CABT-B8533

antibody from Creative Diagnostics

Targeting: NPPA ANP, PND

ELISA (Recommended by provider)

Antibody Data

Product number

CABT-B8533

Provider

Creative Diagnostics

Product name

Anti-ANP (aa 12-25) monoclonal antibody, clone B247-23

Antibody type

Monoclonal

Description

Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilatation. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. Defects in NPPA are the cause of atrial fibrillation familial type 6 (ATFB6) [MIM:612201]. Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in asmall subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure.

Reactivity

Human, Mouse, Rat, Hamster, Simian

Host

Mouse

Conjugate

Unconjugated

Antibody clone number

B247-23

Storage

Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C.