19953-1-AP

antibody from Proteintech Group

Targeting: GRIN2A GluN2A, NMDAR2A

Provider product page for 19953-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [28]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 19953-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#19953-1-AP, RRID:AB_10640434
Product name: NMDAR2A/GRIN2A antibody
Antibody type: Polyclonal
Description: NMDAR2A/GRIN2A antibody (Cat. #19953-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IF, IHC, WB, ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

GRIN2A protein structure - 19953-1-AP shown in red.

Submitted references Neuro-stimulating effect of Citri Reticulata Pericarpium Viride essential oil through regulating Glu/NMDAR on olfactory bulb to improve anxiety-like behavior.

Chen J, Liu Y, Song Y, Liang H, Zhu G, Zhang B, Liao L, Luo J, Yang M, Su D
Journal of ethnopharmacology 2024 Sep 15;331:118332

Integrin α3 is required for high-frequency repetitive transcranial magnetic stimulation-induced glutamatergic synaptic transmission in mice with ischemia.

Liu L, Hu H, Wu J, Koleske AJ, Chen H, Wang N, Yu K, Wu Y, Xiao X, Zhang Q
CNS neuroscience & therapeutics 2024 Apr;30(4):e14498

SorCS2 is involved in promoting periodontitis-induced depression-like behaviour in mice.

Li Y, Yang Y, Guan X, Liu Z, Pan L, Wang Y, Jia X, Yang J, Hou T
Oral diseases 2024 Apr 3;

Increased level of RAB39B leads to neuronal dysfunction and behavioural changes in mice.

Wang Z, Niu M, Zheng N, Meng J, Jiang Y, Yang D, Yao P, Yao T, Luo H, Xu H, Ge Y, Zhang YW, Zhang X
Journal of cellular and molecular medicine 2023 May;27(9):1214-1226

Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function.

Yang ZH, Cai X, Ding ZL, Li W, Zhang CY, Huo JH, Zhang Y, Wang L, Zhang LM, Li SW, Li M, Zhang C, Chang H, Xiao X
BMC medicine 2023 Jul 13;21(1):254

Effects of Prolonged High-Fat Diet Consumption Starting at Different Ages on Behavioral Parameters and Hippocampal Neuroplasticity in Male Mice.

Yang C, Yao X, Zhang H, Wang C, Zhao J, Xu D, Xiao Y, Li Q, Zhuang H, Kang X, Sun C, Liu L
Journal of integrative neuroscience 2023 Jan 13;22(1):16

RNF220 is an E3 ubiquitin ligase for AMPA receptors to regulate synaptic transmission.

Ma P, Wan LP, Li Y, He CH, Song NN, Zhao S, Wang H, Ding YQ, Mao B, Sheng N
Science advances 2022 Sep 30;8(39):eabq4736

Microglial Tmem59 Deficiency Impairs Phagocytosis of Synapse and Leads to Autism-Like Behaviors in Mice.

Meng J, Han L, Zheng N, Wang T, Xu H, Jiang Y, Wang Z, Liu Z, Zheng Q, Zhang X, Luo H, Can D, Lu J, Xu H, Zhang YW
The Journal of neuroscience : the official journal of the Society for Neuroscience 2022 Jun 22;42(25):4958-4979

A recurrent SHANK1 mutation implicated in autism spectrum disorder causes autistic-like core behaviors in mice via downregulation of mGluR1-IP3R1-calcium signaling.

Qin Y, Du Y, Chen L, Liu Y, Xu W, Liu Y, Li Y, Leng J, Wang Y, Zhang XY, Feng J, Zhang F, Jin L, Qiu Z, Gong X, Wang H
Molecular psychiatry 2022 Jul;27(7):2985-2998

Resveratrol Improves Synaptic Plasticity in Hypoxic-Ischemic Brain Injury in Neonatal Mice via Alleviating SIRT1/NF-κB Signaling-Mediated Neuroinflammation.

Peng X, Wang J, Peng J, Jiang H, Le K
Journal of molecular neuroscience : MN 2022 Jan;72(1):113-125

KDM6B cooperates with Tau and regulates synaptic plasticity and cognition via inducing VGLUT1/2.

Wang Y, Khandelwal N, Liu S, Zhou M, Bao L, Wang JE, Kumar A, Xing C, Gibson JR, Wang Y
Molecular psychiatry 2022 Dec;27(12):5213-5226

Loss of schizophrenia-related miR-501-3p in mice impairs sociability and memory by enhancing mGluR5-mediated glutamatergic transmission.

Liang W, Hou Y, Huang W, Wang Y, Jiang T, Huang X, Wang Z, Wu F, Zheng J, Zhang J, Ou H, Li S, Ping J, Zhang Y, Ye J, Li Z, Yang Q, Zhang J, Zheng X, Li S, Zhu XH, Chen R, Zhao C
Science advances 2022 Aug 19;8(33):eabn7357

Profiling of Sexually Dimorphic Genes in Neural Cells to Identify Eif2s3y, Whose Overexpression Causes Autism-Like Behaviors in Male Mice.

Zhang M, Zhou Y, Jiang Y, Lu Z, Xiao X, Ning J, Sun H, Zhang X, Luo H, Can D, Lu J, Xu H, Zhang YW
Frontiers in cell and developmental biology 2021;9:669798

Injection of Anti-proBDNF Attenuates Hippocampal-Dependent Learning and Memory Dysfunction in Mice With Sepsis-Associated Encephalopathy.

Cui YH, Zhou SF, Liu Y, Wang S, Li F, Dai RP, Hu ZL, Li CQ
Frontiers in neuroscience 2021;15:665757

Impaired Learning and Memory Ability Induced by a Bilaterally Hippocampal Injection of Streptozotocin in Mice: Involved With the Adaptive Changes of Synaptic Plasticity.

Qi CC, Chen XX, Gao XR, Xu JX, Liu S, Ge JF
Frontiers in aging neuroscience 2021;13:633495

Vitamin D3 reduces hippocampal NR2A and anxiety in nicotine withdrawal mice.

Wu B, Tao X, Liu C, Li H, Jiang T, Chen Z, Wang Q, Liu F, Mu M, Chen Z
Translational neuroscience 2021 Jan 1;12(1):273-281

Enriched environment remedies cognitive dysfunctions and synaptic plasticity through NMDAR-Ca(2+)-Activin A circuit in chronic cerebral hypoperfusion rats.

Zhang X, Shi X, Wang J, Xu Z, He J
Aging 2021 Aug 30;13(16):20748-20761

RAB39B Deficiency Impairs Learning and Memory Partially Through Compromising Autophagy.

Niu M, Zheng N, Wang Z, Gao Y, Luo X, Chen Z, Fu X, Wang Y, Wang T, Liu M, Yao T, Yao P, Meng J, Zhou Y, Ge Y, Wang Z, Ma Q, Xu H, Zhang YW
Frontiers in cell and developmental biology 2020;8:598622

Corticosterone Induced the Increase of proBDNF in Primary Hippocampal Neurons Via Endoplasmic Reticulum Stress.

Liu Y, Zou GJ, Tu BX, Hu ZL, Luo C, Cui YH, Xu Y, Li F, Dai RP, Bi FF, Li CQ
Neurotoxicity research 2020 Aug;38(2):370-384

STK24 modulates excitatory synaptic transmission in epileptic hippocampal neurons.

Yang J, Jiang Q, Yu X, Xu T, Wang Y, Deng J, Liu Y, Chen Y
CNS neuroscience & therapeutics 2020 Aug;26(8):851-861

Inhibition of Nwd1 activity attenuates neuronal hyperexcitability and GluN2B phosphorylation in the hippocampus.

Yang Q, Huang Z, Luo Y, Zheng F, Hu Y, Liu H, Zhu S, He M, Xu D, Li Y, Yang M, Yang Y, Wei X, Gao X, Wang W, Ma J, Ma Y, Wang X, Wang Q
EBioMedicine 2019 Sep;47:470-483

TMEM25 modulates neuronal excitability and NMDA receptor subunit NR2B degradation.

Zhang H, Tian X, Lu X, Xu D, Guo Y, Dong Z, Li Y, Ma Y, Chen C, Yang Y, Yang M, Yang Y, Liu F, Zhou R, He M, Xiao F, Wang X
The Journal of clinical investigation 2019 Sep 3;129(9):3864-3876

The second PDZ domain of scaffold protein Frmpd2 binds to GluN2A of NMDA receptors.

Lu X, Zhang Q, Wang T
Biochemical and biophysical research communications 2019 Aug 13;516(1):63-67

The effects of fluoride on neuronal function occurs via cytoskeleton damage and decreased signal transmission.

Chen L, Ning H, Yin Z, Song X, Feng Y, Qin H, Li Y, Wang J, Ge Y, Wang W
Chemosphere 2017 Oct;185:589-594

Down-regulation of Pin1 in Temporal Lobe Epilepsy Patients and Mouse Model.

Tang L, Zhang Y, Chen G, Xiong Y, Wang X, Zhu B
Neurochemical research 2017 Apr;42(4):1211-1218

NR4A1 Knockdown Suppresses Seizure Activity by Regulating Surface Expression of NR2B.

Zhang Y, Chen G, Gao B, Li Y, Liang S, Wang X, Wang X, Zhu B
Scientific reports 2016 Nov 23;6:37713

Central nervous system-specific knockout of Brg1 causes growth retardation and neuronal degeneration.

Deng L, Li G, Rao B, Li H
Brain research 2015 Oct 5;1622:186-95

Specificity protein 4 functionally regulates the transcription of NMDA receptor subunits GluN1, GluN2A, and GluN2B.

Priya A, Johar K, Wong-Riley MTT
Biochimica et biophysica acta 2013 Dec;1833(12):2745-2756

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse brain tissue were subjected to SDS PAGE followed by western blot with 19953-1-AP(GRIN2A antibody) at dilution of 1:500
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of Hela cells, using GRIN2A antibody 19953-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line