Antibody data
- Antibody Data
- Antigen structure
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- Product number
- BS8341 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- NLK polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human NLK.
- Description
- The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated through two closely related MAP kinases, p44 and p42, designated extracellular-signal related kinase 1 (ERK 1) and ERK 2 , respectively. ERK proteins are regulated by dual phosphorylation at specific tyrosine and threonine sites mapping within a characteristic Thr-Glu-Tyr motif . Phosphorylation at both Thr-183 and Tyr-185 is required for full enzymatic activation . In response to activation, MAP kinases phosphorylate downstream components on serine and threonine. Nlk, or nemo-like kinase, is a murine homolog of the Drosophila nemo (nmo) gene. Nlk and Nmo have sequence homology to both the ERK MAP kinases and the cyclin dependent kinases. Nlk is a nuclear protein with the ability to autophosphorylate .
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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