BS7876

antibody from Bioworld Technology, Inc
Targeting: GUSB
Provider product page for BS7876
Western blot
Immunohistochemistry

Antibody data

Product number
BS7876 - Provider product page
Provider
Bioworld Technology, Inc
Product name
GUSB polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human GUSB.
Description
The enzyme ÉÇ-glucuronidase catalyzes the conversion of ÉÇ-D-glucuronoside and water to an alcohol and D-glucuronate. Deficiency of ÉÇ-glucuronidase is the cause of the human lysosomal storage disorder mucopolysaccharidosis type VII (MPS VII). Specifically, two residues appear important for catalytic activity: Glu 451 and Glu 540. Mutations at these sites affect the overall structure of the protein, which normally consists of a homotetramer with each promoter including a jelly roll barrel, an immunoglobulin constant domain and a TIM barrel. Regulation of ÉÇ-glucuronidase activity may play a role in tumorigenesis and the invasiveness of a number of cancers, and is also an important factor in the development of functional prodrugs that require the cleavage of an active cytostatic by endogenous enzymes for antitumor activity.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
GUSB protein structure - BS7876 shown in red.