orb1951620

antibody from Biorbyt

Targeting: DAXX DAP6

Western blot

Immunocytochemistry

Immunohistochemistry

Flow cytometry

Antibody data

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Validation data

Product number: orb1951620 - Provider product page
Provider: Biorbyt
Product name: Daxx Rabbit mAb [KD Validated]
Antibody type: Recombinant
Description: Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Vial size: 50 ul
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

DAXX protein structure - orb1951620 shown in red.