18696-1-AP

antibody from Proteintech Group

Targeting: KIT C-Kit, CD117, PBT, SCFR

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Flow cytometry (Supportive data in Antibodypedia)

Antibody Data

Product number

18696-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#18696-1-AP, RRID:AB_2249558

Product name

c-Kit/CD117 antibody

Antibody type

Polyclonal

Description

c-Kit/CD117 antibody (Cat. #18696-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IF, IHC, WB,ELISA.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

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LL37-induced mitochondrial stress activates the mtDNA/cGAS/STING pathway to promote mast cell-mediated rosacea inflammation.

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Immunobiology 2026 Apr 6;231(3):153180

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Yinchenhao Decoction Protects Against Intrahepatic Cholestasis During Pregnancy Through the miR-370-3p/TM9SF4/KIT Axis.

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Olive Oil Solution of Volatile Oil from Citri Reticulatae Pericarpium Viride Alleviates Slow-Transit Constipation via Regulating SCF/c-Kit Signaling Pathway and Intestinal Flora.

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A Canine c-kit Novel Mutation Isolated from a Gastrointestinal Stromal Tumor (GIST) Retains the Ability to Form Dimers but Lacks Autophosphorylation.

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Comprehensive single-cell transcriptomic reveals different destinies of melanocytes and dynamic changes of immune microenvironment in a psychological stress-induced leukoderma and leukotrichia mouse model.

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Human molecular genetics 2025 Mar 20;34(7):586-598

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ROS-Responsive Hydrogel Delivering METRNL Enhances Bone Regeneration via Dual Stem Cell Homing and Vasculogenesis Activation.

Xu Y, Huang R, Shi W, Zhou R, Xie X, Wang M, Wang Y, Gu P, Ni N, Bi X
Advanced healthcare materials 2025 Jun;14(16):e2500060

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Synthesis and biological evaluation of asiatic acid derivatives as c-Kit inhibitors.

Ma JJ, Zhang LF, Chen G, Liu LM, Wang Z, Meng YQ
Journal of Asian natural products research 2025 Jul 18;:1-19

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Bispecific Aptamer-Drug Conjugates Selectively Eliminate Malignant Hematologic Cells for Treating Acute Myeloid Leukemia.

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c-Kit-Mediated PI3K/AKT and Wnt/β-Catenin Signaling Drives Resistance to 5α-Reductase Inhibitors in Benign Prostatic Hyperplasia.

Zhu J, Wang J, Gu M, Xu H, Chen Y, Xu B, Chen Q
The Prostate 2025 Dec;85(16):1541-1555

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Alpha-1 Antitrypsin Mediates Spontaneous Resolution of Acute Gouty Inflammation Via Inhibiting Caspase 3/GSDME-dependent Macrophage Pyroptosis.

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A biodegradable, microstructured, electroconductive and nano-integrated drug eluting patch (MENDEP) for myocardial tissue engineering.

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Mitochondrial activity related genes of mast cells identify poor prognosis and metastasis of ovarian cancer.

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Immunohistochemical and ultrastructural identification of telocytes in the infantile hemangioma.

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Network pharmacology combined with experimental validation reveals the mechanism of action of erpixing granules on functional dyspepsia.

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p21/Zbtb18 repress the expression of cKit to regulate the self-renewal of hematopoietic stem cells.

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Hydrogen-rich water alleviates constipation by attenuating oxidative stress through the sirtuin1/nuclear factor-erythroid-2-related factor 2/heme oxygenase-1 signaling pathway.

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Elevated c-kit expression in failed autologous arteriovenous fistulas in end-stage renal disease patients.

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The journal of vascular access 2024 Mar;25(2):423-431

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A novel regulatory sex-skewing method that inhibits testicular DPY30 expression to increase female rate of dairy goat offspring.

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Primary extra-gastrointestinal stromal tumor of retroperitoneum: Clinicopathologic characteristics and prognosis of six cases.

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Characterization of a Human Gastrointestinal Stromal Tumor Cell Line Established by SV40LT-Mediated Immortalization.

Hu X, Su P, Liu B, Guo J, Wang Z, He C, Wang Z, Kou Y
International journal of molecular sciences 2023 Sep 4;24(17)

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Treatment with imatinib was useful to delay the neointimal hyperplasia of aortocaval fistula in adenine-induced renal failure rats.

Du J, Song J, Ding L, Fan X, Lin L, Li A, Liang L, Kong X
Biochemical and biophysical research communications 2023 Sep 10;672:10-16

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Characteristics of the Cajal interstitial cells and intestinal microbiota in children with refractory constipation.

Yuan Y, Lu Y, Zhang Z, Cheng W, Yan K, Zheng Y, Jin Y, Liu Z
Microbial pathogenesis 2023 Nov;184:106373

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Accelerating Wound Closure With Metrnl in Normal and Diabetic Mouse Skin.

Song L, Chang X, Hu L, Liu L, Wang G, Huang Y, Xu L, Jin B, Song J, Hu L, Zhang T, Wang Y, Xiao Y, Zhang F, Shi M, Liu L, Chen Q, Guo B, Zhou Y
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Exposure to elevated temperature affects the expression of PIWI-interacting RNAs and associated transcripts in mouse testes.

Chen W, Zhao Z, Cen S, Lv D, Wu J, Zhou X, Yang T, Zhao T, Hou L, Mao X
Andrology 2023 May;11(4):724-737

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Receptor tyrosine kinase C-kit promotes a destructive phenotype of FLS in osteoarthritis via intracellular EMT signaling.

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Electroacupuncture improves cardiac function after myocardial infarction by regulating the mobilization and migration of endogenous stem cells.

Xuan SS, Zhao Y, Zheng Y, Zhu J, Li H, Lu PP, Shao SJ, Guo HD, Mou FF
Acupuncture in medicine : journal of the British Medical Acupuncture Society 2023 Dec;41(6):354-363

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Acceleration of melanocyte senescence by the proinflammatory cytokines IFNγ and TNFα impairs the repigmentation response of vitiligo patients to narrowband ultraviolet B (NBUVB) phototherapy.

Dong BQ, Liao ZK, Le Y, Jiang S, Luo LF, Miao F, Le Poole IC, Lei TC
Mechanisms of ageing and development 2023 Apr;211:111779

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Identification of the Prognostic Biomarkers CBX6 and CBX7 in Bladder Cancer.

Li X, Li L, Xiong X, Kuang Q, Peng M, Zhu K, Luo P
Diagnostics (Basel, Switzerland) 2023 Apr 11;13(8)

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Preclinical Evaluation of the Multiple Tyrosine Kinases Inhibitor Anlotinib in Leukemia Stem Cells.

Jiang Y, Liu L, Jiang Y, Li Z, Feng L, Zhuang X, Lin Z, Chen Q, Chen G, He J, Li G, Zha J, Xu B
Pharmaceuticals (Basel, Switzerland) 2022 Oct 25;15(11)

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SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing.

Liu W, Lu X, Zhao ZH, Su R, Li QL, Xue Y, Gao Z, Sun SS, Lei WL, Li L, An G, Liu H, Han Z, Ouyang YC, Hou Y, Wang ZB, Sun QY, Liu J
eLife 2022 Nov 10;11

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Bufalin Inhibits Tumorigenesis, Stemness, and Epithelial-Mesenchymal Transition in Colorectal Cancer through a C-Kit/Slug Signaling Axis.

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International journal of molecular sciences 2022 Nov 1;23(21)

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Single-Cell Sequencing Unveils the Heterogeneity of Nonimmune Cells in Chronic Apical Periodontitis.

Lin X, Chi D, Meng Q, Gong Q, Tong Z
Frontiers in cell and developmental biology 2021;9:820274

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Comparative Transcriptome Analysis Reveals Relationship among mRNAs, lncRNAs, and circRNAs of Slow Transit Constipation.

Yan S, Yue Y, Sun M, Chen Y, Wang X, Qian H
BioMed research international 2021;2021:6672899

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Immune Infiltrating Cells-Derived Risk Signature Based on Large-scale Analysis Defines Immune Landscape and Predicts Immunotherapy Responses in Glioma Tumor Microenvironment.

Zhang N, Zhang H, Wang Z, Dai Z, Zhang X, Cheng Q, Liu Z
Frontiers in immunology 2021;12:691811

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SDF-1α promotes repair of myocardial ischemic necrosis zones in rats.

Cai X, Zhu Z, Zhang Y, Tian X
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The role of high serum CXCL13 level in Waldenström macroglobulinemia.

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RNA-Seq-based transcriptomic profiling of primary interstitial cells of Cajal in response to bovine viral diarrhea virus infection.

Li S, Hu X, Tian R, Guo Y, Chen J, Li Z, Zhao X, Kuang L, Ran D, Zhao H, Zhang X, Wang J, Xia L, Yue J, Yao G, Fu Q, Shi H
Veterinary research communications 2019 Aug;43(3):143-153

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Journal of experimental & clinical cancer research : CR 2018 Mar 22;37(1):66

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Orai1 mediates tumor-promoting store-operated Ca(2+) entry in human gastrointestinal stromal tumors via c-KIT and the extracellular signal-regulated kinase pathway.

Wang L, Hao J, Zhang Y, Yang Z, Cao Y, Lu W, Shu Y, Jiang L, Hu Y, Lv W, Liu Y, Dong P
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Feb;39(2):1010428317691426

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Effects and mechanism of RhoC downregulation in suppressing ovarian cancer stem cell proliferation, drug resistance, invasion and metastasis.

Sang XB, Sun KX, Wang LL, Chen S, Wu DD, Zong ZH, Zhao Y
Oncology reports 2016 Dec;36(6):3267-3274

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

MCF7 cells were subjected to SDS PAGE followed by western blot with 18696-1-AP(KIT antibody) at dilution of 1:200

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human testis using 18696-1-AP(KIT antibody) at dilution of 1:400 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human testis using 18696-1-AP(KIT antibody) at dilution of 1:400 (under 40x lens)

Sample type

tissue

Flow cytometry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The c-Kit/CD117 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human c-Kit/CD117. This antibody recognizes human antigen. The c-Kit/CD117 antibody has been validated for the following applications: ELISA, WB, IHC, FC analysis.

Appendix

18696-1-AP.pdf

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