Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [15]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 21582-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21582-1-AP, RRID:AB_10792804
- Product name
- CYP24A1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CYP24A1 antibody (Cat. #21582-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references A novel mouse model for familial hypocalciuric hypercalcemia (FHH1) reveals PTH-dependent and independent CaSR defects.
Accumulated LPS induced by colitis altered the activities of vitamin D-metabolizing hydroxylases and decreased the generation of 25-hydroxyvitamin D.
CYP24A1 Involvement in Inflammatory Factor Regulation Occurs via the Wnt Signaling Pathway.
1,25(OH)(2) vitamin D(3) stimulates active phosphate transport but not paracellular phosphate absorption in mouse intestine.
Fibroblast growth factor 23 leads to endolysosomal routing of the renal phosphate cotransporters NaPi-IIa and NaPi-IIc in vivo.
Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediated MAPK signaling.
Intestinal epithelial ablation of Pit-2/Slc20a2 in mice leads to sustained elevation of vitamin D(3) upon dietary restriction of phosphate.
Exercise May Ameliorate the Detrimental Side Effects of High Vitamin D Supplementation on Muscle Function in Mice.
The effects of CYP24A1 on clinicopathological features and the prognosis of pancreatic ductal adenocarcinoma.
Elevated FGF23 and disordered renal mineral handling with reduced bone mineralization in chronically erythropoietin over-expressing transgenic mice.
MAPK inhibition and growth hormone: a promising therapy in XLH.
Regulation of vitamin D metabolizing enzymes in murine renal and extrarenal tissues by dietary phosphate, FGF23, and 1,25(OH)2D3.
The intestinal phosphate transporter NaPi-IIb (Slc34a2) is required to protect bone during dietary phosphate restriction.
TAZ regulates cell proliferation and sensitivity to vitamin D3 in intrahepatic cholangiocarcinoma.
Eldecalcitol (ED-71), an analog of 1α,25-dihydroxyvitamin D3 as a potential anti-cancer agent for oral squamous cell carcinomas.
Küng CJ, Daryadel A, Fuente R, Haykir B, de Angelis MH, Hernando N, Rubio-Aliaga I, Wagner CA
Pflugers Archiv : European journal of physiology 2024 May;476(5):833-845
Pflugers Archiv : European journal of physiology 2024 May;476(5):833-845
Accumulated LPS induced by colitis altered the activities of vitamin D-metabolizing hydroxylases and decreased the generation of 25-hydroxyvitamin D.
Lu Y, Chen H, Chen Y, Zhao L, Hou S
Chemico-biological interactions 2024 May 25;395:110997
Chemico-biological interactions 2024 May 25;395:110997
CYP24A1 Involvement in Inflammatory Factor Regulation Occurs via the Wnt Signaling Pathway.
Chen XQ, Mao JY, Wang CS, Li WB, Han TT, Lv K, Li JN
Current medical science 2022 Oct;42(5):1022-1032
Current medical science 2022 Oct;42(5):1022-1032
1,25(OH)(2) vitamin D(3) stimulates active phosphate transport but not paracellular phosphate absorption in mouse intestine.
Hernando N, Pastor-Arroyo EM, Marks J, Schnitzbauer U, Knöpfel T, Bürki M, Bettoni C, Wagner CA
The Journal of physiology 2021 Feb;599(4):1131-1150
The Journal of physiology 2021 Feb;599(4):1131-1150
Fibroblast growth factor 23 leads to endolysosomal routing of the renal phosphate cotransporters NaPi-IIa and NaPi-IIc in vivo.
Küng CJ, Haykir B, Schnitzbauer U, Egli-Spichtig D, Hernando N, Wagner CA
American journal of physiology. Renal physiology 2021 Dec 1;321(6):F785-F798
American journal of physiology. Renal physiology 2021 Dec 1;321(6):F785-F798
Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediated MAPK signaling.
He L, Li H, Pan C, Hua Y, Peng J, Zhou Z, Zhao Y, Lin M
Cancer communications (London, England) 2021 Aug;41(8):726-746
Cancer communications (London, England) 2021 Aug;41(8):726-746
Intestinal epithelial ablation of Pit-2/Slc20a2 in mice leads to sustained elevation of vitamin D(3) upon dietary restriction of phosphate.
Pastor-Arroyo EM, Knöpfel T, Imenez Silva PH, Schnitzbauer U, Poncet N, Biber J, Wagner CA, Hernando N
Acta physiologica (Oxford, England) 2020 Oct;230(2):e13526
Acta physiologica (Oxford, England) 2020 Oct;230(2):e13526
Exercise May Ameliorate the Detrimental Side Effects of High Vitamin D Supplementation on Muscle Function in Mice.
Debruin DA, Timpani CA, Lalunio H, Rybalka E, Goodman CA, Hayes A
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2020 Jun;35(6):1092-1106
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2020 Jun;35(6):1092-1106
The effects of CYP24A1 on clinicopathological features and the prognosis of pancreatic ductal adenocarcinoma.
Gao W, Wang TF, Yi W, Tong WM
Translational cancer research 2020 Aug;9(8):4476-4487
Translational cancer research 2020 Aug;9(8):4476-4487
Elevated FGF23 and disordered renal mineral handling with reduced bone mineralization in chronically erythropoietin over-expressing transgenic mice.
Daryadel A, Natale L, Seebeck P, Bettoni C, Schnitzbauer U, Gassmann M, Wagner CA
Scientific reports 2019 Oct 18;9(1):14989
Scientific reports 2019 Oct 18;9(1):14989
MAPK inhibition and growth hormone: a promising therapy in XLH.
Fuente R, Gil-Peña H, Claramunt-Taberner D, Hernández-Frías O, Fernández-Iglesias Á, Alonso-Durán L, Rodríguez-Rubio E, Hermida-Prado F, Anes-González G, Rubio-Aliaga I, Wagner C, Santos F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jul;33(7):8349-8362
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jul;33(7):8349-8362
Regulation of vitamin D metabolizing enzymes in murine renal and extrarenal tissues by dietary phosphate, FGF23, and 1,25(OH)2D3.
Kägi L, Bettoni C, Pastor-Arroyo EM, Schnitzbauer U, Hernando N, Wagner CA
PloS one 2018;13(5):e0195427
PloS one 2018;13(5):e0195427
The intestinal phosphate transporter NaPi-IIb (Slc34a2) is required to protect bone during dietary phosphate restriction.
Knöpfel T, Pastor-Arroyo EM, Schnitzbauer U, Kratschmar DV, Odermatt A, Pellegrini G, Hernando N, Wagner CA
Scientific reports 2017 Sep 8;7(1):11018
Scientific reports 2017 Sep 8;7(1):11018
TAZ regulates cell proliferation and sensitivity to vitamin D3 in intrahepatic cholangiocarcinoma.
Xiao H, Tong R, Yang B, Lv Z, Du C, Peng C, Ding C, Cheng S, Zhou L, Xie H, Wu J, Zheng S
Cancer letters 2016 Oct 28;381(2):370-9
Cancer letters 2016 Oct 28;381(2):370-9
Eldecalcitol (ED-71), an analog of 1α,25-dihydroxyvitamin D3 as a potential anti-cancer agent for oral squamous cell carcinomas.
Shintani T, Rosli SNZ, Takatsu F, Choon YF, Hayashido Y, Toratani S, Usui E, Okamoto T
The Journal of steroid biochemistry and molecular biology 2016 Nov;164:79-84
The Journal of steroid biochemistry and molecular biology 2016 Nov;164:79-84
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 21582-1-AP(CYP24A1 antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 21582-1-AP(CYP24A1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CYP24A1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human CYP24A1. This antibody recognizes human, mouse, rat antigen. The CYP24A1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
