20253-1-AP

antibody from Proteintech Group

Targeting: IGF2R CD222, CI-M6PR, CI-MPR, CIMPR, M6P-R, MPR1, MPR300, MPRI

Provider product page for 20253-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [27]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 20253-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#20253-1-AP, RRID:AB_10859779
Product name: IGF2R-Specific antibody
Antibody type: Polyclonal
Description: IGF2R-Specific antibody (Cat. #20253-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

IGF2R protein structure - 20253-1-AP shown in red.

Submitted references Protocol for dissecting the aggregation-prone protein interactome with optogenetic-induced aggregation and biotin labeling proximity assay.

Teixeira M, Musiol D, Lambert JP, Oueslati A
STAR protocols 2026 Mar 20;7(1):104303

Progranulin-driven lysosomal acidification facilitates exocytosis of PHEV-hijacked lysosomes for viral release.

Wang Z, Chen Y, He W, Liu Y, Jiao Y, Wang G, Guan J, Zhao K, Zhang Q, Gao F, Li Z, Lan Y
mBio 2026 Jan 14;17(1):e0290325

Secreted Clever-1 modulates T cell responses and impacts cancer immunotherapy efficacy.

Prince S, Viitala M, Sjöroos R, Bendes ÁÁ, Rannikko JH, Patten DA, di Benedetto I, Turpin R, Ylitalo A, Tyni L, Figueiredo CR, Boström P, Koskivuo I, Salminen TA, Shetty S, Hollmén M
Theranostics 2025;15(15):7501-7527

Genome-wide mapping of RNA-protein associations through sequencing.

Qi Z, Xue S, Chen J, Zhao W, Johnson K, Wen X, Charles Richard JL, Lin P, Zhong S
Nature biotechnology 2025 Sep 9;

CD34(+)CLDN5(+) tumor associated senescent endothelial cells through IGF2-IGF2R signaling increased cholangiocellular phenotype in hepatocellular carcinoma.

Zhu XY, Liu WT, Hou XJ, Zong C, Yu W, Shen ZM, Qu SP, Tao M, Xue MM, Zhou DY, Bai HR, Gao L, Jiang JH, Zhao QD, Wei LX, Yang X, Han ZP, Zhang L
Journal of advanced research 2025 Oct;76:511-528

GRASP55 regulates sorting and maturation of the lysosomal enzyme β-hexosaminidase A.

Akaaboune SR, Javed A, Bui S, Wierenga A, Wang Y
Molecular biology of the cell 2025 Mar 1;36(3):ar30

Combining light-induced aggregation and biotin proximity labeling implicates endolysosomal proteins in early α-synuclein oligomerization.

Teixeira M, Sheta R, Musiol D, Ranjakasoa V, Loehr J, Lambert JP, Oueslati A
iScience 2025 Jul 18;28(7):112823

Identification and Validation of Novel Metastasis-Related Immune Gene Signature in Breast Cancer.

Ma S, Hao R, Lu YW, Wang HP, Hu J, Qi YX
Breast cancer (Dove Medical Press) 2024;16:199-219

GRASP55 Regulates Sorting and Maturation of the Lysosomal Enzyme β-Hexosaminidase A.

Akaaboune SR, Javed A, Bui S, Wierenga A, Wang Y
bioRxiv : the preprint server for biology 2024 Oct 17;

Genetic variation perspective reveals potential drug targets for subtypes of endometrial cancer.

Zhu J, Zhang T, Jiang J, Yang M, Xia N, Chen Y
Scientific reports 2024 Nov 15;14(1):28180

SARS-CoV-2 remodels the Golgi apparatus to facilitate viral assembly and secretion.

Zhang J, Kennedy A, de Melo Jorge DM, Xing L, Reid W, Bui S, Joppich J, Rose M, Ercan S, Tang Q, Tai AW, Wang Y
bioRxiv : the preprint server for biology 2024 Mar 15;

Blocking the interaction between circTNRC18 and LIN28A promotes trophoblast epithelial-mesenchymal transformation and alleviates preeclampsia.

Chen LL, Li YQ, Kang ZH, Zhang X, Gu SY, Wang N, Shen XY
Molecular and cellular endocrinology 2024 Jan 1;579:112073

Large-Scale CRISPR Screen of LDLR Pathogenic Variants.

Li M, Ma L, Chen Y, Li J, Wang Y, You W, Yuan H, Tang X, Ouyang H, Pang D
Research (Washington, D.C.) 2023;6:0203

Synchronized proinsulin trafficking reveals delayed Golgi export accompanies β-cell secretory dysfunction in rodent models of hyperglycemia.

Boyer CK, Bauchle CJ, Zhang J, Wang Y, Stephens SB
Scientific reports 2023 Mar 30;13(1):5218

Nonenzymatic function of DPP4 promotes diabetes-associated cognitive dysfunction through IGF-2R/PKA/SP1/ERp29/IP3R2 pathway-mediated impairment of Treg function and M1 microglia polarization.

Hui Y, Xu Z, Li J, Kuang L, Zhong Y, Tang Y, Wei J, Zhou H, Zheng T
Metabolism: clinical and experimental 2023 Jan;138:155340

A proteomic signature and potential pharmacological opportunities in the adaptive resistance to MEK and PI3K kinase inhibition in pancreatic cancer cells.

Aguilar-Valdés A, González-Vela F, Sánchez-Vidal H, Martínez-Aguilar J
Proteomics 2023 Aug;23(16):e2300041

Proteomics analysis of cancer tissues identifies IGF2R as a potential therapeutic target in laryngeal carcinoma.

Liu B, Hu Y, Wan L, Wang L, Cheng L, Sun H, Liu Y, Wu D, Zhu J, Hong X, Li Y, Zhou C
Frontiers in endocrinology 2022;13:1031210

GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway.

Zhang W, Yang X, Li Y, Yu L, Zhang B, Zhang J, Cho WJ, Venkatarangan V, Chen L, Burugula BB, Bui S, Wang Y, Duan C, Kitzman JO, Li M
Nature communications 2022 Sep 12;13(1):5351

Identification and characterization of a membrane receptor that binds to human STC1.

Wan HT, Ng AH, Lee WK, Shi F, Wong CK
Life science alliance 2022 Nov;5(11)

Liquid-liquid phase separation facilitates the biogenesis of secretory storage granules.

Parchure A, Tian M, Stalder D, Boyer CK, Bearrows SC, Rohli KE, Zhang J, Rivera-Molina F, Ramazanov BR, Mahata SK, Wang Y, Stephens SB, Gershlick DC, von Blume J
The Journal of cell biology 2022 Dec 5;221(12)

Trop2 binding IGF2R induces gefitinib resistance in NSCLC by remodeling the tumor microenvironment.

Sun X, Jia L, Wang T, Zhang Y, Zhao W, Wang X, Chen H
Journal of Cancer 2021;12(17):5310-5319

Autophagy-associated circular RNA hsa_circ_0007813 modulates human bladder cancer progression via hsa-miR-361-3p/IGF2R regulation.

Zhang Z, Mou Z, Xu C, Wu S, Dai X, Chen X, Ou Y, Chen Y, Yang C, Jiang H
Cell death & disease 2021 Aug 7;12(8):778

Grandmaternal betaine supplementation enhances hepatic IGF2 expression in F2 rat offspring through modification of promoter DNA methylation.

Yang S, Zhao N, Sun B, Yang Y, Hu Y, Zhao R
Journal of the science of food and agriculture 2020 Mar 15;100(4):1486-1494

Rumen-Protected Glucose Stimulates the Insulin-Like Growth Factor System and mTOR/AKT Pathway in the Endometrium of Early Postpartum Dairy Cows.

Wang Y, Han X, Tan Z, Kang J, Wang Z
Animals : an open access journal from MDPI 2020 Feb 23;10(2)

Hydrogen peroxide induces Arl1 degradation and impairs Golgi-mediated trafficking.

Ireland SC, Huang H, Zhang J, Li J, Wang Y
Molecular biology of the cell 2020 Aug 1;31(17):1931-1942

Mitotically Stable Modification of DNA Methylation in IGF2/H19 Imprinting Control Region Is Associated with Activated Hepatic IGF2 Expression in Offspring Rats from Betaine-Supplemented Dams.

Yang S, Zhao N, Yang Y, Hu Y, Dong H, Zhao R
Journal of agricultural and food chemistry 2018 Mar 21;66(11):2704-2713

Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.

Tanaka Y, Suzuki G, Matsuwaki T, Hosokawa M, Serrano G, Beach TG, Yamanouchi K, Hasegawa M, Nishihara M
Human molecular genetics 2017 Mar 1;26(5):969-988

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HepG2 cells were subjected to SDS PAGE followed by western blot with 20253-1-AP(IGF2R-Specific antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The IGF2R-Specific antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human IGF2R-Specific. This antibody recognizes human antigen. The IGF2R-Specific antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 20253-1-AP.pdf

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