P2RX3

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage. [provided by RefSeq, Jul 2008]

Description

purinergic receptor P2X, ligand gated ion channel, 3

Protein family

Mapped to UniProt SWISS-PROT, Predicted membrane proteins, Transporters

Chromosome

11:q12.1 (57338374 - 57370600)

Ensembl ID

ENSG00000109991  (ver. 84.38)

Orthologs

Mouse P2rx3: ENSMUSG00000027071

UniProt

P56373

neXtProt

NX_P56373

Human splice variants
Mouse splice variants