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- Antibody Data
- Antigen structure
- References [15]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 14743-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14743-1-AP, RRID:AB_2230800
- Product name
- DRG2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated DRG2 antibody (Cat. #14743-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Role of endosomal RANKL-LGR4 signaling during osteoclast differentiation.
DRG2 levels in prostate cancer cell lines predict response to PARP inhibitor during docetaxel treatment.
Elevated reactive oxygen species can drive the alternative lengthening of telomeres pathway in ATRX-null cancers.
Rewiring protein binding specificity in paralogous DRG/DFRP complexes.
DRG2 is required for surface localization of PD-L1 and the efficacy of anti-PD-1 therapy.
DRG2 in macrophages is crucial for initial inflammatory response and protection against Listeria monocytogenes infection.
DRG2 Depletion Promotes Endothelial Cell Senescence and Vascular Endothelial Dysfunction.
Global analyses of mRNA expression in human sensory neurons reveal eIF5A as a conserved target for inflammatory pain.
DRG2 Accelerates Senescence via Negative Regulation of SIRT1 in Human Diploid Fibroblasts.
Developmentally regulated GTP-binding protein 2 levels in prostate cancer cell lines impact docetaxel-induced apoptosis.
Translatome and Transcriptome Profiling of Hypoxic-Induced Rat Cardiomyocytes.
The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases.
DRG2 Deficiency Causes Impaired Microtubule Dynamics in HeLa Cells.
Developmentally regulated GTP-binding protein 2 depletion leads to mitochondrial dysfunction through downregulation of dynamin-related protein 1.
RWDD1 interacts with the ligand binding domain of the androgen receptor and acts as a coactivator of androgen-dependent transactivation.
Kim BC, Cho YJ, Jang Y, Ko KY, Lee CM, Lim W
Journal of molecular medicine (Berlin, Germany) 2025 Mar;103(3):339-354
Journal of molecular medicine (Berlin, Germany) 2025 Mar;103(3):339-354
DRG2 levels in prostate cancer cell lines predict response to PARP inhibitor during docetaxel treatment.
Lee JM, Lee WH, Cho SH, Park JW, Kwon HN, Kim JH, Lee SH, Yoon JH, Park S, Kim SC
Investigative and clinical urology 2025 Jan;66(1):56-66
Investigative and clinical urology 2025 Jan;66(1):56-66
Elevated reactive oxygen species can drive the alternative lengthening of telomeres pathway in ATRX-null cancers.
Goncalves T, Cunniffe S, Ma TS, Mattis N, Rose AW, Kent T, Mole DR, Geiller HEB, van Bijsterveldt L, Humphrey TC, Hammond EM, Gibbons RJ, Clynes D, Rose AM
Nucleic acids research 2025 Feb 8;53(4)
Nucleic acids research 2025 Feb 8;53(4)
Rewiring protein binding specificity in paralogous DRG/DFRP complexes.
Westrip CAE, Smerdon SJ, Coleman ML
Structure (London, England : 1993) 2024 Nov 7;32(11):2049-2062.e4
Structure (London, England : 1993) 2024 Nov 7;32(11):2049-2062.e4
DRG2 is required for surface localization of PD-L1 and the efficacy of anti-PD-1 therapy.
Choi SH, Mani M, Kim J, Cho WJ, Martin TFJ, Kim JH, Chu HS, Jeong WJ, Won YW, Lee BJ, Ahn B, Kim J, Jeon DY, Park JW
Cell death discovery 2024 May 27;10(1):260
Cell death discovery 2024 May 27;10(1):260
DRG2 in macrophages is crucial for initial inflammatory response and protection against Listeria monocytogenes infection.
Lee UH, Park SJ, Ju SA, Lee SC, Kim BS, Ahn B, Yi J, Park J, Won YW, Han IS, Lee BJ, Cho WJ, Park JW
Clinical immunology (Orlando, Fla.) 2023 Dec;257:109819
Clinical immunology (Orlando, Fla.) 2023 Dec;257:109819
DRG2 Depletion Promotes Endothelial Cell Senescence and Vascular Endothelial Dysfunction.
Le AN, Park SS, Le MX, Lee UH, Ko BK, Lim HR, Yu R, Choi SH, Lee BJ, Ham SY, Ha CM, Park JW
International journal of molecular sciences 2022 Mar 6;23(5)
International journal of molecular sciences 2022 Mar 6;23(5)
Global analyses of mRNA expression in human sensory neurons reveal eIF5A as a conserved target for inflammatory pain.
Chase R, de la Peña JB, Smith PR, Lawson J, Lou TF, Stanowick AD, Black BJ, Campbell ZT
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jul;36(7):e22422
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jul;36(7):e22422
DRG2 Accelerates Senescence via Negative Regulation of SIRT1 in Human Diploid Fibroblasts.
Li BS, Jin AL, Zhou Z, Seo JH, Choi BM
Oxidative medicine and cellular longevity 2021;2021:7301373
Oxidative medicine and cellular longevity 2021;2021:7301373
Developmentally regulated GTP-binding protein 2 levels in prostate cancer cell lines impact docetaxel-induced apoptosis.
Kim SC, Lee WH, Kim SH, Abdulkhayevich AA, Park JW, Kim YM, Moon KH, Lee SH, Park S
Investigative and clinical urology 2021 Jul;62(4):485-495
Investigative and clinical urology 2021 Jul;62(4):485-495
Translatome and Transcriptome Profiling of Hypoxic-Induced Rat Cardiomyocytes.
Shen Z, Zeng L, Zhang Z
Molecular therapy. Nucleic acids 2020 Dec 4;22:1016-1024
Molecular therapy. Nucleic acids 2020 Dec 4;22:1016-1024
The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases.
Markolovic S, Zhuang Q, Wilkins SE, Eaton CD, Abboud MI, Katz MJ, McNeil HE, Leśniak RK, Hall C, Struwe WB, Konietzny R, Davis S, Yang M, Ge W, Benesch JLP, Kessler BM, Ratcliffe PJ, Cockman ME, Fischer R, Wappner P, Chowdhury R, Coleman ML, Schofield CJ
Nature chemical biology 2018 Jul;14(7):688-695
Nature chemical biology 2018 Jul;14(7):688-695
DRG2 Deficiency Causes Impaired Microtubule Dynamics in HeLa Cells.
Dang T, Jang SH, Back SH, Park JW, Han IS
Molecules and cells 2018 Dec 31;41(12):1045-1051
Molecules and cells 2018 Dec 31;41(12):1045-1051
Developmentally regulated GTP-binding protein 2 depletion leads to mitochondrial dysfunction through downregulation of dynamin-related protein 1.
Vo MT, Ko MS, Lee UH, Yoon EH, Lee BJ, Cho WJ, Ha CM, Kim K, Park JW
Biochemical and biophysical research communications 2017 May 13;486(4):1014-1020
Biochemical and biophysical research communications 2017 May 13;486(4):1014-1020
RWDD1 interacts with the ligand binding domain of the androgen receptor and acts as a coactivator of androgen-dependent transactivation.
Grötsch H, Kunert M, Mooslehner KA, Gao Z, Struve D, Hughes IA, Hiort O, Werner R
Molecular and cellular endocrinology 2012 Jul 6;358(1):53-62
Molecular and cellular endocrinology 2012 Jul 6;358(1):53-62
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 14743-1-AP(DRG2 antibody) at dilution of 1:2500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using DRG2 antibody 14743-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 14743-1-AP(DRG2 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 14743-1-AP(DRG2 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
