Antibody data
- Antibody Data
- Antigen structure
- References [21]
- Comments [0]
- Validations [0]
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- Product number
- 28525-1-AP - Provider product page

- Provider
- Proteintech Group
- Product name
- NMDAR2A/GRIN2A antibody
- Antibody type
- Polyclonal
- Description
- NMDAR2A/GRIN2A antibody (Cat. #28525-1-AP) is a rabbit polyclonal antibody that shows reactivity with Human, mouse, rat and has been validated for the following applications: WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Downregulation of integrin α3 in ADHD mirrored in mutant mouse model by dopamine-dependent hippocampal AMPAR expression.
HMGCS2-dependent β-OHB/H3K9bhb ameliorates synaptic plasticity and cognition in Alzheimer's disease.
Abnormal FKN-CX3CR1-NR signal triggers hippocampal synaptic dysfunction in rheumatoid arthritis-related depression.
Prognostic value of palmitoylation-regulated mechanisms in glioblastoma: integrated multi-omics analysis via least absolute shrinkage and selection operator (LASSO) regression and single-cell sequencing.
NMDAR inhibitor preconditioned mesenchymal stromal cell-derived extracellular vesicles enhance post-stroke recovery by targeting excitotoxicity and neuronal regeneration.
Alisol A ameliorates vascular cognitive impairment via AMPK/NAMPT/SIRT1-mediated regulation of cholesterol and autophagy.
Ethyl Acetate Fraction of Zanthoxylum bungeanum Ameliorates Cognitive Deficit by Facilitating the PHGDH-Dependent Astrocyte-Neuron Serine Shuttle in Aging Mice.
A new specific GluN2B partial antagonist ameliorates brain injury caused by ischemic stroke in rats.
Discovery of HZS60 as a Novel Brain Penetrant NMDAR/TRPM4 Interaction Interface Inhibitor with Improved Activity and Pharmacokinetic Properties for the Treatment of Cerebral Ischemia.
Cortex-Specific Tmem169 Deficiency Induces Defects in Cortical Neuron Development and Autism-Like Behaviors in Mice.
Effects of esketamine on electrophysiology and metabolic reprogramming in brain organoids: insights into antidepressant mechanisms.
CMTR1-catalyzed 2'-O-methylation promotes NMDA receptor signaling, long-term potentiation and memory.
Increased expression of mesencephalic astrocyte-derived neurotrophic factor (MANF) contributes to synapse loss in Alzheimer's disease.
JRM-28, a Novel HDAC2 Inhibitor, Upregulates Plasticity-Associated Proteins in Hippocampal Neurons and Enhances Morphological Plasticity via Activation of CREB: Implications for Alzheimer's Disease.
Sorbs2 regulates seizure activity by influencing AMPAR-mediated excitatory synaptic transmission in temporal lobe epilepsy.
Reduction of p11 in dorsal raphe nucleus serotonergic neurons mediates depression-like behaviors.
Dysregulation of striatal dopamine D2/D3 receptor-mediated by hypocretin induces depressive behaviors in rats.
Characterization of three naturally occurring lignans, sesamol, sesamolin, and sesamin, as potent inhibitors of human cytochrome P450 46A1: Implications for treating excitatory neurotoxicity.
The role of reelin in the pathological mechanism of depression from clinical to rodents.
Single-Nucleus RNA Sequencing Reveals that Decorin Expression in the Amygdala Regulates Perineuronal Nets Expression and Fear Conditioning Response after Traumatic Brain Injury.
Catch-up fat in male adults induces low testosterone and consequently promotes metabolic abnormalities and cognitive impairment.
Yao X, Chen R, Zhu J, Hou R, Xiang S, Jia T, Gu Y, Wang Z, Hu H, Chen H, Wang H, Feng J, Robbins TW, Wang Y, Higley MJ, Koleske AJ, Xiao X
Molecular psychiatry 2026 May;31(5):2542-2560
Molecular psychiatry 2026 May;31(5):2542-2560
HMGCS2-dependent β-OHB/H3K9bhb ameliorates synaptic plasticity and cognition in Alzheimer's disease.
Yu H, Wang F, Yuan JQ, Chen J, Zhang KY, Jia D, Gong J, Mao Y, Bi S, Zhang YQ, Lan ZC, Yu HY, Chai GS
Experimental & molecular medicine 2026 Mar;58(3):813-831
Experimental & molecular medicine 2026 Mar;58(3):813-831
Abnormal FKN-CX3CR1-NR signal triggers hippocampal synaptic dysfunction in rheumatoid arthritis-related depression.
Yao SX, Luo SY, Zhao HQ, Tan H, Liu PA, Liu J
International immunopharmacology 2026 Jul 15;181:116693
International immunopharmacology 2026 Jul 15;181:116693
Prognostic value of palmitoylation-regulated mechanisms in glioblastoma: integrated multi-omics analysis via least absolute shrinkage and selection operator (LASSO) regression and single-cell sequencing.
Ji Y, Dai X, Jiang L, Zeng H, Cai Z, Li B
Translational cancer research 2026 Jan 31;15(1):27
Translational cancer research 2026 Jan 31;15(1):27
NMDAR inhibitor preconditioned mesenchymal stromal cell-derived extracellular vesicles enhance post-stroke recovery by targeting excitotoxicity and neuronal regeneration.
Zhang X, Tian H, Bo H, Zhong L
Frontiers in cellular neuroscience 2025;19:1608615
Frontiers in cellular neuroscience 2025;19:1608615
Alisol A ameliorates vascular cognitive impairment via AMPK/NAMPT/SIRT1-mediated regulation of cholesterol and autophagy.
Xu P, Zhou W, Wang S, Wang L, Bai Y, Xing S, Xue W, Li M, Shi J, Wu H
Theranostics 2025;15(18):9415-9446
Theranostics 2025;15(18):9415-9446
Ethyl Acetate Fraction of Zanthoxylum bungeanum Ameliorates Cognitive Deficit by Facilitating the PHGDH-Dependent Astrocyte-Neuron Serine Shuttle in Aging Mice.
Zhao M, Zeng L, Zhou Y, Yang C, Sheng R, Liu X, Wen W, Yang S, Zhang S, Xu S
Journal of agricultural and food chemistry 2025 Jul 2;73(26):16301-16316
Journal of agricultural and food chemistry 2025 Jul 2;73(26):16301-16316
A new specific GluN2B partial antagonist ameliorates brain injury caused by ischemic stroke in rats.
Fan Y, Wu H, Yin D, Liu Q, Yuan C, Zhong T, Xia B, Xiong L, Li Y, Zeng L, Li Y, Li Y, Tang L
Bioorganic chemistry 2025 Jul 1;161:108547
Bioorganic chemistry 2025 Jul 1;161:108547
Discovery of HZS60 as a Novel Brain Penetrant NMDAR/TRPM4 Interaction Interface Inhibitor with Improved Activity and Pharmacokinetic Properties for the Treatment of Cerebral Ischemia.
Sun M, Wang L, Cao Q, Wang X, Zhang Y, Guo M, Chen J, Ma Y, Niu L, Zhang Y, Hu M, Gu M, Zhu Z, Yao X, Yao J, Zhao C, Wu J, Liu X, Lu Y, Wang Z, Xiang Q, Han F, Zhu D
Journal of medicinal chemistry 2025 Jan 23;68(2):2008-2043
Journal of medicinal chemistry 2025 Jan 23;68(2):2008-2043
Cortex-Specific Tmem169 Deficiency Induces Defects in Cortical Neuron Development and Autism-Like Behaviors in Mice.
Wang J, Zhang J, Li J, Gao Q, Chen J, Jia C, Gu X
The Journal of neuroscience : the official journal of the Society for Neuroscience 2025 Feb 26;45(9)
The Journal of neuroscience : the official journal of the Society for Neuroscience 2025 Feb 26;45(9)
Effects of esketamine on electrophysiology and metabolic reprogramming in brain organoids: insights into antidepressant mechanisms.
Li M, Duan W, Hao X, Li S, Wang C, Liang Y, Hu Z, Ma D, Guo M, Zuo C, Wang Z, Feng Y, Hao C, Qi S, Sun Y, Tang M, Mao C, Hashimoto K, Xu Y, Yuan J, Yang J, Shi C
Molecular psychiatry 2025 Dec;30(12):6107-6118
Molecular psychiatry 2025 Dec;30(12):6107-6118
CMTR1-catalyzed 2'-O-methylation promotes NMDA receptor signaling, long-term potentiation and memory.
Azeem S, Chang TT, Peng C, Lee YL, Yeh NH, Huang YS
Progress in neurobiology 2025 Aug;251:102802
Progress in neurobiology 2025 Aug;251:102802
Increased expression of mesencephalic astrocyte-derived neurotrophic factor (MANF) contributes to synapse loss in Alzheimer's disease.
Zhang Y, Chen X, Chen L, Shao M, Zhu W, Xing T, Guo T, Jia Q, Yang H, Yin P, Yan XX, Yu J, Li S, Li XJ, Yang S
Molecular neurodegeneration 2024 Oct 18;19(1):75
Molecular neurodegeneration 2024 Oct 18;19(1):75
JRM-28, a Novel HDAC2 Inhibitor, Upregulates Plasticity-Associated Proteins in Hippocampal Neurons and Enhances Morphological Plasticity via Activation of CREB: Implications for Alzheimer's Disease.
Rahman AFMT, Bulbule S, Belayet JB, Benko A, Gottschalk CG, Frick DN, Arnold LA, Hossain MM, Roy A
Cells 2024 Nov 27;13(23)
Cells 2024 Nov 27;13(23)
Sorbs2 regulates seizure activity by influencing AMPAR-mediated excitatory synaptic transmission in temporal lobe epilepsy.
Ban Y, Yang X, Tan D, Gong C, Gao Y, Yuan J, Chen Y, Wang Y, Xu T
Neurochemistry international 2024 Jun;176:105727
Neurochemistry international 2024 Jun;176:105727
Reduction of p11 in dorsal raphe nucleus serotonergic neurons mediates depression-like behaviors.
Li W, Shen Z, Yin X, Chang W, Chen X, Yu J, Xu S
Translational psychiatry 2023 Nov 22;13(1):359
Translational psychiatry 2023 Nov 22;13(1):359
Dysregulation of striatal dopamine D2/D3 receptor-mediated by hypocretin induces depressive behaviors in rats.
Chen B, Xu J, Chen S, Mou T, Wang Y, Wang H, Zhang Z, Ren F, Wang Z, Jin K, Lu J
Journal of affective disorders 2023 Mar 15;325:256-263
Journal of affective disorders 2023 Mar 15;325:256-263
Characterization of three naturally occurring lignans, sesamol, sesamolin, and sesamin, as potent inhibitors of human cytochrome P450 46A1: Implications for treating excitatory neurotoxicity.
Du J, Chen X, Zhao Y, Zhao T, Wang D, Chen Z, Wang C, Meng Q, Yao J, Sun H, Liu K, Wu J
Frontiers in pharmacology 2022;13:1046814
Frontiers in pharmacology 2022;13:1046814
The role of reelin in the pathological mechanism of depression from clinical to rodents.
Jin K, Zhang S, Jiang C, Liu R, Chen B, Zhao H, Zhang Q, Shen Z, Xu P, Hu X, Jiao J, Lu J, Huang M
Psychiatry research 2022 Nov;317:114838
Psychiatry research 2022 Nov;317:114838
Single-Nucleus RNA Sequencing Reveals that Decorin Expression in the Amygdala Regulates Perineuronal Nets Expression and Fear Conditioning Response after Traumatic Brain Injury.
Shi Y, Wu X, Zhou J, Cui W, Wang J, Hu Q, Zhang S, Han L, Zhou M, Luo J, Wang Q, Liu H, Feng D, Ge S, Qu Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Mar;9(7):e2104112
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Mar;9(7):e2104112
Catch-up fat in male adults induces low testosterone and consequently promotes metabolic abnormalities and cognitive impairment.
Liu X, He Y, Zhang Q, Zeng T, Zhang J, Min J, Tian S, Huang H, Wang W, Dong F, Wang P, Zhang L, Shuang Z, Chen L, Hu X
Andrology 2022 Jul;10(5):871-884
Andrology 2022 Jul;10(5):871-884
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