Antibody data
- Antibody Data
- Antigen structure
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- Product number
- AMM01693G - Provider product page
- Provider
- Leading Biology
- Product name
- SARM1 / SARM Antibody (clone Sarmy-1)
- Antibody type
- Monoclonal
- Description
- Negative regulator of MYD88- and TRIF-dependent toll- like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88- dependent activation of JUN/AP-1, TRIF-dependent activation of NF- kappa-B and IRF3, and the phosphorylation of MAPK14/p38.
- Reactivity
- Human
- Host
- Mouse
- Antibody clone number
- Sarmy-1
- Storage
- Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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