ABIN968819

antibody from antibodies-online

Targeting: KIT C-Kit, CD117, PBT, SCFR

Western blot (Data presented on provider website)

Antibody Data

Product number

ABIN968819

Provider

antibodies-online

Product name

anti-Mast/stem Cell Growth Factor Receptor (KIT) (AA 1-115) antibody

Antibody type

Monoclonal

Antigen

Human c-Kit

Description

Purified from tissue culture supernatant or ascites by affinity chromatography.

Reactivity

Human

Host

Mouse

Epitope

AA 1-115

Isotype

IgG

Antibody clone number

MOC-31

Vial size

50 μg

Concentration

250 μg/ml

Storage

-20°C

References

Submitted references

The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations.

Ma Y, Zeng S, Metcalfe DD, Akin C, Dimitrijevic S, Butterfield JH, McMahon G, Longley BJ
Blood 2002 Mar 1;99(5):1741-4

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Basic fibroblast growth factor modulates the expression of glycophorin A and c-kit and inhibits erythroid differentiation in K562 cells.

Burger PE, Lukey PT, Coetzee S, Wilson EL
Journal of cellular physiology 2002 Jan;190(1):83-91

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Germ cell specific expression of c-kit in the human fetal gonad.

Robinson LL, Gaskell TL, Saunders PT, Anderson RA
Molecular human reproduction 2001 Sep;7(9):845-52

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STAT3 activation is required for Asp(816) mutant c-Kit induced tumorigenicity.

Ning ZQ, Li J, McGuinness M, Arceci RJ
Oncogene 2001 Jul 27;20(33):4528-36

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Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.

Yarden Y, Kuang WJ, Yang-Feng T, Coussens L, Munemitsu S, Dull TJ, Chen E, Schlessinger J, Francke U, Ullrich A
The EMBO journal 1987 Nov;6(11):3341-51