14513-1-AP

antibody from Proteintech Group

Targeting: PSPH PSP

Provider product page for 14513-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [17]
Comments [0]
Validations
Western blot [1]

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Product number: 14513-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14513-1-AP, RRID:AB_2171464
Product name: PSPH antibody
Antibody type: Polyclonal
Description: KD/KO validated PSPH antibody (Cat. #14513-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PSPH protein structure - 14513-1-AP shown in red.

Submitted references CircMYH9 drives colorectal cancer growth by regulating serine metabolism and redox homeostasis in a p53-dependent manner.

Liu X, Liu Y, Liu Z, Lin C, Meng F, Xu L, Zhang X, Zhang C, Zhang P, Gong S, Wu N, Ren Z, Song J, Zhang Y
Molecular cancer 2021 Sep 8;20(1):114

Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin.

Byles V, Cormerais Y, Kalafut K, Barrera V, Hughes Hallett JE, Sui SH, Asara JM, Adams CM, Hoxhaj G, Ben-Sahra I, Manning BD
Molecular metabolism 2021 Nov;53:101309

Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation.

Shen L, Hu P, Zhang Y, Ji Z, Shan X, Ni L, Ning N, Wang J, Tian H, Shui G, Yuan Y, Li G, Zheng H, Yang XP, Huang D, Feng X, Li MJ, Liu Z, Wang T, Yu Q
Cell metabolism 2021 May 4;33(5):971-987.e6

Extracellular serine and glycine are required for mouse and human skeletal muscle stem and progenitor cell function.

Gheller BJ, Blum JE, Lim EW, Handzlik MK, Hannah Fong EH, Ko AC, Khanna S, Gheller ME, Bender EL, Alexander MS, Stover PJ, Field MS, Cosgrove BD, Metallo CM, Thalacker-Mercer AE
Molecular metabolism 2021 Jan;43:101106

Targeting p300/CBP Attenuates Hepatocellular Carcinoma Progression through Epigenetic Regulation of Metabolism.

Cai LY, Chen SJ, Xiao SH, Sun QJ, Ding CH, Zheng BN, Zhu XY, Liu SQ, Yang F, Yang YX, Zhou B, Luo C, Zhang X, Xie WF
Cancer research 2021 Feb 15;81(4):860-872

Bone metastatic breast cancer cells display downregulation of PKC-ζ with enhanced glutamine metabolism.

Tandon M, Othman AH, Winogradzki M, Pratap J
Gene 2021 Apr 5;775:145419

The breast cancer oncogene IKKε coordinates mitochondrial function and serine metabolism.

Xu R, Jones W, Wilcz-Villega E, Costa AS, Rajeeve V, Bentham RB, Bryson K, Nagano A, Yaman B, Olendo Barasa S, Wang Y, Chelala C, Cutillas P, Szabadkai G, Frezza C, Bianchi K
EMBO reports 2020 Sep 3;21(9):e48260

Interfering Expression of Chimeric Transcript SEPT7P2-PSPH Promotes Cell Proliferation in Patients with Nasopharyngeal Carcinoma.

Wang J, Xie GF, He Y, Deng L, Long YK, Yang XH, Ma JJ, Gong R, Cen WJ, Ye ZL, Zeng YX, Wang HY, Shao JY
Journal of oncology 2019;2019:1654724

PSPH Mediates the Metastasis and Proliferation of Non-small Cell Lung Cancer through MAPK Signaling Pathways.

Liao L, Ge M, Zhan Q, Huang R, Ji X, Liang X, Zhou X
International journal of biological sciences 2019;15(1):183-194

Berberine Inhibits Growth of Liver Cancer Cells by Suppressing Glutamine Uptake.

Zhang P, Wang Q, Lin Z, Yang P, Dou K, Zhang R
OncoTargets and therapy 2019;12:11751-11763

Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation.

Wang LW, Shen H, Nobre L, Ersing I, Paulo JA, Trudeau S, Wang Z, Smith NA, Ma Y, Reinstadler B, Nomburg J, Sommermann T, Cahir-McFarland E, Gygi SP, Mootha VK, Weekes MP, Gewurz BE
Cell metabolism 2019 Sep 3;30(3):539-555.e11

Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modifications.

Tian S, Feng J, Cao Y, Shen S, Cai Y, Yang D, Yan R, Wang L, Zhang H, Zhong X, Gao P
Life science alliance 2019 Oct;2(5)

The SIRT2/cMYC Pathway Inhibits Peroxidation-Related Apoptosis In Cholangiocarcinoma Through Metabolic Reprogramming.

Xu L, Wang L, Zhou L, Dorfman RG, Pan Y, Tang D, Wang Y, Yin Y, Jiang C, Zou X, Wu J, Zhang M
Neoplasia (New York, N.Y.) 2019 May;21(5):429-441

Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer.

Jin N, Bi A, Lan X, Xu J, Wang X, Liu Y, Wang T, Tang S, Zeng H, Chen Z, Tan M, Ai J, Xie H, Zhang T, Liu D, Huang R, Song Y, Leung EL, Yao X, Ding J, Geng M, Lin SH, Huang M
Nature communications 2019 Jun 20;10(1):2701

A novel inhibitor of tumorspheres reveals the activation of the serine biosynthetic pathway upon mitochondrial inhibition.

Subedi A, Muroi M, Futamura Y, Kawamura T, Aono H, Nishi M, Ryo A, Watanabe N, Osada H
FEBS letters 2019 Apr;593(8):763-776

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle.

Ben-Sahra I, Hoxhaj G, Ricoult SJH, Asara JM, Manning BD
Science (New York, N.Y.) 2016 Feb 12;351(6274):728-733

cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.

Sun L, Song L, Wan Q, Wu G, Li X, Wang Y, Wang J, Liu Z, Zhong X, He X, Shen S, Pan X, Li A, Wang Y, Gao P, Tang H, Zhang H
Cell research 2015 Apr;25(4):429-44

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The PSPH antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PSPH. This antibody recognizes human, mouse, rat antigen. The PSPH antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 14513-1-AP.pdf

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