66826-1-Ig

antibody from Proteintech Group

Targeting: PPARA hPPAR, NR1C1, PPAR

Provider product page for 66826-1-Ig

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ELISA

Antibody data

Antibody Data
Antigen structure
References [63]
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Product number: 66826-1-Ig - Provider product page
Provider: Proteintech Group
Product name: PPARA antibody
Antibody type: Monoclonal
Description: PPARA antibody (Cat. #66826-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, rat and has been validated for the following applications: WB,ELISA.
Reactivity: Human, Rat
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 1G1E10
Vial size: 20ul, 150ul

PPARA protein structure - 66826-1-Ig shown in red.

Submitted references Palmitoylation of PKCδ by ZDHHC5 in hypothalamic microglia presents as a therapeutic target for fatty liver disease.

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Theranostics 2024;14(3):988-1009

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Translational research : the journal of laboratory and clinical medicine 2024 Sep;271:26-39

Gemfibrozil-Platinum(IV) Precursors for New Enhanced-Starvation and Chemotherapy In Vitro and In Vivo.

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Journal of medicinal chemistry 2024 May 9;67(9):7033-7047

Effects of replacing fishmeal with different proportions of mixed protein source in the diet of largemouth bass (Micropterus salmoides).

Chen L, Zhong J, Shi M, Liu Y, Qu K, Tan B, Yang H, Xie S
Comparative biochemistry and physiology. Part D, Genomics & proteomics 2024 Mar;49:101181

f25, a novel synthetic quinoline derivative, inhibits tongue cancer cell invasion and survival by the PPAR pathway in vitro and vivo.

Liu T, Yang L, Li Z, Sun M, Lv N
Chemico-biological interactions 2024 Mar 1;391:110891

Mechanistic of AMPK/ACC2 regulating myoblast differentiation by fatty acid oxidation of goat.

Kang Z, Zhang Z, Li J, Deng K, Wang F, Fan Y
International journal of biological macromolecules 2024 Jun;270(Pt 2):132243

Procyanidin B1 and Coumaric Acid from Highland Barley Alleviated High-Fat-Diet-Induced Hyperlipidemia by Regulating PPARα-Mediated Hepatic Lipid Metabolism and Gut Microbiota in Diabetic C57BL/6J Mice.

Liu Z, Liu J, Tang R, Zhang Z, Tian S
Foods (Basel, Switzerland) 2024 Jun 12;13(12)

Luteolin alleviates cadmium-induced metabolism disorder through antioxidant and anti-inflammatory mechanisms in chicken kidney.

Wang X, Zhang K, Ali W, Li J, Huang Q, Liu D, Liu G, Ran D, Liu Z
Poultry science 2024 Jul;103(7):103817

Podophyllotoxin via SIRT1/PPAR /NF-κB axis induced cardiac injury in rats based on the toxicological evidence chain (TEC) concept.

Jiang T, Sun L, Wang Y, Zhang F, Guo J, Sun L, Jiang Y, Xue J, Duan J, Liu C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155655

Liver Lipidomics Analysis Revealed the Protective mechanism of Zuogui Jiangtang Qinggan Formula in type 2 diabetes mellitus with non-alcoholic fatty liver disease.

Zhou M, Liu X, Wu Y, Xiang Q, Yu R
Journal of ethnopharmacology 2024 Jul 15;329:118160

Hydrangea paniculata coumarins alleviate adriamycin-induced renal lipotoxicity through activating AMPK and inhibiting C/EBPβ.

Chen Y, Liu X, Ma J, Wang W, Li Z, Wu H, Lu Z, Zhang D, Zhang X, Zhang Y, Zhang S
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Muscular lipidomics and transcriptomics reveal the effects of bile acids on lipid metabolism in high-fat diet-fed grouper.

Xu J, Shi M, Chen L, Chi S, Zhang S, Cao J, Tan B, Xie S
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Diosgenin attenuates nonalcoholic hepatic steatosis through the hepatic SIRT1/PGC-1α pathway.

Meng D, Yin G, Chen S, Zhang X, Yu W, Wang L, Liu H, Jiang W, Sun Y, Zhang F
European journal of pharmacology 2024 Aug 15;977:176737

Sodium butyrate alleviates free fatty acid-induced steatosis in primary chicken hepatocytes via the AMPK/PPARα pathway.

Ding J, Liu J, Chen J, Cheng X, Cao H, Guo X, Hu G, Zhuang Y
Poultry science 2024 Apr;103(4):103482

Klotho exerts protection in chronic kidney disease associated with regulating inflammatory response and lipid metabolism.

Liu J, Wang H, Liu Q, Long S, Wu Y, Wang N, Lin W, Chen G, Lin M, Wen J
Cell & bioscience 2024 Apr 7;14(1):46

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Jiang Q, Wang N, Lu S, Xiong J, Yuan Y, Liu J, Chen S
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Chu Y, Gui S, Zheng Y, Zhao J, Zhao Y, Li Y, Chen X
European journal of pharmacology 2024 Apr 15;969:176438

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Yao Z, Li X, Wang W, Ren P, Song S, Wang H, Xie Y, Li X, Li Z
Food & nutrition research 2023;67

Herpetrione, a New Type of PPARα Ligand as a Therapeutic Strategy Against Nonalcoholic Steatohepatitis.

Linghu L, Zong W, Liao Y, Chen Q, Meng F, Wang G, Liao Z, Lan X, Chen M
Research (Washington, D.C.) 2023;6:0276

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Xu J, Huang B, Chi S, Zhang S, Cao J, Tan B, Xie S
Aquaculture nutrition 2023;2023:6723677

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Shi M, Hu B, Hong Y, Wang M, Yao Y
Diabetes, metabolic syndrome and obesity : targets and therapy 2023;16:245-258

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Li SC, Yan LJ, Wei XL, Jia ZK, Yang JJ, Ning XH
Frontiers in pharmacology 2023;14:1038457

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Hu Y, Wang S, Wu L, Yang K, Yang F, Yang J, Hu S, Yao Y, Xia X, Liu Y, Peng L, Wan J, Shen C, Xu T
Chinese journal of natural medicines 2023 Sep;21(9):670-681

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Yang X, Yang R, Zhang Y, Shi Y, Ma M, Li F, Xie Y, Han X, Liu S
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γ-glutamylcysteine alleviates insulin resistance and hepatic steatosis by regulating adenylate cyclase and IGF-1R/IRS1/PI3K/Akt signaling pathways.

Zhou J, Shi Y, Yang C, Lu S, Zhao L, Liu X, Zhou D, Luo L, Yin Z
The Journal of nutritional biochemistry 2023 Sep;119:109404

HMGCS2 serves as a potential biomarker for inhibition of renal clear cell carcinoma growth.

Mao H, Wang R, Shao F, Zhao M, Tian D, Xia H, Zhao Y
Scientific reports 2023 Sep 5;13(1):14629

Metabolic characteristics of voriconazole - Induced liver injury in rats.

Du Q, Teng M, Yang L, Meng C, Qiu Y, Wang C, Chen J, Wang T, Chen S, Luo Y, Sun J, Dong Y
Chemico-biological interactions 2023 Sep 25;383:110693

Bo's abdominal acupuncture improves disordered metabolism in obese type 2 diabetic rats through regulating fibroblast growth factor 21 and its related adipokines.

Xihui Q, Jianli P, Guan X, Jie F
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Investigation of the potential ameliorative effects of DHA-enriched phosphatidylserine on bisphenol A-induced murine nephrotoxicity.

Pu Q, Yang F, Zhao R, Jiang S, Tang Y, Han T
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WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.

Song K, Sun H, Tu B, Zhou Y, Lin LC, Liu ZY, Li R, Yang JJ, Zhang Y, Zhao JY, Tao H
iScience 2023 Oct 20;26(10):107931

RAE1 promotes nitrosamine-induced malignant transformation of human esophageal epithelial cells through PPARα-mediated lipid metabolism.

He L, Zhou X, Liu J, Yao Y, Lin J, Chen J, Qiu S, Liu Z, He Y, Yi Y, Zhou X, Zou F
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Guo F, Xiong H, Tsao R, Shahidi F, Wen X, Liu J, Jiang L, Sun Y
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Butyrate mitigates metabolic dysfunctions via the ERα-AMPK pathway in muscle in OVX mice with diet-induced obesity.

Fu Q, Li T, Zhang C, Ma X, Meng L, Liu L, Shao K, Wu G, Zhu X, Zhao X
Cell communication and signaling : CCS 2023 May 4;21(1):95

Insoluble Dietary Fiber from Soybean Residue (Okara) Exerts Anti-Obesity Effects by Promoting Hepatic Mitochondrial Fatty Acid Oxidation.

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Local glucose elevation activates pyroptosis via NLRP3 inflammasome in ovarian granulosa cells of overweight patients.

Xu R, Zhao H, Qi J, Yao G, He Y, Lu Y, Zhu Q, Wang Y, Ding Y, Zhu Z, Li X, Vankelecom H, Sun Y
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Zhang X, Yun Y, Lai Z, Ji S, Yu G, Xie Z, Zhang H, Zhong X, Wang T, Zhang L
Journal of animal science and biotechnology 2023 Mar 13;14(1):36

Hepatocyte-derived extracellular vesicles miR-122-5p promotes hepatic ischemia reperfusion injury by regulating Kupffer cell polarization.

Liu L, Xiao F, Sun J, Wang Q, Wang A, Zhang F, Li Z, Wang X, Fang Z, Qiao Y
International immunopharmacology 2023 Jun;119:110060

Modulation of the Microbiome-Fat-Liver Axis by Lactic Acid Bacteria: A Potential Alleviated Role in High-Fat-Diet-Induced Obese Mice.

Wei B, Peng Z, Xiao M, Huang T, Yang S, Liu K, Wu M, Zheng W, Xie M, Xiong T
Journal of agricultural and food chemistry 2023 Jul 12;71(27):10361-10374

PPARα agonist fenofibrate prevents postoperative cognitive dysfunction by enhancing fatty acid oxidation in mice.

Liu T, Chen X, Wei Z, Han X, Liu Y, Ma Z, Xia T, Gu X
Translational neuroscience 2023 Jan 1;14(1):20220317

STAT6 promoting oxalate crystal deposition-induced renal fibrosis by mediating macrophage-to-myofibroblast transition via inhibiting fatty acid oxidation.

Yuan T, Xia Y, Pan S, Li B, Ye Z, Yan X, Hu W, Li L, Song B, Yu W, Li H, Rao T, Lin F, Zhou X, Cheng F
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Dec;72(12):2111-2126

Nobiletin Ameliorates Hepatic Lipid Deposition, Oxidative Stress, and Inflammation by Mechanisms That Involve the Nrf2/NF-κB Axis in Nonalcoholic Fatty Liver Disease.

Fan C, Ling-Hu A, Sun D, Gao W, Zhang C, Duan X, Li H, Tian W, Yu Q, Ke Z
Journal of agricultural and food chemistry 2023 Dec 20;71(50):20105-20117

Therapeutic Potential of Ginsenoside Rb1-PLGA Nanoparticles for Heart Failure Treatment via the ROS/PPARα/PGC1α Pathway.

Du L, Lu H, Wang Z, Liu C, Xiao Y, Guo Z, Li Y
Molecules (Basel, Switzerland) 2023 Dec 15;28(24)

Theabrownin of raw and ripened pu-erh tea varies in the alleviation of HFD-induced obesity via the regulation of gut microbiota.

Deng X, Zhang N, Wang Q, Huang Y, Huang Y, Lin Y, Huang M, Zheng F, Xiao M, Ye J
European journal of nutrition 2023 Aug;62(5):2177-2194

Melatonin alleviates cadmium-induced nonalcoholic fatty liver disease in ducks by alleviating autophagic flow arrest via PPAR-α and reducing oxidative stress.

Sun J, Bian Y, Ma Y, Ali W, Wang T, Yuan Y, Gu J, Bian J, Liu Z, Zou H
Poultry science 2023 Aug;102(8):102835

Diosgenin attenuates nonalcoholic hepatic steatosis through the hepatic FXR-SHP-SREBP1C/PPARα/CD36 pathway.

Chen S, Sun S, Feng Y, Li X, Yin G, Liang P, Yu W, Meng D, Zhang X, Liu H, Zhang F
European journal of pharmacology 2023 Aug 5;952:175808

Derivation and comprehensive analysis of ageing-related genes in intervertebral disc degeneration for prediction and immunology.

Xu S, Fu H, Weng S, Gu X, Li J
Mechanisms of ageing and development 2023 Apr;211:111794

Anti-inflammatory effect of Irisin on LPS-stimulated macrophages through inhibition of MAPK pathway.

Ma Y, Du Y, Yang J, He Q, Wang H, Lin X
Physiological research 2023 Apr 30;72(2):235-249

Berberrubine, a Main Metabolite of Berberine, Alleviates Non-Alcoholic Fatty Liver Disease via Modulating Glucose and Lipid Metabolism and Restoring Gut Microbiota.

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Frontiers in pharmacology 2022;13:913378

Dynein light chain LC8 alleviates nonalcoholic steatohepatitis by inhibiting NF-κB signaling and reducing oxidative stress.

Lee GR, Lee HI, Kim N, Lee J, Kwon M, Kang YH, Song HJ, Yeo CY, Jeong W
Journal of cellular physiology 2022 Sep;237(9):3554-3564

Ban-xia-xie-xin-tang ameliorates hepatic steatosis by regulating Cidea and Cidec expression in HFD-fed mice.

Xia QS, Gao Y, Wen-Bin W, Wu F, Dong H, Xu LJ, Fang K, Hu ML, Yuan F, Lu FE, Gong J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Oct;105:154351

RUNX2 recruits the NuRD(MTA1)/CRL4B complex to promote breast cancer progression and bone metastasis.

Yin X, Teng X, Ma T, Yang T, Zhang J, Huo M, Liu W, Yang Y, Yuan B, Yu H, Huang W, Wang Y
Cell death and differentiation 2022 Nov;29(11):2203-2217

Recombinant Humanized IgG1 Antibody Promotes Reverse Cholesterol Transport through FcRn-ERK1/2-PPARα Pathway in Hepatocytes.

Li Z, Zhang Q, Liu X, Zhao M
International journal of molecular sciences 2022 Nov 23;23(23)

Probiotic-fermented rice buckwheat alleviates high-fat diet-induced hyperlipidemia in mice by suppressing lipid accumulation and modulating gut microbiota.

Yan J, Xue Q, Chen W, Wang K, Peng D, Jiang J, Li P, Du B
Food research international (Ottawa, Ont.) 2022 May;155:111125

Loss of mitochondrial ATPase ATAD3A contributes to nonalcoholic fatty liver disease through accumulation of lipids and damaged mitochondria.

Chen L, Li Y, Sottas C, Lazaris A, Petrillo SK, Metrakos P, Li L, Ishida Y, Saito T, Garza S, Papadopoulos V
The Journal of biological chemistry 2022 Jun;298(6):102008

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Huo Y, Zhao G, Li J, Wang R, Ren F, Li Y, Wang X
Nutrients 2022 Jan 29;14(3)

Farnesoid X receptor regulates PI(3)K/AKT/mTOR signaling pathway, lipid metabolism, and immune response in hybrid grouper.

Xu J, Yao X, Li X, Xie S, Chi S, Zhang S, Cao J, Tan B
Fish physiology and biochemistry 2022 Dec;48(6):1521-1538

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Nature communications 2022 Dec 26;13(1):7940

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Hepatic COX-2 expression protects mice from an alcohol-high fat diet-induced metabolic disorder by involving protein acetylation related energy metabolism.

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Effects of dibutyl phthalate on lipid metabolism in liver and hepatocytes based on PPARα/SREBP-1c/FAS/GPAT/AMPK signal pathway.

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Effect of fenofibrate on proliferation of SMMC-7721 cells via regulating cell cycle.

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Chrysanthemi Flos extract alleviated acetaminophen-induced rat liver injury via inhibiting oxidative stress and apoptosis based on network pharmacology analysis.

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