60034.1

antibody from STEMCELL Technologies Inc

Targeting: KIT C-Kit, CD117, PBT, SCFR

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

60034.1

Provider

STEMCELL Technologies Inc

Product name

Anti-Mouse CD117 Antibody, Clone ACK2

Antibody type

Monoclonal

Description

The ACK2 antibody reacts with CD117 (c-Kit), an ~145 kDa type 1 transmembrane receptor for c-Kit ligand (stem cell factor/steel factor) that is broadly expressed on hematopoietic stem cells in bone marrow, including pluripotent and erythroid progenitor cells and B and T lymphocyte precursors, as well as on mast cells. CD117 belongs to the tyrosine kinase receptor family and possesses five immunoglobulin-like C2-type domains and a cytoplasmic protein kinase domain. Binding of c-Kit ligand to CD117 induces dimerization and autophosphorylation, which activates several intracellular signaling pathways critical for the proliferation and differentiation of hematopoietic stem cells. Signaling by CD117 is modulated by phosphatases and by rapid endocytosis and degradation of the receptor. Mutations in CD117 are associated with various types of tumors and the piebald trait, an autosomal dominant abnormality of pigmentation. It has been reported that binding of the ACK2 antibody blocks the function of CD117.

Reactivity

Mouse

Host

Mouse

Isotype

IgG

Vial size

50 µg

Storage

2 - 8°C