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- Antigen structure
- References [30]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 10801-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10801-1-AP, RRID:AB_2172462
- Product name
- PSAP antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PSAP antibody (Cat. #10801-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Spatial 5mC-seq profiling of embryos and decidua after implantation in mammals.
Secretory full-length human prosaposin (PSAP) inhibits SARS-CoV-2 infection through facilitating the release of S1 subunit of spike protein.
Proteomic analysis identifying proteins relevant for treatment success following experimental neonatal inflammation-sensitized hypoxia-ischemia.
Accumulation of prosaposin and progranulin around the subfornical organ induces polydipsia in SAP-D-deficient mice.
Progranulin-driven lysosomal acidification facilitates exocytosis of PHEV-hijacked lysosomes for viral release.
GRASP55 maintains lysosome function by controlling sorting of lysosomal enzymes at the Golgi.
Temporal biphasic regulation of photoreceptor degeneration by microglial TREM2: A metabolic-immune nexus in retinitis pigmentosa.
AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice.
Oligodendrocytes drive neuroinflammation and neurodegeneration in Parkinson's disease via the prosaposin-GPR37-IL-6 axis.
Intranasal administration of recombinant prosaposin attenuates neuronal apoptosis through GPR37/PI3K/Akt/ASK1 pathway in MCAO rats.
Metabolic reprogramming and heterogeneity during the decidualization process of endometrial stromal cells.
Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents.
Integrative Transcriptomic Analyses of Hippocampal-Entorhinal System Subfields Identify Key Regulators in Alzheimer's Disease.
Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis.
Decreased Prosaposin and Progranulin in the Cingulate Cortex Are Associated with Schizophrenia Pathophysiology.
Multi-omics analysis unravels dysregulated lysosomal function and lipid metabolism involved in sub-chronic particulate matter-induced pulmonary injury.
Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis.
Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer's disease brains.
Proteomic analysis of intracellular protein corona of nanoparticles elucidates nano-trafficking network and nano-bio interactions.
Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant wobbler mice, a model of motor neuron degeneration.
GPR37 Signaling Modulates Migration of Olfactory Ensheathing Cells and Gonadotropin Releasing Hormone Cells in Mice.
The interaction between progranulin and prosaposin is mediated by granulins and the linker region between saposin B and C.
Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations.
Dengue Virus Hijacks a Noncanonical Oxidoreductase Function of a Cellular Oligosaccharyltransferase Complex.
Prosaposin is a regulator of progranulin levels and oligomerization.
Prosaposin, a regulator of estrogen receptor alpha, promotes breast cancer growth.
Sparc-like protein 1 is a new marker of human glioma progression.
Serum prosaposin levels are increased in patients with advanced prostate cancer.
Proteomic analysis of synaptosomal protein expression reveals that cerebral ischemia alters lysosomal Psap processing.
Prosaposin in the secretome of marrow stroma-derived neural progenitor cells protects neural cells from apoptotic death.
Shan X, Tang Y, Hu J, Bian M, Yao X, Gao L, Liu J
Nature methods 2026 May;23(5):924-934
Nature methods 2026 May;23(5):924-934
Secretory full-length human prosaposin (PSAP) inhibits SARS-CoV-2 infection through facilitating the release of S1 subunit of spike protein.
Zhang C, Ding P, Xiao X, Wang B, Huang H, Zhang Q, Ren L, Xiang Z, Zhou Z, Lei X, Wang J
mBio 2026 May 13;17(5):e0012926
mBio 2026 May 13;17(5):e0012926
Proteomic analysis identifying proteins relevant for treatment success following experimental neonatal inflammation-sensitized hypoxia-ischemia.
Burkard H, Osredkar D, Maes E, Bernis ME, Bremer AS, Zweyer M, Dowling P, Ohlendieck K, Thoresen M, Sabir H
Pediatric research 2026 Mar;99(4):1591-1601
Pediatric research 2026 Mar;99(4):1591-1601
Accumulation of prosaposin and progranulin around the subfornical organ induces polydipsia in SAP-D-deficient mice.
Hisaki H, Susa T, Okudaira N, Akimoto M, Iizuka M, Matsuda J, Uchida S, Okinaga H, Okazaki T, Tamamori-Adachi M
Biochemistry and biophysics reports 2026 Mar;45:102388
Biochemistry and biophysics reports 2026 Mar;45:102388
Progranulin-driven lysosomal acidification facilitates exocytosis of PHEV-hijacked lysosomes for viral release.
Wang Z, Chen Y, He W, Liu Y, Jiao Y, Wang G, Guan J, Zhao K, Zhang Q, Gao F, Li Z, Lan Y
mBio 2026 Jan 14;17(1):e0290325
mBio 2026 Jan 14;17(1):e0290325
GRASP55 maintains lysosome function by controlling sorting of lysosomal enzymes at the Golgi.
Nüchel J, Omidi M, Fernandes SA, Tauber M, Pohl S, Plomann M, Demetriades C
EMBO reports 2026 Apr 16;
EMBO reports 2026 Apr 16;
Temporal biphasic regulation of photoreceptor degeneration by microglial TREM2: A metabolic-immune nexus in retinitis pigmentosa.
Li R, Zhang J, Wu JM, Fan JQ, Lin B
Science advances 2025 Sep 12;11(37):eadw9299
Science advances 2025 Sep 12;11(37):eadw9299
AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice.
Hu Z, Yang J, Zhang S, Li M, Zuo C, Mao C, Zhang Z, Tang M, Shi C, Xu Y
Neural regeneration research 2025 Jan 1;20(1):253-264
Neural regeneration research 2025 Jan 1;20(1):253-264
Oligodendrocytes drive neuroinflammation and neurodegeneration in Parkinson's disease via the prosaposin-GPR37-IL-6 axis.
Ma Q, Tian JL, Lou Y, Guo R, Ma XR, Wu JB, Yang J, Tang BJ, Li S, Qiu M, Duan S, Zhao JW, Zhang J, Xu ZZ
Cell reports 2025 Feb 25;44(2):115266
Cell reports 2025 Feb 25;44(2):115266
Intranasal administration of recombinant prosaposin attenuates neuronal apoptosis through GPR37/PI3K/Akt/ASK1 pathway in MCAO rats.
Yu J, Li J, Matei N, Wang W, Tang L, Pang J, Li X, Fang L, Tang J, Zhang JH, Yan M
Experimental neurology 2024 Mar;373:114656
Experimental neurology 2024 Mar;373:114656
Metabolic reprogramming and heterogeneity during the decidualization process of endometrial stromal cells.
Jia Z, Wei Y, Zhang Y, Song K, Yuan J
Cell communication and signaling : CCS 2024 Jul 30;22(1):385
Cell communication and signaling : CCS 2024 Jul 30;22(1):385
Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents.
He Y, Kaya I, Shariatgorji R, Lundkvist J, Wahlberg LU, Nilsson A, Mamula D, Kehr J, Zareba-Paslawska J, Biverstål H, Chergui K, Zhang X, Andren PE, Svenningsson P
Nature communications 2023 Sep 19;14(1):5804
Nature communications 2023 Sep 19;14(1):5804
Integrative Transcriptomic Analyses of Hippocampal-Entorhinal System Subfields Identify Key Regulators in Alzheimer's Disease.
Luo D, Li J, Liu H, Wang J, Xia Y, Qiu W, Wang N, Wang X, Wang X, Ma C, Ge W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Aug;10(22):e2300876
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Aug;10(22):e2300876
Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis.
Boland S, Swarup S, Ambaw YA, Malia PC, Richards RC, Fischer AW, Singh S, Aggarwal G, Spina S, Nana AL, Grinberg LT, Seeley WW, Surma MA, Klose C, Paulo JA, Nguyen AD, Harper JW, Walther TC, Farese RV Jr
Nature communications 2022 Oct 7;13(1):5924
Nature communications 2022 Oct 7;13(1):5924
Decreased Prosaposin and Progranulin in the Cingulate Cortex Are Associated with Schizophrenia Pathophysiology.
He Y, Zhang X, Flais I, Svenningsson P
International journal of molecular sciences 2022 Oct 10;23(19)
International journal of molecular sciences 2022 Oct 10;23(19)
Multi-omics analysis unravels dysregulated lysosomal function and lipid metabolism involved in sub-chronic particulate matter-induced pulmonary injury.
Yan L, Chen S, Hou C, Lin J, Xiong W, Shen Y, Zhou T
The Science of the total environment 2022 Aug 25;836:155642
The Science of the total environment 2022 Aug 25;836:155642
Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis.
Tian R, Abarientos A, Hong J, Hashemi SH, Yan R, Dräger N, Leng K, Nalls MA, Singleton AB, Xu K, Faghri F, Kampmann M
Nature neuroscience 2021 Jul;24(7):1020-1034
Nature neuroscience 2021 Jul;24(7):1020-1034
Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer's disease brains.
Sharoar MG, Palko S, Ge Y, Saido TC, Yan R
Molecular neurodegeneration 2021 Jul 2;16(1):45
Molecular neurodegeneration 2021 Jul 2;16(1):45
Proteomic analysis of intracellular protein corona of nanoparticles elucidates nano-trafficking network and nano-bio interactions.
Qin M, Zhang J, Li M, Yang D, Liu D, Song S, Fu J, Zhang H, Dai W, Wang X, Wang Y, He B, Zhang Q
Theranostics 2020;10(3):1213-1229
Theranostics 2020;10(3):1213-1229
Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant wobbler mice, a model of motor neuron degeneration.
Petit CS, Lee JJ, Boland S, Swarup S, Christiano R, Lai ZW, Mejhert N, Elliott SD, McFall D, Haque S, Huang EJ, Bronson RT, Harper JW, Farese RV Jr, Walther TC
Proceedings of the National Academy of Sciences of the United States of America 2020 May 12;117(19):10565-10574
Proceedings of the National Academy of Sciences of the United States of America 2020 May 12;117(19):10565-10574
GPR37 Signaling Modulates Migration of Olfactory Ensheathing Cells and Gonadotropin Releasing Hormone Cells in Mice.
Saadi H, Shan Y, Marazziti D, Wray S
Frontiers in cellular neuroscience 2019;13:200
Frontiers in cellular neuroscience 2019;13:200
The interaction between progranulin and prosaposin is mediated by granulins and the linker region between saposin B and C.
Zhou X, Sullivan PM, Sun L, Hu F
Journal of neurochemistry 2017 Oct;143(2):236-243
Journal of neurochemistry 2017 Oct;143(2):236-243
Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations.
Zhou X, Sun L, Bracko O, Choi JW, Jia Y, Nana AL, Brady OA, Hernandez JCC, Nishimura N, Seeley WW, Hu F
Nature communications 2017 May 25;8:15277
Nature communications 2017 May 25;8:15277
Dengue Virus Hijacks a Noncanonical Oxidoreductase Function of a Cellular Oligosaccharyltransferase Complex.
Lin DL, Cherepanova NA, Bozzacco L, MacDonald MR, Gilmore R, Tai AW
mBio 2017 Jul 18;8(4)
mBio 2017 Jul 18;8(4)
Prosaposin is a regulator of progranulin levels and oligomerization.
Nicholson AM, Finch NA, Almeida M, Perkerson RB, van Blitterswijk M, Wojtas A, Cenik B, Rotondo S, Inskeep V, Almasy L, Dyer T, Peralta J, Jun G, Wood AR, Frayling TM, Fuchsberger C, Fowler S, Teslovich TM, Manning AK, Kumar S, Curran J, Lehman D, Abecasis G, Duggirala R, Pottier C, Zahir HA, Crook JE, Karydas A, Mitic L, Sun Y, Dickson DW, Bu G, Herz J, Yu G, Miller BL, Ferguson S, Petersen RC, Graff-Radford N, Blangero J, Rademakers R
Nature communications 2016 Jun 30;7:11992
Nature communications 2016 Jun 30;7:11992
Prosaposin, a regulator of estrogen receptor alpha, promotes breast cancer growth.
Wu Y, Sun L, Zou W, Xu J, Liu H, Wang W, Yun X, Gu J
Cancer science 2012 Oct;103(10):1820-5
Cancer science 2012 Oct;103(10):1820-5
Sparc-like protein 1 is a new marker of human glioma progression.
Turtoi A, Musmeci D, Naccarato AG, Scatena C, Ortenzi V, Kiss R, Murtas D, Patsos G, Mazzucchelli G, De Pauw E, Bevilacqua G, Castronovo V
Journal of proteome research 2012 Oct 5;11(10):5011-21
Journal of proteome research 2012 Oct 5;11(10):5011-21
Serum prosaposin levels are increased in patients with advanced prostate cancer.
Koochekpour S, Hu S, Vellasco-Gonzalez C, Bernardo R, Azabdaftari G, Zhu G, Zhau HE, Chung LW, Vessella RL
The Prostate 2012 Feb;72(3):253-69
The Prostate 2012 Feb;72(3):253-69
Proteomic analysis of synaptosomal protein expression reveals that cerebral ischemia alters lysosomal Psap processing.
Costain WJ, Haqqani AS, Rasquinha I, Giguere MS, Slinn J, Zurakowski B, Stanimirovic DB
Proteomics 2010 Sep;10(18):3272-91
Proteomics 2010 Sep;10(18):3272-91
Prosaposin in the secretome of marrow stroma-derived neural progenitor cells protects neural cells from apoptotic death.
Li N, Sarojini H, An J, Wang E
Journal of neurochemistry 2010 Mar;112(6):1527-38
Journal of neurochemistry 2010 Mar;112(6):1527-38
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 10801-1-AP(PSAP antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lung cancer using 10801-1-AP(PSAP antibody) at dilution of 1:200 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PSAP antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PSAP. This antibody recognizes human, mouse antigen. The PSAP antibody has been validated for the following applications: ELISA, IHC, WB analysis.
