Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 11-7501-25 - Provider product page
- Provider
- ABEOMICS Inc.
- Product name
- Anti-BRD4, HUNK1 Antibody
- Antibody type
- Polyclonal
- Description
- BRD4 is a member of the BET (bromo domain and extra terminal domain) family, along with BRD2, BRD3 and BRDT. BRD4 is required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II. A chromosomal aberration involving BRD4 is found in a rare, aggressive and lethal carcinoma arising in midline organs of young people. It expressed ubiquitously and has three isoforms. Isoform B acts as a chromatin insulator in the DNA damage response pathway.
- Reactivity
- Human
- Host
- Rabbit
- Antigen sequence
A partial length recombinant BRD4 p
rotein (amino acids 140-500) was us
ed as the immunogen for this antibo
dy.- Vial size
- 25 µg
- Concentration
- 0.5 mg/ml
- Storage
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
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Supportive validation
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- ABEOMICS Inc. (provider)
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- Experimental details
- Western blot analysis of BRD4, HUNK1. Anti- BRD4, HUNK1 antibody (11-7501) was used at 2 µg/ml on SKM lysate.