28486-1-AP

antibody from Proteintech Group

Targeting: BRD4 CAP, HUNK1, HUNKI, MCAP

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Antibody Data

Product number

28486-1-AP

Provider

Proteintech Group

Product name

BRD4 antibody

Antibody type

Polyclonal

Description

BRD4 antibody (Cat. #28486-1-AP) is a rabbit polyclonal antibody that shows reactivity with Human and has been validated for the following applications: IP, WB, ELISA.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

SHP2 improved Late-onset fetal growth restriction via modulating ROS/BRD4/PI3K/YAP/PIGF signaling induced angiogenesis.

Li F, Li Y, Hao W, Zhang X, Shen X, Yang B, Zhang W, Fu L, Gu S
PloS one 2026;21(2):e0342649

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Bitter gourd peptides (BG) alleviate lupus progression in mice through regulation of miR-146a/BRD4 axis in macrophages.

Wu Y, Han W, Li X, Su X
Frontiers in immunology 2026;17:1666212

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The HSP90-dependent bioorthogonal PROTAC prodrug system enables tumor-selective and enhanced protein degradation.

Yin F, Song T, Song Y, Wang K, Zhang H, Jiang M, Wang Z, Fan X, Zhang Y, Wang S, Teng Y, Lun H, Wang S, Xie A, Wang Z, Zhang Z
Journal of controlled release : official journal of the Controlled Release Society 2026 May 10;393:114828

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Hsp70-Targeting Chimeras Enable Dual Proteasomal and Lysosomal Degradation of Intracellular and Extracellular Proteins.

Wang Z, Li P, Yin F, Zhang H, Wang S, Teng Y, Fan X, Wang K, Zhang Y, Lun H, Song T, Wang Z, Zhang Z
Journal of medicinal chemistry 2026 Apr 9;69(7):8417-8432

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A novel ROR1-targeting antibody-PROTAC conjugate promotes BRD4 degradation for solid tumor treatment.

Wang L, Ke Y, He Q, Paerhati P, Zhuang W, Yue Y, Liu J, Zhang J, Huang L, Yin Q, Zong H, Zhu J, Zhang B
Theranostics 2025;15(4):1238-1254

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Cell-based high-throughput screening using a target-NanoLuc fusion construct to identify molecular glue degraders of c-Myc oncoprotein.

Xu M, Qiu J, Tan L, Xu J, Wang Y, Kong W, Liao H, Chen A, Chen X, Zhang J, Chiu CKC, Zhang M, Tian Y, Li C, Ma B, Wang L, Fu J, Choi SH, Hill J, Shen W
RSC chemical biology 2025 Oct 29;6(11):1759-1771

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Histone demethylase KDM9 activates the CCND1/AKT pathway to promote the malignant progression of gliomas through interaction with BRD2.

Cheng J, Peng X, Tang S, Zhou P, Zhou Z, Mao Z, Li D, Yang L, Peng J
Cellular and molecular life sciences : CMLS 2025 Nov 26;82(1):423

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Specific sDMA modifications on the RGG/RG motif of METTL14 regulate its function in AML.

Zhong Y, Zhang R, Lu L, Tan H, You Y, Mao Y, Yuan Y
Cell communication and signaling : CCS 2025 Mar 8;23(1):126

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USP35 promotes the growth of ER positive breast cancer by inhibiting ferroptosis via BRD4-SLC7A11 axis.

Cao J, Wu T, Zhou T, Jiang Z, Ren Y, Yu J, Wang J, Qian C, Wu G, He L, Li H, Lin R, Liu M, Gu H
Communications biology 2025 Jan 16;8(1):64

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Synergistic Proteolysis Targeting Chimera Chemotherapy Conjugate for Potent Non-small Cell Lung Cancer Treatment.

Zhao Q, Zeng R, Bi T, Yang X, Wang T, Chen L, Huang J, Dai X, Xu H, Sun Q, Liu Z
ACS applied materials & interfaces 2025 Dec 17;17(50):67595-67608

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Inhibition of BRD4 alleviates pyroptosis induced by testicular ischemia/reperfusion injury through the NLRP3 pathway.

Wang J, Ning J, Zhou Z, Li H
Tissue & cell 2025 Aug;95:102919

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BRD4 as the key lactylation related gene in heart failure identified through bioinformatics analysis.

Li K, Han L, Wang X, Zheng Z, Sha M, Ye J, Zhu L
Scientific reports 2025 Apr 1;15(1):11107

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Screening and identification of microRNAs mediating cartilage endplate degeneration in human intervertebral disks.

Jiang B, Bai C, Pan J, Shen B, Li L
Frontiers in medicine 2024;11:1446294

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Vascular restenosis following paclitaxel-coated balloon therapy is attributable to NLRP3 activation and LIN9 upregulation.

Kan Q, Peng Z, Wang K, Deng T, Zhou Z, Wu R, Yao C, Wang R
Journal of translational medicine 2024 Sep 27;22(1):871

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Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA polyubiquitination.

Wang YC, Kelso AA, Karamafrooz A, Chen YH, Chen WK, Cheng CT, Qi Y, Gu L, Malkas L, Kung HJ, Moldovan GL, Ciccia A, Stark JM, Ann DK
bioRxiv : the preprint server for biology 2023 Feb 3;

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BRD4 promotes hepatic stellate cells activation and hepatic fibrosis via mediating P300/H3K27ac/PLK1 axis.

Cheng M, Li JJ, Niu XN, Zhu L, Liu JY, Jia PC, Zhu S, Meng HW, Lv XW, Huang C, Li J
Biochemical pharmacology 2023 Apr;210:115497

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Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination.

Wang YC, Kelso AA, Karamafrooz A, Chen YH, Chen WK, Cheng CT, Qi Y, Gu L, Malkas L, Taglialatela A, Kung HJ, Moldovan GL, Ciccia A, Stark JM, Ann DK
Cell reports 2023 Apr 25;42(4):112296