BS8128

antibody from Bioworld Technology, Inc

Targeting: BCL7C

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

BS8128

Provider

Bioworld Technology, Inc

Product name

BCL7C polyclonal antibody

Antibody type

Polyclonal

Antigen

Recombinant full length Human BCL7C.

Description

Apoptosis is defined as a set of cascades which, when initiated, programs the cell to undergo lethal changes such as membrane blebbing, mitochondrial break down and DNA fragmentation. Bcl-7c (B-cell CLL/lymphoma 7 protein family member C) is a 217 amino acid anti-apoptotic protein that shares 90% sequence similarity to Bcl-7a. Knockdown of IL-10 mRNA induces apoptosis and leads to significant down-regulation of Bcl-7c, suggesting that a modulatory relationship exists between the two proteins. The gene encoding Bcl-7c maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn£ªs disease, which is a gastrointestinal inflammatory condition. There are two isoforms of Bcl-7c that are produced as a result of alternative splicing events.

Reactivity

Human

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.