27630-1-AP

antibody from Proteintech Group

Targeting: GSDMC MLZE

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

27630-1-AP

Provider

Proteintech Group

Product name

GSDMC antibody

Antibody type

Polyclonal

Description

KD/KO validated GSDMC antibody (Cat. #27630-1-AP) is a rabbit polyclonal antibody that shows reactivity with Human, Mouse and has been validated for the following applications: IHC, WB,ELISA.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Gasdermin C sensitizes tumor cells to PARP inhibitor therapy in cancer models.

Wang S, Chang CW, Huang J, Zeng S, Zhang X, Hung MC, Hou J
The Journal of clinical investigation 2024 Jan 2;134(1)

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High pyroptosis activity in pancreatic adenocarcinoma: poor prognosis and oxaliplatin resistance.

Wang G, Chen J, Dai S, Zhang J, Gao Y, Yin L, Jiang K, Miao Y, Lu Z
Apoptosis : an international journal on programmed cell death 2024 Apr;29(3-4):344-356

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Tetracaine hydrochloride induces macrophage pyroptosis through caspase‑1/11‑GSDMD signaling pathways.

Zhang R, Gou W, Yi P, Qin Z, Zhu D, Jia J, Liu L, Jiang X, Feng J
Experimental and therapeutic medicine 2023 Sep;26(3):428

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Pyroptosis impacts the prognosis and treatment response in gastric cancer via immune system modulation.

Yang W, Niu L, Zhao X, Duan L, Wang X, Li Y, Chen J, Zhou W, Zhang Y, Fan D, Hong L
American journal of cancer research 2022;12(4):1511-1534

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System analysis based on the pyroptosis-related genes identifies GSDMC as a novel therapy target for pancreatic adenocarcinoma.

Yan C, Niu Y, Li F, Zhao W, Ma L
Journal of translational medicine 2022 Oct 5;20(1):455

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N(6)-adenomethylation of GsdmC is essential for Lgr5(+) stem cell survival to maintain normal colonic epithelial morphogenesis.

Du J, Sarkar R, Li Y, He L, Kang W, Liao W, Liu W, Nguyen T, Zhang L, Deng Z, Dougherty U, Kupfer SS, Chen M, Pekow J, Bissonnette M, He C, Li YC
Developmental cell 2022 Aug 22;57(16):1976-1994.e8

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siRNAs Targeting Mouse-Specific lncRNA AA388235 Induce Human Tumor Cell Pyroptosis/Apoptosis.

Chen YR, Feng WY, Cheng YX, Zhu H, Liu HJ, Gao Y, Zhou WJ
Frontiers in oncology 2021;11:662444

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Disruption of the endopeptidase ADAM10-Notch signaling axis leads to skin dysbiosis and innate lymphoid cell-mediated hair follicle destruction.

Sakamoto K, Jin SP, Goel S, Jo JH, Voisin B, Kim D, Nadella V, Liang H, Kobayashi T, Huang X, Deming C, Horiuchi K, Segre JA, Kong HH, Nagao K
Immunity 2021 Oct 12;54(10):2321-2337.e10

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PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis.

Hou J, Zhao R, Xia W, Chang CW, You Y, Hsu JM, Nie L, Chen Y, Wang YC, Liu C, Wang WJ, Wu Y, Ke B, Hsu JL, Huang K, Ye Z, Yang Y, Xia X, Li Y, Li CW, Shao B, Tainer JA, Hung MC
Nature cell biology 2020 Oct;22(10):1264-1275