Explore
Validate
Learn
Western blotAntibody data
- Antibody Data
- Antigen structure
- References [91]
- Comments [0]
- Validations [0]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 27426-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- NPPA antibody
- Antibody type
- Polyclonal
- Description
- NPPA antibody (Cat. #27426-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references USP13 ameliorates diabetic cardiomyopathy via deubiquitinating NLRP3 and inhibiting pyroptosis in cardiomyocytes.
TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2.
Structural Diversity of 2-O-(β-d-Glucopyranosyl)benzyl Quinates from Casearia tardieuae and Their Anti-Myocardial Hypertrophy Activity in Rat Cardiomyocytes.
Finerenone improves doxorubicin-induced cardiotoxicity by inhibiting cardiomyocyte apoptosis through the TAK1-p38 axis.
CTRP9 ameliorates heart failure with preserved ejection fraction by regulating lipid metabolism.
Thymoquinone Protects Against Cardiac Hypertrophy via PPAR-γ/PI3K/Akt Pathway.
Phosphoproteomics identification of ERK-dependent activation of Rps6kb1 in cardiac hypertrophy.
Tetrahedral Framework Nucleic Acids Inhibit Oxidative Stress and Cardiomyocyte Apoptosis in Doxorubicin-Induced Cardiotoxicity.
Thymoquinone and aerobic exercise mitigate HFpEF-induced cardiac injury via Apaf1/Cycs axis regulation.
Gut Metabolite Indole-3-Propionic Acid Regulates Macrophage Autophagy Through PPT1 Inhibiting Aging-Related Myocardial Fibrosis.
Novel pH-Responsive PSS-Loaded Chitosan Matrix Nanoparticles Ameliorate Pressure Overload-Induced Cardiac Hypertrophy.
Evodiamine protects against cardiac remodeling in heart failure through modulation of calcium signaling and CD47.
Vericiguat as a novel PPARα ligand alleviates pressure-overload-induced heart failure.
Circular RNA Rftn1 Promotes Cardiac Hypertrophy In Vitro and In Vivo by Sponging miRNA-1192 to Upregulate Tripartite Motif Protein 25 and 41.
Harnessing integrated bioinformatics to identify new diagnostic and therapeutic strategies for heart failure.
Histone H3 Lysine 18 Lactylation Promotes Cardiac Hypertrophy Through Activating GATA Binding Protein 4 Signaling.
YOD1 mediates isoproterenol-induced cardiac remodeling by deubiquitinating PKM2 and reducing PKM2 tetramerization in cardiomyocytes.
Role of EZH2 in regulating c-Myc stability through the E3 ubiquitin ligase HUWE1 in heart failure and its mechanisms.
Identification of novel biomarkers for hypertension and ventricular remodeling based on transcriptomics and machine learning.
A critical role for IL-21/IL-21 receptor signaling in isoproterenol-induced cardiac remodeling.
Asb10 accelerates pathological cardiac remodeling by stabilizing HSP70.
Methylophiopogonanone A alleviates diabetic cardiomyopathy via inhibiting JNK1 signaling.
Single-nuclei multiomics analysis identifies abnormal cardiomyocytes in a murine model of cardiac development.
Podocarpane and cleistanthane diterpenoids from Strophioblachia glandulosa: structural elucidation, anti-hypertrophy activity and network pharmacology.
PINK1 modulates Prdx2 to reduce lipotoxicity-induced apoptosis and attenuate cardiac dysfunction in heart failure mice with a preserved ejection fraction.
The synergistic protective effects of paeoniflorin and β-ecdysterone against cardiac hypertrophy through suppressing oxidative stress and ferroptosis.
Exosomes derived from cardiac fibroblasts with Ang-II stimulation provoke myocardial hypertrophy via miR-15b-5p/PTEN-L axis.
Structure Optimization of Natural Product Catalpol to Obtain Novel and Potent Analogs against Heart Failure.
Bee venom alleviates isoproterenol-induced cardiac hypertrophy via JAK2/NF-κB signaling cascade.
Exercise alleviates programmed necrosis in myocardial ischemia-reperfusion injury through adipose tissue-derived exosomal miR-17-3p targeting CAMKII.
OTUB2 aggravates pathological cardiac hypertrophy through Rac1 activation.
Pegmolesatide ameliorates indoxyl sulfate-induced cardiomyocyte hypertrophy through modulating the EPOR-CD131-dependent JAK2/STAT3 signaling pathway.
Loss of Trim31 Worsens Cardiac Remodeling in a Mouse Model of Heart Failure by Enhancing the Activation of the NLRP3 Inflammasome.
Inflammation-Related Factors S100A9 and TLR2 in Cardiomyocyte Hypertrophy.
SD49-7 attenuates cardiac hypertrophy by upregulation of S100B through KDM4A inhibition.
Fenofibrate Differently Affects the Heart's Morphology and Metabolism in Young and Old Rats.
Asprosin attenuates diabetic cardiomyopathy through inhibiting autophagy mediated by AMPK/mTOR/ULK1 pathway.
Thymoquinone mitigates cardiac hypertrophy by activating adaptive autophagy via the PPAR‑γ/14‑3‑3γ pathway.
Contributing role and molecular basis of Vitamin D/Vitamin D receptor deficiency in hyperhomocysteinemia-induced cardiac hypertrophy.
Protein interactions, network pharmacology, and machine learning work together to predict genes linked to mitochondrial dysfunction in hypertrophic cardiomyopathy.
SNAP25-dependent membrane trafficking of the Kv1.5 channel regulates the onset of atrial fibrillation.
Inhibiting glycosphingolipids alleviates cardiac hypertrophy by reducing reactive oxygen species and restoring autophagic homeostasis.
Comprehensive analysis of disulfidptosis-related genes and the immune microenvironment in heart failure.
Role of KLF4 and SIAT7A interaction accelerates myocardial hypertrophy induced by Ang II.
Vericiguat attenuates doxorubicin-induced cardiotoxicity through the PRKG1/PINK1/STING axis.
Ibrutinib Contributes to Atrial Arrhythmia through the Autophagic Degradation of Connexins by Inhibiting the PI3K-AKT-mTOR Signaling Pathway.
Proline metabolic reprogramming modulates cardiac remodeling induced by pressure overload in the heart.
OTUD1 promotes isoprenaline- and myocardial infarction-induced heart failure by targeting PDE5A in cardiomyocytes.
The mechanisms and therapeutic potential of clopidogrel in mitigating diabetic cardiomyopathy in db/db mice.
MCT4-dependent lactate transport: a novel mechanism for cardiac energy metabolism injury and inflammation in type 2 diabetes mellitus.
The total xanthones extracted from Gentianella acuta alleviates HFpEF by activating the IRE1α/Xbp1s pathway.
Lycorine inhibits Ang II-induced heart remodeling and inflammation by suppressing the PI3K-AKT/NF-κB pathway.
Overexpression of macrophage migration inhibitory factor protects against pressure overload-induced cardiac hypertrophy through regulating the miR-29b-3p/HBP1 axis.
Carnosol attenuates angiotensin II-induced cardiac remodeling and inflammation via directly binding to p38 and inhibiting p38 activation.
Carnosol prevents cardiac remodeling and ventricular arrhythmias in pressure overload-induced heart failure mice.
Inhibition of N-acetylglucosaminyltransferase V alleviates diabetic cardiomyopathy in mice by attenuating cardiac hypertrophy and fibrosis.
PKD knockdown mitigates Ang II-induced cardiac hypertrophy and ferroptosis via the JNK/P53 signaling pathway.
CTRP3 alleviates mitochondrial dysfunction and oxidative stress injury in pathological cardiac hypertrophy by activating UPRmt via the SIRT1/ATF5 axis.
α-Ketoglutarate improves cardiac insufficiency through NAD(+)-SIRT1 signaling-mediated mitophagy and ferroptosis in pressure overload-induced mice.
JOSD2 mediates isoprenaline-induced heart failure by deubiquitinating CaMKIIδ in cardiomyocytes.
Protoilludane-Type and Related Nor-Sesquiterpenes from Phellinus hartigii and Their Anti-Hypertrophic Activities in Rat Cardiomyocytes.
Identification and validation of autophagy‑related genes in hypertrophic cardiomyopathy.
Qianyang yuyin granule ameliorates mitochondrial dysfunction of hypertensive myocardial remodeling.
Interleukin(IL)-37 attenuates isoproterenol (ISO)-induced cardiac hypertrophy by suppressing JAK2/STAT3-signaling associated inflammation and oxidative stress.
Baicalin improves isoproterenol-induced cardiac remodeling by regulating the Nrf2-dependent signaling pathway.
miR-421-mediated suppression of FGF13 as a novel mechanism ameliorates cardiac hypertrophy by inhibiting endoplasmic reticulum stress.
Lactate regulates pathological cardiac hypertrophy via histone lactylation modification.
BCAA mediated microbiota-liver-heart crosstalk regulates diabetic cardiomyopathy via FGF21.
Exercise training affects calcium ion transport by downregulating the CACNA2D1 protein to reduce hypertension-induced myocardial injury in mice.
Identification of diagnostic immune-related gene biomarkers for predicting heart failure after acute myocardial infarction.
Dapagliflozin attenuates myocardial hypertrophy via activating the SIRT1/HIF-1α signaling pathway.
Chronic β-adrenergic stress contributes to cardiomyopathy in rodents with collagen-induced arthritis.
SOX4 as a potential therapeutic target for pathological cardiac hypertrophy.
CD9 exacerbates pathological cardiac hypertrophy through regulating GP130/STAT3 signaling pathway.
GLUT4 mediates the protective function of gastrodin against pressure overload-induced cardiac hypertrophy.
HypERlnc attenuates angiotensin II-induced cardiomyocyte hypertrophy via promoting SIRT1 SUMOylation-mediated activation of PGC-1α/PPARα pathway in AC16 cells.
Trim65 attenuates isoproterenol-induced cardiac hypertrophy by promoting autophagy and ameliorating mitochondrial dysfunction via the Jak1/Stat1 signaling pathway.
Exploring novel biomarkers in dilated cardiomyopathy‑induced heart failure by integrated analysis and in vitro experiments.
G9a inhibition promotes the formation of pacemaker-like cells by reducing the enrichment of H3K9me2 in the HCN4 promoter region.
Muscone inhibits angiotensin II-induced cardiac hypertrophy through the STAT3, MAPK and TGF-β/SMAD signaling pathways.
Soluble epoxide hydrolase and TRPC3 channels jointly contribute to homocysteine-induced cardiac hypertrophy: Interrelation and regulation by C/EBPβ.
Metformin Collaborates with PINK1/Mfn2 Overexpression to Prevent Cardiac Injury by Improving Mitochondrial Function.
SUMOylation of SIRT1 activating PGC-1α/PPARα pathway mediates the protective effect of LncRNA-MHRT in cardiac hypertrophy.
Transient Receptor Potential Vanilloid Type 1 Protects Against Pressure Overload-Induced Cardiac Hypertrophy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes.
Overexpression of cytosolic long noncoding RNA cytb protects against pressure-overload-induced heart failure via sponging microRNA-103-3p.
Cullin-associated and neddylation-dissociated 1 protein (CAND1) governs cardiac hypertrophy and heart failure partially through regulating calcineurin degradation.
Gastrodin Exerts Cardioprotective Action via Inhibition of Insulin-Like Growth Factor Type 2/Insulin-Like Growth Factor Type 2 Receptor Expression in Cardiac Hypertrophy.
CBL aggravates Ang II-induced cardiac hypertrophy via the VHL/HIF-1α pathway.
Pygo1 regulates pathological cardiac hypertrophy via a β-catenin-dependent mechanism.
Examination of the Effect of a 50-Hz Electromagnetic Field at 500 μT on Parameters Related With the Cardiovascular System in Rats.
Ranolazine prevents pressure overload-induced cardiac hypertrophy and heart failure by restoring aberrant Na(+) and Ca(2+) handling.
Xu D, Han J, Ye B, Lin L, Chen J, Jin Y, Zhao Y, Wang Y, Shan P, Liang G
Cell death and differentiation 2026 May;33(5):914-929
Cell death and differentiation 2026 May;33(5):914-929
TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2.
Zhao R, Cui X, Du H, Wang Z, Liu C, Zhang L, Qi J, Yang D, Yu H, Yan S, Liu W, Sun H, Wang M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(17):e21337
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(17):e21337
Structural Diversity of 2-O-(β-d-Glucopyranosyl)benzyl Quinates from Casearia tardieuae and Their Anti-Myocardial Hypertrophy Activity in Rat Cardiomyocytes.
Zhang JJ, Zhang HY, Li N, Jiang F, Luo SZ, Xiao WL, Zheng CB, Li XL
Journal of agricultural and food chemistry 2026 Mar 4;74(8):6850-6863
Journal of agricultural and food chemistry 2026 Mar 4;74(8):6850-6863
Finerenone improves doxorubicin-induced cardiotoxicity by inhibiting cardiomyocyte apoptosis through the TAK1-p38 axis.
Lai X, Wang Y, Zhang J, Xie H, Wu S, Wang L
Biochemical pharmacology 2026 Jul;249:117877
Biochemical pharmacology 2026 Jul;249:117877
CTRP9 ameliorates heart failure with preserved ejection fraction by regulating lipid metabolism.
Xin J, Liu R, Deng M, Song Y, Cui Y, Gao J, Zhang B, Feng L, Mu X, Cui J, Li H, Zhu L, Sun Y, Yi W
Journal of translational medicine 2026 Jan 7;24(1):228
Journal of translational medicine 2026 Jan 7;24(1):228
Thymoquinone Protects Against Cardiac Hypertrophy via PPAR-γ/PI3K/Akt Pathway.
Qiu RB, Wu ZM, Xu ZQ, Hu LJ, Zhao ST, Zeng RY, Qiu ZC, Zhou LF, Lai SQ, Wang WJ, Wan L
Journal of cellular and molecular medicine 2026 Feb;30(3):e70911
Journal of cellular and molecular medicine 2026 Feb;30(3):e70911
Phosphoproteomics identification of ERK-dependent activation of Rps6kb1 in cardiac hypertrophy.
Li C, Zhang P, Zhang K, Cook JA, Song W, Virostek M, Slotabec LA, Rouhi N, Hazari M, Adenawoola MI, Liu X, Zhang H, Zhang G, Niewold EL, Li Q, Fang Y, Elhelaly WM, Sun XN, Guo X, Lemoff A, Deng Y, Gillette TG, Li J, Scherer PE, Wang ZV
JCI insight 2026 Feb 23;11(4)
JCI insight 2026 Feb 23;11(4)
Tetrahedral Framework Nucleic Acids Inhibit Oxidative Stress and Cardiomyocyte Apoptosis in Doxorubicin-Induced Cardiotoxicity.
Pan H, Ye Q, Li Y, Ma L, Ni Y
International journal of nanomedicine 2025;20:9275-9289
International journal of nanomedicine 2025;20:9275-9289
Thymoquinone and aerobic exercise mitigate HFpEF-induced cardiac injury via Apaf1/Cycs axis regulation.
Pei Z, Gao S, Yang J, Liu C, Pan Y
Frontiers in pharmacology 2025;16:1672570
Frontiers in pharmacology 2025;16:1672570
Gut Metabolite Indole-3-Propionic Acid Regulates Macrophage Autophagy Through PPT1 Inhibiting Aging-Related Myocardial Fibrosis.
Lu J, Wang H, Zhang H, Li J, Li H, Chen Q, Han D, Liu J, Lv L, Xiong J, Yuan K, Wei X, Sheng S, Liu F, Shi Y, Dong Z, Li Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(34):e01070
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(34):e01070
Novel pH-Responsive PSS-Loaded Chitosan Matrix Nanoparticles Ameliorate Pressure Overload-Induced Cardiac Hypertrophy.
Xu M, Fan Z, Wang D, Li D, Zou H, Xue Y, Wang S, Li C
Marine drugs 2025 Sep 19;23(9)
Marine drugs 2025 Sep 19;23(9)
Evodiamine protects against cardiac remodeling in heart failure through modulation of calcium signaling and CD47.
Guo L, Niu H, Li J, Shao X, Li N, Sun Y, Ma Y, Wang H
Biochemical and biophysical research communications 2025 Sep 1;777:152168
Biochemical and biophysical research communications 2025 Sep 1;777:152168
Vericiguat as a novel PPARα ligand alleviates pressure-overload-induced heart failure.
Zhang P, Yuan C, Zhan Z, Zhou J, Huang P, Wang W, Qian J, Shan P
Toxicology and applied pharmacology 2025 Oct;503:117473
Toxicology and applied pharmacology 2025 Oct;503:117473
Circular RNA Rftn1 Promotes Cardiac Hypertrophy In Vitro and In Vivo by Sponging miRNA-1192 to Upregulate Tripartite Motif Protein 25 and 41.
Liu G, Zhang H, Zhang J, Qian H, Wang L, Chen L, Shen Z
Journal of cellular and molecular medicine 2025 Oct;29(19):e70892
Journal of cellular and molecular medicine 2025 Oct;29(19):e70892
Harnessing integrated bioinformatics to identify new diagnostic and therapeutic strategies for heart failure.
Sun S, Lai C, Huang C, Wang R, Fu G, Shang M
Biochimica et biophysica acta. Molecular basis of disease 2025 Oct;1871(7):167909
Biochimica et biophysica acta. Molecular basis of disease 2025 Oct;1871(7):167909
Histone H3 Lysine 18 Lactylation Promotes Cardiac Hypertrophy Through Activating GATA Binding Protein 4 Signaling.
Wang M, Liu Z, Ma Y, Li D, Lin Y, Wang Y, Fu D, Guo H, Hu L
MedComm 2025 Nov;6(11):e70421
MedComm 2025 Nov;6(11):e70421
YOD1 mediates isoproterenol-induced cardiac remodeling by deubiquitinating PKM2 and reducing PKM2 tetramerization in cardiomyocytes.
Zheng QS, Xiong YQ, Xu JC, Qian JF, Luo W, Wang QY, Zhao YN, Luo Y, Cui YQ, Fang Y, Guo XC, Chen DD, Wang Y, Liang G
Acta pharmacologica Sinica 2025 Nov;46(11):2938-2950
Acta pharmacologica Sinica 2025 Nov;46(11):2938-2950
Role of EZH2 in regulating c-Myc stability through the E3 ubiquitin ligase HUWE1 in heart failure and its mechanisms.
Yan L, Xie D, Huang T, Zheng H, Huang J, Chen H, Xie Q, Weng G, Zheng F
Cellular signalling 2025 Nov;135:111968
Cellular signalling 2025 Nov;135:111968
Identification of novel biomarkers for hypertension and ventricular remodeling based on transcriptomics and machine learning.
Li Z, Zhang B, Chao L, Tian X, Chen W, Liu C, Tian H
iScience 2025 Nov 21;28(11):113668
iScience 2025 Nov 21;28(11):113668
A critical role for IL-21/IL-21 receptor signaling in isoproterenol-induced cardiac remodeling.
Qi B, Xu R, Jin Y, Wang Y, Cheng T, Liu C, Ji Y, Guo L, Li J, Gao Y, Xu Y, Cui J, Liu J, Jiang Z, Feng L, Qi Z, Yang L
Scientific reports 2025 May 30;15(1):18985
Scientific reports 2025 May 30;15(1):18985
Asb10 accelerates pathological cardiac remodeling by stabilizing HSP70.
Lin K, Wei W, Chen S, Gong Y, Wang X, Wang M, Li R, Zhao Y, Xu S, Jin C, Jiang C, Fu G, Li Q
Cell death & disease 2025 May 22;16(1):409
Cell death & disease 2025 May 22;16(1):409
Methylophiopogonanone A alleviates diabetic cardiomyopathy via inhibiting JNK1 signaling.
Yin J, Song Z, Zhang L, Cong J
Cellular signalling 2025 Jul;131:111762
Cellular signalling 2025 Jul;131:111762
Single-nuclei multiomics analysis identifies abnormal cardiomyocytes in a murine model of cardiac development.
Leonard R, Zhao Y, Eliason S, Zimmerman K, Batz A, Hatcher CJ, Weiss RM, Sweat M, Li X, Amendt BA
Nature communications 2025 Jul 29;16(1):6947
Nature communications 2025 Jul 29;16(1):6947
Podocarpane and cleistanthane diterpenoids from Strophioblachia glandulosa: structural elucidation, anti-hypertrophy activity and network pharmacology.
Wu XW, Huang YX, Li CJ, Li YF, Wang BB, Zeb MA, Xiao WL, Zheng CB, Li XL
Bioorganic chemistry 2025 Jan;154:108026
Bioorganic chemistry 2025 Jan;154:108026
PINK1 modulates Prdx2 to reduce lipotoxicity-induced apoptosis and attenuate cardiac dysfunction in heart failure mice with a preserved ejection fraction.
Zhang H, Xu T, Mei X, Zhao Q, Yang Q, Zeng X, Ma Z, Zhou H, Zeng Q, Xu D, Ren H
Clinical and translational medicine 2025 Jan;15(1):e70166
Clinical and translational medicine 2025 Jan;15(1):e70166
The synergistic protective effects of paeoniflorin and β-ecdysterone against cardiac hypertrophy through suppressing oxidative stress and ferroptosis.
Yan P, Li X, He Y, Zhang Y, Wang Y, Liu J, Ren S, Wu D, Zhao Y, Ding L, Jia W, Lyu Y, Xiao D, Lin S, Lin Y
Cellular signalling 2025 Jan;125:111509
Cellular signalling 2025 Jan;125:111509
Exosomes derived from cardiac fibroblasts with Ang-II stimulation provoke myocardial hypertrophy via miR-15b-5p/PTEN-L axis.
Hu Z, Xiao D, Wang L, You J, Long T, Wang J, Shang Y, Yi D, Ding L, Wang X, Peng X, Zeng J
Experimental cell research 2025 Jan 15;444(2):114380
Experimental cell research 2025 Jan 15;444(2):114380
Structure Optimization of Natural Product Catalpol to Obtain Novel and Potent Analogs against Heart Failure.
Liu H, Guo X, Yang J, Xia C, Yao Y, Li X, Liu X, Yang J, Li X, Xu Y, Li J, Wang M
Journal of medicinal chemistry 2025 Feb 27;68(4):4540-4560
Journal of medicinal chemistry 2025 Feb 27;68(4):4540-4560
Bee venom alleviates isoproterenol-induced cardiac hypertrophy via JAK2/NF-κB signaling cascade.
Shi P, Han S, Sun Y, Li M, Xu X
Tissue & cell 2025 Dec;97:103077
Tissue & cell 2025 Dec;97:103077
Exercise alleviates programmed necrosis in myocardial ischemia-reperfusion injury through adipose tissue-derived exosomal miR-17-3p targeting CAMKII.
Liu Z, Lu W, He Y, Yu F
Archives of biochemistry and biophysics 2025 Dec;774:110640
Archives of biochemistry and biophysics 2025 Dec;774:110640
OTUB2 aggravates pathological cardiac hypertrophy through Rac1 activation.
Xing J, Lin L, Zhao Y, Shen Z, Wei Y, Xue X, Qin F, Liu H
Human cell 2025 Dec 2;39(1):17
Human cell 2025 Dec 2;39(1):17
Pegmolesatide ameliorates indoxyl sulfate-induced cardiomyocyte hypertrophy through modulating the EPOR-CD131-dependent JAK2/STAT3 signaling pathway.
Zhang X, Li S, Lin T, Gan L, Zhu L, Zuo L
International immunopharmacology 2025 Dec 10;167:115643
International immunopharmacology 2025 Dec 10;167:115643
Loss of Trim31 Worsens Cardiac Remodeling in a Mouse Model of Heart Failure by Enhancing the Activation of the NLRP3 Inflammasome.
Duan F, Li H, Lu B, Wang X, Xu X
Inflammation 2025 Aug;48(4):2650-2662
Inflammation 2025 Aug;48(4):2650-2662
Inflammation-Related Factors S100A9 and TLR2 in Cardiomyocyte Hypertrophy.
Jin KJ, Pan L, Huang CX, Yin C, Wang Y, Zhang J, Gong H
Current medical science 2025 Aug;45(4):819-830
Current medical science 2025 Aug;45(4):819-830
SD49-7 attenuates cardiac hypertrophy by upregulation of S100B through KDM4A inhibition.
Zhang Z, Gao M, Yan T, Feng Z, Lu S, Tang L, Li X, Wang W, Yang P, Zhou S, Hu Y, Duan Y, Zhang S
Biochemical pharmacology 2025 Aug 8;242(Pt 1):117218
Biochemical pharmacology 2025 Aug 8;242(Pt 1):117218
Fenofibrate Differently Affects the Heart's Morphology and Metabolism in Young and Old Rats.
Wrońska A, Kieżun J, Kmieć Z
International journal of molecular sciences 2025 Aug 20;26(16)
International journal of molecular sciences 2025 Aug 20;26(16)
Asprosin attenuates diabetic cardiomyopathy through inhibiting autophagy mediated by AMPK/mTOR/ULK1 pathway.
Wang Y, Liu W, Liu C, Zhou Z, Chen S, Huang Q, Wang L, Zeng G, Huang Q
American journal of physiology. Cell physiology 2025 Aug 1;329(2):C377-C394
American journal of physiology. Cell physiology 2025 Aug 1;329(2):C377-C394
Thymoquinone mitigates cardiac hypertrophy by activating adaptive autophagy via the PPAR‑γ/14‑3‑3γ pathway.
Qiu RB, Zhao ST, Xu ZQ, Hu LJ, Zeng RY, Qiu ZC, Peng HZ, Zhou LF, Cao YP, Wan L
International journal of molecular medicine 2025 Apr;55(4)
International journal of molecular medicine 2025 Apr;55(4)
Contributing role and molecular basis of Vitamin D/Vitamin D receptor deficiency in hyperhomocysteinemia-induced cardiac hypertrophy.
Qi H, Zhou Y, Hou HT, Wei JH, He GW, Yang Q
Biochemical pharmacology 2025 Apr;234:116812
Biochemical pharmacology 2025 Apr;234:116812
Protein interactions, network pharmacology, and machine learning work together to predict genes linked to mitochondrial dysfunction in hypertrophic cardiomyopathy.
Chen JL, Xiao D, Liu YJ, Wang Z, Chen ZH, Li R, Li L, He RH, Jiang SY, Chen X, Xu LX, Lu FC, Wang JM, Shan ZG
Scientific reports 2025 Apr 29;15(1):15017
Scientific reports 2025 Apr 29;15(1):15017
SNAP25-dependent membrane trafficking of the Kv1.5 channel regulates the onset of atrial fibrillation.
Su X, Shao B, Chen Z, Gu H, Xiong K, Wang G, Zou Q, Cao Y, Zhang C, Xu H, Yuan Y, Zhao X, Liu Y, Shen Y, Xie D, Chen YH
Nature communications 2025 Apr 19;16(1):3730
Nature communications 2025 Apr 19;16(1):3730
Inhibiting glycosphingolipids alleviates cardiac hypertrophy by reducing reactive oxygen species and restoring autophagic homeostasis.
Jiang C, Tan M, Lai L, Wang Y, Chen Z, Xie Q, Li Y
Frontiers in pharmacology 2024;15:1409625
Frontiers in pharmacology 2024;15:1409625
Comprehensive analysis of disulfidptosis-related genes and the immune microenvironment in heart failure.
Zhao L, Zhang J, Song Q, Dai C, Qin Y, Li A
Frontiers in cell and developmental biology 2024;12:1516898
Frontiers in cell and developmental biology 2024;12:1516898
Role of KLF4 and SIAT7A interaction accelerates myocardial hypertrophy induced by Ang II.
Yao Q, Hu X, Bian T, Zhang Q, Xue Z, Lv Y, Ren S, Chen Y, Zhang D, Chen L
Journal of cellular and molecular medicine 2024 Oct;28(20):e70144
Journal of cellular and molecular medicine 2024 Oct;28(20):e70144
Vericiguat attenuates doxorubicin-induced cardiotoxicity through the PRKG1/PINK1/STING axis.
Zeng X, Zhang H, Xu T, Mei X, Wang X, Yang Q, Luo Z, Zeng Q, Xu D, Ren H
Translational research : the journal of laboratory and clinical medicine 2024 Nov;273:90-103
Translational research : the journal of laboratory and clinical medicine 2024 Nov;273:90-103
Ibrutinib Contributes to Atrial Arrhythmia through the Autophagic Degradation of Connexins by Inhibiting the PI3K-AKT-mTOR Signaling Pathway.
Qin H, Zheng B, Lin Z, Ji Y, Wang C, Zhu H, Cui C, Wang Z, Chen M
Frontiers in bioscience (Landmark edition) 2024 May 22;29(5):201
Frontiers in bioscience (Landmark edition) 2024 May 22;29(5):201
Proline metabolic reprogramming modulates cardiac remodeling induced by pressure overload in the heart.
Lv Q, Li D, Zhao L, Yu P, Tao Y, Zhu Q, Wang Y, Wang M, Fu G, Shang M, Zhang W
Science advances 2024 May 10;10(19):eadl3549
Science advances 2024 May 10;10(19):eadl3549
OTUD1 promotes isoprenaline- and myocardial infarction-induced heart failure by targeting PDE5A in cardiomyocytes.
Wang Q, Liang S, Qian J, Xu J, Zheng Q, Wang M, Guo X, Min J, Wu G, Zhuang Z, Luo W, Liang G
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167018
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167018
The mechanisms and therapeutic potential of clopidogrel in mitigating diabetic cardiomyopathy in db/db mice.
Li B, Zhang Y, Zheng Y, Cai H
iScience 2024 Mar 15;27(3):109134
iScience 2024 Mar 15;27(3):109134
MCT4-dependent lactate transport: a novel mechanism for cardiac energy metabolism injury and inflammation in type 2 diabetes mellitus.
Ma XM, Geng K, Wang P, Jiang Z, Law BY, Xu Y
Cardiovascular diabetology 2024 Mar 14;23(1):96
Cardiovascular diabetology 2024 Mar 14;23(1):96
The total xanthones extracted from Gentianella acuta alleviates HFpEF by activating the IRE1α/Xbp1s pathway.
Zhao L, Qin Y, Liu Y, An L, Liu W, Zhang C, Song Q, Dai C, Zhang J, Li A
Journal of cellular and molecular medicine 2024 Jun;28(11):e18466
Journal of cellular and molecular medicine 2024 Jun;28(11):e18466
Lycorine inhibits Ang II-induced heart remodeling and inflammation by suppressing the PI3K-AKT/NF-κB pathway.
Tuo P, Zhao R, Li N, Yan S, Yang G, Wang C, Sun J, Sun H, Wang M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155464
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155464
Overexpression of macrophage migration inhibitory factor protects against pressure overload-induced cardiac hypertrophy through regulating the miR-29b-3p/HBP1 axis.
Wen L, Chen W, Zhu C, Li J, Zhou J, Zhang M, Zhang W, Xue Q
Physiological reports 2024 Jun;12(12):e16022
Physiological reports 2024 Jun;12(12):e16022
Carnosol attenuates angiotensin II-induced cardiac remodeling and inflammation via directly binding to p38 and inhibiting p38 activation.
Xu D, Ye B, Lin L, Jin Y, Jiang Y, Zheng Z, Chen Y, Han X, Wang W, Wu G, Zhuang Z, Shan P, Liang G
International immunopharmacology 2024 Jun 15;134:112143
International immunopharmacology 2024 Jun 15;134:112143
Carnosol prevents cardiac remodeling and ventricular arrhythmias in pressure overload-induced heart failure mice.
Fang Z, Lu M, Huang R, Wang G, Yushanjiang F, Jiang X, Li J
Phytotherapy research : PTR 2024 Jul;38(7):3763-3781
Phytotherapy research : PTR 2024 Jul;38(7):3763-3781
Inhibition of N-acetylglucosaminyltransferase V alleviates diabetic cardiomyopathy in mice by attenuating cardiac hypertrophy and fibrosis.
Zhao R, Hu J, Wen H, Zhao J, Wang Y, Niu X, Zhang M, Wang T, Li Y
Nutrition & metabolism 2024 Jul 30;21(1):53
Nutrition & metabolism 2024 Jul 30;21(1):53
PKD knockdown mitigates Ang II-induced cardiac hypertrophy and ferroptosis via the JNK/P53 signaling pathway.
Lv C, Zhou L, Meng Y, Yuan H, Geng J
Cellular signalling 2024 Jan;113:110974
Cellular signalling 2024 Jan;113:110974
CTRP3 alleviates mitochondrial dysfunction and oxidative stress injury in pathological cardiac hypertrophy by activating UPRmt via the SIRT1/ATF5 axis.
Shi L, Tan Y, Zheng W, Cao G, Zhou H, Li P, Cui J, Song Y, Feng L, Li H, Shan W, Zhang B, Yi W
Cell death discovery 2024 Jan 26;10(1):53
Cell death discovery 2024 Jan 26;10(1):53
α-Ketoglutarate improves cardiac insufficiency through NAD(+)-SIRT1 signaling-mediated mitophagy and ferroptosis in pressure overload-induced mice.
Yu H, Gan D, Luo Z, Yang Q, An D, Zhang H, Hu Y, Ma Z, Zeng Q, Xu D, Ren H
Molecular medicine (Cambridge, Mass.) 2024 Jan 22;30(1):15
Molecular medicine (Cambridge, Mass.) 2024 Jan 22;30(1):15
JOSD2 mediates isoprenaline-induced heart failure by deubiquitinating CaMKIIδ in cardiomyocytes.
Xu J, Liang S, Wang Q, Zheng Q, Wang M, Qian J, Yu T, Lou S, Luo W, Zhou H, Liang G
Cellular and molecular life sciences : CMLS 2024 Jan 10;81(1):18
Cellular and molecular life sciences : CMLS 2024 Jan 10;81(1):18
Protoilludane-Type and Related Nor-Sesquiterpenes from Phellinus hartigii and Their Anti-Hypertrophic Activities in Rat Cardiomyocytes.
Fu Q, Yuan J, Yang TH, Su JH, Zhang JJ, Wu XW, Zhang HY, Xiao WL, Zheng CB, Li XL
Journal of natural products 2024 Feb 23;87(2):297-303
Journal of natural products 2024 Feb 23;87(2):297-303
Identification and validation of autophagy‑related genes in hypertrophic cardiomyopathy.
Qiu RB, Zhao ST, Li ZW, Zeng RY, Qiu ZC, Peng HZ, Xu ZQ, Zhou LF, Lai SQ, Wan L
Experimental and therapeutic medicine 2024 Dec;28(6):440
Experimental and therapeutic medicine 2024 Dec;28(6):440
Qianyang yuyin granule ameliorates mitochondrial dysfunction of hypertensive myocardial remodeling.
Zheng Y, Fang Y, Luo Y, Fan Y, Fang Z
Journal of ethnopharmacology 2024 Dec 5;335:118610
Journal of ethnopharmacology 2024 Dec 5;335:118610
Interleukin(IL)-37 attenuates isoproterenol (ISO)-induced cardiac hypertrophy by suppressing JAK2/STAT3-signaling associated inflammation and oxidative stress.
Guo X, Wang P, Wei H, Yan J, Zhang D, Qian Y, Guo B
International immunopharmacology 2024 Dec 5;142(Pt B):113134
International immunopharmacology 2024 Dec 5;142(Pt B):113134
Baicalin improves isoproterenol-induced cardiac remodeling by regulating the Nrf2-dependent signaling pathway.
Qian K, Song L, Guo JM, Fu D, Shi J, Ma Y, Ge ZJ, Li L, Zhang SQ
BMC cardiovascular disorders 2024 Dec 20;24(1):733
BMC cardiovascular disorders 2024 Dec 20;24(1):733
miR-421-mediated suppression of FGF13 as a novel mechanism ameliorates cardiac hypertrophy by inhibiting endoplasmic reticulum stress.
Zhi Y, Duan Y, Zhang Y, Hu H, Hu F, Wang P, Liu B, Wang C, Liu D, Gu G
European journal of pharmacology 2024 Dec 15;985:177085
European journal of pharmacology 2024 Dec 15;985:177085
Lactate regulates pathological cardiac hypertrophy via histone lactylation modification.
Zhao SS, Liu J, Wu QC, Zhou XL
Journal of cellular and molecular medicine 2024 Aug;28(16):e70022
Journal of cellular and molecular medicine 2024 Aug;28(16):e70022
BCAA mediated microbiota-liver-heart crosstalk regulates diabetic cardiomyopathy via FGF21.
Zheng H, Zhang X, Li C, Wang D, Shen Y, Lu J, Zhao L, Li X, Gao H
Microbiome 2024 Aug 24;12(1):157
Microbiome 2024 Aug 24;12(1):157
Exercise training affects calcium ion transport by downregulating the CACNA2D1 protein to reduce hypertension-induced myocardial injury in mice.
Gao S, Yao W, Zhou R, Pei Z
iScience 2024 Apr 19;27(4):109351
iScience 2024 Apr 19;27(4):109351
Identification of diagnostic immune-related gene biomarkers for predicting heart failure after acute myocardial infarction.
Hu Y, Chen X, Mei X, Luo Z, Wu H, Zhang H, Zeng Q, Ren H, Xu D
Open medicine (Warsaw, Poland) 2023;18(1):20230878
Open medicine (Warsaw, Poland) 2023;18(1):20230878
Dapagliflozin attenuates myocardial hypertrophy via activating the SIRT1/HIF-1α signaling pathway.
Yang J, Li L, Zheng X, Lu Z, Zhou H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115125
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115125
Chronic β-adrenergic stress contributes to cardiomyopathy in rodents with collagen-induced arthritis.
Zhu ZD, Zhang M, Wang Z, Jiang CR, Huang CJ, Cheng HJ, Guan QY, Su TT, Wang MM, Gao Y, Wu HF, Wei W, Han YS, Wang QT
Acta pharmacologica Sinica 2023 Oct;44(10):1989-2003
Acta pharmacologica Sinica 2023 Oct;44(10):1989-2003
SOX4 as a potential therapeutic target for pathological cardiac hypertrophy.
Bin S, Xinyi F, Huan P, Xiaoqin Z, Jiming W, Yi H, Ziyue L, Xiaochun Z, Zhouqi L, Bangwei Z, Jing J, Shihui L, Jinlai G
European journal of pharmacology 2023 Nov 5;958:176071
European journal of pharmacology 2023 Nov 5;958:176071
CD9 exacerbates pathological cardiac hypertrophy through regulating GP130/STAT3 signaling pathway.
Li Y, Fan S, Kong L, Hao Z, Zhou Y, Shangguan J, Gao L, Wang M, Kang Y, Li X, Huang K, Zhang C, Liu Z
iScience 2023 Nov 17;26(11):108070
iScience 2023 Nov 17;26(11):108070
GLUT4 mediates the protective function of gastrodin against pressure overload-induced cardiac hypertrophy.
Zhang M, Tan Y, Song Y, Zhu M, Zhang B, Chen C, Liu Y, Shi L, Cui J, Shan W, Jia Z, Feng L, Cao G, Yi W, Sun Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114324
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114324
HypERlnc attenuates angiotensin II-induced cardiomyocyte hypertrophy via promoting SIRT1 SUMOylation-mediated activation of PGC-1α/PPARα pathway in AC16 cells.
Yue L, Sheng S, Yuan M, Lu J, Li T, Shi Y, Dong Z
Cell biology international 2023 Jun;47(6):1068-1080
Cell biology international 2023 Jun;47(6):1068-1080
Trim65 attenuates isoproterenol-induced cardiac hypertrophy by promoting autophagy and ameliorating mitochondrial dysfunction via the Jak1/Stat1 signaling pathway.
Liu H, Zhou Z, Deng H, Tian Z, Wu Z, Liu X, Ren Z, Jiang Z
European journal of pharmacology 2023 Jun 15;949:175735
European journal of pharmacology 2023 Jun 15;949:175735
Exploring novel biomarkers in dilated cardiomyopathy‑induced heart failure by integrated analysis and in vitro experiments.
Zhou L, Peng F, Li J, Gong H
Experimental and therapeutic medicine 2023 Jul;26(1):325
Experimental and therapeutic medicine 2023 Jul;26(1):325
G9a inhibition promotes the formation of pacemaker-like cells by reducing the enrichment of H3K9me2 in the HCN4 promoter region.
Xu P, Jin K, Zhou J, Gu J, Gu X, Dong L, Sun X
Molecular medicine reports 2023 Feb;27(2)
Molecular medicine reports 2023 Feb;27(2)
Muscone inhibits angiotensin II-induced cardiac hypertrophy through the STAT3, MAPK and TGF-β/SMAD signaling pathways.
Liu YJ, Xu JJ, Yang C, Li YL, Chen MW, Liu SX, Zheng XH, Luo P, Li R, Xiao D, Shan ZG
Molecular biology reports 2023 Dec 29;51(1):39
Molecular biology reports 2023 Dec 29;51(1):39
Soluble epoxide hydrolase and TRPC3 channels jointly contribute to homocysteine-induced cardiac hypertrophy: Interrelation and regulation by C/EBPβ.
Zhou Y, Wang XC, Wei JH, Xue HM, Sun WT, He GW, Yang Q
Biochimica et biophysica acta. Molecular basis of disease 2023 Apr;1869(4):166643
Biochimica et biophysica acta. Molecular basis of disease 2023 Apr;1869(4):166643
Metformin Collaborates with PINK1/Mfn2 Overexpression to Prevent Cardiac Injury by Improving Mitochondrial Function.
Ma Z, Liu Z, Li X, Zhang H, Han D, Xiong W, Zhou H, Yang X, Zeng Q, Ren H, Xu D
Biology 2023 Apr 11;12(4)
Biology 2023 Apr 11;12(4)
SUMOylation of SIRT1 activating PGC-1α/PPARα pathway mediates the protective effect of LncRNA-MHRT in cardiac hypertrophy.
Liu MY, Yue LJ, Luo YC, Lu J, Wu GD, Sheng SQ, Shi YQ, Dong ZX
European journal of pharmacology 2022 Sep 5;930:175155
European journal of pharmacology 2022 Sep 5;930:175155
Transient Receptor Potential Vanilloid Type 1 Protects Against Pressure Overload-Induced Cardiac Hypertrophy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes.
Wang Y, Li X, Xu X, Qu X, Yang Y
Journal of cardiovascular pharmacology 2022 Sep 1;80(3):430-441
Journal of cardiovascular pharmacology 2022 Sep 1;80(3):430-441
Overexpression of cytosolic long noncoding RNA cytb protects against pressure-overload-induced heart failure via sponging microRNA-103-3p.
Zhang X, Yuan S, Liu J, Tang Y, Wang Y, Zhan J, Fan J, Nie X, Zhao Y, Wen Z, Li H, Chen C, Wang DW
Molecular therapy. Nucleic acids 2022 Mar 8;27:1127-1145
Molecular therapy. Nucleic acids 2022 Mar 8;27:1127-1145
Cullin-associated and neddylation-dissociated 1 protein (CAND1) governs cardiac hypertrophy and heart failure partially through regulating calcineurin degradation.
Li X, Zhang Y, Zhao Y, Zhou Y, Han Q, Yang Y, Zhang L, Shi L, Jin X, Zhang R, Gao H, Xue G, Li D, Zhang ZR, Lu Y, Yang B, Pan Z
Pharmacological research 2022 Aug;182:106284
Pharmacological research 2022 Aug;182:106284
Gastrodin Exerts Cardioprotective Action via Inhibition of Insulin-Like Growth Factor Type 2/Insulin-Like Growth Factor Type 2 Receptor Expression in Cardiac Hypertrophy.
Lu J, Ma X, Gao WC, Zhang X, Fu Y, Liu Q, Tian L, Qin XD, Yang W, Zheng HY, Zheng CB
ACS omega 2021 Jul 6;6(26):16763-16774
ACS omega 2021 Jul 6;6(26):16763-16774
CBL aggravates Ang II-induced cardiac hypertrophy via the VHL/HIF-1α pathway.
Yang Y, Zou P, He L, Shao J, Tang Y, Li J
Experimental cell research 2021 Aug 15;405(2):112730
Experimental cell research 2021 Aug 15;405(2):112730
Pygo1 regulates pathological cardiac hypertrophy via a β-catenin-dependent mechanism.
Lin L, Xu W, Li Y, Zhu P, Yuan W, Liu M, Shi Y, Chen Y, Liang J, Chen J, Yang B, Cai W, Wen Y, Zhu X, Peng X, Zhou Z, Mo X, Wan Y, Yuan H, Li F, Ye X, Jiang Z, Wang Y, Zhuang J, Fan X, Wu X
American journal of physiology. Heart and circulatory physiology 2021 Apr 1;320(4):H1634-H1645
American journal of physiology. Heart and circulatory physiology 2021 Apr 1;320(4):H1634-H1645
Examination of the Effect of a 50-Hz Electromagnetic Field at 500 μT on Parameters Related With the Cardiovascular System in Rats.
Zhang Y, Li L, Liu X, Ding L, Wu X, Wang J, He M, Hou H, Ruan G, Lai J, Chen C
Frontiers in public health 2020;8:87
Frontiers in public health 2020;8:87
Ranolazine prevents pressure overload-induced cardiac hypertrophy and heart failure by restoring aberrant Na(+) and Ca(2+) handling.
Nie J, Duan Q, He M, Li X, Wang B, Zhou C, Wu L, Wen Z, Chen C, Wang DW, Alsina KM, Wehrens XHT, Wang DW, Ni L
Journal of cellular physiology 2019 Jul;234(7):11587-11601
Journal of cellular physiology 2019 Jul;234(7):11587-11601
No comments: Submit comment
No validations: Submit validation data