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- References [26]
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- Product number
- 14513-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14513-1-AP, RRID:AB_2171464
- Product name
- PSPH antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PSPH antibody (Cat. #14513-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references ZEB1 Transcriptionally Activates PHGDH to Facilitate Carcinogenesis and Progression of HCC.
Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence.
Arginine limitation drives a directed codon-dependent DNA sequence evolution response in colorectal cancer cells.
PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma.
Ailanthone Inhibits Proliferation, Migration and Invasion of Osteosarcoma Cells by Downregulating the Serine Biosynthetic Pathway.
Phosphoserine phosphatase as an indicator for survival through potentially influencing the infiltration levels of immune cells in neuroblastoma.
The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis.
CHCHD2 and CHCHD10 regulate mitochondrial dynamics and integrated stress response.
CircMYH9 drives colorectal cancer growth by regulating serine metabolism and redox homeostasis in a p53-dependent manner.
Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells.
Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin.
Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation.
Extracellular serine and glycine are required for mouse and human skeletal muscle stem and progenitor cell function.
Targeting p300/CBP Attenuates Hepatocellular Carcinoma Progression through Epigenetic Regulation of Metabolism.
Bone metastatic breast cancer cells display downregulation of PKC-ζ with enhanced glutamine metabolism.
The breast cancer oncogene IKKε coordinates mitochondrial function and serine metabolism.
Interfering Expression of Chimeric Transcript SEPT7P2-PSPH Promotes Cell Proliferation in Patients with Nasopharyngeal Carcinoma.
PSPH Mediates the Metastasis and Proliferation of Non-small Cell Lung Cancer through MAPK Signaling Pathways.
Berberine Inhibits Growth of Liver Cancer Cells by Suppressing Glutamine Uptake.
Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation.
Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modifications.
The SIRT2/cMYC Pathway Inhibits Peroxidation-Related Apoptosis In Cholangiocarcinoma Through Metabolic Reprogramming.
Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer.
A novel inhibitor of tumorspheres reveals the activation of the serine biosynthetic pathway upon mitochondrial inhibition.
mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle.
cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.
Wang H, Lin F, Xu Z, Yu S, Li G, Liao S, Zhao W, Zhang F, Wang J, Wang S, Ouyang C, Zhang C, Xia H, Wu Y, Jiang B, Li Q
Cellular and molecular gastroenterology and hepatology 2023;16(4):541-556
Cellular and molecular gastroenterology and hepatology 2023;16(4):541-556
Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence.
Wu Y, Tang L, Huang H, Yu Q, Hu B, Wang G, Ge F, Yin T, Li S, Yu X
Nature communications 2023 Mar 10;14(1):1323
Nature communications 2023 Mar 10;14(1):1323
Arginine limitation drives a directed codon-dependent DNA sequence evolution response in colorectal cancer cells.
Hsu DJ, Gao J, Yamaguchi N, Pinzaru A, Wu Q, Mandayam N, Liberti M, Heissel S, Alwaseem H, Tavazoie S, Tavazoie SF
Science advances 2023 Jan 6;9(1):eade9120
Science advances 2023 Jan 6;9(1):eade9120
PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma.
Wang K, Luo L, Fu S, Wang M, Wang Z, Dong L, Wu X, Dai L, Peng Y, Shen G, Chen HN, Nice EC, Wei X, Huang C
Nature communications 2023 Feb 23;14(1):1011
Nature communications 2023 Feb 23;14(1):1011
Ailanthone Inhibits Proliferation, Migration and Invasion of Osteosarcoma Cells by Downregulating the Serine Biosynthetic Pathway.
Zhang Y, Gong R, Liu Y, Sun X, Liang J, Zhou Y, Wang Y, Yu W, Wang Y, Tang L, He A, Shen Z, Yao Y, Hu H, Liu X, Zhang J
Frontiers in oncology 2022;12:842406
Frontiers in oncology 2022;12:842406
Phosphoserine phosphatase as an indicator for survival through potentially influencing the infiltration levels of immune cells in neuroblastoma.
Zeng L, Liu XY, Chen K, Qin LJ, Wang FH, Miao L, Li L, Wang HY
Frontiers in cell and developmental biology 2022;10:873710
Frontiers in cell and developmental biology 2022;10:873710
The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis.
Zhu Y, Jin L, Shi R, Li J, Wang Y, Zhang L, Liang CZ, Narayana VK, De Souza DP, Thorne RF, Zhang LR, Zhang XD, Wu M
Molecular cell 2022 Feb 3;82(3):542-554.e6
Molecular cell 2022 Feb 3;82(3):542-554.e6
CHCHD2 and CHCHD10 regulate mitochondrial dynamics and integrated stress response.
Ruan Y, Hu J, Che Y, Liu Y, Luo Z, Cheng J, Han Q, He H, Zhou Q
Cell death & disease 2022 Feb 16;13(2):156
Cell death & disease 2022 Feb 16;13(2):156
CircMYH9 drives colorectal cancer growth by regulating serine metabolism and redox homeostasis in a p53-dependent manner.
Liu X, Liu Y, Liu Z, Lin C, Meng F, Xu L, Zhang X, Zhang C, Zhang P, Gong S, Wu N, Ren Z, Song J, Zhang Y
Molecular cancer 2021 Sep 8;20(1):114
Molecular cancer 2021 Sep 8;20(1):114
Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells.
Wang J, Filippakis H, Hougard T, Du H, Ye C, Liu HJ, Zhang L, Hindi K, Bagwe S, Nijmeh J, Asara JM, Shi W, El-Chemaly S, Henske EP, Lam HC
Proceedings of the National Academy of Sciences of the United States of America 2021 Sep 28;118(39)
Proceedings of the National Academy of Sciences of the United States of America 2021 Sep 28;118(39)
Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin.
Byles V, Cormerais Y, Kalafut K, Barrera V, Hughes Hallett JE, Sui SH, Asara JM, Adams CM, Hoxhaj G, Ben-Sahra I, Manning BD
Molecular metabolism 2021 Nov;53:101309
Molecular metabolism 2021 Nov;53:101309
Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation.
Shen L, Hu P, Zhang Y, Ji Z, Shan X, Ni L, Ning N, Wang J, Tian H, Shui G, Yuan Y, Li G, Zheng H, Yang XP, Huang D, Feng X, Li MJ, Liu Z, Wang T, Yu Q
Cell metabolism 2021 May 4;33(5):971-987.e6
Cell metabolism 2021 May 4;33(5):971-987.e6
Extracellular serine and glycine are required for mouse and human skeletal muscle stem and progenitor cell function.
Gheller BJ, Blum JE, Lim EW, Handzlik MK, Hannah Fong EH, Ko AC, Khanna S, Gheller ME, Bender EL, Alexander MS, Stover PJ, Field MS, Cosgrove BD, Metallo CM, Thalacker-Mercer AE
Molecular metabolism 2021 Jan;43:101106
Molecular metabolism 2021 Jan;43:101106
Targeting p300/CBP Attenuates Hepatocellular Carcinoma Progression through Epigenetic Regulation of Metabolism.
Cai LY, Chen SJ, Xiao SH, Sun QJ, Ding CH, Zheng BN, Zhu XY, Liu SQ, Yang F, Yang YX, Zhou B, Luo C, Zhang X, Xie WF
Cancer research 2021 Feb 15;81(4):860-872
Cancer research 2021 Feb 15;81(4):860-872
Bone metastatic breast cancer cells display downregulation of PKC-ζ with enhanced glutamine metabolism.
Tandon M, Othman AH, Winogradzki M, Pratap J
Gene 2021 Apr 5;775:145419
Gene 2021 Apr 5;775:145419
The breast cancer oncogene IKKε coordinates mitochondrial function and serine metabolism.
Xu R, Jones W, Wilcz-Villega E, Costa AS, Rajeeve V, Bentham RB, Bryson K, Nagano A, Yaman B, Olendo Barasa S, Wang Y, Chelala C, Cutillas P, Szabadkai G, Frezza C, Bianchi K
EMBO reports 2020 Sep 3;21(9):e48260
EMBO reports 2020 Sep 3;21(9):e48260
Interfering Expression of Chimeric Transcript SEPT7P2-PSPH Promotes Cell Proliferation in Patients with Nasopharyngeal Carcinoma.
Wang J, Xie GF, He Y, Deng L, Long YK, Yang XH, Ma JJ, Gong R, Cen WJ, Ye ZL, Zeng YX, Wang HY, Shao JY
Journal of oncology 2019;2019:1654724
Journal of oncology 2019;2019:1654724
PSPH Mediates the Metastasis and Proliferation of Non-small Cell Lung Cancer through MAPK Signaling Pathways.
Liao L, Ge M, Zhan Q, Huang R, Ji X, Liang X, Zhou X
International journal of biological sciences 2019;15(1):183-194
International journal of biological sciences 2019;15(1):183-194
Berberine Inhibits Growth of Liver Cancer Cells by Suppressing Glutamine Uptake.
Zhang P, Wang Q, Lin Z, Yang P, Dou K, Zhang R
OncoTargets and therapy 2019;12:11751-11763
OncoTargets and therapy 2019;12:11751-11763
Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation.
Wang LW, Shen H, Nobre L, Ersing I, Paulo JA, Trudeau S, Wang Z, Smith NA, Ma Y, Reinstadler B, Nomburg J, Sommermann T, Cahir-McFarland E, Gygi SP, Mootha VK, Weekes MP, Gewurz BE
Cell metabolism 2019 Sep 3;30(3):539-555.e11
Cell metabolism 2019 Sep 3;30(3):539-555.e11
Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modifications.
Tian S, Feng J, Cao Y, Shen S, Cai Y, Yang D, Yan R, Wang L, Zhang H, Zhong X, Gao P
Life science alliance 2019 Oct;2(5)
Life science alliance 2019 Oct;2(5)
The SIRT2/cMYC Pathway Inhibits Peroxidation-Related Apoptosis In Cholangiocarcinoma Through Metabolic Reprogramming.
Xu L, Wang L, Zhou L, Dorfman RG, Pan Y, Tang D, Wang Y, Yin Y, Jiang C, Zou X, Wu J, Zhang M
Neoplasia (New York, N.Y.) 2019 May;21(5):429-441
Neoplasia (New York, N.Y.) 2019 May;21(5):429-441
Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer.
Jin N, Bi A, Lan X, Xu J, Wang X, Liu Y, Wang T, Tang S, Zeng H, Chen Z, Tan M, Ai J, Xie H, Zhang T, Liu D, Huang R, Song Y, Leung EL, Yao X, Ding J, Geng M, Lin SH, Huang M
Nature communications 2019 Jun 20;10(1):2701
Nature communications 2019 Jun 20;10(1):2701
A novel inhibitor of tumorspheres reveals the activation of the serine biosynthetic pathway upon mitochondrial inhibition.
Subedi A, Muroi M, Futamura Y, Kawamura T, Aono H, Nishi M, Ryo A, Watanabe N, Osada H
FEBS letters 2019 Apr;593(8):763-776
FEBS letters 2019 Apr;593(8):763-776
mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle.
Ben-Sahra I, Hoxhaj G, Ricoult SJH, Asara JM, Manning BD
Science (New York, N.Y.) 2016 Feb 12;351(6274):728-733
Science (New York, N.Y.) 2016 Feb 12;351(6274):728-733
cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.
Sun L, Song L, Wan Q, Wu G, Li X, Wang Y, Wang J, Liu Z, Zhong X, He X, Shen S, Pan X, Li A, Wang Y, Gao P, Tang H, Zhang H
Cell research 2015 Apr;25(4):429-44
Cell research 2015 Apr;25(4):429-44
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PSPH antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PSPH. This antibody recognizes human, mouse, rat antigen. The PSPH antibody has been validated for the following applications: ELISA, WB analysis.
