21644-1-AP

antibody from Proteintech Group

Targeting: CCNB2 HsT17299

Provider product page for 21644-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [23]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [2]

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Product number: 21644-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#21644-1-AP, RRID:AB_10755304
Product name: Cyclin B2 antibody
Antibody type: Polyclonal
Description: Cyclin B2 antibody (Cat. #21644-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CCNB2 protein structure - 21644-1-AP shown in red.

Submitted references Suppression of N-Glycosylation of Zinc Finger Protein 471 Affects Proliferation, Invasion, and Docetaxel Sensitivity of Tongue Squamous Cell Carcinoma via Regulation of c-Myc.

Liu Y, Cai X, Hu S, Wang Z, Tian H, Wang H
The American journal of pathology 2024 Jun;194(6):1106-1125

Epigallocatechin gallate suppresses mitotic clonal expansion and adipogenic differentiation of preadipocytes through impeding JAK2/STAT3-mediated transcriptional cascades.

Peng H, Lin X, Wang Y, Chen J, Zhao Q, Chen S, Cheng Q, Chen C, Sang T, Zhou H, Xiao J, Wang W, Fang L, Wang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155563

The anti-non-small cell lung cancer effect of Diosbulbin B: Targeting YY1 induced cell cycle arrest and apoptosis.

Zhao JQ, Zhou QQ, Sun Y, Yu T, Jiang Y, Li HJ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155734

Exploring diverse programmed cell-death patterns to develop a novel gene signature for predicting the prognosis of lung adenocarcinoma patients.

Ma Z, Wang Y, Yu Y, Fu F, Zhang Y
Journal of thoracic disease 2024 Feb 29;16(2):911-923

Chrysin Inhibits TAMs-Mediated Autophagy Activation via CDK1/ULK1 Pathway and Reverses TAMs-Mediated Growth-Promoting Effects in Non-Small Cell Lung Cancer.

Tang X, Luo X, Wang X, Zhang Y, Xie J, Niu X, Lu X, Deng X, Xu Z, Wu F
Pharmaceuticals (Basel, Switzerland) 2024 Apr 17;17(4)

Rab11-FIP4 interacts with ARF5 to promote cancer stemness in hepatocellular carcinoma.

Song F, Zhang Q, Lu X, Xu T, Hu Q, Hu X, Fan W, Zhang Y, Huang P
Journal of physiology and biochemistry 2023 Nov;79(4):757-770

Identification of a transcription factor‑cyclin family genes network in lung adenocarcinoma through bioinformatics analysis and validation through RT‑qPCR.

Yang X, Zhou Y, Ge H, Tian Z, Li P, Zhao X
Experimental and therapeutic medicine 2023 Jan;25(1):63

Revealing active components and action mechanism of Fritillariae Bulbus against non-small cell lung cancer through spectrum-effect relationship and proteomics.

Liu FJ, Chen XY, Yang J, Zhao Z, Wang QL, Li P, Jiang Y, Li HJ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154635

Ganoderma lucidum polysaccharide inhibits HSC activation and liver fibrosis via targeting inflammation, apoptosis, cell cycle, and ECM-receptor interaction mediated by TGF-β/Smad signaling.

Chen C, Chen J, Wang Y, Fang L, Guo C, Sang T, Peng H, Zhao Q, Chen S, Lin X, Wang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154626

Therapy-resistant and -sensitive lncRNAs, SNHG1 and UBL7-AS1 promote glioblastoma cell proliferation.

Cao M, Ma R, Li H, Cui J, Zhang C, Zhao J
Oxidative medicine and cellular longevity 2022;2022:2623599

Single-nucleus RNA Sequencing reveals the mechanism of cigarette smoke exposure on diminished ovarian reserve in mice.

Li F, Wang Y, Xu M, Hu N, Miao J, Zhao Y, Wang L
Ecotoxicology and environmental safety 2022 Oct 15;245:114093

Mad2 promotes Cyclin B2 recruitment to the kinetochore for guiding accurate mitotic checkpoint.

Liu S, Yuan X, Gui P, Liu R, Durojaye O, Hill DL, Fu C, Yao X, Dou Z, Liu X
EMBO reports 2022 Jun 7;23(6):e54171

Disruption of mitochondrial redox homeostasis as a mechanism of antimony-induced reactive oxygen species and cytotoxicity.

Su L, Fang W, Zhao X, Zhu L, Gao L, Chen G
Ecotoxicology and environmental safety 2022 Jun 1;237:113519

Protective role of m(6)A binding protein YTHDC2 on CCNB2 in manganese-induced spermatogenesis dysfunction.

Qi Z, Liu Y, Yang H, Yang X, Wang H, Liu B, Yuan Y, Wang G, Xu B, Liu W, Xu Z, Deng Y
Chemico-biological interactions 2022 Jan 5;351:109754

miR-550a-5p promotes the proliferation and migration of hepatocellular carcinoma by targeting GNE via the Wnt/β-catenin signaling pathway.

Li CM, Wu W, Zhu Z, Lu PL, Gong JP, Ma R
Neoplasma 2022 Dec;69(6):1359-1372

N6-methyladenosine regulates ATM expression and downstream signaling.

Zhang X, Liu P, Zheng X, Wang J, Peng Q, Li Z, Wei L, Liu C, Wu Y, Wen Y, Yan Q, Ma J
Journal of Cancer 2021;12(23):7041-7051

Identifying and Validating Potential Biomarkers of Early Stage Lung Adenocarcinoma Diagnosis and Prognosis.

Chen Y, Jin L, Jiang Z, Liu S, Feng W
Frontiers in oncology 2021;11:644426

Elevated FBXO45 promotes liver tumorigenesis through enhancing IGF2BP1 ubiquitination and subsequent PLK1 upregulation.

Lin XT, Yu HQ, Fang L, Tan Y, Liu ZY, Wu D, Zhang J, Xiong HJ, Xie CM
eLife 2021 Nov 15;10

ALG3 contributes to stemness and radioresistance through regulating glycosylation of TGF-β receptor II in breast cancer.

Sun X, He Z, Guo L, Wang C, Lin C, Ye L, Wang X, Li Y, Yang M, Liu S, Hua X, Wen W, Lin C, Long Z, Zhang W, Li H, Jian Y, Zhu Z, Wu X, Lin H
Journal of experimental & clinical cancer research : CR 2021 Apr 30;40(1):149

Identification of biomarkers for the transition from low-grade glioma to secondary glioblastoma by an integrated bioinformatic analysis.

Zhao L, Zhang J, Liu Z, Zhao P
American journal of translational research 2020;12(4):1222-1238

ODC1 promotes proliferation and mobility via the AKT/GSK3β/β-catenin pathway and modulation of acidotic microenvironment in human hepatocellular carcinoma.

Ye Z, Zeng Z, Shen Y, Yang Q, Chen D, Chen Z, Shen S
OncoTargets and therapy 2019;12:4081-4092

Formononetin inhibits colon carcinoma cell growth and invasion by microRNA‑149‑mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways.

Wang AL, Li Y, Zhao Q, Fan LQ
Molecular medicine reports 2018 Jun;17(6):7721-7729

The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis.

Fan L, Cao X, Yan H, Wang Q, Tian X, Zhang L, He X, Borjihan G, Morigen
Oncotarget 2017 Jul 18;8(29):47250-47268

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: A431 cells were subjected to SDS PAGE followed by western blot with 21644-1-AP(CCNB2 antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of Hela cells, using CCNB2 antibody 21644-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human lung cancer using 21644-1-AP(CCNB2 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human lung cancer using 21644-1-AP(CCNB2 antibody) at dilution of 1:50 (under 40x lens)
Sample type: tissue