27791-1-AP

antibody from Proteintech Group

Targeting: USP8 HumORF8, KIAA0055, SPG59, UBPY

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

27791-1-AP

Provider

Proteintech Group

Product name

USP8 antibody

Antibody type

Polyclonal

Description

KD/KO validated USP8 antibody (Cat. #27791-1-AP) is a rabbit polyclonal antibody that shows reactivity with Human, Mouse and has been validated for the following applications: IHC, WB,ELISA.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

USP8 attenuates ischemic stroke by inhibiting the microglial NF-κB/NLRP3 inflammatory axis via TRAF6 deubiquitination.

Ma L, Cheng Z, Shao J, Zhao M, Wang J, Zhu X, Xu T, Han Z
International immunopharmacology 2026 May 1;176:116480

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Male-biased Cyp17a2 orchestrates antiviral sexual dimorphism in fish via STING stabilization and viral protein degradation.

Lu LF, Cui BJ, Shi SC, Wang YY, Zhang C, Xu X, Tian MZ, Li ZQ, Xu N, Li ZC, Chen DD, Zhou L, Zhai G, Yin Z, Li S
eLife 2026 Feb 18;14

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USP8-Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity.

Zhang Q, Huang S, He Y, Wang W, Tong C, Ma M, Zhao M, Yi L, Knobeloch KP, Zhang P
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(34):e03865

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USP8 suppresses porcine reproductive and respiratory syndrome virus replication by positively regulating MAVS mediated Ⅰ-IFN signaling.

Chang X, Li Z, Wang M, Pei K, Wang J, Hu J, Ding K, Chang Y
Veterinary microbiology 2024 Nov;298:110286

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Tumorigenesis of basal muscle invasive bladder cancer was mediated by PTEN protein degradation resulting from SNHG1 upregulation.

Li T, Huang M, Sun N, Hua X, Chen R, Xie Q, Huang S, Du M, Zhao Y, Lin Q, Xu J, Han X, Zhao Y, Tian Z, Zhang Y, Chen W, Shen X, Huang C
Journal of experimental & clinical cancer research : CR 2024 Feb 17;43(1):50

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Mitochondria-targeted catalase induced cell malignant transformation by the downregulation of p53 protein stability via USP28/miR-200b/PP2A-Cα axis.

Wen C, Huang C, Liao X, Luo Z, Huang C
Archives of biochemistry and biophysics 2024 Aug;758:110047

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Targeting ubiquitin-specific protease 8 sensitizes anti-programmed death-ligand 1 immunotherapy of pancreatic cancer.

Yang H, Zhang X, Lao M, Sun K, He L, Xu J, Duan Y, Chen Y, Ying H, Li M, Guo C, Lu Q, Wang S, Su W, Liang T, Bai X
Cell death and differentiation 2023 Feb;30(2):560-575

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Knockdown of USP8 inhibits prostate cancer cell growth, proliferation, and metastasis and promotes docetaxel's activity by suppressing the NF-kB signaling pathway.

Islam MT, Chen FZ, Chen HC, Wahid A
Frontiers in oncology 2022;12:923270

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The Expression of Cell Cycle-Related Genes in USP8-Mutated Corticotroph Neuroendocrine Pituitary Tumors and Their Possible Role in Cell Cycle-Targeting Treatment.

Mossakowska BJ, Rusetska N, Konopinski R, Kober P, Maksymowicz M, Pekul M, Zieliński G, Styk A, Kunicki J, Bujko M
Cancers 2022 Nov 14;14(22)

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USP15 participates in DBP-induced testicular oxidative stress injury through regulating the Keap1/Nrf2 signaling pathway.

Zhang L, Gao X, Qin Z, Shi X, Xu K, Wang S, Tang M, Wang W, Gao S, Zuo L, Zhang L, Zhang W
The Science of the total environment 2021 Aug 20;783:146898

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Down-regulation of USP8 Inhibits Cholangiocarcinoma Cell Proliferation and Invasion.

Jing X, Chen Y, Chen Y, Shi G, Lv S, Cheng N, Feng C, Xin Z, Zhang L, Wu J
Cancer management and research 2020;12:2185-2194

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Exogenous H(2)S Promoted USP8 Sulfhydration to Regulate Mitophagy in the Hearts of db/db Mice.

Sun Y, Lu F, Yu X, Wang B, Chen J, Lu F, Peng S, Sun X, Yu M, Chen H, Wang Y, Zhang L, Liu N, Du H, Zhao D, Zhang W
Aging and disease 2020 Apr;11(2):269-285

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Glucocorticoid modulatory element-binding protein 1 (GMEB1) interacts with the de-ubiquitinase USP40 to stabilize CFLAR(L) and inhibit apoptosis in human non-small cell lung cancer cells.

An W, Yao S, Sun X, Hou Z, Lin Y, Su L, Liu X
Journal of experimental & clinical cancer research : CR 2019 May 2;38(1):181