BS8227

antibody from Bioworld Technology, Inc
Targeting: SPAG5 DEEPEST, hMAP126, MAP126
Provider product page for BS8227
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS8227 - Provider product page
Provider
Bioworld Technology, Inc
Product name
SPAG5 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human SPAG5.
Description
SPAG5 (sperm associated antigen 5), also known as MAP126, hMAP126, DEEPEST or Astrin, is a 1,193 amino acid protein that is expressed at high levels in testis and at lower levels in liver, placenta, pancreas, colon and thymus. Localized specifically to spindle poles during prophase and throughout the spindle during metaphase and anaphase, SPAG5 is essential for proper spindle formation and is thought to be involved in the dynamic and functional regulation of mitotic spindles. Additionally, SPAG5 plays a role in sister chromatid cohesion and subsequent chromatid separation and, via its association with chromatids, is an important regulator of chromosome integrity. SPAG5 has a long stalk and a globular head domain through which if forms a homodimer that is characterized by aster-like structures. Upon DNA damage, SPAG5 may be phosphorylated by ATR or ATM.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
SPAG5 protein structure - BS8227 shown in red.