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- References [18]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 11840-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11840-1-AP, RRID:AB_2183413
- Product name
- SDCCAG1 antibody
- Antibody type
- Polyclonal
- Description
- SDCCAG1 antibody (Cat. #11840-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The coordinated action of UFMylation and the RQC pathways clears arrested polypeptides at the ER.
BCR::ABL1 tyrosine kinase inhibitors induce ribosome collisions to activate ZAK-dependent ribotoxic stress and apoptosis in chronic myeloid leukemia.
Mitochondrial Protein Carboxyl-Terminal Alanine-Threonine Tailing Promotes Human Glioblastoma Growth by Regulating Mitochondrial Function.
Mitochondrial protein carboxyl-terminal alanine-threonine tailing promotes human glioblastoma growth by regulating mitochondrial function.
NEMF-mediated CAT tailing facilitates translocation-associated quality control.
Translation stalling induced mitochondrial entrapment of ribosomal quality control related proteins offers cancer cell vulnerability.
Arsenic trioxide and p97 inhibitor synergize against acute myeloid leukemia by targeting nascent polypeptides and activating the ZAKα-JNK pathway.
UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER.
NEMF-mediated Listerin-independent mitochondrial translational surveillance by E3 ligase Pirh2 and mitochondrial protease ClpXP.
LTN1 promotes RLR degradation to inhibit immune response to RNA virus through the ESCRT pathway.
Ribosomal quality control factors inhibit repeat-associated non-AUG translation from GC-rich repeats.
Protocol for identification of NEMF-mediated C-terminal extensions on mitochondrial nonstop proteins via customized MS/MS spectra database searching.
NEMF-mediated CAT-tailing defines distinct branches of translocation-associated quality control.
Poly-alanine-tailing is a modifier of neurodegeneration caused by Listerin mutation.
Ribosomal quality control factors inhibit repeat-associated non-AUG translation from GC-rich repeats.
Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer's disease.
Convergence of mammalian RQC and C-end rule proteolytic pathways via alanine tailing.
NEMF mutations that impair ribosome-associated quality control are associated with neuromuscular disease.
Mihailovic M, Anisimova AS, Erte B, Zhan N, Styliara I, Dagdas Y, Karagöz GE
The EMBO journal 2026 May;45(9):3252-3275
The EMBO journal 2026 May;45(9):3252-3275
BCR::ABL1 tyrosine kinase inhibitors induce ribosome collisions to activate ZAK-dependent ribotoxic stress and apoptosis in chronic myeloid leukemia.
Park J, Kim SH, Park J, Park H, Kim H, Kim DW, Lim C
Leukemia 2026 May;40(5):955-969
Leukemia 2026 May;40(5):955-969
Mitochondrial Protein Carboxyl-Terminal Alanine-Threonine Tailing Promotes Human Glioblastoma Growth by Regulating Mitochondrial Function.
Zhang B, Cai T, Reddy E, Wu Y, Mondal I, Tang Y, Gbufor AS, Wang J, Shen Y, Liu Q, Sun R, Ho WS, Lu RO, Wu Z
bioRxiv : the preprint server for biology 2026 Jan 9;
bioRxiv : the preprint server for biology 2026 Jan 9;
Mitochondrial protein carboxyl-terminal alanine-threonine tailing promotes human glioblastoma growth by regulating mitochondrial function.
Zhang B, Cai T, Reddy E, Wu Y, Mondal I, Tang Y, Gbufor AS, Wang J, Shen Y, Liu Q, Sun R, Ho WS, Lu RO, Wu Z
eLife 2026 Jan 29;13
eLife 2026 Jan 29;13
NEMF-mediated CAT tailing facilitates translocation-associated quality control.
Ennis A, Wang L, Xu Y, Saidi L, Wang X, Yu C, Yun S, Huang L, Ye Y
The Journal of cell biology 2025 Jun 2;224(6)
The Journal of cell biology 2025 Jun 2;224(6)
Translation stalling induced mitochondrial entrapment of ribosomal quality control related proteins offers cancer cell vulnerability.
Ojha R, Tantray I, Banerjee S, Rimal S, Thirunavukkarasu S, Srikrishna S, Chiu W, Mete U, Sharma A, Kakkar N, Lu B
Research square 2024 Sep 13;
Research square 2024 Sep 13;
Arsenic trioxide and p97 inhibitor synergize against acute myeloid leukemia by targeting nascent polypeptides and activating the ZAKα-JNK pathway.
Xie S, Liu H, Zhu S, Chen Z, Wang R, Zhang W, Xian H, Xiang R, Xia X, Sun Y, Long J, Wang Y, Wang M, Wang Y, Yu Y, Huang Z, Lu C, Xu Z, Liu H
Cancer gene therapy 2024 Oct;31(10):1486-1497
Cancer gene therapy 2024 Oct;31(10):1486-1497
UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER.
DaRosa PA, Penchev I, Gumbin SC, Scavone F, Wąchalska M, Paulo JA, Ordureau A, Peter JJ, Kulathu Y, Harper JW, Becker T, Beckmann R, Kopito RR
Nature 2024 Mar;627(8003):445-452
Nature 2024 Mar;627(8003):445-452
NEMF-mediated Listerin-independent mitochondrial translational surveillance by E3 ligase Pirh2 and mitochondrial protease ClpXP.
Lv L, Mo J, Qing Y, Wang S, Chen L, Mei A, Xu R, Huang H, Tan J, Li Y, Liu J
Cell reports 2024 Mar 26;43(3):113860
Cell reports 2024 Mar 26;43(3):113860
LTN1 promotes RLR degradation to inhibit immune response to RNA virus through the ESCRT pathway.
Qin F, Cai B, Wang P, Cao R, Zhang Y, Wen H, Zheng Y, Zhao W, Gao C, Liu B
Autophagy 2024 Jun;20(6):1270-1285
Autophagy 2024 Jun;20(6):1270-1285
Ribosomal quality control factors inhibit repeat-associated non-AUG translation from GC-rich repeats.
Tseng YJ, Krans A, Malik I, Deng X, Yildirim E, Ovunc S, Tank EMH, Jansen-West K, Kaufhold R, Gomez NB, Sher R, Petrucelli L, Barmada SJ, Todd PK
Nucleic acids research 2024 Jun 10;52(10):5928-5949
Nucleic acids research 2024 Jun 10;52(10):5928-5949
Protocol for identification of NEMF-mediated C-terminal extensions on mitochondrial nonstop proteins via customized MS/MS spectra database searching.
Chen L, Mo J, Tan Y, Lv L, Liu J
STAR protocols 2024 Dec 20;5(4):103366
STAR protocols 2024 Dec 20;5(4):103366
NEMF-mediated CAT-tailing defines distinct branches of translocation-associated quality control.
Ennis A, Wang L, Wang X, Yu C, Saidi L, Xu Y, Yun S, Huang L, Ye Y
bioRxiv : the preprint server for biology 2024 Aug 28;
bioRxiv : the preprint server for biology 2024 Aug 28;
Poly-alanine-tailing is a modifier of neurodegeneration caused by Listerin mutation.
Hung HC, Costas-Insua C, Holbrook SE, Stauffer JE, Martin PB, Müller TA, Schroeder DG, Kigoshi-Tansho Y, Xu H, Rudolf R, Cox GA, Joazeiro CAP
bioRxiv : the preprint server for biology 2024 Aug 24;
bioRxiv : the preprint server for biology 2024 Aug 24;
Ribosomal quality control factors inhibit repeat-associated non-AUG translation from GC-rich repeats.
Tseng YJ, Malik I, Deng X, Krans A, Jansen-West K, Tank EMH, Gomez NB, Sher R, Petrucelli L, Barmada SJ, Todd PK
bioRxiv : the preprint server for biology 2023 Jun 7;
bioRxiv : the preprint server for biology 2023 Jun 7;
Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer's disease.
Rimal S, Li Y, Vartak R, Geng J, Tantray I, Li S, Huh S, Vogel H, Glabe C, Grinberg LT, Spina S, Seeley WW, Guo S, Lu B
Acta neuropathologica communications 2021 Oct 18;9(1):169
Acta neuropathologica communications 2021 Oct 18;9(1):169
Convergence of mammalian RQC and C-end rule proteolytic pathways via alanine tailing.
Thrun A, Garzia A, Kigoshi-Tansho Y, Patil PR, Umbaugh CS, Dallinger T, Liu J, Kreger S, Patrizi A, Cox GA, Tuschl T, Joazeiro CAP
Molecular cell 2021 May 20;81(10):2112-2122.e7
Molecular cell 2021 May 20;81(10):2112-2122.e7
NEMF mutations that impair ribosome-associated quality control are associated with neuromuscular disease.
Martin PB, Kigoshi-Tansho Y, Sher RB, Ravenscroft G, Stauffer JE, Kumar R, Yonashiro R, Müller T, Griffith C, Allen W, Pehlivan D, Harel T, Zenker M, Howting D, Schanze D, Faqeih EA, Almontashiri NAM, Maroofian R, Houlden H, Mazaheri N, Galehdari H, Douglas G, Posey JE, Ryan M, Lupski JR, Laing NG, Joazeiro CAP, Cox GA
Nature communications 2020 Sep 15;11(1):4625
Nature communications 2020 Sep 15;11(1):4625
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A549 cells were subjected to SDS PAGE followed by western blot with 11840-1-AP(SDCCAG1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SDCCAG1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SDCCAG1. This antibody recognizes human, mouse, rat antigen. The SDCCAG1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
