Antibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Western blot [2]
- Immunohistochemistry [1]
- Other assay [4]
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Validation data
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- Product number
- PA5-35377 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- NMDAR2A Polyclonal Antibody
- Antibody type
- Polyclonal
- Antigen
- Other
- Description
- PA5-35377 will not cross-react with NR2B and NR2C subunits.
- Concentration
- ~0.2 mg/mL
Submitted references A novel bio-inspired strategy to prevent amyloidogenesis and synaptic damage in Alzheimer's disease.
Timing-dependent LTP and LTD in mouse primary visual cortex following different visual deprivation models.
SorCS2-mediated NR2A trafficking regulates motor deficits in Huntington's disease.
Catania M, Colombo L, Sorrentino S, Cagnotto A, Lucchetti J, Barbagallo MC, Vannetiello I, Vecchi ER, Favagrossa M, Costanza M, Giaccone G, Salmona M, Tagliavini F, Di Fede G
Molecular psychiatry 2022 Dec;27(12):5227-5234
Molecular psychiatry 2022 Dec;27(12):5227-5234
Timing-dependent LTP and LTD in mouse primary visual cortex following different visual deprivation models.
Guo Y, Zhang W, Chen X, Fu J, Cheng W, Song D, Qu X, Yang Z, Zhao K
PloS one 2017;12(5):e0176603
PloS one 2017;12(5):e0176603
SorCS2-mediated NR2A trafficking regulates motor deficits in Huntington's disease.
Ma Q, Yang J, Milner TA, Vonsattel JG, Palko ME, Tessarollo L, Hempstead BL
JCI insight 2017 May 4;2(9)
JCI insight 2017 May 4;2(9)
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Western blot analysis of NMDA Receptor 2A in rat hippocampal lysate (10 µg) using a NMDA Receptor 2A polyclonal antibody (Product # PA5-35377). Results show a band at ~180 kDa.
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Western blot of NMDAR2A in rat hippocampal lysate (10 µg), showing specific immunolabeling of a band at ~180 kDa corresponding to the NR2A subunit of the NMDAR2A polyclonal antibody (Product # PA5-35377) receptor.
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunohistochemistry analysis of NMDAR2A in rabbit retina showing NMDAR2A polyclonal antibody (Product # PA5-35377) in the rod and cone photoreceptors in the outer plexiform layer as well as the entire inner plexiform layer.
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Fig 3 DE and MD modify NMDAR subunit composition in synaptoneurosomes from mice visual cortex. (A-B) top: Representative immunoblots of synaptoneurosome samples prepared from frontal (F) and visual (V) cortices of mice that were normal-reared (NR), dark-exposured (DE) and monocular deprived mice. Blots were probed with subunit-specific antibodies for NR2A (Fig A), NR2B(Fig B). Bottom: Summary of immunoblot analysis of synaptoneurosome samples prepared from Visual cortices (V) of NR and DE mice or NR and MD mice. NR2A protein levels in visual cortex weresignificantly reduced after 6 days of DE ( t -test p0.6)(Fig B). Data are expressed as mean values +- SEM normalized to the average NR protein level, n = 8 from 4 animals for each group. (C) The NR2A/2B ratio is reduced in the deprived visual cortex from mice that were under dark exposure (t -test p