RA0443

antibody from Oursmab

Targeting: KIT C-Kit, CD117, PBT, SCFR

Western blot (Supportive data in Antibodypedia)

ELISA (Supportive data in Antibodypedia)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0443

Provider

Oursmab

Product name

Barzolvolimab (Biosimilar Reference Antibody) (KIT)

Antibody type

Monoclonal

Description

Barzolvolimab is a humanized, anti-KIT (CD117) monoclonal antibody of the IgG1 isotype designed to selectively deplete tissue-resident mast cells and inhibit the stem cell factor (SCF)/KIT signaling pathway. It functions by binding to the extracellular domain of KIT with high affinity, which both blocks SCF-mediated activation and triggers antibody-dependent cellular cytotoxicity (ADCC) against mast cells. It is currently in clinical development (Phase II) for the treatment of chronic inducible urticaria (CindU), chronic spontaneous urticaria (CSU), eosinophilic esophagitis (EoE), and prurigo nodularis, conditions where mast cells and their mediators (like histamine) are central drivers of pathology.

Reactivity

Human

Isotype

IgG

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.

Western blot

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

Barzolvolimab (Biosimilar Reference Antibody) (KIT)-RA0443-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.

ELISA

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

ELISA plate pre-coated Antigen protein, can bind Barzolvolimab (Biosimilar Reference Antibody) (KIT)-RA0443 in a linear range of 0.18-125 ng/mL.