, Jiang K, Yuan G, Guo Z, Yu S, He S, Zhong F
Scientific reports 2024 Sep 10;14(1):21135
Scientific reports 2024 Sep 10;14(1):21135
Epicatechin and β-glucan from whole highland barley grain ameliorates hyperlipidemia associated with attenuating intestinal barrier dysfunction and modulating gut microbiota in high-fat-diet-fed mice.
Liu Z, Tang R, Liu J, Zhang Z, Li Y, Zhao R
International journal of biological macromolecules 2024 Oct;278(Pt 3):134917
International journal of biological macromolecules 2024 Oct;278(Pt 3):134917
Mitochondria-related HSDL2 is a potential biomarker in temporal lobe epilepsy by modulating astrocytic lipid metabolism.
Yang X, Zhang J, Wang Z, Yao Z, Yang X, Wang X, Zhao X, Xu S
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2024 Oct;21(6):e00447
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2024 Oct;21(6):e00447
SMYD2 Promotes Calcium Oxalate-Induced Glycolysis in Renal Tubular Epithelial Cells via PTEN Methylation.
Pan S, Yuan T, Xia Y, Yu W, Li H, Rao T, Ye Z, Li L, Zhou X, Cheng F
Biomedicines 2024 Oct 8;12(10)
Biomedicines 2024 Oct 8;12(10)
Activation of NOD1 on tumor-associated macrophages augments CD8(+) T cell-mediated antitumor immunity in hepatocellular carcinoma.
Zhang F, Jiang Q, Cai J, Meng F, Tang W, Liu Z, Lin X, Liu W, Zhou Y, Shen X, Xue R, Dong L, Zhang S
Science advances 2024 Oct 4;10(40):eadp8266
Science advances 2024 Oct 4;10(40):eadp8266
The transcription factor PPARA mediates SIRT1 regulation of NCOR1 to protect damaged heart cells.
Wang M, Zhou F, Luo Y, Deng X, Chen X, Yi Q
Cardiovascular diagnosis and therapy 2024 Oct 31;14(5):832-847
Cardiovascular diagnosis and therapy 2024 Oct 31;14(5):832-847
IGFBP1 promotes the proliferation and migration of lung adenocarcinoma cells through the PPARα pathway.
Li Y, Yang X, Han T, Zhou J, Liu Y, Guo J, Liu Z, Bai Y, Xing Y, Ding X, Wu J, Hu D
Translational oncology 2024 Nov;49:102095
Translational oncology 2024 Nov;49:102095
Non-Sugar Sweetener Rubusoside Alleviates Lipid Metabolism Disorder In Vivo and In Vitro by Targeting PPARγ/α, Lgals3, and Mknk2.
Huang W, Jiang M, Wang X, Pan D, Chen W, Fan L
Journal of agricultural and food chemistry 2024 Nov 20;72(46):25601-25619
Journal of agricultural and food chemistry 2024 Nov 20;72(46):25601-25619
Resistance Exercise Improves Glycolipid Metabolism and Mitochondrial Biogenesis in Skeletal Muscle of T2DM Mice via miR-30d-5p/SIRT1/PGC-1α Axis.
Zheng L, Rao Z, Wu J, Ma X, Jiang Z, Xiao W
International journal of molecular sciences 2024 Nov 19;25(22)
International journal of molecular sciences 2024 Nov 19;25(22)
Gemfibrozil-Platinum(IV) Precursors for New Enhanced-Starvation and Chemotherapy In Vitro and In Vivo.
Song XQ, Guo X, Ding YX, Han YX, You ZH, Song Y, Yuan Y, Li L
Journal of medicinal chemistry 2024 May 9;67(9):7033-7047
Journal of medicinal chemistry 2024 May 9;67(9):7033-7047
Probiotic-fermented tomato with hepatic lipid metabolism modulation effects: analysis of physicochemical properties, bioactivities, and potential bioactive compounds.
Wei B, Zheng W, Peng Z, Xiao M, Huang T, Xie M, Xiong T
Food & function 2024 May 7;15(9):4874-4886
Food & function 2024 May 7;15(9):4874-4886
Effects of replacing fishmeal with different proportions of mixed protein source in the diet of largemouth bass (Micropterus salmoides).
Chen L, Zhong J, Shi M, Liu Y, Qu K, Tan B, Yang H, Xie S
Comparative biochemistry and physiology. Part D, Genomics & proteomics 2024 Mar;49:101181
Comparative biochemistry and physiology. Part D, Genomics & proteomics 2024 Mar;49:101181
f25, a novel synthetic quinoline derivative, inhibits tongue cancer cell invasion and survival by the PPAR pathway in vitro and vivo.
Liu T, Yang L, Li Z, Sun M, Lv N
Chemico-biological interactions 2024 Mar 1;391:110891
Chemico-biological interactions 2024 Mar 1;391:110891
Mechanistic of AMPK/ACC2 regulating myoblast differentiation by fatty acid oxidation of goat.
Kang Z, Zhang Z, Li J, Deng K, Wang F, Fan Y
International journal of biological macromolecules 2024 Jun;270(Pt 2):132243
International journal of biological macromolecules 2024 Jun;270(Pt 2):132243
Procyanidin B1 and Coumaric Acid from Highland Barley Alleviated High-Fat-Diet-Induced Hyperlipidemia by Regulating PPARα-Mediated Hepatic Lipid Metabolism and Gut Microbiota in Diabetic C57BL/6J Mice.
Liu Z, Liu J, Tang R, Zhang Z, Tian S
Foods (Basel, Switzerland) 2024 Jun 12;13(12)
Foods (Basel, Switzerland) 2024 Jun 12;13(12)
PPARα phosphorylation regulates colorectal tumor immune escape.
Gou Q, Tian X, Dong C, Yan B, Chen M, Shi J, Yang L, Hou Y
The Journal of biological chemistry 2024 Jul;300(7):107447
The Journal of biological chemistry 2024 Jul;300(7):107447
Luteolin alleviates cadmium-induced metabolism disorder through antioxidant and anti-inflammatory mechanisms in chicken kidney.
Wang X, Zhang K, Ali W, Li J, Huang Q, Liu D, Liu G, Ran D, Liu Z
Poultry science 2024 Jul;103(7):103817
Poultry science 2024 Jul;103(7):103817
Chrysanthemum morifolium attenuates metabolic and alcohol-associated liver disease via gut microbiota and PPARα/γ activation.
Liu D, Zhan J, Wang S, Chen L, Zhu Q, Nie R, Zhou X, Zheng W, Luo X, Wang B, Nie J, Ye X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155774
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155774
Podophyllotoxin via SIRT1/PPAR /NF-κB axis induced cardiac injury in rats based on the toxicological evidence chain (TEC) concept.
Jiang T, Sun L, Wang Y, Zhang F, Guo J, Sun L, Jiang Y, Xue J, Duan J, Liu C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155655
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155655
Intermittent hypoxia exacerbates metabolic dysfunction-associated fatty liver disease by aggravating hepatic copper deficiency-induced ferroptosis.
Wang R, Lv Y, Ni Z, Feng W, Fan P, Wang Y, Lin Y, Chen X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 15;38(13):e23788
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 15;38(13):e23788
Liver Lipidomics Analysis Revealed the Protective mechanism of Zuogui Jiangtang Qinggan Formula in type 2 diabetes mellitus with non-alcoholic fatty liver disease.
Zhou M, Liu X, Wu Y, Xiang Q, Yu R
Journal of ethnopharmacology 2024 Jul 15;329:118160
Journal of ethnopharmacology 2024 Jul 15;329:118160
Hydrangea paniculata coumarins alleviate adriamycin-induced renal lipotoxicity through activating AMPK and inhibiting C/EBPβ.
Chen Y, Liu X, Ma J, Wang W, Li Z, Wu H, Lu Z, Zhang D, Zhang X, Zhang Y, Zhang S
Journal of ethnopharmacology 2024 Jul 15;329:118156
Journal of ethnopharmacology 2024 Jul 15;329:118156
Metabolomics analyses reveal the liver-protective mechanism of Wang's metabolic formula on metabolic-associated fatty liver disease.
Chen S, Huang J, Huang Y, Zhou C, Wang N, Zhang L, Zhang Z, Li B, He X, Wang K, Zhi Y, Lv G, Shen S
Heliyon 2024 Jul 15;10(13):e33418
Heliyon 2024 Jul 15;10(13):e33418
A mixed animal and plant protein source replacing fishmeal affects bile acid metabolism and apoptosis in largemouth bass (Micropterus salmoides).
Chen L, Qi Y, Shi M, Qu K, Liu Y, Tan B, Xie S
Journal of animal science 2024 Jan 3;102
Journal of animal science 2024 Jan 3;102
Muscular lipidomics and transcriptomics reveal the effects of bile acids on lipid metabolism in high-fat diet-fed grouper.
Xu J, Shi M, Chen L, Chi S, Zhang S, Cao J, Tan B, Xie S
Fish physiology and biochemistry 2024 Feb;50(1):127-143
Fish physiology and biochemistry 2024 Feb;50(1):127-143
Efficacy of DHA-enriched phosphatidylserine and its underlying mechanism in alleviating polystyrene nanoplastics-induced hepatotoxicity in mice.
Zhang Y, Zhao Q, Zhao R, Lu Y, Jiang S, Tang Y
International immunopharmacology 2024 Dec 5;142(Pt A):113154
International immunopharmacology 2024 Dec 5;142(Pt A):113154
Therapeutic potential of palmitoleic acid in non-alcoholic fatty liver disease: Targeting ferroptosis and lipid metabolism disorders.
Wang H, Shan C, Guo G, Ning D, Miao F
International immunopharmacology 2024 Dec 5;142(Pt A):113025
International immunopharmacology 2024 Dec 5;142(Pt A):113025
High-iron diet damages brown adipose tissue mitochondria and exacerbates metabolic hazards of a high-fat diet.
Zhang Y, Bai Z, Song K, Liu Y, Zhang W
Biochemical and biophysical research communications 2024 Dec 20;739:151008
Biochemical and biophysical research communications 2024 Dec 20;739:151008
mTORC2 knockdown mediates lipid metabolism to alleviate hyperlipidemic pancreatitis through PPARα.
Wang X, Liu Y, Zhou Y, Li M, Mo T, Xu X, Chen Z, Zhang Y, Yang L
Journal of biochemical and molecular toxicology 2024 Aug;38(8):e23802
Journal of biochemical and molecular toxicology 2024 Aug;38(8):e23802
PFDA promotes cancer metastasis through macrophage M2 polarization mediated by Wnt/β-catenin signaling.
Cui Z, Liu Z, Yuan X, Lu K, Li M, Xu S, Chen K, Zheng F, Li Y, Héroux P, Wu Y, Xia D
Chemosphere 2024 Aug;362:142758
Chemosphere 2024 Aug;362:142758
Permethrin exposure impacts zebrafish lipid metabolism via the KRAS-PPAR-GLUT signaling pathway, which is mediated by oxidative stress.
Khan A, Khan B, Hussain S, Wang Y, Mai W, Hou Y
Aquatic toxicology (Amsterdam, Netherlands) 2024 Aug;273:107021
Aquatic toxicology (Amsterdam, Netherlands) 2024 Aug;273:107021
CD9 Counteracts Liver Steatosis and Mediates GCGR Agonist Hepatic Effects.
Zheng Y, Wang Y, Xiong X, Zhang L, Zhu J, Huang B, Liu X, Liu J, Zhu Z, Yang G, Qu H, Zheng H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(29):e2400819
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(29):e2400819
Berberine alleviates high-energy and low-protein diet-induced fatty liver hemorrhagic syndrome in laying hens: insights from microbiome and metabolomics.
Cheng X, Hu Y, Kuang J, Guo X, Cao H, Wu H, Hu G, Zhuang Y
Poultry science 2024 Aug;103(8):103968
Poultry science 2024 Aug;103(8):103968
Polypeptide N-acetylgalactosaminyltransferase-15 regulates adipogenesis in human SGBS cells.
Takahashi A, Koike R, Watanabe S, Kuribayashi K, Wabitsch M, Miyamoto M, Komuro A, Seki M, Nashimoto M, Shimizu-Ibuka A, Yamashita K, Iwata T
Scientific reports 2024 Aug 29;14(1):20049
Scientific reports 2024 Aug 29;14(1):20049
Diosgenin attenuates nonalcoholic hepatic steatosis through the hepatic SIRT1/PGC-1α pathway.
Meng D, Yin G, Chen S, Zhang X, Yu W, Wang L, Liu H, Jiang W, Sun Y, Zhang F
European journal of pharmacology 2024 Aug 15;977:176737
European journal of pharmacology 2024 Aug 15;977:176737
Sodium butyrate alleviates free fatty acid-induced steatosis in primary chicken hepatocytes via the AMPK/PPARα pathway.
Ding J, Liu J, Chen J, Cheng X, Cao H, Guo X, Hu G, Zhuang Y
Poultry science 2024 Apr;103(4):103482
Poultry science 2024 Apr;103(4):103482
Klotho exerts protection in chronic kidney disease associated with regulating inflammatory response and lipid metabolism.
Liu J, Wang H, Liu Q, Long S, Wu Y, Wang N, Lin W, Chen G, Lin M, Wen J
Cell & bioscience 2024 Apr 7;14(1):46
Cell & bioscience 2024 Apr 7;14(1):46
Targeting hepatic ceruloplasmin mitigates nonalcoholic steatohepatitis by modulating bile acid metabolism.
Jiang Q, Wang N, Lu S, Xiong J, Yuan Y, Liu J, Chen S
Journal of molecular cell biology 2024 Apr 4;15(9)
Journal of molecular cell biology 2024 Apr 4;15(9)
The natural compounds, Magnolol or Honokiol, promote adipose tissue browning and resist obesity through modulating PPARα/γ activity.
Chu Y, Gui S, Zheng Y, Zhao J, Zhao Y, Li Y, Chen X
European journal of pharmacology 2024 Apr 15;969:176438
European journal of pharmacology 2024 Apr 15;969:176438
Corn peptides attenuate non-alcoholic fatty liver disease via PINK1/Parkin-mediated mitochondrial autophagy.
Yao Z, Li X, Wang W, Ren P, Song S, Wang H, Xie Y, Li X, Li Z
Food & nutrition research 2023;67
Food & nutrition research 2023;67
Herpetrione, a New Type of PPARα Ligand as a Therapeutic Strategy Against Nonalcoholic Steatohepatitis.
Linghu L, Zong W, Liao Y, Chen Q, Meng F, Wang G, Liao Z, Lan X, Chen M
Research (Washington, D.C.) 2023;6:0276
Research (Washington, D.C.) 2023;6:0276
Replacement of Dietary Fishmeal with Clostridium autoethanogenum Protein on Lipidomics and Lipid Metabolism in Muscle of Pearl Gentian Grouper.
Xu J, Huang B, Chi S, Zhang S, Cao J, Tan B, Xie S
Aquaculture nutrition 2023;2023:6723677
Aquaculture nutrition 2023;2023:6723677
Deep Sea Water Inhibited Pancreatic β-Cell Apoptosis and Regulated Glucose Homeostasis by Affecting Lipid Metabolism in Db/Db Mice.
Shi M, Hu B, Hong Y, Wang M, Yao Y
Diabetes, metabolic syndrome and obesity : targets and therapy 2023;16:245-258
Diabetes, metabolic syndrome and obesity : targets and therapy 2023;16:245-258
A novel risk model of three SUMOylation genes based on RNA expression for potential prognosis and treatment sensitivity prediction in kidney cancer.
Li SC, Yan LJ, Wei XL, Jia ZK, Yang JJ, Ning XH
Frontiers in pharmacology 2023;14:1038457
Frontiers in pharmacology 2023;14:1038457
Puerarin inhibits inflammation and lipid accumulation in alcoholic liver disease through regulating MMP8.
Hu Y, Wang S, Wu L, Yang K, Yang F, Yang J, Hu S, Yao Y, Xia X, Liu Y, Peng L, Wan J, Shen C, Xu T
Chinese journal of natural medicines 2023 Sep;21(9):670-681
Chinese journal of natural medicines 2023 Sep;21(9):670-681
Xianlinglianxiafang Inhibited the growth and metastasis of triple-negative breast cancer via activating PPARγ/AMPK signaling pathway.
Yang X, Yang R, Zhang Y, Shi Y, Ma M, Li F, Xie Y, Han X, Liu S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115164
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115164
γ-glutamylcysteine alleviates insulin resistance and hepatic steatosis by regulating adenylate cyclase and IGF-1R/IRS1/PI3K/Akt signaling pathways.
Zhou J, Shi Y, Yang C, Lu S, Zhao L, Liu X, Zhou D, Luo L, Yin Z
The Journal of nutritional biochemistry 2023 Sep;119:109404
The Journal of nutritional biochemistry 2023 Sep;119:109404
HMGCS2 serves as a potential biomarker for inhibition of renal clear cell carcinoma growth.
Mao H, Wang R, Shao F, Zhao M, Tian D, Xia H, Zhao Y
Scientific reports 2023 Sep 5;13(1):14629
Scientific reports 2023 Sep 5;13(1):14629
Metabolic characteristics of voriconazole - Induced liver injury in rats.
Du Q, Teng M, Yang L, Meng C, Qiu Y, Wang C, Chen J, Wang T, Chen S, Luo Y, Sun J, Dong Y
Chemico-biological interactions 2023 Sep 25;383:110693
Chemico-biological interactions 2023 Sep 25;383:110693
Bo's abdominal acupuncture improves disordered metabolism in obese type 2 diabetic rats through regulating fibroblast growth factor 21 and its related adipokines.
Xihui Q, Jianli P, Guan X, Jie F
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2023 Oct;43(6):1200-1208
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2023 Oct;43(6):1200-1208
Investigation of the potential ameliorative effects of DHA-enriched phosphatidylserine on bisphenol A-induced murine nephrotoxicity.
Pu Q, Yang F, Zhao R, Jiang S, Tang Y, Han T
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Oct;180:114012
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Oct;180:114012
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
Song K, Sun H, Tu B, Zhou Y, Lin LC, Liu ZY, Li R, Yang JJ, Zhang Y, Zhao JY, Tao H
iScience 2023 Oct 20;26(10):107931
iScience 2023 Oct 20;26(10):107931
RAE1 promotes nitrosamine-induced malignant transformation of human esophageal epithelial cells through PPARα-mediated lipid metabolism.
He L, Zhou X, Liu J, Yao Y, Lin J, Chen J, Qiu S, Liu Z, He Y, Yi Y, Zhou X, Zou F
Ecotoxicology and environmental safety 2023 Oct 15;265:115513
Ecotoxicology and environmental safety 2023 Oct 15;265:115513
Green Pea (Pisum sativum L.) Hull Polyphenol Extract Alleviates NAFLD through VB6/TLR4/NF-κB and PPAR Pathways.
Guo F, Xiong H, Tsao R, Shahidi F, Wen X, Liu J, Jiang L, Sun Y
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16067-16078
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16067-16078
Butyrate mitigates metabolic dysfunctions via the ERα-AMPK pathway in muscle in OVX mice with diet-induced obesity.
Fu Q, Li T, Zhang C, Ma X, Meng L, Liu L, Shao K, Wu G, Zhu X, Zhao X
Cell communication and signaling : CCS 2023 May 4;21(1):95
Cell communication and signaling : CCS 2023 May 4;21(1):95
Insoluble Dietary Fiber from Soybean Residue (Okara) Exerts Anti-Obesity Effects by Promoting Hepatic Mitochondrial Fatty Acid Oxidation.
Zhang J, Wang S, Wang J, Liu W, Gong H, Zhang Z, Lyu B, Yu H
Foods (Basel, Switzerland) 2023 May 22;12(10)
Foods (Basel, Switzerland) 2023 May 22;12(10)
Local glucose elevation activates pyroptosis via NLRP3 inflammasome in ovarian granulosa cells of overweight patients.
Xu R, Zhao H, Qi J, Yao G, He Y, Lu Y, Zhu Q, Wang Y, Ding Y, Zhu Z, Li X, Vankelecom H, Sun Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Mar;37(3):e22807
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Mar;37(3):e22807
Supplemental Clostridium butyricum modulates lipid metabolism by reshaping the gut microbiota composition and bile acid profile in IUGR suckling piglets.
Zhang X, Yun Y, Lai Z, Ji S, Yu G, Xie Z, Zhang H, Zhong X, Wang T, Zhang L
Journal of animal science and biotechnology 2023 Mar 13;14(1):36
Journal of animal science and biotechnology 2023 Mar 13;14(1):36
Hepatocyte-derived extracellular vesicles miR-122-5p promotes hepatic ischemia reperfusion injury by regulating Kupffer cell polarization.
Liu L, Xiao F, Sun J, Wang Q, Wang A, Zhang F, Li Z, Wang X, Fang Z, Qiao Y
International immunopharmacology 2023 Jun;119:110060
International immunopharmacology 2023 Jun;119:110060
Modulation of the Microbiome-Fat-Liver Axis by Lactic Acid Bacteria: A Potential Alleviated Role in High-Fat-Diet-Induced Obese Mice.
Wei B, Peng Z, Xiao M, Huang T, Yang S, Liu K, Wu M, Zheng W, Xie M, Xiong T
Journal of agricultural and food chemistry 2023 Jul 12;71(27):10361-10374
Journal of agricultural and food chemistry 2023 Jul 12;71(27):10361-10374
PPARα agonist fenofibrate prevents postoperative cognitive dysfunction by enhancing fatty acid oxidation in mice.
Liu T, Chen X, Wei Z, Han X, Liu Y, Ma Z, Xia T, Gu X
Translational neuroscience 2023 Jan 1;14(1):20220317
Translational neuroscience 2023 Jan 1;14(1):20220317
STAT6 promoting oxalate crystal deposition-induced renal fibrosis by mediating macrophage-to-myofibroblast transition via inhibiting fatty acid oxidation.
Yuan T, Xia Y, Pan S, Li B, Ye Z, Yan X, Hu W, Li L, Song B, Yu W, Li H, Rao T, Lin F, Zhou X, Cheng F
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Dec;72(12):2111-2126
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Dec;72(12):2111-2126
Nobiletin Ameliorates Hepatic Lipid Deposition, Oxidative Stress, and Inflammation by Mechanisms That Involve the Nrf2/NF-κB Axis in Nonalcoholic Fatty Liver Disease.
Fan C, Ling-Hu A, Sun D, Gao W, Zhang C, Duan X, Li H, Tian W, Yu Q, Ke Z
Journal of agricultural and food chemistry 2023 Dec 20;71(50):20105-20117
Journal of agricultural and food chemistry 2023 Dec 20;71(50):20105-20117
Therapeutic Potential of Ginsenoside Rb1-PLGA Nanoparticles for Heart Failure Treatment via the ROS/PPARα/PGC1α Pathway.
Du L, Lu H, Wang Z, Liu C, Xiao Y, Guo Z, Li Y
Molecules (Basel, Switzerland) 2023 Dec 15;28(24)
Molecules (Basel, Switzerland) 2023 Dec 15;28(24)
Theabrownin of raw and ripened pu-erh tea varies in the alleviation of HFD-induced obesity via the regulation of gut microbiota.
Deng X, Zhang N, Wang Q, Huang Y, Huang Y, Lin Y, Huang M, Zheng F, Xiao M, Ye J
European journal of nutrition 2023 Aug;62(5):2177-2194
European journal of nutrition 2023 Aug;62(5):2177-2194
Melatonin alleviates cadmium-induced nonalcoholic fatty liver disease in ducks by alleviating autophagic flow arrest via PPAR-α and reducing oxidative stress.
Sun J, Bian Y, Ma Y, Ali W, Wang T, Yuan Y, Gu J, Bian J, Liu Z, Zou H
Poultry science 2023 Aug;102(8):102835
Poultry science 2023 Aug;102(8):102835
Diosgenin attenuates nonalcoholic hepatic steatosis through the hepatic FXR-SHP-SREBP1C/PPARα/CD36 pathway.
Chen S, Sun S, Feng Y, Li X, Yin G, Liang P, Yu W, Meng D, Zhang X, Liu H, Zhang F
European journal of pharmacology 2023 Aug 5;952:175808
European journal of pharmacology 2023 Aug 5;952:175808
Derivation and comprehensive analysis of ageing-related genes in intervertebral disc degeneration for prediction and immunology.
Xu S, Fu H, Weng S, Gu X, Li J
Mechanisms of ageing and development 2023 Apr;211:111794
Mechanisms of ageing and development 2023 Apr;211:111794
Anti-inflammatory effect of Irisin on LPS-stimulated macrophages through inhibition of MAPK pathway.
Ma Y, Du Y, Yang J, He Q, Wang H, Lin X
Physiological research 2023 Apr 30;72(2):235-249
Physiological research 2023 Apr 30;72(2):235-249
Berberrubine, a Main Metabolite of Berberine, Alleviates Non-Alcoholic Fatty Liver Disease via Modulating Glucose and Lipid Metabolism and Restoring Gut Microbiota.
Yang S, Cao S, Li C, Zhang J, Liu C, Qiu F, Kang N
Frontiers in pharmacology 2022;13:913378
Frontiers in pharmacology 2022;13:913378
Dynein light chain LC8 alleviates nonalcoholic steatohepatitis by inhibiting NF-κB signaling and reducing oxidative stress.
Lee GR, Lee HI, Kim N, Lee J, Kwon M, Kang YH, Song HJ, Yeo CY, Jeong W
Journal of cellular physiology 2022 Sep;237(9):3554-3564
Journal of cellular physiology 2022 Sep;237(9):3554-3564
Ban-xia-xie-xin-tang ameliorates hepatic steatosis by regulating Cidea and Cidec expression in HFD-fed mice.
Xia QS, Gao Y, Wen-Bin W, Wu F, Dong H, Xu LJ, Fang K, Hu ML, Yuan F, Lu FE, Gong J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Oct;105:154351
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Oct;105:154351
RUNX2 recruits the NuRD(MTA1)/CRL4B complex to promote breast cancer progression and bone metastasis.
Yin X, Teng X, Ma T, Yang T, Zhang J, Huo M, Liu W, Yang Y, Yuan B, Yu H, Huang W, Wang Y
Cell death and differentiation 2022 Nov;29(11):2203-2217
Cell death and differentiation 2022 Nov;29(11):2203-2217
Recombinant Humanized IgG1 Antibody Promotes Reverse Cholesterol Transport through FcRn-ERK1/2-PPARα Pathway in Hepatocytes.
Li Z, Zhang Q, Liu X, Zhao M
International journal of molecular sciences 2022 Nov 23;23(23)
International journal of molecular sciences 2022 Nov 23;23(23)
Probiotic-fermented rice buckwheat alleviates high-fat diet-induced hyperlipidemia in mice by suppressing lipid accumulation and modulating gut microbiota.
Yan J, Xue Q, Chen W, Wang K, Peng D, Jiang J, Li P, Du B
Food research international (Ottawa, Ont.) 2022 May;155:111125
Food research international (Ottawa, Ont.) 2022 May;155:111125
Loss of mitochondrial ATPase ATAD3A contributes to nonalcoholic fatty liver disease through accumulation of lipids and damaged mitochondria.
Chen L, Li Y, Sottas C, Lazaris A, Petrillo SK, Metrakos P, Li L, Ishida Y, Saito T, Garza S, Papadopoulos V
The Journal of biological chemistry 2022 Jun;298(6):102008
The Journal of biological chemistry 2022 Jun;298(6):102008
Bifidobacterium animalis subsp. lactis A6 Enhances Fatty Acid β-Oxidation of Adipose Tissue to Ameliorate the Development of Obesity in Mice.
Huo Y, Zhao G, Li J, Wang R, Ren F, Li Y, Wang X
Nutrients 2022 Jan 29;14(3)
Nutrients 2022 Jan 29;14(3)
Farnesoid X receptor regulates PI(3)K/AKT/mTOR signaling pathway, lipid metabolism, and immune response in hybrid grouper.
Xu J, Yao X, Li X, Xie S, Chi S, Zhang S, Cao J, Tan B
Fish physiology and biochemistry 2022 Dec;48(6):1521-1538
Fish physiology and biochemistry 2022 Dec;48(6):1521-1538
Pharmacological inhibition of Lin28 promotes ketogenesis and restores lipid homeostasis in models of non-alcoholic fatty liver disease.
Lekka E, Kokanovic A, Mosole S, Civenni G, Schmidli S, Laski A, Ghidini A, Iyer P, Berk C, Behera A, Catapano CV, Hall J
Nature communications 2022 Dec 26;13(1):7940
Nature communications 2022 Dec 26;13(1):7940
Effects of heat-processed Gynostemma pentaphyllum on high-fat diet-fed mice of obesity and functional analysis on network pharmacology and molecular docking strategy.
Xie P, Guo M, Xie JB, Xiao MY, Qi YS, Duan Y, Li FF, Piao XL
Journal of ethnopharmacology 2022 Aug 10;294:115335
Journal of ethnopharmacology 2022 Aug 10;294:115335
Pterostilbene and Its Derivative 3'-Hydroxypterostilbene Ameliorated Nonalcoholic Fatty Liver Disease Through Synergistic Modulation of the Gut Microbiota and SIRT1/AMPK Signaling Pathway.
Tsai HY, Shih YY, Yeh YT, Huang CH, Liao CA, Hu CY, Nagabhushanam K, Ho CT, Chen YK
Journal of agricultural and food chemistry 2022 Apr 27;70(16):4966-4980
Journal of agricultural and food chemistry 2022 Apr 27;70(16):4966-4980
Hepatic COX-2 expression protects mice from an alcohol-high fat diet-induced metabolic disorder by involving protein acetylation related energy metabolism.
Chen M, Sun X, Wei W, Cucarella C, Martín-Sanz P, Casado M, Pi L, Ren B, Cao Q
Alcohol (Fayetteville, N.Y.) 2021 May;92:41-52
Alcohol (Fayetteville, N.Y.) 2021 May;92:41-52
Effects of dibutyl phthalate on lipid metabolism in liver and hepatocytes based on PPARα/SREBP-1c/FAS/GPAT/AMPK signal pathway.
Zhang W, Li JY, Wei XC, Wang Q, Yang JY, Hou H, Du ZW, Wu XA
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Mar;149:112029
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Mar;149:112029
Effect of fenofibrate on proliferation of SMMC-7721 cells via regulating cell cycle.
Li B, Jiang HY, Wang ZH, Ma YC, Bao YN, Jin Y
Human & experimental toxicology 2021 Jul;40(7):1208-1221
Human & experimental toxicology 2021 Jul;40(7):1208-1221
Chrysanthemi Flos extract alleviated acetaminophen-induced rat liver injury via inhibiting oxidative stress and apoptosis based on network pharmacology analysis.
Zhou Y, Wang C, Kou J, Wang M, Rong X, Pu X, Xie X, Han G, Pang X
Pharmaceutical biology 2021 Dec;59(1):1378-1387
Pharmaceutical biology 2021 Dec;59(1):1378-1387
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