Ab096640

antibody from Aladdin Scientific
Targeting: KIT C-Kit, CD117, PBT, SCFR
Provider product page for Ab096640

Antibody data

Product number
Ab096640 - Provider product page
Provider
Aladdin Scientific
Product name
Recombinant c-Kit Antibody
Antibody type
Recombinant
Description
Rabbit anti Human c-Kit Antibody, Recombinant, could be used for WB, IHC and so on.ApplicationWB: 1/500-1/1000IHC: 1/50-1/100Protein FunctionTyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.
Reactivity
Human
Host
Rabbit
Conjugate
Unconjugated
Antigen sequence
AA 926-976
Vial size
10_l
Concentration
1,055 mg/ml
Storage
Store at 4¡C short term (1-2 weeks). Store at -20¡C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
KIT protein structure - Ab096640 shown in red.