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- Antibody Data
- Antigen structure
- References [10]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 12735-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12735-1-AP, RRID:AB_2175788
- Product name
- RabGEF1 antibody
- Antibody type
- Polyclonal
- Description
- RabGEF1 antibody (Cat. #12735-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Osimertinib activates a TGF-β2-dependent secretory program that drives lung adenocarcinoma progression.
Rab21 recruits EEA1 and competes with Rab5 for Rabex-5 activation.
ATP7A Maintains Bactericidal Function of Neutrophils and Macrophages via Regulating the Formation and Activation of Phagolysosomes.
Loss of Diphthamide Increases DNA Replication Stress in Mammalian Cells by Modulating the Translation of RRM1.
ATP6V0A1-dependent cholesterol absorption in colorectal cancer cells triggers immunosuppressive signaling to inactivate memory CD8(+) T cells.
Vps9d1 regulates tubular endosome formation through specific activation of Rab22A.
LncRNA TM1-3P Regulates Proliferation, Apoptosis and Inflammation of Fibroblasts in Osteoarthritis through miR-144-3p/ONECUT2 Axis.
RabGEF1 functions as an oncogene in U251 glioblastoma cells and is involved in regulating AKT and Erk pathways.
Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease.
AP-1/σ1A and AP-1/σ1B adaptor-proteins differentially regulate neuronal early endosome maturation via the Rab5/Vps34-pathway.
Ghosh M, Wu C, Kumar A, Nilsson M, Heymach JV, Zhao W, Yu J, Liu X, Ding N, Wang S, Xiao GY, Chen A, Grimley K, Russell WK, Creighton CJ, Tan X, Kurie JM
The Journal of clinical investigation 2026 Feb 2;136(3)
The Journal of clinical investigation 2026 Feb 2;136(3)
Rab21 recruits EEA1 and competes with Rab5 for Rabex-5 activation.
Yanguas F, Progida C
Frontiers in cell and developmental biology 2025;13:1588308
Frontiers in cell and developmental biology 2025;13:1588308
ATP7A Maintains Bactericidal Function of Neutrophils and Macrophages via Regulating the Formation and Activation of Phagolysosomes.
Jing Y, Shi J, Xie Z, Shen Z, Zhang J, Wang F, Li K, Su J, Liu JX
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 15;39(11):e70661
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 15;39(11):e70661
Loss of Diphthamide Increases DNA Replication Stress in Mammalian Cells by Modulating the Translation of RRM1.
Zhao J, Ahn B, Lin H
ACS central science 2024 Oct 23;10(10):1835-1847
ACS central science 2024 Oct 23;10(10):1835-1847
ATP6V0A1-dependent cholesterol absorption in colorectal cancer cells triggers immunosuppressive signaling to inactivate memory CD8(+) T cells.
Huang TX, Huang HS, Dong SW, Chen JY, Zhang B, Li HH, Zhang TT, Xie Q, Long QY, Yang Y, Huang LY, Zhao P, Bi J, Lu XF, Pan F, Zou C, Fu L
Nature communications 2024 Jul 6;15(1):5680
Nature communications 2024 Jul 6;15(1):5680
Vps9d1 regulates tubular endosome formation through specific activation of Rab22A.
Nakashima S, Matsui T, Fukuda M
Journal of cell science 2023 Mar 15;136(6)
Journal of cell science 2023 Mar 15;136(6)
LncRNA TM1-3P Regulates Proliferation, Apoptosis and Inflammation of Fibroblasts in Osteoarthritis through miR-144-3p/ONECUT2 Axis.
Yi Y, Yang N, Yang Z, Tao X, Li Y
Orthopaedic surgery 2022 Nov;14(11):3078-3091
Orthopaedic surgery 2022 Nov;14(11):3078-3091
RabGEF1 functions as an oncogene in U251 glioblastoma cells and is involved in regulating AKT and Erk pathways.
Fan H, Xin T, Dong X, Yang F, Zhang R, Feng S, He D, Guo H, Pang Q
Experimental and molecular pathology 2021 Feb;118:104571
Experimental and molecular pathology 2021 Feb;118:104571
Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease.
Pensalfini A, Kim S, Subbanna S, Bleiwas C, Goulbourne CN, Stavrides PH, Jiang Y, Lee JH, Darji S, Pawlik M, Huo C, Peddy J, Berg MJ, Smiley JF, Basavarajappa BS, Nixon RA
Cell reports 2020 Nov 24;33(8):108420
Cell reports 2020 Nov 24;33(8):108420
AP-1/σ1A and AP-1/σ1B adaptor-proteins differentially regulate neuronal early endosome maturation via the Rab5/Vps34-pathway.
Candiello E, Kratzke M, Wenzel D, Cassel D, Schu P
Scientific reports 2016 Jul 14;6:29950
Scientific reports 2016 Jul 14;6:29950
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- PC-3 cells were subjected to SDS PAGE followed by western blot with 12735-1-AP(RABGEF1 antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The RABGEF1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human RABGEF1. This antibody recognizes human, mouse, rat antigen. The RABGEF1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
