BS8377

antibody from Bioworld Technology, Inc

Targeting: RAE1 Gle2, Mnrp41

Immunocytochemistry

Immunohistochemistry

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Validation data

Product number: BS8377 - Provider product page
Provider: Bioworld Technology, Inc
Product name: RAE1 polyclonal antibody
Antibody type: Polyclonal
Antigen: Recombinant full length Human RAE1.
Description: Natural killer (NK) cells attack tumor and infected cells, but the receptors and ligands that stimulate them are poorly understood. Two murine ligands for the lectin-like receptor NKG2D, H60 and retinoic acid early inducible (Rae- 1Ï«, ÉÇ, ÎÛ, Ñ´ and ÷), are distant relatives of major histocompatibility complex class I molecules. These molecules are encoded by Rae-1 and H60 minor histocompatibility antigen genes on mouse chromosome 10 and show weak homology with MHC class I. Expression of the NKG2D ligands is low or absent on normal, adult tissues; however, they are constitutively expressed on some tumors and upregulated by retinoic acid. Ectopic expression of Rae-1 and H60 confers target susceptibility to NK cell attack. NKG2D binds to H60 with approximately 25-fold higher affinity than to Rae-1. Rae-1 and H60 compete directly for occupancy of NKG2D; therefore, NKG2D can be occupied by only one ligand at a time. Additionally, Rae-1 and H60 ligands of the NKG2D receptor stimulate tumor immunity.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

RAE1 protein structure - BS8377 shown in red.